Motif ID: SOX17.p2

Z-value: 1.578


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX17chr8_+_553704940.421.0e-01Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_151032866 2.856 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 2.587 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032683 2.107 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr18_-_53257033 2.101 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr1_-_26232890 2.037 NM_001145454
NM_005563
STMN1

stathmin 1

chr12_-_21810720 1.801 NM_001174097
LDHB
lactate dehydrogenase B
chr12_-_21810733 1.784 LDHB
lactate dehydrogenase B
chr12_-_21810754 1.780 LDHB
lactate dehydrogenase B
chr12_-_21810769 1.732 LDHB
lactate dehydrogenase B
chr12_-_21810779 1.707 NM_002300
LDHB
lactate dehydrogenase B
chr1_-_26232643 1.538 NM_203401
STMN1
stathmin 1
chr13_-_31040035 1.537 NM_002128
HMGB1
high mobility group box 1
chr14_-_23388380 1.469 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr12_-_6233684 1.469 NM_000552
VWF
von Willebrand factor
chr7_-_131241321 1.466 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr14_-_23388359 1.447 RBM23
RNA binding motif protein 23
chr1_-_26233367 1.446 NM_203399
STMN1
stathmin 1
chr11_+_114167168 1.411 NNMT
nicotinamide N-methyltransferase
chr14_-_23388294 1.363 RBM23
RNA binding motif protein 23
chr1_-_153643456 1.311 ILF2
interleukin enhancer binding factor 2, 45kDa
chr13_-_31039966 1.295 HMGB1
high mobility group box 1
chr1_-_153643433 1.271 ILF2
interleukin enhancer binding factor 2, 45kDa
chr7_-_44887663 1.246 H2AFV
H2A histone family, member V
chr1_-_153643428 1.229 ILF2
interleukin enhancer binding factor 2, 45kDa
chr11_+_114167197 1.229 NNMT
nicotinamide N-methyltransferase
chr1_-_153643474 1.220 NM_004515
ILF2
interleukin enhancer binding factor 2, 45kDa
chr18_-_53177999 1.209 NM_001243231
TCF4
transcription factor 4
chr17_-_73150493 1.209 HN1
hematological and neurological expressed 1
chr1_-_153643417 1.206 ILF2
interleukin enhancer binding factor 2, 45kDa
chrX_+_15518899 1.150 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr14_-_106994001 1.127 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr14_-_107131217 1.127 IGHA1
immunoglobulin heavy constant alpha 1
chr18_-_52969714 1.111 NM_001243236
TCF4
transcription factor 4
chr3_-_121379757 1.090 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr16_-_103557 1.072 NM_016310
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
chr1_+_151032150 1.066 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr11_-_122932806 1.066 HSPA8
heat shock 70kDa protein 8
chr16_+_30194925 1.060 CORO1A
coronin, actin binding protein, 1A
chr11_-_122932844 1.036 NM_006597
NM_153201
HSPA8

heat shock 70kDa protein 8

chr6_+_80714389 1.028 TTK
TTK protein kinase
chr14_+_24641204 1.020 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr15_-_35087748 1.010 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr7_+_99775346 1.009 STAG3
stromal antigen 3
chr1_-_221915393 1.000 DUSP10
dual specificity phosphatase 10
chr14_-_106926393 0.997 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_221915458 0.977 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr10_+_17271276 0.975 VIM
vimentin
chr5_+_177631534 0.954 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr3_-_121379701 0.943 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr4_+_154387450 0.940 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr10_+_17271277 0.934 VIM
vimentin
chr7_-_27205123 0.923 HOXA9
homeobox A9
chr12_-_6960406 0.913 NM_031299
CDCA3
cell division cycle associated 3
chr3_+_48507621 0.905 TREX1
three prime repair exonuclease 1
chr1_+_101185195 0.899 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr14_+_24641084 0.898 REC8
REC8 homolog (yeast)
chr10_+_17271302 0.894 VIM
vimentin
chr5_+_177631533 0.886 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr7_-_44887697 0.884 NM_012412
NM_138635
NM_201436
NM_201516
NM_201517
H2AFV




H2A histone family, member V




chr15_-_45670624 0.884 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_-_27205148 0.884 NM_152739
HOXA9
homeobox A9
chr1_-_221915426 0.882 DUSP10
dual specificity phosphatase 10
chr5_+_177631496 0.880 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr2_-_61765394 0.879 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr16_+_30194730 0.866 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr7_-_150329285 0.862 GIMAP6
GTPase, IMAP family member 6
chr10_+_11047253 0.859 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr4_-_103266577 0.852 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr8_+_26435590 0.850 DPYSL2
dihydropyrimidinase-like 2
chr12_+_98909410 0.845 TMPO
thymopoietin
chr8_+_55370494 0.845 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr17_+_80416530 0.844 NM_001083608
NM_012336
NM_031968
NARF


nuclear prelamin A recognition factor


chr12_+_98909405 0.833 TMPO
thymopoietin
chr21_-_15918635 0.832 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr2_-_37898768 0.830 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr13_+_53029494 0.827 NM_001098525
NM_018204
CKAP2

cytoskeleton associated protein 2

chr17_-_8113862 0.820 NM_004217
AURKB
aurora kinase B
chr1_+_203274646 0.813 NM_006763
BTG2
BTG family, member 2
chr17_+_45286713 0.800 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr7_+_69064316 0.793 AUTS2
autism susceptibility candidate 2
chr11_+_128563772 0.787 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr2_-_188312872 0.786 NM_005795
CALCRL
calcitonin receptor-like
chr5_+_68462948 0.779 CCNB1
cyclin B1
chr10_+_11047274 0.777 CELF2
CUGBP, Elav-like family member 2
chr17_+_80416606 0.769 NARF
nuclear prelamin A recognition factor
chr2_-_9771101 0.767 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr10_+_17271956 0.761 VIM
vimentin
chr12_-_25055228 0.758 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr11_-_67120943 0.753 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr13_-_46756295 0.753 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_+_82192717 0.752 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr3_+_48507209 0.747 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr12_+_75874512 0.744 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr5_+_68462985 0.737 CCNB1
cyclin B1
chr8_-_101965096 0.729 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_-_122744782 0.728 CCNA2
cyclin A2
chr19_-_55919324 0.720 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr3_+_51422716 0.711 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr22_-_19512859 0.710 NM_001130861
NM_003277
CLDN5

claudin 5

chrX_-_15872905 0.707


chr5_+_148737569 0.706 NM_024028
PCYOX1L
prenylcysteine oxidase 1 like
chr10_+_17271859 0.704 VIM
vimentin
chr6_-_24877453 0.703 NM_015864
FAM65B
family with sequence similarity 65, member B
chr17_-_61777478 0.700 NM_030576
LIMD2
LIM domain containing 2
chr17_+_67498391 0.696 MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_25291474 0.692 NM_001031680
RUNX3
runt-related transcription factor 3
chr11_-_6676851 0.681 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr8_-_22550708 0.679 NM_004430
EGR3
early growth response 3
chr5_+_102465256 0.676 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr9_+_90112754 0.670 NM_004938
DAPK1
death-associated protein kinase 1
chr14_-_91884138 0.670 CCDC88C
coiled-coil domain containing 88C
chr7_+_120590816 0.669 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr10_+_31610063 0.667 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr10_+_71078575 0.666 NM_000188
HK1
hexokinase 1
chr2_-_9770999 0.665 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chrX_+_12993224 0.665 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr15_-_45670955 0.661 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr3_+_51422691 0.660 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr7_-_44887567 0.656 H2AFV
H2A histone family, member V
chrX_-_15872921 0.654 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_148737613 0.644 PCYOX1L
prenylcysteine oxidase 1 like
chr10_-_75410778 0.643 NM_024875
SYNPO2L
synaptopodin 2-like
chr1_+_25071759 0.642 NM_013943
CLIC4
chloride intracellular channel 4
chr12_-_21654484 0.640 NM_002907
NM_032941
RECQL

RecQ protein-like (DNA helicase Q1-like)

chr5_+_40680021 0.637 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr7_-_44887620 0.636 H2AFV
H2A histone family, member V
chr10_+_17271341 0.623 VIM
vimentin
chr2_+_33738941 0.623 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_25071906 0.623 CLIC4
chloride intracellular channel 4
chr14_-_106691698 0.622


chr2_-_175869910 0.620 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr14_+_85996454 0.618 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_25071967 0.618 CLIC4
chloride intracellular channel 4
chrX_-_15872882 0.616 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr16_+_103892 0.615 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr2_+_27008881 0.612 NM_001809
NM_001042426
CENPA

centromere protein A

chr12_+_98909331 0.611 NM_001032283
NM_001032284
NM_003276
TMPO


thymopoietin


chr14_+_85996512 0.609 FLRT2
fibronectin leucine rich transmembrane protein 2
chr16_+_103859 0.609 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chrX_-_15872938 0.607 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_33661392 0.604 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_-_137071703 0.602 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr5_+_112312392 0.599 NM_001242377
NM_152624
DCP2

DCP2 decapping enzyme homolog (S. cerevisiae)

chr6_+_80714321 0.599 NM_001166691
NM_003318
TTK

TTK protein kinase

chr3_+_157154579 0.598 NM_002852
PTX3
pentraxin 3, long
chr4_-_186732208 0.596 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr12_-_21654206 0.593 RECQL
RecQ protein-like (DNA helicase Q1-like)
chr7_+_150264457 0.592 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr7_-_120498128 0.592 NM_012338
TSPAN12
tetraspanin 12
chr17_+_1733263 0.591 NM_002945
RPA1
replication protein A1, 70kDa
chr7_+_116660291 0.590 ST7
suppression of tumorigenicity 7
chr17_+_1733313 0.588 RPA1
replication protein A1, 70kDa
chr4_-_186732047 0.584 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr15_+_85923739 0.584 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr4_-_40936640 0.580 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr14_-_106725620 0.579 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr2_-_158300517 0.577 NM_004288
CYTIP
cytohesin 1 interacting protein
chr7_+_116660263 0.572 ST7
suppression of tumorigenicity 7
chr14_+_20937537 0.571 NM_000270
PNP
purine nucleoside phosphorylase
chr1_+_43824598 0.570 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr13_-_46756326 0.565 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr15_-_69113213 0.565 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr16_+_56817367 0.556 NM_001242796
NUP93
nucleoporin 93kDa
chr1_+_24286300 0.555 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr18_-_53071225 0.549 NM_001243232
TCF4
transcription factor 4
chr20_+_9494995 0.549 NM_001199897
NM_012261
LAMP5

lysosomal-associated membrane protein family, member 5

chr9_+_126773851 0.546 NM_004789
LHX2
LIM homeobox 2
chr10_+_3109708 0.545 NM_002627
PFKP
phosphofructokinase, platelet
chr2_+_10262694 0.539 NM_001165931
RRM2
ribonucleotide reductase M2
chr6_-_79944397 0.537 NM_001201362
NM_001201363
NM_004242
NM_138730
HMGN3



high mobility group nucleosomal binding domain 3



chr1_+_44115804 0.534 KDM4A
lysine (K)-specific demethylase 4A
chr10_+_124220990 0.531 NM_002775
HTRA1
HtrA serine peptidase 1
chr19_+_799281 0.530 PTBP1
polypyrimidine tract binding protein 1
chr7_+_44788175 0.527 ZMIZ2
zinc finger, MIZ-type containing 2
chr7_-_121036355 0.526 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr2_+_10262853 0.526 NM_001034
RRM2
ribonucleotide reductase M2
chr5_-_88178964 0.524 MEF2C
myocyte enhancer factor 2C
chr7_-_121036320 0.523 FAM3C
family with sequence similarity 3, member C
chr11_+_75526236 0.523 UVRAG
UV radiation resistance associated gene
chr2_-_61765345 0.522 XPO1
exportin 1 (CRM1 homolog, yeast)
chr20_-_56285576 0.522 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr2_-_61765367 0.522 XPO1
exportin 1 (CRM1 homolog, yeast)
chr7_-_99774821 0.520 NM_152742
GPC2
glypican 2
chr2_+_27008912 0.517 CENPA
centromere protein A
chr13_-_41593405 0.516 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_213123853 0.512 NM_001136474
NM_001136475
NM_024749
VASH2


vasohibin 2


chr6_+_12290528 0.510 NM_001168319
NM_001955
EDN1

endothelin 1

chr14_-_88459469 0.507 NM_000153
NM_001201401
GALC

galactosylceramidase

chr8_+_133787611 0.506 PHF20L1
PHD finger protein 20-like 1
chr20_+_9495297 0.505 LAMP5
lysosomal-associated membrane protein family, member 5
chr15_-_69113089 0.504 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr15_+_59397276 0.504 NM_004701
CCNB2
cyclin B2
chr10_+_70748476 0.503 NM_015634
KIAA1279
KIAA1279
chr14_-_107218786 0.502 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr13_-_99630243 0.502 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr5_+_68462836 0.501 NM_031966
CCNB1
cyclin B1
chr11_+_75526211 0.499 NM_003369
UVRAG
UV radiation resistance associated gene
chr6_-_79944324 0.498 HMGN3
high mobility group nucleosomal binding domain 3
chr6_+_84569394 0.497 CYB5R4
cytochrome b5 reductase 4
chr4_-_122744978 0.497 NM_001237
CCNA2
cyclin A2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
210.84 2.34e-03 GO:0030893 meiotic cohesin complex
131.79 6.52e-03 GO:0008278 cohesin complex
75.33 2.11e-02 GO:0001673 male germ cell nucleus
70.31 2.43e-02 GO:0043073 germ cell nucleus
55.52 3.93e-02 GO:0000795 synaptonemal complex

Nothing significant found in function category.