Motif ID: NR3C1.p2

Z-value: 0.969


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR3C1chr5_-_1428150760.581.9e-02Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_23286390 2.230 GPNMB
glycoprotein (transmembrane) nmb
chr17_-_46115135 2.197 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr7_+_23286386 2.109 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286384 2.051 GPNMB
glycoprotein (transmembrane) nmb
chr12_-_91572328 1.996 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr7_-_124405029 1.819 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr11_-_58343308 1.752 NM_004811
LPXN
leupaxin
chr10_+_91152321 1.412 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr10_+_70847817 1.318 NM_002727
SRGN
serglycin
chr8_+_54793516 1.318 RGS20
regulator of G-protein signaling 20
chr6_+_36644236 1.234 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr6_+_134210264 1.156 TCF21
transcription factor 21
chr6_+_134210247 1.148 NM_198392
NM_003206
TCF21

transcription factor 21

chr11_+_5710926 1.118 TRIM22
tripartite motif containing 22
chr6_-_6320897 1.026 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr19_-_36643770 1.025 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr6_-_6320875 1.010 F13A1
coagulation factor XIII, A1 polypeptide
chr7_+_23286277 1.001 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr5_-_172755418 0.955 STC2
stanniocalcin 2
chr16_+_30386097 0.892 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr1_+_162602308 0.862 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_+_183114214 0.858 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr7_+_93551015 0.824 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr1_-_204459445 0.807 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr10_-_101690655 0.797 DNMBP
dynamin binding protein
chr1_+_209859524 0.760 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr21_-_46340821 0.756 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_+_35856990 0.752 NM_002185
IL7R
interleukin 7 receptor
chr21_-_46340776 0.723 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr4_+_72204769 0.715 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr16_+_4674819 0.691 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr6_-_75970566 0.682 TMEM30A
transmembrane protein 30A
chr22_+_22712091 0.668 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr8_+_54793409 0.649 NM_003702
RGS20
regulator of G-protein signaling 20
chr16_+_4674829 0.644 MGRN1
mahogunin, ring finger 1
chr12_+_7055736 0.603 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chrX_-_135749436 0.596 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr13_+_76194569 0.595 NM_005358
LMO7
LIM domain 7
chr15_-_45670955 0.578 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr3_-_69129502 0.577 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr10_+_11206928 0.566 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr19_+_39899749 0.558


chr2_+_31456879 0.535 NM_014600
EHD3
EH-domain containing 3
chr18_-_53068755 0.534 TCF4
transcription factor 4
chr17_-_48264039 0.520 COL1A1
collagen, type I, alpha 1
chr1_+_32645259 0.519 TXLNA
taxilin alpha
chr3_-_123339423 0.518 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr1_-_207095198 0.511 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chrX_+_106045880 0.498 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr9_+_131388167 0.478 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr1_+_163038395 0.466 NM_001102445
RGS4
regulator of G-protein signaling 4
chr11_-_8739398 0.459 ST5
suppression of tumorigenicity 5
chr10_+_180404 0.458 NM_006624
NM_001202465
NM_001202466
NM_212479
ZMYND11



zinc finger, MYND-type containing 11



chr2_+_182321618 0.448 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr3_-_45267068 0.434 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr5_-_111093792 0.434 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chrX_+_2609224 0.433 NM_001122898
NM_002414
CD99

CD99 molecule

chr17_-_9929567 0.431 NM_001130831
GAS7
growth arrest-specific 7
chrX_+_100878101 0.431 NM_016607
NM_177947
ARMCX3

armadillo repeat containing, X-linked 3

chr8_-_120651019 0.425 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr14_-_106774311 0.421 IGHA1
immunoglobulin heavy constant alpha 1
chr1_-_111743261 0.413 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr12_+_7055753 0.393 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_+_174843523 0.392 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr1_+_162602198 0.388 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr10_+_121578768 0.374 NM_001243194
INPP5F
inositol polyphosphate-5-phosphatase F
chr1_+_32739711 0.362 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr3_+_45067750 0.361 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chrX_+_128913881 0.355 NM_018990
SASH3
SAM and SH3 domain containing 3
chr20_-_20033005 0.354 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr5_+_125800786 0.349 NM_001146322
GRAMD3
GRAM domain containing 3
chrX_+_128913897 0.347 SASH3
SAM and SH3 domain containing 3
chr1_+_32645322 0.346 NM_175852
TXLNA
taxilin alpha
chr14_+_65877309 0.344 NM_004480
NM_178155
NM_178156
FUT8


fucosyltransferase 8 (alpha (1,6) fucosyltransferase)


chr1_-_221910801 0.319 NM_144728
DUSP10
dual specificity phosphatase 10
chr2_+_214149102 0.318 NM_001025436
NM_024532
SPAG16

sperm associated antigen 16

chr14_-_106746056 0.316


chr3_-_149375584 0.310 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr1_+_111770280 0.308 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr1_-_111743297 0.304 DENND2D
DENN/MADD domain containing 2D
chr1_+_44115804 0.297 KDM4A
lysine (K)-specific demethylase 4A
chr3_+_16974581 0.296 NM_015184
PLCL2
phospholipase C-like 2
chr15_+_25101697 0.296 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr14_-_107131217 0.295 IGHA1
immunoglobulin heavy constant alpha 1
chr13_+_102104941 0.295 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr17_-_29641094 0.294 NM_006495
EVI2B
ecotropic viral integration site 2B
chr9_+_116343169 0.293 RGS3
regulator of G-protein signaling 3
chr12_+_56109832 0.291 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr6_+_35436177 0.289 NM_007104
RPL10A
ribosomal protein L10a
chr11_+_19372270 0.286 NM_001111018
NAV2
neuron navigator 2
chr7_-_150945731 0.286 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr7_-_124405680 0.281 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr12_+_13349601 0.278 NM_001423
EMP1
epithelial membrane protein 1
chr2_-_175462428 0.278 WIPF1
WAS/WASL interacting protein family, member 1
chr7_-_86974693 0.277 TP53TG1
TP53 target 1 (non-protein coding)
chr5_-_42811959 0.275 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr6_+_35436196 0.273 RPL10A
ribosomal protein L10a
chr1_+_163038934 0.270 NM_001113381
RGS4
regulator of G-protein signaling 4
chr14_+_23067128 0.269 NM_022060
ABHD4
abhydrolase domain containing 4
chr12_+_13349720 0.268 EMP1
epithelial membrane protein 1
chr17_-_10325266 0.263 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr3_-_123339178 0.262 MYLK
myosin light chain kinase
chr2_-_89292396 0.260 IGKC
immunoglobulin kappa constant
chr14_-_106471439 0.259 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr4_+_15704572 0.256 NM_004334
BST1
bone marrow stromal cell antigen 1
chr3_+_132316080 0.254 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_+_11267666 0.253 NM_001098211
HRH1
histamine receptor H1
chr5_+_140810126 0.253 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr19_+_58570606 0.251 NM_001164527
NM_001164529
NM_001164530
NM_003436
NM_007134
ZNF135




zinc finger protein 135




chr12_+_59989847 0.250 SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr14_+_88471467 0.249 NM_003608
GPR65
G protein-coupled receptor 65
chrX_+_118714297 0.245 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A
chr22_+_44395090 0.243 NM_001003828
PARVB
parvin, beta
chr5_-_151066445 0.238 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr4_+_169013687 0.237 NM_007193
ANXA10
annexin A10
chrX_+_149613719 0.232 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr3_-_165555252 0.229 NM_000055
BCHE
butyrylcholinesterase
chr1_-_27998700 0.222 IFI6
interferon, alpha-inducible protein 6
chr7_-_87856282 0.221 NM_198901
SRI
sorcin
chr12_+_7167979 0.220 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr11_-_117186918 0.218 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr1_+_13495253 0.217 NM_001045480
PRAMEF17
PRAMEF16
PRAME family member 17
PRAME family member 16
chr10_-_92680784 0.214 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr10_-_92681025 0.212 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr11_+_119039415 0.211 NM_024618
NM_170722
NLRX1

NLR family member X1

chr19_-_43709692 0.211 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr1_-_173176314 0.207 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_+_160709038 0.203 NM_021181
SLAMF7
SLAM family member 7
chr1_-_170038055 0.203 NM_001204517
KIFAP3
kinesin-associated protein 3
chr11_-_102668822 0.203 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr7_+_143079925 0.199 ZYX
zyxin
chr8_+_79428335 0.197 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr5_+_140560979 0.195 NM_020957
PCDHB16
protocadherin beta 16
chr1_+_171060017 0.194 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr17_-_33759518 0.194 NM_018042
SLFN12
schlafen family member 12
chr2_-_24307529 0.192 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr10_+_102672685 0.191 FAM178A
family with sequence similarity 178, member A
chr4_+_55095433 0.190 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_+_140710203 0.188 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr1_-_201390845 0.186 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr11_-_26743545 0.186 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr1_+_145663156 0.185 RNF115
ring finger protein 115
chr5_-_169816637 0.184 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr4_+_113970784 0.184 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr17_-_62009620 0.183 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr22_+_23040394 0.181 IGL@
immunoglobulin lambda locus
chr1_+_20964414 0.179


chr3_+_98250742 0.178 NM_005290
GPR15
G protein-coupled receptor 15
chr5_-_16738346 0.177 MYO10
myosin X
chr7_-_150946031 0.176 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chrX_+_78200828 0.174 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr7_-_37393271 0.173 NM_001206482
ELMO1
engulfment and cell motility 1
chr19_-_43690558 0.173 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chr2_-_158300517 0.170 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_+_44115828 0.168 KDM4A
lysine (K)-specific demethylase 4A
chr1_+_174844655 0.164 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr8_-_18541441 0.164 PSD3
pleckstrin and Sec7 domain containing 3
chr6_+_32605182 0.164 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr9_+_97521930 0.163 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr12_+_81101407 0.163 NM_002469
MYF6
myogenic factor 6 (herculin)
chr3_-_165555167 0.163 BCHE
butyrylcholinesterase
chr3_+_134204557 0.159 NM_001042383
NM_001042384
CEP63

centrosomal protein 63kDa

chr1_+_168195257 0.155 SFT2D2
SFT2 domain containing 2
chr8_-_62602285 0.155 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr12_+_56109817 0.154 NM_001487
BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr12_-_117742856 0.154 NM_001204213
NOS1
nitric oxide synthase 1 (neuronal)
chr7_+_129932973 0.154 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr9_+_116356199 0.152 NM_144489
RGS3
regulator of G-protein signaling 3
chr6_-_32908583 0.151 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr9_+_116342939 0.150 NM_021106
RGS3
regulator of G-protein signaling 3
chr11_+_67776016 0.150 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr5_-_149669187 0.149 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr20_+_9198036 0.145 NM_182797
PLCB4
phospholipase C, beta 4
chr10_+_91087601 0.143 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_-_117747017 0.142 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_+_35722428 0.142 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_+_201473942 0.140 AOX1
aldehyde oxidase 1
chrX_+_100878350 0.140 NM_177948
ARMCX3
armadillo repeat containing, X-linked 3
chrX_-_10645726 0.139 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr10_+_70847857 0.139 SRGN
serglycin
chr6_-_24877453 0.138 NM_015864
FAM65B
family with sequence similarity 65, member B
chr11_-_102668892 0.132 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr16_-_5115939 0.129 C16orf89
chromosome 16 open reading frame 89
chr1_+_168195248 0.128 NM_199344
SFT2D2
SFT2 domain containing 2
chr2_-_45795104 0.127 SRBD1
S1 RNA binding domain 1
chr14_-_107078578 0.121


chr5_+_149887673 0.120 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr2_-_74607425 0.120 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr20_-_4795768 0.119 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr16_-_21222867 0.118 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr17_+_4843883 0.116 RNF167
ring finger protein 167
chr2_+_163200623 0.116 GCA
grancalcin, EF-hand calcium binding protein
chr6_-_99873129 0.116 NM_015491
NM_032870
PNISR

PNN-interacting serine/arginine-rich protein

chr10_-_64578926 0.112 NM_001136178
EGR2
early growth response 2
chr4_+_15779887 0.112 NM_001775
CD38
CD38 molecule
chr14_-_20020271 0.112 NM_001145442
POTEG
POTEM
POTE ankyrin domain family, member G
POTE ankyrin domain family, member M
chr14_-_80697396 0.111 NM_000793
DIO2
deiodinase, iodothyronine, type II
chr20_-_18477811 0.109 NM_006606
RBBP9
retinoblastoma binding protein 9
chr20_+_43850009 0.106 NM_003008
SEMG2
semenogelin II
chr14_-_24616429 0.106 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.