Motif ID: NKX6-1,2.p2

Z-value: 1.519


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-1chr4_-_854193860.009.9e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_169418167 6.476 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr2_-_238322840 4.649 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr4_+_41258895 4.340 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_175712276 4.086 NM_001206602
CHN1
chimerin (chimaerin) 1
chr2_-_238322815 3.864 COL6A3
collagen, type VI, alpha 3
chr2_-_151344145 3.836 NM_005168
RND3
Rho family GTPase 3
chr4_+_55095263 3.830 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr12_-_91505541 3.788 NM_002345
LUM
lumican
chr4_+_41258909 3.532 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_-_91505215 3.400 LUM
lumican
chr3_-_79817058 3.341 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr13_-_38172862 3.084 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr7_-_137028533 2.678 NM_002825
PTN
pleiotrophin
chr5_-_111091947 2.623 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr21_+_30517897 2.294 C21orf7
chromosome 21 open reading frame 7
chrX_-_10535476 2.289 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr9_+_116263706 2.198 NM_130795
RGS3
regulator of G-protein signaling 3
chr2_-_217560247 2.128 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr20_+_19915716 2.092 RIN2
Ras and Rab interactor 2
chr6_+_114178516 2.077 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr8_+_79428335 2.017 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chrX_+_135230736 1.988 NM_001159700
FHL1
four and a half LIM domains 1
chr5_+_140729723 1.957 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr7_+_23286420 1.918 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_102553343 1.869 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr13_-_33760215 1.837 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr1_-_93342706 1.802 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr4_+_41258941 1.748 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_+_23286384 1.743 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_110933635 1.702 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr10_+_63808968 1.684 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_7307413 1.670 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chr8_+_132991171 1.664 EFR3A
EFR3 homolog A (S. cerevisiae)
chr5_+_35856990 1.636 NM_002185
IL7R
interleukin 7 receptor
chr1_-_226926875 1.629 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr7_+_23286386 1.515 GPNMB
glycoprotein (transmembrane) nmb
chr9_+_82186846 1.480 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_91573264 1.473 NM_133503
DCN
decorin
chr1_+_114522029 1.470 NM_020190
OLFML3
olfactomedin-like 3
chrX_+_47441650 1.453 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr7_+_23286390 1.450 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_46293628 1.425 NM_005822
RCAN2
regulator of calcineurin 2
chrX_+_102840412 1.421 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr3_-_114790221 1.386 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_114252132 1.380 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr4_-_71532206 1.370 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_+_55095433 1.343 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr7_+_23286277 1.323 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr7_-_137028275 1.320 PTN
pleiotrophin
chr5_+_140739589 1.304 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr1_+_155853546 1.293 SYT11
synaptotagmin XI
chr4_-_16900256 1.242 LDB2
LIM domain binding 2
chr7_+_94297448 1.232 PEG10
paternally expressed 10
chr4_-_16900028 1.230 LDB2
LIM domain binding 2
chrX_+_47441802 1.223 TIMP1
TIMP metallopeptidase inhibitor 1
chr12_-_53600999 1.219 NM_000889
ITGB7
integrin, beta 7
chrX_-_10544852 1.200 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_31610063 1.185 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr4_+_169013687 1.171 NM_007193
ANXA10
annexin A10
chr12_+_119616594 1.143 NM_014365
HSPB8
heat shock 22kDa protein 8
chr1_+_210501595 1.141 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr4_-_16900348 1.135 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr1_+_79115476 1.101 NM_006417
IFI44
interferon-induced protein 44
chrX_+_80457302 1.096 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr15_+_25068793 1.087 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr1_+_157963062 1.073 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr1_+_84647342 1.060 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_221915393 1.053 DUSP10
dual specificity phosphatase 10
chrX_-_100872926 1.052 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr18_-_500583 1.050 NM_130386
COLEC12
collectin sub-family member 12
chr6_+_26440699 1.047 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr7_-_137028370 1.030 PTN
pleiotrophin
chr7_-_41742666 0.992 NM_002192
INHBA
inhibin, beta A
chr1_-_221915458 0.937 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr5_+_155753755 0.924 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr18_+_72922725 0.915 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr3_-_105421044 0.912 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr11_-_27681195 0.907 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr12_-_53601051 0.883 ITGB7
integrin, beta 7
chr20_-_18477811 0.857 NM_006606
RBBP9
retinoblastoma binding protein 9
chr6_-_75970566 0.849 TMEM30A
transmembrane protein 30A
chr7_-_83824216 0.846 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr22_-_36562224 0.841 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr3_+_132318980 0.823 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr19_-_48759141 0.804 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr2_-_217559497 0.799 IGFBP5
insulin-like growth factor binding protein 5
chr6_-_33041266 0.787 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr5_+_140800536 0.786 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr18_+_43306917 0.782 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chrX_-_10851808 0.778 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr8_-_23712297 0.769 NM_003155
STC1
stanniocalcin 1
chr1_-_207095198 0.768 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr5_+_49961732 0.760 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr7_-_137028433 0.758 PTN
pleiotrophin
chr2_-_190927321 0.753 NM_005259
MSTN
myostatin
chr1_+_209878135 0.735 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr10_-_14372807 0.722 NM_018027
FRMD4A
FERM domain containing 4A
chr4_-_71532341 0.717 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr3_+_132036210 0.709 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr3_-_149421059 0.684 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr2_-_144994905 0.678 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr9_+_82187599 0.676 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr13_-_45048436 0.673 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr15_+_100173182 0.665 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr5_+_95066628 0.659 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr18_+_61554938 0.656 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr12_+_62954275 0.647 MON2
MON2 homolog (S. cerevisiae)
chr1_-_21377387 0.642 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_-_57045235 0.636 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr6_+_32605182 0.635 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chrX_+_80457597 0.631 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr2_+_33359607 0.627 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr4_+_41700736 0.616 LIMCH1
LIM and calponin homology domains 1
chr7_-_137686814 0.608 NM_001253775
NM_194071
CREB3L2

cAMP responsive element binding protein 3-like 2

chr5_+_140749830 0.607 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr21_-_27253197 0.603 APP
amyloid beta (A4) precursor protein
chr5_+_31193761 0.599 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr5_+_140810181 0.594 PCDHGA12
protocadherin gamma subfamily A, 12
chr16_+_31271277 0.593 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chrX_+_102631267 0.591 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr1_+_204913353 0.589 NM_001160331
NFASC
neurofascin
chr13_-_110802708 0.585 COL4A1
collagen, type IV, alpha 1
chr5_+_140810126 0.575 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr16_+_31271327 0.575 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr6_+_25962978 0.575 NM_006355
TRIM38
tripartite motif containing 38
chr1_+_186798031 0.571 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr2_+_102770401 0.557 NM_000877
IL1R1
interleukin 1 receptor, type I
chr9_+_34652125 0.532 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr4_-_169239816 0.528 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr10_-_69752385 0.525 HERC4
hect domain and RLD 4
chrX_+_66788682 0.524 NM_001011645
AR
androgen receptor
chr1_+_196621007 0.520 NM_000186
NM_001014975
CFH

complement factor H

chrX_+_51486479 0.518 NM_018094
GSPT2
G1 to S phase transition 2
chr3_+_132036276 0.516 ACPP
acid phosphatase, prostate
chr5_+_140868721 0.502 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr12_+_48513012 0.501 NM_000289
PFKM
phosphofructokinase, muscle
chr16_+_31271311 0.498 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr12_-_6233684 0.489 NM_000552
VWF
von Willebrand factor
chr5_+_42548144 0.469 NM_001242402
GHR
growth hormone receptor
chr7_-_76829109 0.468 NM_006682
FGL2
fibrinogen-like 2
chr18_+_66465316 0.464 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr10_+_91152321 0.464 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_+_111770280 0.460 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr12_+_7023490 0.458 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr12_+_60083125 0.457 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr14_-_61115906 0.455 NM_005982
SIX1
SIX homeobox 1
chr15_+_49715374 0.454 NM_002009
FGF7
fibroblast growth factor 7
chr12_+_25205488 0.451 LRMP
lymphoid-restricted membrane protein
chr9_-_13250313 0.448 NM_003829
MPDZ
multiple PDZ domain protein
chr6_+_14117486 0.443 NM_001251901
CD83
CD83 molecule
chr9_+_97488943 0.438 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr2_-_169103886 0.437 NM_013233
STK39
serine threonine kinase 39
chr3_+_135741576 0.435 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr3_-_149095413 0.430 TM4SF1
transmembrane 4 L six family member 1
chr3_+_12392993 0.421 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr12_-_53558276 0.418 NM_001244706
CSAD
cysteine sulfinic acid decarboxylase
chr9_+_97488993 0.413 C9orf3
chromosome 9 open reading frame 3
chr16_-_3074225 0.412 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr2_-_163099877 0.411 NM_004460
FAP
fibroblast activation protein, alpha
chr18_-_21977711 0.411 OSBPL1A
oxysterol binding protein-like 1A
chr1_-_221915426 0.407 DUSP10
dual specificity phosphatase 10
chr14_+_60558628 0.405 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr1_+_20959946 0.400 NM_032409
PINK1
PTEN induced putative kinase 1
chr7_+_94024201 0.393 COL1A2
collagen, type I, alpha 2
chr20_-_34025955 0.392 NM_000557
GDF5
growth differentiation factor 5
chr16_+_15596122 0.391 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr10_+_225932 0.385 NM_001202467
NM_001202468
ZMYND11

zinc finger, MYND-type containing 11

chr9_-_26947234 0.380 PLAA
phospholipase A2-activating protein
chr6_+_26365397 0.379 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr6_+_26402464 0.378 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr4_+_83956238 0.373 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr11_+_7618416 0.372 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_84630374 0.367 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_120612301 0.364 NM_001200001
NM_024408
NOTCH2

notch 2

chr1_-_150738292 0.359 NM_001199739
NM_004079
CTSS

cathepsin S

chr16_-_31505247 0.358 C16orf58
chromosome 16 open reading frame 58
chr2_-_183387063 0.356 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr21_+_35190586 0.355 ITSN1
intersectin 1 (SH3 domain protein)
chr13_-_99959649 0.350 NM_004951
GPR183
G protein-coupled receptor 183
chrX_-_10645726 0.349 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr11_-_67205151 0.345 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr5_-_136834887 0.344 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr20_+_9198036 0.341 NM_182797
PLCB4
phospholipase C, beta 4
chr22_-_39268214 0.339 CBX6
chromobox homolog 6
chr10_+_51837885 0.339 NM_018232
FAM21B
family with sequence similarity 21, member B
chr2_+_210444154 0.333 MAP2
microtubule-associated protein 2
chr3_-_194090459 0.332 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr11_+_17332454 0.329


chr18_-_51690988 0.328 MBD2
methyl-CpG binding domain protein 2
chr22_-_39268169 0.328 CBX6
chromobox homolog 6
chr11_+_5641173 0.325 NM_001003827
TRIM34
tripartite motif containing 34
chr2_+_228356287 0.325 AGFG1
ArfGAP with FG repeats 1
chr2_+_33661392 0.321 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_+_30457182 0.320 NM_005516
HLA-E
major histocompatibility complex, class I, E
chr2_-_211168315 0.315 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr14_-_107013474 0.315 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_101983170 0.314 NM_001195045
YAP1
Yes-associated protein 1
chr6_-_116447225 0.313 NM_000493
COL10A1
collagen, type X, alpha 1
chr12_+_20963637 0.311 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr3_-_17782398 0.304 NM_014744
TBC1D5
TBC1 domain family, member 5

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
147.95 3.69e-03 GO:0005589 collagen type VI

Nothing significant found in function category.