Motif ID: NKX3-2.p2

Z-value: 1.456


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2chr4_-_135460370.146.0e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_32497925 2.575 NM_002125
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr14_-_107179043 2.374 IGHA1
immunoglobulin heavy constant alpha 1
chr5_-_149792370 2.336 NM_001025158
NM_001025159
NM_004355
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr17_-_38721701 2.058 NM_001838
 CCR7
chemokine (C-C motif) receptor 7
chr14_-_106471439 1.844 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr5_+_118604504 1.825 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_118604417 1.653 NM_001077654
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr10_-_98031154 1.651 NM_001114094
NM_013314
 BLNK

B-cell linker

chr11_-_111249902 1.552 POU2AF1
POU class 2 associating factor 1
chr11_+_60223281 1.513 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_+_32407618 1.352 NM_019111
 HLA-DRA
major histocompatibility complex, class II, DR alpha
chr6_-_32557431 1.327 NM_001243965
NM_002124
 HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_-_149792276 1.300 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_41715078 1.296 NM_001166424
NM_002630
 PGC

progastricsin (pepsinogen C)

chr2_+_17721983 1.291 VSNL1
visinin-like 1
chr1_-_111743261 1.222 NM_024901
 DENND2D
DENN/MADD domain containing 2D
chr10_-_90712510 1.190 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_+_105953531 1.186 CRIP1
cysteine-rich protein 1 (intestinal)
chr8_+_123793894 1.161 NM_014943
 ZHX2
zinc fingers and homeoboxes 2
chr8_+_123793988 1.160 ZHX2
zinc fingers and homeoboxes 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
158.15 1.34e-06 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
60.86 2.21e-06 GO:0019882 antigen processing and presentation
24.07 4.28e-02 GO:0006959 humoral immune response
16.48 1.45e-02 GO:0051251 positive regulation of lymphocyte activation
15.38 1.89e-02 GO:0002696 positive regulation of leukocyte activation
15.11 2.03e-02 GO:0050867 positive regulation of cell activation
13.16 3.47e-02 GO:0051249 regulation of lymphocyte activation
11.98 4.98e-02 GO:0002694 regulation of leukocyte activation
11.85 2.12e-09 GO:0006955 immune response
7.36 5.56e-07 GO:0002376 immune system process

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
180.74 2.01e-07 GO:0042613 MHC class II protein complex
84.37 5.41e-06 GO:0042611 MHC protein complex
40.42 2.47e-03 GO:0031902 late endosome membrane
26.68 5.91e-04 GO:0005770 late endosome
20.90 1.77e-02 GO:0005765 lysosomal membrane
15.73 4.09e-02 GO:0005774 vacuolar membrane
15.11 4.60e-02 GO:0044437 vacuolar part
14.87 4.81e-02 GO:0009897 external side of plasma membrane
12.33 1.22e-02 GO:0010008 endosome membrane
12.21 1.26e-02 GO:0044440 endosomal part
11.44 1.62e-02 GO:0000323 lytic vacuole
11.44 1.62e-02 GO:0005764 lysosome
9.63 3.12e-02 GO:0005773 vacuole
8.53 1.00e-02 GO:0005768 endosome

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
Enrichment   P-value GO Accession GO Term
47.48 4.77e-04 GO:0003823 antigen binding