Motif ID: POU5F1.p2

Z-value: 2.077


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU5F1chr6_-_311346140.351.8e-01Click!


Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_67410825 7.988 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_-_98031154 7.774 NM_001114094
NM_013314
BLNK

B-cell linker

chr14_-_106733392 6.011 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr22_+_22697538 5.672


chr22_+_23213671 5.551 IGLV4-3
immunoglobulin lambda variable 4-3
chr10_+_11207053 5.476 CELF2
CUGBP, Elav-like family member 2
chr10_+_11206928 5.364 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr15_-_80263460 5.252 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr22_+_22735134 5.201 CYAT1
immunoglobulin lambda light chain-like
chr22_+_22758538 5.129


chr14_-_107179043 4.854 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_23010757 4.742


chr14_-_107066061 4.654 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106405633 4.468 IGHM
immunoglobulin heavy constant mu
chr22_+_23040394 4.380 IGL@
immunoglobulin lambda locus
chr16_+_23847321 4.365 PRKCB
protein kinase C, beta
chr6_+_12717036 4.330 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr14_-_107131217 4.208 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_23134980 4.143


chr14_-_107013474 4.105 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
47.44 1.46e-02 GO:0045576 mast cell activation
39.53 6.09e-05 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
14.60 1.67e-03 GO:0019882 antigen processing and presentation
14.52 2.46e-04 GO:0060333 interferon-gamma-mediated signaling pathway
13.22 4.73e-04 GO:0071346 cellular response to interferon-gamma
13.15 7.74e-05 GO:0034341 response to interferon-gamma
11.69 6.25e-03 GO:0042113 B cell activation
11.25 2.63e-04 GO:0050851 antigen receptor-mediated signaling pathway
10.33 5.07e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
10.03 6.39e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
7.72 3.13e-04 GO:0002757 immune response-activating signal transduction
7.58 3.70e-04 GO:0002764 immune response-regulating signaling pathway
6.87 3.68e-02 GO:0002252 immune effector process
6.83 2.81e-04 GO:0002253 activation of immune response
6.60 3.94e-04 GO:0045321 leukocyte activation
6.30 2.73e-15 GO:0006955 immune response
6.03 2.75e-02 GO:0050867 positive regulation of cell activation
5.40 2.80e-03 GO:0050778 positive regulation of immune response
5.21 5.34e-04 GO:0045087 innate immune response
4.57 9.37e-04 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
45.18 4.66e-06 GO:0042613 MHC class II protein complex
21.09 3.01e-04 GO:0042611 MHC protein complex
10.77 4.59e-02 GO:0031902 late endosome membrane
8.35 7.09e-03 GO:0005765 lysosomal membrane
6.28 3.39e-02 GO:0005774 vacuolar membrane
6.03 4.22e-02 GO:0044437 vacuolar part
1.98 1.53e-02 GO:0044459 plasma membrane part
1.75 4.03e-03 GO:0071944 cell periphery
1.73 6.79e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
34.79 7.82e-13 GO:0003823 antigen binding
22.33 3.49e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled