Motif ID: NKX2-1,4.p2

Z-value: 1.222


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-1chr14_-_369889020.332.2e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_12058963 4.331 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_-_154563735 4.007 NM_001289
CLIC2
chloride intracellular channel 2
chr21_-_15918635 3.648 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chrX_+_78200828 3.227 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr11_+_60223281 2.493 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr17_-_29641087 2.278 EVI2B
ecotropic viral integration site 2B
chr1_+_212475147 2.276 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chrX_+_48542159 2.200 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_29641094 2.049 NM_006495
EVI2B
ecotropic viral integration site 2B
chr3_-_141747434 1.635 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr15_-_55562483 1.625 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr5_-_88119604 1.611 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chrX_-_137821514 1.402 NM_033642
FGF13
fibroblast growth factor 13
chr2_-_89165652 1.386


chr15_-_55563091 1.371 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chrX_+_49160124 1.144 NM_001098413
GAGE10
G antigen 10
chr10_-_11574273 1.143 NM_001080491
USP6NL
USP6 N-terminal like
chr2_+_33701320 1.132 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_+_143886898 1.128 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr19_-_6670598 1.049 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr1_-_160681552 1.027 NM_001778
CD48
CD48 molecule
chr11_+_22689653 1.000 NM_177553
GAS2
growth arrest-specific 2
chr5_-_98262217 0.978 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr1_+_32716839 0.968 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_+_49363615 0.953 NM_001040663
NM_001468
GAGE1

G antigen 1

chr6_+_101846668 0.937 GRIK2
glutamate receptor, ionotropic, kainate 2
chr2_+_143886969 0.924 ARHGAP15
Rho GTPase activating protein 15
chr12_-_53600999 0.923 NM_000889
ITGB7
integrin, beta 7
chr7_+_120629444 0.922 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chrX_+_49178508 0.912 NM_001098406
GAGE1
GAGE4
GAGE5
GAGE6
GAGE12J
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 12J
chr7_-_7758237 0.898 NM_002947
RPA3
replication protein A3, 14kDa
chr1_+_198608136 0.894 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr9_+_131445933 0.813 NM_001122821
SET
SET nuclear oncogene
chr14_-_95599794 0.773 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_+_161632904 0.760 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chrX_+_49197555 0.749 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE12J
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 12J
G antigen 2D
G antigen 2A
chr3_-_119278402 0.743 NM_005191
CD80
CD80 molecule
chr5_-_176836488 0.741 F12
coagulation factor XII (Hageman factor)
chr16_+_28943259 0.734 NM_001178098
NM_001770
CD19

CD19 molecule

chr12_-_53601051 0.729 ITGB7
integrin, beta 7
chrX_+_49226137 0.725 NM_001472
NM_001098407
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr17_-_29641068 0.720 EVI2B
ecotropic viral integration site 2B
chrX_+_49325433 0.708 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr14_+_64682671 0.706 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chrX_+_49334991 0.701 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr12_-_102591547 0.686 NM_002674
PMCH
pro-melanin-concentrating hormone
chr17_+_67498391 0.678 MAP2K6
mitogen-activated protein kinase kinase 6
chr18_-_60986508 0.667 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr21_+_38792600 0.648 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr1_-_25256364 0.643 RUNX3
runt-related transcription factor 3
chr4_-_176733413 0.630 GPM6A
glycoprotein M6A
chr14_+_75988765 0.628 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr5_+_156820161 0.624 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_105954008 0.614 NM_024093
C2orf49
chromosome 2 open reading frame 49
chrX_+_49207115 0.595 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr2_+_162272619 0.592 NM_006593
TBR1
T-box, brain, 1
chr1_+_161551128 0.579 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chrX_+_70765479 0.576 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr9_+_131446105 0.556 SET
SET nuclear oncogene
chrX_+_49216616 0.553 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr18_-_46469118 0.552 NM_001190823
SMAD7
SMAD family member 7
chr19_-_55668956 0.550 NM_000363
TNNI3
troponin I type 3 (cardiac)
chrX_-_33229428 0.549 NM_004006
DMD
dystrophin
chr12_+_25205488 0.540 LRMP
lymphoid-restricted membrane protein
chr19_-_55767103 0.534 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr1_+_198608244 0.531 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_-_110655384 0.526 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr5_-_88199868 0.512 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr4_+_102734982 0.499 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr7_-_16505292 0.498 NM_015464
SOSTDC1
sclerostin domain containing 1
chrX_-_131573638 0.474 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr21_-_46348633 0.463 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_-_7848324 0.455 NM_020634
GDF3
growth differentiation factor 3
chr7_+_129847699 0.447 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr4_+_15779887 0.443 NM_001775
CD38
CD38 molecule
chr7_-_104909442 0.428 NM_182691
SRPK2
SRSF protein kinase 2
chrX_+_49354117 0.405 NM_001127212
GAGE1
GAGE2C
GAGE2A
G antigen 1
G antigen 2C
G antigen 2A
chr19_-_11688508 0.401 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_41703938 0.400 NM_001167827
TFEB
transcription factor EB
chr10_+_112344076 0.392 SMC3
structural maintenance of chromosomes 3
chrX_+_30261847 0.385 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr15_+_81517639 0.378 NM_172217
IL16
interleukin 16
chr11_-_128457452 0.378 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chrX_-_48216100 0.375 NM_021014
NM_175711
SSX3

synovial sarcoma, X breakpoint 3

chr20_-_34243118 0.374 RBM12
RNA binding motif protein 12
chr1_-_247054277 0.373 AHCTF1
AT hook containing transcription factor 1
chr16_+_31539202 0.369 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr2_-_170430312 0.362 NM_024622
FASTKD1
FAST kinase domains 1
chr9_-_124984018 0.358 NM_001242335
LHX6
LIM homeobox 6
chr1_-_144994839 0.357 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_9129620 0.348 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr14_+_75988838 0.345 BATF
basic leucine zipper transcription factor, ATF-like
chr8_-_30706532 0.342 NM_031271
TEX15
testis expressed 15
chr2_+_103035148 0.341 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_-_231560789 0.341 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chrX_+_129139163 0.336 NM_021946
BCORL1
BCL6 corepressor-like 1
chr4_-_123542165 0.327 NM_001207006
NM_021803
IL21

interleukin 21

chr1_+_41204509 0.323 NFYC
nuclear transcription factor Y, gamma
chr5_+_140235594 0.321 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr7_-_37024664 0.318 NM_001039459
ELMO1
engulfment and cell motility 1
chr6_+_152011630 0.313 NM_001122742
ESR1
estrogen receptor 1
chr6_+_5261212 0.311 FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr6_-_32160289 0.307 GPSM3
G-protein signaling modulator 3
chr2_-_179315756 0.306 NM_003690
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr5_-_142815076 0.303 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr1_-_41625539 0.302 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_-_108231122 0.302 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_100316530 0.296 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr10_+_11047274 0.294 CELF2
CUGBP, Elav-like family member 2
chr7_+_28725597 0.291 NM_001011666
CREB5
cAMP responsive element binding protein 5
chrX_-_72434667 0.291 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr12_+_56414688 0.289 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_9129666 0.288 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr10_+_114135013 0.286 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_217250230 0.285 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr1_-_26393984 0.285 NM_032588
TRIM63
tripartite motif containing 63
chr10_+_35484054 0.278 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chrX_+_64708614 0.276 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr17_-_3461030 0.276 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr13_+_34392254 0.275 RFC3
replication factor C (activator 1) 3, 38kDa
chr2_-_175462428 0.274 WIPF1
WAS/WASL interacting protein family, member 1
chr18_+_21032786 0.270 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr17_+_7905911 0.269 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr3_+_142342265 0.263 NM_002670
PLS1
plastin 1
chr19_+_34663311 0.262 NM_001114093
NM_015578
LSM14A

LSM14A, SCD6 homolog A (S. cerevisiae)

chr1_+_174933904 0.259 NM_001243764
RABGAP1L
RAB GTPase activating protein 1-like
chr2_-_74382352 0.258


chr8_+_124194751 0.257 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr1_-_151431648 0.256 POGZ
pogo transposable element with ZNF domain
chr11_-_102826433 0.255 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr4_-_73434467 0.247 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr12_+_113416267 0.247 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr11_+_118958696 0.243 NM_001024382
HMBS
hydroxymethylbilane synthase
chrX_-_124097601 0.243 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chrX_-_72434656 0.241 NAP1L2
nucleosome assembly protein 1-like 2
chr15_+_81489218 0.240 NM_001172128
IL16
interleukin 16
chrX_+_48542193 0.239 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_-_58882274 0.238 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_-_72434623 0.238 NAP1L2
nucleosome assembly protein 1-like 2
chr17_-_53800074 0.235 NM_018286
TMEM100
transmembrane protein 100
chr7_-_1595746 0.233 NM_001097620
TMEM184A
transmembrane protein 184A
chr3_-_57234279 0.230 NM_003865
HESX1
HESX homeobox 1
chr19_-_10291056 0.224


chr18_-_3011944 0.224 NM_014646
LPIN2
lipin 2
chr19_-_6670078 0.220 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr4_+_114214102 0.218 ANK2
ankyrin 2, neuronal
chr4_+_110834039 0.215 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr19_-_11688441 0.215 ACP5
acid phosphatase 5, tartrate resistant
chr10_+_18629613 0.214 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr4_+_22694547 0.213 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr17_-_39222126 0.213 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr17_-_35656691 0.210 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr12_+_12878718 0.203 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr5_-_94417185 0.202 MCTP1
multiple C2 domains, transmembrane 1
chr1_-_226926875 0.201 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr5_-_148016576 0.199 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr10_-_104211244 0.199 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr11_+_117947726 0.196 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr10_+_70980058 0.194 NM_025130
HKDC1
hexokinase domain containing 1
chr2_+_28616360 0.193 FOSL2
FOS-like antigen 2
chr2_+_105953815 0.186 C2orf49
chromosome 2 open reading frame 49
chr2_-_96956458 0.186 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr16_-_68057769 0.185 NM_018380
DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr15_-_25650647 0.185 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr10_+_69869249 0.181 NM_032578
MYPN
myopalladin
chr3_-_47621729 0.181 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr1_-_203320287 0.180 NM_002023
FMOD
fibromodulin
chrX_-_108725284 0.177 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr2_-_191184770 0.171 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr7_-_107443631 0.168 NM_000111
SLC26A3
solute carrier family 26, member 3
chr16_+_3062456 0.164 NM_020982
CLDN9
claudin 9
chr5_+_161494647 0.164 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chrX_-_109683457 0.159 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_+_152126807 0.154 NM_001122741
ESR1
estrogen receptor 1
chr13_-_75901897 0.154 TBC1D4
TBC1 domain family, member 4
chr6_+_45296053 0.151 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr6_-_32076997 0.151 NM_019105
TNXB
tenascin XB
chr20_+_2276612 0.149 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_+_45478420 0.149 UROD
uroporphyrinogen decarboxylase
chr6_-_155777036 0.149 NM_015718
NOX3
NADPH oxidase 3
chr10_-_65225605 0.148 NM_032776
JMJD1C
jumonji domain containing 1C
chr12_+_50869531 0.146 LARP4
La ribonucleoprotein domain family, member 4
chr7_+_39017608 0.142 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr1_+_153232178 0.142 NM_000427
LOR
loricrin
chr4_-_76928601 0.142 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chrX_+_49091926 0.141 NM_014008
CCDC22
coiled-coil domain containing 22
chr1_-_160549226 0.141 CD84
CD84 molecule
chr5_-_160279045 0.140 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_+_50571963 0.140 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr10_-_116527955 0.138 ABLIM1
actin binding LIM protein 1
chr19_+_45452427 0.136 APOC2
apolipoprotein C-II
chrX_-_70474402 0.135 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chrX_+_49091931 0.133 CCDC22
coiled-coil domain containing 22
chr15_+_80364902 0.133 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr1_-_42801529 0.129 NM_001198850
FOXJ3
forkhead box J3
chr7_-_96339074 0.127 SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr1_-_160492982 0.127 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr4_-_123377471 0.125 NM_000586
IL2
interleukin 2
chr3_-_187009469 0.125 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chrX_-_101112548 0.123 NM_032946
NXF5
nuclear RNA export factor 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
18.98 4.62e-05 GO:0045321 leukocyte activation
19.75 4.34e-04 GO:0046649 lymphocyte activation
9.52 2.57e-03 GO:0001775 cell activation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
6.42 8.05e-04 GO:0030234 enzyme regulator activity
11.38 5.96e-03 GO:0005083 small GTPase regulator activity