Motif ID: RUNX1..3.p2

Z-value: 2.883


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RUNX3chr1_-_252914740.783.7e-04Click!
RUNX1chr21_-_36421586,
chr21_-_36421630
-0.621.1e-02Click!
RUNX2chr6_+_45390376,
chr6_+_45390284
0.185.2e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_23847321 10.944 PRKCB
protein kinase C, beta
chr16_+_23847271 9.107 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr1_-_25291474 7.526 NM_001031680
RUNX3
runt-related transcription factor 3
chr17_-_29641094 6.570 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_29641068 6.323 EVI2B
ecotropic viral integration site 2B
chr16_+_23847359 6.322 PRKCB
protein kinase C, beta
chr17_-_29641087 6.179 EVI2B
ecotropic viral integration site 2B
chr8_-_102803438 6.084 NM_032041
NCALD
neurocalcin delta
chr2_-_158300517 6.010 NM_004288
CYTIP
cytohesin 1 interacting protein
chr8_-_102803178 5.967 NCALD
neurocalcin delta
chr8_-_102803196 5.813 NCALD
neurocalcin delta
chr10_+_70847857 4.898 SRGN
serglycin
chr1_+_198608136 4.810 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr13_-_46756295 4.757 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_-_123688352 4.649 TRAF1
TNF receptor-associated factor 1
chr4_-_71532206 4.601 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr11_+_1889902 4.486 NM_001013253
LSP1
lymphocyte-specific protein 1
chr1_+_198608216 4.250 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_34524054 4.172 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr4_-_71532341 4.099 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
28.69 5.89e-03 GO:0050854 regulation of antigen receptor-mediated signaling pathway
9.63 5.04e-03 GO:0050852 T cell receptor signaling pathway
8.93 1.94e-03 GO:0050851 antigen receptor-mediated signaling pathway
8.20 3.69e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
7.96 4.62e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
7.14 6.85e-05 GO:0046649 lymphocyte activation
6.19 1.03e-04 GO:0045321 leukocyte activation
5.76 1.68e-02 GO:0050863 regulation of T cell activation
5.52 2.38e-02 GO:0002757 immune response-activating signal transduction
5.42 3.63e-03 GO:0002253 activation of immune response
5.42 2.74e-02 GO:0002764 immune response-regulating signaling pathway
5.07 1.03e-03 GO:0050778 positive regulation of immune response
4.55 4.47e-02 GO:0050865 regulation of cell activation
4.53 1.90e-05 GO:0001775 cell activation
4.38 1.15e-08 GO:0006955 immune response
4.15 8.53e-04 GO:0050776 regulation of immune response
3.88 8.13e-12 GO:0002376 immune system process
3.68 1.63e-02 GO:0002684 positive regulation of immune system process
3.59 1.72e-04 GO:0002682 regulation of immune system process
3.56 1.20e-02 GO:0007596 blood coagulation

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
50.20 2.39e-03 GO:0001891 phagocytic cup
36.51 3.66e-04 GO:0005833 hemoglobin complex
21.52 4.11e-02 GO:0042613 MHC class II protein complex
15.69 1.81e-03 GO:0005884 actin filament

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
33.47 6.22e-04 GO:0005344 oxygen transporter activity
20.08 6.08e-07 GO:0003823 antigen binding