Motif ID: POU6F1.p2

Z-value: 1.522


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU6F1chr12_-_51591949-0.591.5e-02Click!


Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_49833823 5.370 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr10_+_5005685 4.757 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_+_153003677 3.606 NM_003125
SPRR1B
small proline-rich protein 1B
chr5_+_125758818 3.408 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chrX_+_65382432 3.257 NM_138737
HEPH
hephaestin
chr10_+_5005453 3.210 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_+_5005601 2.720 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_-_5045967 2.484 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr5_+_125759076 2.164 GRAMD3
GRAM domain containing 3
chr13_-_45010994 2.153 TSC22D1
TSC22 domain family, member 1
chr17_-_48945338 2.139 NM_001243877
TOB1
transducer of ERBB2, 1
chr11_+_69467210 2.127 CCND1
cyclin D1
chr12_-_28124915 2.035 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr13_-_45010974 1.954 TSC22D1
TSC22 domain family, member 1
chr13_-_45010937 1.828 TSC22D1
TSC22 domain family, member 1
chr18_+_61144143 1.770 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr3_-_111314181 1.585 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr1_-_93342706 1.467 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr3_+_142375738 1.410 NM_001172312
PLS1
plastin 1
chr2_-_158731622 1.350 NM_001105
ACVR1
activin A receptor, type I
chr1_-_193155723 1.208 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr4_-_145061787 1.132 NM_002099
GYPA
glycophorin A (MNS blood group)
chr6_-_47254143 1.128 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr13_-_45011389 1.095 NM_001243797
TSC22D1
TSC22 domain family, member 1
chrX_+_65382627 1.064 HEPH
hephaestin
chr3_-_196911001 1.032 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr22_-_36236421 0.945 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chrX_+_135278912 0.924 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr1_-_116311161 0.908 CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116311330 0.889 CASQ2
calsequestrin 2 (cardiac muscle)
chr3_-_123339178 0.887 MYLK
myosin light chain kinase
chr20_-_6104056 0.860 NM_017671
FERMT1
fermitin family member 1
chr13_-_45011059 0.838 NM_006022
TSC22D1
TSC22 domain family, member 1
chr6_-_136847078 0.809 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr1_-_116311398 0.807 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr4_-_144826659 0.803 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr1_+_15272414 0.801 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr11_-_59633942 0.742 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr2_-_216241321 0.736 FN1
fibronectin 1
chr22_-_36236264 0.731 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_+_56324945 0.663 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr5_+_125695787 0.662 NM_001146319
GRAMD3
GRAM domain containing 3
chr6_-_47253962 0.634 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_196621007 0.625 NM_000186
NM_001014975
CFH

complement factor H

chr17_-_38978824 0.610 NM_000421
KRT10
keratin 10
chr22_-_36236330 0.599 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_-_95166827 0.595 NM_014057
NM_033014
OGN

osteoglycin

chr6_-_2840683 0.567 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr7_-_83824216 0.560 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr16_-_31439650 0.538 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr3_-_138478184 0.536 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr13_-_45048436 0.530 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr17_-_49124128 0.528 NM_001251971
SPAG9
sperm associated antigen 9
chrX_-_107682600 0.528 NM_001847
COL4A6
collagen, type IV, alpha 6
chr2_-_200325200 0.506 SATB2
SATB homeobox 2
chr11_-_83393436 0.501 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr20_+_62795826 0.497 NM_004535
MYT1
myelin transcription factor 1
chr17_-_10325266 0.488 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr12_-_90049818 0.460 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr6_-_47277646 0.445 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chrX_+_123234462 0.440 STAG2
stromal antigen 2
chr18_+_29027731 0.431 NM_001944
DSG3
desmoglein 3
chr20_+_9198036 0.430 NM_182797
PLCB4
phospholipase C, beta 4
chrX_-_13835012 0.411 GPM6B
glycoprotein M6B
chr21_-_36421586 0.402 NM_001754
RUNX1
runt-related transcription factor 1
chr16_-_32688052 0.401 NM_016212
TP53TG3
TP53 target 3
chr9_-_95298251 0.393 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr12_-_71148063 0.383 PTPRR
protein tyrosine phosphatase, receptor type, R
chr13_+_78109808 0.375 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr1_+_215178884 0.375 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr15_+_52201590 0.371 TMOD3
tropomodulin 3 (ubiquitous)
chr8_-_12973752 0.361 NM_001164271
DLC1
deleted in liver cancer 1
chr16_+_33261514 0.352 NM_016212
TP53TG3
TP53 target 3
chr5_+_140220811 0.351 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr7_+_134464372 0.336 CALD1
caldesmon 1
chr12_-_11062160 0.335 NM_023920
TAS2R13
taste receptor, type 2, member 13
chrX_-_55057408 0.334 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr16_+_33204979 0.331 NM_016212
TP53TG3
TP53 target 3
chr12_-_46633551 0.325 SLC38A1
solute carrier family 38, member 1
chr21_-_36421630 0.320 RUNX1
runt-related transcription factor 1
chr15_+_49715374 0.319 NM_002009
FGF7
fibroblast growth factor 7
chr17_-_56492938 0.317 RNF43
ring finger protein 43
chr1_+_26503973 0.314 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr1_-_247054277 0.313 AHCTF1
AT hook containing transcription factor 1
chr2_+_74057969 0.312 STAMBP
STAM binding protein
chr12_-_91572328 0.308 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr17_-_67240955 0.304 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr7_+_120702818 0.301 C7orf58
chromosome 7 open reading frame 58
chr7_-_41742666 0.294 NM_002192
INHBA
inhibin, beta A
chr15_+_52121855 0.293 TMOD3
tropomodulin 3 (ubiquitous)
chr3_+_69985750 0.290 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr7_+_134464417 0.283 CALD1
caldesmon 1
chr4_+_146031528 0.279 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr8_+_19796581 0.278 NM_000237
LPL
lipoprotein lipase
chr16_+_56817367 0.263 NM_001242796
NUP93
nucleoporin 93kDa
chr2_-_106055229 0.254 NM_201557
FHL2
four and a half LIM domains 2
chr1_-_108786663 0.250 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chrX_+_150884506 0.250 NM_033085
FATE1
fetal and adult testis expressed 1
chr5_+_147443534 0.245 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr15_+_74422742 0.242 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr4_+_70861647 0.242 NM_001009181
NM_003154
STATH

statherin

chr2_+_183582667 0.241 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr3_-_185826748 0.240 NM_004454
ETV5
ets variant 5
chr12_-_71148331 0.239 PTPRR
protein tyrosine phosphatase, receptor type, R
chr10_+_102107256 0.239


chr6_+_152011630 0.238 NM_001122742
ESR1
estrogen receptor 1
chr5_+_140529619 0.233 NM_018939
PCDHB6
protocadherin beta 6
chr3_+_128445024 0.230 RAB7A
RAB7A, member RAS oncogene family
chr1_-_93257950 0.226 NM_005665
EVI5
ecotropic viral integration site 5
chr22_-_22863504 0.225 NM_080764
ZNF280B
zinc finger protein 280B
chr14_+_39703119 0.222 NM_054024
MIA2
melanoma inhibitory activity 2
chr4_-_144940439 0.221 NM_002100
GYPB
glycophorin B (MNS blood group)
chr8_-_59412695 0.220 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr1_+_151032683 0.220 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_+_128445026 0.220 RAB7A
RAB7A, member RAS oncogene family
chr2_-_55237255 0.219 NM_007008
RTN4
reticulon 4
chr9_-_134955243 0.218 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr5_+_140602914 0.212 NM_018934
PCDHB14
protocadherin beta 14
chr1_-_179833581 0.210


chr12_-_71148383 0.208 NM_130846
NM_001207016
PTPRR

protein tyrosine phosphatase, receptor type, R

chr16_-_70835067 0.198 VAC14
Vac14 homolog (S. cerevisiae)
chr3_-_42305438 0.192 NM_001174138
CCK
cholecystokinin
chr16_-_70835060 0.191 NM_018052
VAC14
Vac14 homolog (S. cerevisiae)
chr2_+_166326156 0.184 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr14_-_65409445 0.183 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr21_-_36231794 0.182 RUNX1
runt-related transcription factor 1
chr17_-_66951381 0.181 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chrX_+_78003205 0.178 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr1_-_116383323 0.173 NM_001111061
NHLH2
nescient helix loop helix 2
chr2_+_202098165 0.173 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr7_-_50628744 0.173 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr19_-_49658645 0.168 NM_002152
HRC
histidine rich calcium binding protein
chr3_+_128445033 0.167 RAB7A
RAB7A, member RAS oncogene family
chr16_+_1728256 0.166 NM_144570
HN1L
hematological and neurological expressed 1-like
chr21_-_36421578 0.165 RUNX1
runt-related transcription factor 1
chrX_-_33229428 0.164 NM_004006
DMD
dystrophin
chr19_-_21950322 0.163 NM_173531
ZNF100
zinc finger protein 100
chr3_+_189349215 0.162 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr10_-_15902455 0.162 NM_024948
FAM188A
family with sequence similarity 188, member A
chr14_+_70918873 0.160 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr16_+_85645014 0.158 NM_001134473
KIAA0182
KIAA0182
chr15_+_40509628 0.156 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr12_-_48963802 0.156 NM_002289
LALBA
lactalbumin, alpha-
chr16_-_70835061 0.154 VAC14
Vac14 homolog (S. cerevisiae)
chr5_-_147162251 0.153 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr3_-_18480203 0.147 NM_001131010
SATB1
SATB homeobox 1
chr6_-_49834188 0.147 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr4_-_87028805 0.147 NM_138981
MAPK10
mitogen-activated protein kinase 10
chrX_+_28605558 0.146 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr7_-_93189121 0.143 NM_001164738
CALCR
calcitonin receptor
chr6_+_72926462 0.143 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_104159953 0.143 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr5_-_39203061 0.142 FYB
FYN binding protein
chr4_+_71587674 0.141 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr12_-_10562744 0.136 NM_001199805
KLRC4-KLRK1
KLRC4-KLRK1 readthrough
chr3_+_128444978 0.135 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr3_+_46919235 0.133 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr1_+_101003692 0.132 NM_022049
GPR88
G protein-coupled receptor 88
chr3_-_149086884 0.131 TM4SF1
transmembrane 4 L six family member 1
chr12_-_16760935 0.130 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr6_+_72926144 0.130 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr7_+_55433140 0.130 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr2_+_166428845 0.130 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr7_+_93535819 0.130 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr7_-_64023444 0.130


chr20_+_32150139 0.126 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr4_+_107236766 0.125 NM_001142415
NM_004757
AIMP1

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

chr15_+_74422920 0.122 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_+_27925018 0.119 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr8_-_72274466 0.117 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr8_+_1993157 0.116 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr10_-_29754478 0.116 SVIL
supervillin
chr16_+_4902076 0.115 NM_016936
UBN1
ubinuclein 1
chr17_-_39023461 0.114 NM_000223
KRT12
keratin 12
chr2_+_201756639 0.112 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr12_-_14132920 0.112 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chrX_-_152736602 0.112 NM_017518
HAUS7
HAUS augmin-like complex, subunit 7
chr16_-_70834884 0.111 VAC14
Vac14 homolog (S. cerevisiae)
chr2_+_234526290 0.111 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr14_+_32047121 0.110 NM_001201573
NUBPL
nucleotide binding protein-like
chr19_+_13134782 0.109 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_74701070 0.109 NM_015978
TNNI3K
TNNI3 interacting kinase
chr1_-_38455636 0.108 NM_006802
SF3A3
splicing factor 3a, subunit 3, 60kDa
chr4_-_69434215 0.108 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr8_+_32579350 0.107 NM_001159996
NRG1
neuregulin 1
chr9_-_215892 0.107 NM_152569
C9orf66
chromosome 9 open reading frame 66
chrX_-_33357725 0.106 NM_000109
DMD
dystrophin
chr3_+_158787040 0.106 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr18_+_8717368 0.105 NM_015210
CCDC165
coiled-coil domain containing 165
chr13_-_52980628 0.104 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr20_+_123230 0.104 NM_030931
DEFB126
defensin, beta 126
chr5_+_140254930 0.102 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chrX_+_91090459 0.101 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr17_-_7218665 0.100 GPS2
G protein pathway suppressor 2
chr19_+_39899749 0.099


chr3_+_49506079 0.098 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chrX_+_22050920 0.098 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr5_-_147162264 0.097 JAKMIP2
janus kinase and microtubule interacting protein 2
chr12_-_8219001 0.097 C3AR1
complement component 3a receptor 1
chr9_-_27005649 0.096 NM_022901
LRRC19
leucine rich repeat containing 19

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.88 1.08e-02 GO:0060429 epithelium development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
632.45 1.38e-07 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
474.35 5.52e-07 GO:0047023 androsterone dehydrogenase activity
632.45 1.02e-04 GO:0047026 androsterone dehydrogenase (A-specific) activity
632.45 1.02e-04 GO:0047718 indanol dehydrogenase activity
90.39 1.81e-04 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
86.29 2.09e-04 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
73.02 3.52e-04 GO:0016229 steroid dehydrogenase activity
253.01 1.02e-03 GO:0032052 bile acid binding
40.42 2.15e-03 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
79.10 1.21e-02 GO:0004033 aldo-keto reductase activity
20.23 1.70e-02 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
19.02 2.04e-02 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors