Motif ID: SMAD1..7,9.p2

Z-value: 2.093


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD6chr15_+_67000929-0.836.8e-05Click!
SMAD4chr18_+_48556600-0.552.8e-02Click!
SMAD2chr18_-_454571450.533.5e-02Click!
SMAD1chr4_+_1464027040.505.1e-02Click!
SMAD7chr18_-_464770800.439.7e-02Click!
SMAD5chr5_+_135468538-0.351.8e-01Click!
SMAD9chr13_-_37494370-0.312.4e-01Click!
SMAD3chr15_+_67358161-0.116.9e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_35607218 4.997 FXYD3
FXYD domain containing ion transport regulator 3
chr11_+_66824308 4.668 RHOD
ras homolog gene family, member D
chr8_+_32504250 4.611 NM_013959
NRG1
neuregulin 1
chr18_+_21269528 4.445 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr1_+_183155393 3.510 LAMC2
laminin, gamma 2
chr12_-_52867521 3.395 NM_173086
KRT6C
keratin 6C
chr15_-_83953465 3.353 NM_001717
BNC1
basonuclin 1
chr2_-_110874142 2.855 NM_005434
MALL
mal, T-cell differentiation protein-like
chr20_-_14318200 2.788 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr12_-_47473424 2.730 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr5_-_151066445 2.557 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr6_+_29913400 2.464


chr5_-_151066492 2.455 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr17_-_74581934 2.411 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr1_+_183155173 2.353 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr16_+_70502824 2.320 FUK
fucokinase
chr16_+_22825481 2.251 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_+_183155361 2.250 LAMC2
laminin, gamma 2
chr11_+_66824285 2.171 NM_014578
RHOD
ras homolog gene family, member D
chr7_+_134464417 2.129 CALD1
caldesmon 1
chr19_+_38755097 2.118 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr1_-_6445737 2.054 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr11_+_35160666 2.021 CD44
CD44 molecule (Indian blood group)
chr2_-_110873638 1.986 MALL
mal, T-cell differentiation protein-like
chr17_+_70117154 1.982 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr12_-_52914080 1.945 NM_000424
KRT5
keratin 5
chr6_+_106959729 1.907 NM_001624
AIM1
absent in melanoma 1
chr21_+_39628663 1.874 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_-_44285012 1.862 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr9_-_99801365 1.842 NM_001333
CTSL2
cathepsin L2
chr11_-_58345593 1.833 NM_001143995
LPXN
leupaxin
chr21_+_39628869 1.826 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_-_125366048 1.761 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_-_152009467 1.755 S100A11
S100 calcium binding protein A11
chr16_+_57662301 1.751 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_+_101420004 1.728 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr1_+_27189628 1.681 NM_006142
SFN
stratifin
chr10_+_8096772 1.677 GATA3
GATA binding protein 3
chr17_-_74582144 1.643 NM_006456
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr1_-_152009440 1.624 S100A11
S100 calcium binding protein A11
chr1_-_152009406 1.590 S100A11
S100 calcium binding protein A11
chr20_+_44441671 1.586 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr18_+_21452981 1.570 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr15_+_41136178 1.561 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr2_+_71295428 1.553 NAGK
N-acetylglucosamine kinase
chr9_+_124086842 1.543 GSN
gelsolin
chr1_-_27998719 1.541 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr17_-_74581881 1.535 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr2_+_71295407 1.534 NM_017567
NAGK
N-acetylglucosamine kinase
chr6_-_138428477 1.533 NM_022121
PERP
PERP, TP53 apoptosis effector
chr2_-_85637473 1.514 CAPG
capping protein (actin filament), gelsolin-like
chr10_-_91011516 1.507 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr12_+_66218141 1.502 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr10_-_91011562 1.478 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr8_-_134309448 1.476 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chrX_+_154114609 1.455 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr19_+_751108 1.449 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr17_-_7297826 1.433 PLSCR3
phospholipid scramblase 3
chr19_-_44285407 1.421 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr12_-_52967608 1.405 NM_175053
KRT74
keratin 74
chrX_+_152086408 1.404 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr9_-_110251754 1.391 KLF4
Kruppel-like factor 4 (gut)
chr13_-_114526166 1.372 GAS6
growth arrest-specific 6
chrX_-_154688260 1.370 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr9_-_21975131 1.336 NM_000077
NM_001195132
CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

chr15_+_101420032 1.307 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr15_+_41136622 1.300 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr19_+_41281281 1.290 NM_006533
MIA
melanoma inhibitory activity
chr10_-_91011586 1.277 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr11_+_35160815 1.272 CD44
CD44 molecule (Indian blood group)
chr9_-_110251308 1.263 KLF4
Kruppel-like factor 4 (gut)
chr7_+_134464161 1.235 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_+_71295685 1.231 NAGK
N-acetylglucosamine kinase
chr5_+_17217474 1.225 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr11_-_118135197 1.200 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr7_-_41742666 1.194 NM_002192
INHBA
inhibin, beta A
chr22_+_38035683 1.192 NM_018957
SH3BP1
SH3-domain binding protein 1
chr19_+_41281081 1.186 NM_001202553
MIA
melanoma inhibitory activity
chr17_+_73717515 1.178 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr1_-_153538305 1.170 NM_005978
S100A2
S100 calcium binding protein A2
chr3_-_149688638 1.149 NM_002628
NM_053024
PFN2

profilin 2

chr19_-_51456159 1.137 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chrX_-_62974942 1.128 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr12_-_76425207 1.126 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr8_+_104310660 1.113 NM_001164615
FZD6
frizzled family receptor 6
chr14_-_24037266 1.108 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr11_-_118134956 1.102 MPZL2
myelin protein zero-like 2
chr2_-_56150862 1.092 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr1_+_36636690 1.091 MAP7D1
MAP7 domain containing 1
chr4_-_102268333 1.091 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chrX_-_106960028 1.081 TSC22D3
TSC22 domain family, member 3
chr3_-_16555128 1.077 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr1_-_43919345 1.074 HYI
hydroxypyruvate isomerase (putative)
chr1_-_152009490 1.073 NM_005620
S100A11
S100 calcium binding protein A11
chr9_-_32526164 1.061 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_+_13043955 1.049 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr10_+_8096633 1.049 NM_001002295
NM_002051
GATA3

GATA binding protein 3

chr6_+_106960326 1.044 AIM1
absent in melanoma 1
chr1_+_44398991 1.013 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chrX_+_49028183 1.013 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr17_+_26662547 1.011 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr17_-_7307413 1.008 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chr1_-_94147201 1.003 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr3_+_36421944 1.001 NM_003149
STAC
SH3 and cysteine rich domain
chr17_+_48610045 0.997 NM_017957
EPN3
epsin 3
chr17_+_73717556 0.986 ITGB4
integrin, beta 4
chr10_-_98031154 0.984 NM_001114094
NM_013314
BLNK

B-cell linker

chr19_-_11689591 0.976 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr17_-_39780762 0.968 NM_000422
KRT17
keratin 17
chr4_-_84256304 0.968 NM_001166498
NM_006665
HPSE

heparanase

chr20_-_6104056 0.968 NM_017671
FERMT1
fermitin family member 1
chr6_-_111927059 0.966 TRAF3IP2
TRAF3 interacting protein 2
chr11_+_69467210 0.959 CCND1
cyclin D1
chr10_+_88728187 0.958 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr6_-_128841432 0.950 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr11_-_8892909 0.948 ST5
suppression of tumorigenicity 5
chr10_+_8097350 0.941 GATA3
GATA binding protein 3
chr5_-_57755787 0.940 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr17_-_1395950 0.931 NM_001080779
MYO1C
myosin IC
chr22_-_45608232 0.928 KIAA0930
KIAA0930
chr11_-_118134986 0.923 MPZL2
myelin protein zero-like 2
chr1_-_27998700 0.916 IFI6
interferon, alpha-inducible protein 6
chr8_+_104311058 0.912 NM_001164616
NM_003506
FZD6

frizzled family receptor 6

chr6_-_32821592 0.911 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_+_49962920 0.909 PARP8
poly (ADP-ribose) polymerase family, member 8
chr2_-_161350304 0.908 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr1_-_43919547 0.905 NM_001190880
NM_001243526
NM_031207
HYI


hydroxypyruvate isomerase (putative)


chr10_-_116392099 0.904 ABLIM1
actin binding LIM protein 1
chr14_+_64680858 0.897 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr8_-_143867931 0.886 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr8_-_145050896 0.886 NM_000445
PLEC
plectin
chrX_-_62975005 0.882 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr16_+_68771192 0.881 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_-_11714471 0.880 FBXO2
F-box protein 2
chr8_-_145018057 0.878 NM_201382
PLEC
plectin
chr12_-_106641675 0.875 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr9_+_124043719 0.867 GSN
gelsolin
chr14_-_61748510 0.857 NM_001017970
TMEM30B
transmembrane protein 30B
chr11_+_130029663 0.854 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr17_+_73717596 0.844 ITGB4
integrin, beta 4
chr3_-_51993955 0.833 PCBP4
poly(rC) binding protein 4
chr1_-_109584589 0.833 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr12_+_56325788 0.833 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr9_+_124048869 0.830 GSN
gelsolin
chr22_+_31489343 0.813 SMTN
smoothelin
chr9_+_123963728 0.806 GSN
gelsolin
chr19_-_51529869 0.805 NM_001136032
KLK11
kallikrein-related peptidase 11
chr2_+_120125141 0.787 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr22_+_31477231 0.784 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr1_-_27998658 0.782 IFI6
interferon, alpha-inducible protein 6
chr11_+_130029712 0.776 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr1_-_209979388 0.775 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr2_+_18059923 0.753 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr17_+_40985444 0.749 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr17_-_38657814 0.749 NM_032865
TNS4
tensin 4
chr11_-_102668822 0.745 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr3_-_79068542 0.744 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr9_-_139890984 0.741 NM_004669
CLIC3
chloride intracellular channel 3
chrX_-_106960268 0.740 NM_004089
TSC22D3
TSC22 domain family, member 3
chrX_-_84634664 0.740 POF1B
premature ovarian failure, 1B
chr14_-_69446038 0.739 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr3_-_127541975 0.736 NM_001003794
MGLL
monoglyceride lipase
chr16_+_68771214 0.731 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chrX_-_8700170 0.730 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr2_-_85637486 0.728 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr2_+_17721806 0.723 NM_003385
VSNL1
visinin-like 1
chr3_-_49395697 0.716 GPX1
glutathione peroxidase 1
chr2_-_20425166 0.711 NM_001006946
SDC1
syndecan 1
chr19_-_11689765 0.711 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr11_+_60869929 0.696 NM_014207
CD5
CD5 molecule
chrX_-_106959597 0.694 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr3_-_49395751 0.692 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr5_-_73936299 0.690 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr1_-_11714396 0.688 FBXO2
F-box protein 2
chr14_+_93260630 0.680 NM_005113
GOLGA5
golgin A5
chr22_+_43547526 0.679 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr16_+_3070310 0.674 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr16_-_4562979 0.669 C16orf5
chromosome 16 open reading frame 5
chr9_-_21974825 0.668 NM_058197
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr16_-_31147062 0.668 NM_002773
PRSS8
protease, serine, 8
chr12_-_106533810 0.666 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr3_-_45187843 0.663 CDCP1
CUB domain containing protein 1
chr1_+_156123321 0.663 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr2_+_37571752 0.663 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr2_-_163174816 0.658 NM_022168
IFIH1
interferon induced with helicase C domain 1
chrX_+_102840412 0.657 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr22_-_45608346 0.653 NM_015264
KIAA0930
KIAA0930
chr9_-_35111534 0.649 FAM214B
family with sequence similarity 214, member B
chr10_-_105677986 0.648 NM_024928
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr16_-_79634610 0.644 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr19_-_2038937 0.642 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr3_-_124930192 0.641 NM_001195483
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr2_-_216300444 0.640 FN1
fibronectin 1
chr11_-_57335080 0.639 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chrX_+_135614310 0.636 NM_016267
VGLL1
vestigial like 1 (Drosophila)
chr3_-_46718898 0.633 NM_182775
ALS2CL
ALS2 C-terminal like
chr5_+_131409484 0.633 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr19_+_45281125 0.624 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr9_-_110252045 0.623 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chrX_-_62974987 0.619 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
63.02 1.25e-04 GO:0031581 hemidesmosome assembly
8.90 1.02e-03 GO:0008544 epidermis development
24.77 7.19e-03 GO:0007044 cell-substrate junction assembly
3.38 3.11e-02 GO:0009888 tissue development

Nothing significant found in compartment category.

Nothing significant found in function category.