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Motif ID: NKX3-2.p2

Z-value: 1.456

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_-_32497925	2.575	NM_002125	HLA-DRB5	major histocompatibility complex, class II, DR beta 5
chr14_-_107179043	2.374		IGHA1	immunoglobulin heavy constant alpha 1
chr5_-_149792370	2.336	NM_001025158 NM_001025159 NM_004355	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr17_-_38721701	2.058	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr14_-_106471439	1.844		IGHA1 IGHG1 IGHM	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant mu
chr5_+_118604504	1.825		TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chr5_+_118604417	1.653	NM_001077654	TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chr10_-_98031154	1.651	NM_001114094 NM_013314	BLNK	B-cell linker
chr11_-_111249902	1.552		POU2AF1	POU class 2 associating factor 1
chr11_+_60223281	1.513	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr6_+_32407618	1.352	NM_019111	HLA-DRA	major histocompatibility complex, class II, DR alpha
chr6_-_32557431	1.327	NM_001243965 NM_002124	HLA-DRB1 HLA-DRB4 HLA-DRB5	major histocompatibility complex, class II, DR beta 1 major histocompatibility complex, class II, DR beta 4 major histocompatibility complex, class II, DR beta 5
chr5_-_149792276	1.300		CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_41715078	1.296	NM_001166424 NM_002630	PGC	progastricsin (pepsinogen C)
chr2_+_17721983	1.291		VSNL1	visinin-like 1
chr1_-_111743261	1.222	NM_024901	DENND2D	DENN/MADD domain containing 2D
chr10_-_90712510	1.190	NM_001613	ACTA2	actin, alpha 2, smooth muscle, aorta
chr14_+_105953531	1.186		CRIP1	cysteine-rich protein 1 (intestinal)
chr8_+_123793894	1.161	NM_014943	ZHX2	zinc fingers and homeoboxes 2
chr8_+_123793988	1.160		ZHX2	zinc fingers and homeoboxes 2
chr2_+_228678556	1.127	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr7_+_26403944	1.123	NM_001199838	SNX10	sorting nexin 10
chr1_-_111743297	1.055		DENND2D	DENN/MADD domain containing 2D
chr11_-_111250156	1.046	NM_006235	POU2AF1	POU class 2 associating factor 1
chr8_+_123794043	1.032		ZHX2	zinc fingers and homeoboxes 2
chr16_-_88717395	0.960	NM_000101	CYBA	cytochrome b-245, alpha polypeptide
chr3_+_121774208	0.937	NM_001206924 NM_001206925 NM_175862	CD86	CD86 molecule
chr9_+_2621740	0.897	NM_001018056 NM_003383	VLDLR	very low density lipoprotein receptor
chr13_+_31287614	0.830	NM_001204406	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr7_+_26331611	0.824		SNX10	sorting nexin 10
chr6_+_29974352	0.807		HLA-J	major histocompatibility complex, class I, J (pseudogene)
chr7_+_26331493	0.805	NM_001199835 NM_013322	SNX10	sorting nexin 10
chr22_+_22569155	0.787
chr7_+_94292816	0.781		PEG10	paternally expressed 10
chr16_-_11680756	0.779	NM_001136472 NM_001136473	LITAF	lipopolysaccharide-induced TNF factor
chr7_-_37488408	0.771		ELMO1	engulfment and cell motility 1
chr1_-_25256767	0.770	NM_004350	RUNX3	runt-related transcription factor 3
chr10_+_7745341	0.767		ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr17_-_29648631	0.757	NM_001003927 NM_014210	EVI2A	ecotropic viral integration site 2A
chr1_-_25291474	0.750	NM_001031680	RUNX3	runt-related transcription factor 3
chr2_-_238322770	0.747		COL6A3	collagen, type VI, alpha 3
chr8_-_122653493	0.739	NM_005328	HAS2	hyaluronan synthase 2
chr2_+_17721806	0.734	NM_003385	VSNL1	visinin-like 1
chr10_+_7745325	0.726		ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr19_+_50922194	0.724	NM_001243998 NM_001243999 NM_001244000 NM_003121	SPIB	Spi-B transcription factor (Spi-1/PU.1 related)
chr6_+_32605182	0.707	NM_002122	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1
chr2_-_238322840	0.704	NM_004369 NM_057164 NM_057165 NM_057166 NM_057167	COL6A3	collagen, type VI, alpha 3
chr9_+_2622052	0.703		VLDLR	very low density lipoprotein receptor
chr11_+_1889902	0.698	NM_001013253	LSP1	lymphocyte-specific protein 1
chrX_+_128913881	0.692	NM_018990	SASH3	SAM and SH3 domain containing 3
chr6_-_31324955	0.692		HLA-B	major histocompatibility complex, class I, B
chr6_-_31324898	0.692		HLA-B	major histocompatibility complex, class I, B
chr14_-_106733392	0.687		IGHG1 IGHG3	immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chrX_+_128913897	0.683		SASH3	SAM and SH3 domain containing 3
chr2_+_68592432	0.678		PLEK	pleckstrin
chr20_-_52199635	0.675	NM_006526	ZNF217	zinc finger protein 217
chr10_+_7745354	0.675		ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr16_+_57406398	0.674	NM_002996	CX3CL1	chemokine (C-X3-C motif) ligand 1
chr22_+_37257004	0.671	NM_000631 NM_013416	NCF4	neutrophil cytosolic factor 4, 40kDa
chr1_-_221915458	0.665	NM_007207 NM_144729	DUSP10	dual specificity phosphatase 10
chr5_-_42811959	0.664	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr17_-_29641094	0.657	NM_006495	EVI2B	ecotropic viral integration site 2B
chr6_-_31324975	0.657	NM_005514	HLA-B	major histocompatibility complex, class I, B
chr3_+_133495925	0.649		TF	transferrin
chrX_-_32173585	0.649	NM_004013 NM_004020 NM_004021 NM_004022 NM_004023	DMD	dystrophin
chr10_+_7745284	0.646		ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_186330711	0.646		AHSG	alpha-2-HS-glycoprotein
chr22_-_37545944	0.639	NM_000878	IL2RB	interleukin 2 receptor, beta
chr19_-_7766978	0.638	NM_001220500 NM_002002	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)
chr1_-_221915393	0.638		DUSP10	dual specificity phosphatase 10
chr17_-_29641087	0.632		EVI2B	ecotropic viral integration site 2B
chr22_+_23165273	0.622
chr6_+_29855506	0.612
chr3_+_179370779	0.610	NM_003940	USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)
chr2_+_86668488	0.609	NM_001146688	KDM3A	lysine (K)-specific demethylase 3A
chr3_-_79817058	0.608	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_32634287	0.608	NM_001243961 NM_002123	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1
chr17_-_29641068	0.607		EVI2B	ecotropic viral integration site 2B
chr12_+_100867739	0.602		NR1H4	nuclear receptor subfamily 1, group H, member 4
chr10_-_95360959	0.601	NM_006744	RBP4	retinol binding protein 4, plasma
chr3_-_55515361	0.599		WNT5A	wingless-type MMTV integration site family, member 5A
chr19_-_6720585	0.597	NM_000064	C3	complement component 3
chr3_-_81810816	0.595		GBE1	glucan (1,4-alpha-), branching enzyme 1
chr1_+_64088886	0.594	NM_001172818	PGM1	phosphoglucomutase 1
chr7_+_94292737	0.591		PEG10	paternally expressed 10
chr14_-_106539099	0.591		IGHA1 IGHG1 IGHG3	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr19_+_42381189	0.590	NM_001783 NM_021601	CD79A	CD79a molecule, immunoglobulin-associated alpha
chr3_+_186330844	0.590	NM_001622	AHSG	alpha-2-HS-glycoprotein
chr10_+_7745229	0.588	NM_002216	ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_221915426	0.585		DUSP10	dual specificity phosphatase 10
chr3_-_182880463	0.585	NM_014398	LAMP3	lysosomal-associated membrane protein 3
chr20_+_46130656	0.583		NCOA3	nuclear receptor coactivator 3
chr1_+_212738675	0.583	NM_001030287	ATF3	activating transcription factor 3
chr3_+_186330859	0.573		AHSG	alpha-2-HS-glycoprotein
chr3_-_114343791	0.569	NM_001164346	ZBTB20	zinc finger and BTB domain containing 20
chr16_+_81812925	0.568		PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr9_+_117092068	0.567	NM_000608	ORM2	orosomucoid 2
chr2_+_231729623	0.564		ITM2C	integral membrane protein 2C
chr13_+_31309644	0.563	NM_001629	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr14_-_106829736	0.561		IGHA1 IGHD IGHG3 IGHM SKAP2	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant delta immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu src kinase associated phosphoprotein 2
chr9_+_2622099	0.560		VLDLR	very low density lipoprotein receptor
chr12_+_7169192	0.555
chr2_+_102979096	0.554	NM_003855	IL18R1	interleukin 18 receptor 1
chr14_-_106494166	0.553		IGHV4-31 IGHA1	immunoglobulin heavy variable 4-31 immunoglobulin heavy constant alpha 1
chr5_-_150537306	0.551		ANXA6	annexin A6
chr1_-_156399183	0.546	NM_006365	C1orf61	chromosome 1 open reading frame 61
chr9_+_2622134	0.543		VLDLR	very low density lipoprotein receptor
chr2_-_239197091	0.534	NM_022817	PER2	period homolog 2 (Drosophila)
chr16_+_81812899	0.526		PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr2_+_86668428	0.526		KDM3A	lysine (K)-specific demethylase 3A
chr16_-_4896197	0.525		GLYR1	glyoxylate reductase 1 homolog (Arabidopsis)
chr6_-_31550065	0.524	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr7_-_37488554	0.518	NM_014800	ELMO1	engulfment and cell motility 1
chr13_-_46756326	0.515	NM_002298	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_41703938	0.513	NM_001167827	TFEB	transcription factor EB
chr4_-_110723127	0.512		CFI	complement factor I
chr14_-_106877689	0.511		IGHV4-31 IGH@ IGHA1 IGHA2 IGHG1 IGHG4 IGHM	immunoglobulin heavy variable 4-31 immunoglobulin heavy locus immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 4 (G4m marker) immunoglobulin heavy constant mu
chr1_-_25256364	0.505		RUNX3	runt-related transcription factor 3
chr5_-_150537335	0.503	NM_001155	ANXA6	annexin A6
chr3_+_53195214	0.503	NM_006254 NM_212539	PRKCD	protein kinase C, delta
chr5_+_156696351	0.503	NM_014376	CYFIP2	cytoplasmic FMR1 interacting protein 2
chr21_-_46340821	0.502		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr20_-_61557818	0.499		DIDO1	death inducer-obliterator 1
chr10_-_74856590	0.497		P4HA1	prolyl 4-hydroxylase, alpha polypeptide I
chr13_-_46756295	0.497		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_81810618	0.496		GBE1	glucan (1,4-alpha-), branching enzyme 1
chr13_+_76334796	0.495	NM_015842	LMO7	LIM domain 7
chr16_-_21289637	0.492		CRYM	crystallin, mu
chr3_+_48507209	0.488	NM_016381 NM_033629	TREX1	three prime repair exonuclease 1
chr5_-_150467220	0.488	NM_001252390	TNIP1	TNFAIP3 interacting protein 1
chr21_-_46340776	0.485		ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_127413739	0.485		GYPC	glycophorin C (Gerbich blood group)
chr12_-_53601051	0.483		ITGB7	integrin, beta 7
chr8_+_26435920	0.481	NM_001244604	DPYSL2	dihydropyrimidinase-like 2
chr20_+_46130600	0.478	NM_001174087 NM_001174088 NM_006534 NM_181659	NCOA3	nuclear receptor coactivator 3
chr1_+_156119734	0.478	NM_001193301	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_+_100211554	0.475		TMEM45A	transmembrane protein 45A
chr10_-_74856656	0.474	NM_000917 NM_001017962 NM_001142595 NM_001142596	P4HA1	prolyl 4-hydroxylase, alpha polypeptide I
chr4_+_113970784	0.473	NM_001148 NM_020977	ANK2	ankyrin 2, neuronal
chr7_+_94297448	0.473		PEG10	paternally expressed 10
chr12_-_103311053	0.472		PAH	phenylalanine hydroxylase
chr17_+_25958245	0.471		LGALS9	lectin, galactoside-binding, soluble, 9
chr10_+_16478941	0.466	NM_001001484 NM_030664	PTER	phosphotriesterase related
chr12_+_53693454	0.464	NM_021640	C12orf10	chromosome 12 open reading frame 10
chr14_+_24563369	0.462	NM_001018073 NM_004563	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr12_+_25205180	0.462	NM_001204126 NM_001204127 NM_006152	LRMP	lymphoid-restricted membrane protein
chr2_-_37899227	0.460	NM_006449	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3
chr5_-_88119604	0.457	NM_001193348 NM_001193349	MEF2C	myocyte enhancer factor 2C
chr7_+_101928390	0.454	NM_020979	SH2B2	SH2B adaptor protein 2
chr14_+_65878579	0.454		FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_-_17942410	0.451	NM_001127505 NM_004315	ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr10_+_76586299	0.448	NM_012330	KAT6B	K(lysine) acetyltransferase 6B
chr7_+_101928417	0.447		SH2B2	SH2B adaptor protein 2
chr1_+_26644458	0.443		CD52	CD52 molecule
chr17_+_53342356	0.443		HLF	hepatic leukemia factor
chr14_-_106452693	0.439		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_+_117085302	0.437	NM_000607	ORM1	orosomucoid 1
chr19_+_49838673	0.435	NM_001040031 NM_001774	CD37	CD37 molecule
chr2_-_220436267	0.435	NM_001173408 NM_001173431 NM_015311	OBSL1	obscurin-like 1
chr20_-_22564893	0.432		FOXA2	forkhead box A2
chr20_+_55966440	0.430	NM_017495 NM_183425	RBM38	RNA binding motif protein 38
chr10_+_114135937	0.429	NM_016234	ACSL5	acyl-CoA synthetase long-chain family member 5
chr5_-_150466696	0.428	NM_001252391 NM_001252392	TNIP1	TNFAIP3 interacting protein 1
chr12_+_4382882	0.427	NM_001759	CCND2	cyclin D2
chr5_-_150537261	0.427		ANXA6	annexin A6
chr2_+_62932786	0.424	NM_001142616 NM_015252	EHBP1	EH domain binding protein 1
chr12_+_54447660	0.422	NM_153633	HOXC4 HOXC6	homeobox C4 homeobox C6
chr6_+_29855349	0.422		HLA-H	major histocompatibility complex, class I, H (pseudogene)
chr4_+_74301932	0.421	NM_001134	AFP	alpha-fetoprotein
chr6_-_32821743	0.418	NM_000593	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr13_-_47012324	0.418		KIAA0226L	KIAA0226-like
chr14_-_107113943	0.414		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_12391708	0.413		CAMK1D	calcium/calmodulin-dependent protein kinase ID
chr9_-_132805256	0.413		FNBP1	formin binding protein 1
chr3_+_16974581	0.412	NM_015184	PLCL2	phospholipase C-like 2
chr13_+_113777112	0.412	NM_000504	F10	coagulation factor X
chr1_-_31230594	0.411		LAPTM5	lysosomal protein transmembrane 5
chr2_-_242255114	0.411	NM_005336	HDLBP	high density lipoprotein binding protein
chr4_-_110723334	0.410	NM_000204	CFI	complement factor I
chr4_-_141348760	0.407	NM_001130675 NM_004362	CLGN	calmegin
chr4_+_100495972	0.406		MTTP	microsomal triglyceride transfer protein
chr6_+_57037333	0.405		BAG2	BCL2-associated athanogene 2
chr1_+_12185955	0.404	NM_152942	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr3_+_48507621	0.400		TREX1	three prime repair exonuclease 1
chr16_+_57392694	0.399	NM_002990	CCL22	chemokine (C-C motif) ligand 22
chr14_-_107013474	0.399		IGHA1 IGHG1	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_178789597	0.395	NM_022470 NM_152240	ZMAT3	zinc finger, matrin-type 3
chr5_+_53751430	0.393	NM_006308	HSPB3	heat shock 27kDa protein 3
chr1_+_212782103	0.392		ATF3	activating transcription factor 3
chr2_-_220436010	0.392		OBSL1	obscurin-like 1
chr19_+_49838700	0.392		CD37	CD37 molecule
chr5_+_133451297	0.391	NM_001134851 NM_201632 NM_201634 NM_213648	TCF7	transcription factor 7 (T-cell specific, HMG-box)
chr1_+_181002560	0.390	NM_001194999 NM_001195000 NM_001195035 NM_001531	MR1	major histocompatibility complex, class I-related
chr3_-_178789535	0.387		ZMAT3	zinc finger, matrin-type 3
chr19_+_49838646	0.386		CD37	CD37 molecule
chr1_-_57045129	0.385		PPAP2B	phosphatidic acid phosphatase type 2B
chr7_-_37488894	0.383	NM_001206480	ELMO1	engulfment and cell motility 1
chr14_+_75988765	0.382	NM_006399	BATF	basic leucine zipper transcription factor, ATF-like
chr7_-_99573637	0.380	NM_001185	AZGP1	alpha-2-glycoprotein 1, zinc-binding
chr17_+_34171647	0.378		TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
11.85	2.12e-09	GO:0006955	immune response
7.36	5.56e-07	GO:0002376	immune system process
158.15	1.34e-06	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
60.86	2.21e-06	GO:0019882	antigen processing and presentation
16.48	1.45e-02	GO:0051251	positive regulation of lymphocyte activation
15.38	1.89e-02	GO:0002696	positive regulation of leukocyte activation
15.11	2.03e-02	GO:0050867	positive regulation of cell activation
13.16	3.47e-02	GO:0051249	regulation of lymphocyte activation
24.07	4.28e-02	GO:0006959	humoral immune response
11.98	4.98e-02	GO:0002694	regulation of leukocyte activation

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
180.74	2.01e-07	GO:0042613	MHC class II protein complex
84.37	5.41e-06	GO:0042611	MHC protein complex
26.68	5.91e-04	GO:0005770	late endosome
40.42	2.47e-03	GO:0031902	late endosome membrane
8.53	1.00e-02	GO:0005768	endosome
12.33	1.22e-02	GO:0010008	endosome membrane
12.21	1.26e-02	GO:0044440	endosomal part
11.44	1.62e-02	GO:0000323	lytic vacuole
11.44	1.62e-02	GO:0005764	lysosome
20.90	1.77e-02	GO:0005765	lysosomal membrane
9.63	3.12e-02	GO:0005773	vacuole
15.73	4.09e-02	GO:0005774	vacuolar membrane
15.11	4.60e-02	GO:0044437	vacuolar part
14.87	4.81e-02	GO:0009897	external side of plasma membrane

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
47.48	4.77e-04	GO:0003823	antigen binding