Motif ID: NKX2-2,8.p2

Z-value: 0.912


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8chr14_-_37051785-0.175.2e-01Click!
NKX2-2chr20_-_214946630.048.8e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_121379757 5.139 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_121379701 4.913 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_33661392 2.625 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_29641094 2.513 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_29641087 2.316 EVI2B
ecotropic viral integration site 2B
chr17_-_29641068 2.153 EVI2B
ecotropic viral integration site 2B
chr19_+_49838700 1.999 CD37
CD37 molecule
chr4_-_71532206 1.984 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr19_+_49838673 1.961 NM_001040031
NM_001774
CD37

CD37 molecule

chr4_-_71532341 1.787 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr12_+_25205488 1.599 LRMP
lymphoid-restricted membrane protein
chr19_+_49838646 1.581 CD37
CD37 molecule
chr17_-_38721701 1.566 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr21_-_15918635 1.561 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_+_198608136 1.498 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr9_+_100263461 1.489 NM_001166116
TMOD1
tropomodulin 1
chr19_+_49838734 1.406 CD37
CD37 molecule
chr1_+_198608216 1.349 PTPRC
protein tyrosine phosphatase, receptor type, C
chr22_+_22723972 1.332


chr12_-_102591547 1.309 NM_002674
PMCH
pro-melanin-concentrating hormone
chr13_-_46756326 1.306 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_25205180 1.225 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chrX_-_154563735 1.099 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_198608244 1.045 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_102953716 1.041 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr2_+_143886898 1.016 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr13_-_41556188 0.965 ELF1
E74-like factor 1 (ets domain transcription factor)
chr15_-_55563091 0.962 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr1_-_23886284 0.944 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr22_+_40322609 0.937 GRAP2
GRB2-related adaptor protein 2
chr1_-_207095198 0.924 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_-_153273683 0.869 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr4_+_87928083 0.860 NM_005935
AFF1
AF4/FMR2 family, member 1
chr3_+_152017193 0.845 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr7_-_120498128 0.793 NM_012338
TSPAN12
tetraspanin 12
chr5_+_156820161 0.782 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr11_+_22689653 0.739 NM_177553
GAS2
growth arrest-specific 2
chr10_+_97515408 0.710 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_111415721 0.698 NM_000560
CD53
CD53 molecule
chr17_+_67498391 0.669 MAP2K6
mitogen-activated protein kinase kinase 6
chr3_+_63953419 0.667 NM_001128149
ATXN7
ataxin 7
chr18_+_29671817 0.663 NM_016271
RNF138
ring finger protein 138
chrX_-_70474402 0.643 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr18_+_32558207 0.643 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr4_-_84035908 0.629 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chrX_-_118726852 0.618 NM_001173488
NKRF
NFKB repressing factor
chrX_+_11777734 0.617 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr2_-_158300517 0.613 NM_004288
CYTIP
cytohesin 1 interacting protein
chr14_-_106471439 0.599 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_23284565 0.595 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr14_+_65877309 0.594 NM_004480
NM_178155
NM_178156
FUT8


fucosyltransferase 8 (alpha (1,6) fucosyltransferase)


chr14_-_23284617 0.591 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr22_+_40297085 0.567 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr10_+_35456443 0.564 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr4_-_84035888 0.556 PLAC8
placenta-specific 8
chr2_+_143886969 0.553 ARHGAP15
Rho GTPase activating protein 15
chr1_-_226926875 0.528 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chrX_+_108779009 0.515 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chrX_-_70331297 0.514 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr3_+_88188261 0.514 NM_018293
ZNF654
zinc finger protein 654
chr10_-_121296044 0.512 NM_002925
RGS10
regulator of G-protein signaling 10
chr22_+_40297183 0.503 GRAP2
GRB2-related adaptor protein 2
chr1_-_202129705 0.493 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr8_-_80993009 0.489 NM_001025252
TPD52
tumor protein D52
chr1_+_111415791 0.484 CD53
CD53 molecule
chr10_+_35484054 0.482 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_+_241695433 0.477 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr5_-_88119604 0.475 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr14_+_67831484 0.473 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_-_163113129 0.472 RGS5
regulator of G-protein signaling 5
chr11_+_33563772 0.471 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr1_+_66458389 0.456 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_+_100326765 0.446 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr17_-_67138013 0.445 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_+_167298280 0.440 NM_001198783
POU2F1
POU class 2 homeobox 1
chr14_+_21249209 0.439 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr6_-_32163299 0.439 NM_022107
GPSM3
G-protein signaling modulator 3
chr11_+_94277005 0.439 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr2_-_191872322 0.436 STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_-_98262217 0.425 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr13_+_58205788 0.424 NM_001040429
PCDH17
protocadherin 17
chr1_+_212475147 0.420 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_-_51887740 0.419 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr21_+_42733916 0.417 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_174844655 0.410 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr6_+_16143281 0.406 MYLIP
myosin regulatory light chain interacting protein
chr7_-_37024664 0.405 NM_001039459
ELMO1
engulfment and cell motility 1
chr7_+_115863004 0.404 NM_152829
TES
testis derived transcript (3 LIM domains)
chr1_-_111743261 0.403 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr4_-_36245893 0.396 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_58273651 0.395 NM_001130480
NM_001130482
NM_001130483
NM_006296
NM_001130481
VRK2




vaccinia related kinase 2




chr11_-_47510518 0.381 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr4_-_140060601 0.376 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr2_-_225378320 0.371 CUL3
cullin 3
chr5_+_115898218 0.368


chr3_+_119316694 0.367 NM_001206960
NM_001206961
NM_015900
PLA1A


phospholipase A1 member A


chrX_+_99839789 0.363 NM_022144
TNMD
tenomodulin
chr12_+_69004614 0.360 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr14_+_88471467 0.356 NM_003608
GPR65
G protein-coupled receptor 65
chr14_-_100841793 0.355 WARS
tryptophanyl-tRNA synthetase
chrX_-_30595883 0.352 NM_025159
CXorf21
chromosome X open reading frame 21
chr9_-_20622476 0.351 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr16_-_1821503 0.351 NME3
non-metastatic cells 3, protein expressed in
chr12_-_772525 0.346 NM_016533
NINJ2
ninjurin 2
chr14_-_20801427 0.346 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr4_-_103245468 0.344 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr5_+_102465256 0.342 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr3_-_33700480 0.334 CLASP2
cytoplasmic linker associated protein 2
chr2_+_85804613 0.334 NM_003761
VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr5_+_70944968 0.331 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr6_-_119252887 0.331 NM_017696
MCM9
minichromosome maintenance complex component 9
chr16_-_21289637 0.325 CRYM
crystallin, mu
chr10_+_91498724 0.322 KIF20B
kinesin family member 20B
chrX_-_55057408 0.321 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr1_+_168195248 0.319 NM_199344
SFT2D2
SFT2 domain containing 2
chr9_+_116263706 0.318 NM_130795
RGS3
regulator of G-protein signaling 3
chr1_-_183559463 0.313 NCF2
neutrophil cytosolic factor 2
chr1_+_15990300 0.311


chr4_-_105416050 0.308 CXXC4
CXXC finger protein 4
chr4_-_153303663 0.306 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr9_-_15510209 0.305 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr17_+_7591666 0.304 NM_001143992
NM_018081
WRAP53

WD repeat containing, antisense to TP53

chr9_-_20622433 0.302 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr8_+_17822093 0.301 PCM1
pericentriolar material 1
chr1_-_225616556 0.300 NM_194442
LBR
lamin B receptor
chr10_-_65028825 0.296 NM_004241
JMJD1C
jumonji domain containing 1C
chr3_-_56698073 0.296 NM_015224
FAM208A
family with sequence similarity 208, member A
chrX_+_107288199 0.289 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr18_-_67624159 0.286 NM_006566
CD226
CD226 molecule
chr13_-_41556360 0.281 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_48987017 0.274 LPAR6
lysophosphatidic acid receptor 6
chr10_+_57358749 0.271 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr3_-_167191808 0.271 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr6_-_55740358 0.269 NM_021073
BMP5
bone morphogenetic protein 5
chr1_+_104159953 0.269 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr1_+_168195257 0.268 SFT2D2
SFT2 domain containing 2
chr2_-_89513056 0.266 IGKC
immunoglobulin kappa constant
chr4_+_86699846 0.264 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr22_-_17690778 0.263 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr1_-_75199091 0.262 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chrX_-_32173585 0.260 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr2_+_162272619 0.258 NM_006593
TBR1
T-box, brain, 1
chr2_+_162272892 0.257 TBR1
T-box, brain, 1
chr4_+_128802064 0.257 NM_001190801
PLK4
polo-like kinase 4
chrX_+_123095598 0.257 STAG2
stromal antigen 2
chr6_+_4890225 0.256 NM_001143971
CDYL
chromodomain protein, Y-like
chrX_-_70475046 0.256 NM_001171162
ZMYM3
zinc finger, MYM-type 3
chr6_-_55740387 0.254 BMP5
bone morphogenetic protein 5
chr1_+_167298382 0.253 POU2F1
POU class 2 homeobox 1
chr2_-_215896809 0.251 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_58240746 0.250 NM_005730
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr2_-_20512016 0.249 PUM2
pumilio homolog 2 (Drosophila)
chr11_-_102496049 0.248 NM_004771
MMP20
matrix metallopeptidase 20
chr5_+_43609261 0.238 NNT
nicotinamide nucleotide transhydrogenase
chr16_-_21289571 0.236 CRYM
crystallin, mu
chr3_-_57234279 0.235 NM_003865
HESX1
HESX homeobox 1
chrX_-_70473979 0.234 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr3_+_148583042 0.233 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr9_+_19290748 0.232 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr8_+_26150731 0.232 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr12_-_54689536 0.232 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr14_-_100841926 0.231 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr8_+_22210311 0.230 PIWIL2
piwi-like 2 (Drosophila)
chr7_+_139528951 0.230 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr5_+_169780880 0.229 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr2_+_89185055 0.229


chr5_-_150521200 0.228 NM_001193544
ANXA6
annexin A6
chrX_+_49091926 0.228 NM_014008
CCDC22
coiled-coil domain containing 22
chr1_-_111743297 0.223 DENND2D
DENN/MADD domain containing 2D
chr12_-_58240493 0.222 CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr3_+_39509069 0.222 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr1_-_26393984 0.221 NM_032588
TRIM63
tripartite motif containing 63
chr17_+_25958151 0.221 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr17_-_38859976 0.218 NM_019016
KRT24
keratin 24
chr8_+_107738239 0.217 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_-_246670518 0.216 SMYD3
SET and MYND domain containing 3
chr2_-_75937993 0.213 NM_001201335
NM_003203
GCFC2

GC-rich sequence DNA-binding factor 2

chr4_-_151770611 0.213 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr2_-_99279935 0.212 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr18_-_3845295 0.212 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr11_+_22696318 0.211 NM_005256
GAS2
growth arrest-specific 2
chr1_+_244214576 0.209 ZNF238
zinc finger protein 238
chr5_+_162930230 0.209 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr12_-_10021932 0.208 CLEC2B
C-type lectin domain family 2, member B
chr13_+_111855406 0.207 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr8_+_17829848 0.205 PCM1
pericentriolar material 1
chr1_-_41627045 0.205 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr16_-_46782104 0.204 NM_182493
MYLK3
myosin light chain kinase 3
chr1_+_151032683 0.203 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_+_162272800 0.202 TBR1
T-box, brain, 1
chr6_+_96025343 0.201 NM_024641
MANEA
mannosidase, endo-alpha
chr14_-_23285011 0.200 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_+_244214552 0.199 NM_205768
ZNF238
zinc finger protein 238
chr6_-_46922533 0.198 NM_015234
GPR116
G protein-coupled receptor 116
chr7_+_102715580 0.198 ARMC10
armadillo repeat containing 10
chr2_-_142889269 0.196 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr21_-_43816123 0.196 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr4_+_114214102 0.196 ANK2
ankyrin 2, neuronal
chr22_-_24096551 0.194 NM_013378
VPREB3
pre-B lymphocyte 3
chr7_-_115670828 0.191 NM_001018058
NM_012252
TFEC

transcription factor EC


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.