Motif ID: SOX5.p2

Z-value: 1.422


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX5chr12_-_247153490.647.5e-03Click!


Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_69742130 7.236 NM_000239
LYZ
lysozyme
chr12_+_69742140 6.431 LYZ
lysozyme
chr3_-_148939784 3.693 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_+_198608244 3.263 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_49124128 3.165 NM_001251971
SPAG9
sperm associated antigen 9
chr1_+_198608136 3.124 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_+_22696318 3.081 NM_005256
GAS2
growth arrest-specific 2
chr6_-_49604524 2.910 NM_000324
RHAG
Rh-associated glycoprotein
chr1_+_198608216 2.818 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_-_116840673 2.800 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_228678556 2.787 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr4_+_100495972 2.499 MTTP
microsomal triglyceride transfer protein
chr1_+_116925991 2.304 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr4_+_71062241 2.174 NM_017855
ODAM
odontogenic, ameloblast asssociated
chrY_+_15016018 2.076 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr17_+_65822242 2.074 BPTF
bromodomain PHD finger transcription factor
chrX_+_152908819 2.013 DUSP9
dual specificity phosphatase 9
chr17_+_65822206 1.980 BPTF
bromodomain PHD finger transcription factor
chr16_+_69680959 1.848 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_+_123234462 1.829 STAG2
stromal antigen 2
chrX_-_137821514 1.818 NM_033642
FGF13
fibroblast growth factor 13
chr20_-_45985411 1.780 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr4_+_88896801 1.747 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr11_-_35440514 1.737 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_-_103311380 1.710 NM_000277
PAH
phenylalanine hydroxylase
chr6_+_37137882 1.682 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr6_+_27777713 1.638 NM_003536
HIST1H3H
histone cluster 1, H3h
chr12_-_24103953 1.635 SOX5
SRY (sex determining region Y)-box 5
chr3_-_120401401 1.584 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr9_-_130712866 1.570 NM_203305
FAM102A
family with sequence similarity 102, member A
chr7_-_100239136 1.527 NM_003227
TFR2
transferrin receptor 2
chr6_+_64356430 1.517 NM_015153
PHF3
PHD finger protein 3
chr1_-_182360181 1.512 GLUL
glutamate-ammonia ligase
chr4_+_88896838 1.469 SPP1
secreted phosphoprotein 1
chr16_+_69726751 1.452 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_-_48987652 1.437 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr4_+_88896868 1.409 SPP1
secreted phosphoprotein 1
chr17_-_26697293 1.402 VTN
vitronectin
chr2_+_143886898 1.386 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr9_-_98268866 1.352 PTCH1
patched 1
chrX_-_40036581 1.346 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr2_+_143886969 1.325 ARHGAP15
Rho GTPase activating protein 15
chr20_+_32150139 1.317 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_-_26697224 1.284 VTN
vitronectin
chr11_+_22688156 1.278 NM_001143830
GAS2
growth arrest-specific 2
chr8_-_102803178 1.273 NCALD
neurocalcin delta
chr4_+_88896899 1.271 SPP1
secreted phosphoprotein 1
chr9_-_86584079 1.267 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr11_-_35441099 1.238 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_-_182360400 1.237 NM_001033056
GLUL
glutamate-ammonia ligase
chr12_-_24715349 1.202 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr2_+_75061234 1.180 HK2
hexokinase 2
chr11_+_73359734 1.150 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr6_+_119215240 1.149 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr11_+_46402333 1.147 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr3_-_120400957 1.134 HGD
homogentisate 1,2-dioxygenase
chr2_-_200325200 1.133 SATB2
SATB homeobox 2
chr10_-_5060191 1.128 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr8_-_102803196 1.114 NCALD
neurocalcin delta
chrX_+_105937067 1.102 NM_024539
RNF128
ring finger protein 128
chr3_+_52828783 1.097 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr20_+_306205 1.092 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr12_-_103311053 1.083 PAH
phenylalanine hydroxylase
chr4_-_140060601 1.076 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr10_+_114133838 1.071 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_12677347 1.069 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr7_+_29519485 1.067 NM_001039936
CHN2
chimerin (chimaerin) 2
chr5_+_102465256 1.041 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr16_+_56817367 1.030 NM_001242796
NUP93
nucleoporin 93kDa
chr1_+_167298280 1.020 NM_001198783
POU2F1
POU class 2 homeobox 1
chr7_+_111846642 1.012 NM_021994
ZNF277
zinc finger protein 277
chr6_+_122720685 1.002 NM_001135564
NM_001243094
NM_004506
HSF2


heat shock transcription factor 2


chr4_-_155511838 1.000 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr10_-_101841593 0.998 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_+_114133775 0.994 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_167298382 0.968 POU2F1
POU class 2 homeobox 1
chr7_-_16505292 0.958 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_-_20512016 0.952 PUM2
pumilio homolog 2 (Drosophila)
chr12_-_24103842 0.937 SOX5
SRY (sex determining region Y)-box 5
chr1_-_53018630 0.932 ZCCHC11
zinc finger, CCHC domain containing 11
chr14_-_89883306 0.925 NM_005197
FOXN3
forkhead box N3
chr11_-_35441501 0.924 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr7_+_26400503 0.922 NM_001199837
SNX10
sorting nexin 10
chr2_+_86668488 0.915 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr8_-_57123827 0.915 PLAG1
pleiomorphic adenoma gene 1
chr2_+_86668428 0.914 KDM3A
lysine (K)-specific demethylase 3A
chr4_-_83347222 0.904 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr8_-_57123858 0.902 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr6_-_79675672 0.899 PHIP
pleckstrin homology domain interacting protein
chr1_+_150337145 0.899 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr4_-_73434467 0.897 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr17_-_46703613 0.886 NM_024017
HOXB9
homeobox B9
chr17_-_39092714 0.885 KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_32388595 0.884 ZFR
zinc finger RNA binding protein
chr6_+_122720750 0.880 HSF2
heat shock transcription factor 2
chr10_+_72163914 0.877 EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr7_+_111846736 0.873 ZNF277
zinc finger protein 277
chrX_+_70503041 0.870 NM_001145408
NM_001145409
NM_001145410
NM_007363
NONO



non-POU domain containing, octamer-binding



chr4_+_69962191 0.869 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr6_+_155538096 0.868 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_-_102591547 0.868 NM_002674
PMCH
pro-melanin-concentrating hormone
chr4_+_124317884 0.866 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_-_56492938 0.865 RNF43
ring finger protein 43
chr19_-_47217576 0.862 NM_001079882
PRKD2
protein kinase D2
chrX_+_30261847 0.860 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chrX_+_107288199 0.854 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_-_12941547 0.851 IQSEC1
IQ motif and Sec7 domain 1
chr18_+_55711388 0.851 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr6_-_43027114 0.847 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr6_+_100054649 0.842 NM_021620
PRDM13
PR domain containing 13
chr4_+_170581212 0.838 NM_001243374
CLCN3
chloride channel 3
chr3_-_47933997 0.838 MAP4
microtubule-associated protein 4
chr17_+_58677489 0.837 NM_003620
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr9_-_124989755 0.834 NM_001242334
LHX6
LIM homeobox 6
chrX_+_9432980 0.827 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr3_-_141747434 0.812 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_-_53018721 0.811 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr1_-_231560789 0.811 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr14_-_20801427 0.811 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr6_+_87969619 0.790 ZNF292
zinc finger protein 292
chr5_-_71803119 0.787 NM_152625
ZNF366
zinc finger protein 366
chr1_-_161008710 0.786 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr12_-_102872329 0.783 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_-_175964223 0.779 NM_014901
RNF44
ring finger protein 44
chr15_+_75074714 0.775 CSK
c-src tyrosine kinase
chr22_+_40322609 0.774 GRAP2
GRB2-related adaptor protein 2
chr10_-_99094427 0.771 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr1_-_161008733 0.766 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr5_+_179159799 0.766 NM_014757
MAML1
mastermind-like 1 (Drosophila)
chr2_-_174767282 0.765


chr12_+_100897137 0.747 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr6_+_15246299 0.741 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr10_+_101542460 0.739 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_20527120 0.732 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chrX_+_49160124 0.732 NM_001098413
GAGE10
G antigen 10
chr2_-_70475563 0.731 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr1_+_11751778 0.730 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr1_-_75199091 0.729 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr15_+_82944821 0.725 AGSK1
golgin subfamily A member 2-like
chr9_+_137218324 0.719 RXRA
retinoid X receptor, alpha
chr1_-_51887740 0.711 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr19_+_4007690 0.711 NM_015897
PIAS4
protein inhibitor of activated STAT, 4
chr18_+_29171729 0.705 NM_000371
TTR
transthyretin
chr2_+_211458078 0.704 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr4_-_105416050 0.702 CXXC4
CXXC finger protein 4
chr16_-_67977956 0.702 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr17_-_1248346 0.701 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr13_-_48987247 0.697 LPAR6
lysophosphatidic acid receptor 6
chr6_+_31982538 0.696 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr16_-_47005339 0.691 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr11_-_102323353 0.686 NM_052932
TMEM123
transmembrane protein 123
chr2_-_238499317 0.685 RAB17
RAB17, member RAS oncogene family
chr15_-_56388662 0.672 RFX7
regulatory factor X, 7
chr14_+_39583426 0.671 NM_001009182
NM_001009183
NM_003616
GEMIN2


gem (nuclear organelle) associated protein 2


chr1_+_212475147 0.670 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr20_-_45976626 0.666 ZMYND8
zinc finger, MYND-type containing 8
chr15_+_82944772 0.658 AGSK1
golgin subfamily A member 2-like
chr6_-_138820580 0.658


chr2_+_86947387 0.656 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr1_-_150241409 0.652 NM_001077628
NM_001243771
NM_001243772
NM_016022
APH1A



anterior pharynx defective 1 homolog A (C. elegans)



chr15_+_75074417 0.650 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr2_+_86947429 0.650 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr4_-_186877413 0.645 SORBS2
sorbin and SH3 domain containing 2
chr3_-_57234279 0.640 NM_003865
HESX1
HESX homeobox 1
chr2_+_232573249 0.639 PTMA
prothymosin, alpha
chr3_+_142342265 0.635 NM_002670
PLS1
plastin 1
chr1_+_50571963 0.632 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr6_+_17600504 0.631 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr1_-_150241210 0.630 APH1A
anterior pharynx defective 1 homolog A (C. elegans)
chr7_+_50344255 0.630 NM_001220765
NM_001220766
NM_001220767
NM_001220768
NM_001220769
NM_001220770
NM_001220771
NM_001220772
NM_001220773
NM_001220774
NM_001220775
NM_001220776
NM_006060
IKZF1












IKAROS family zinc finger 1 (Ikaros)












chr3_+_171561138 0.626 NM_001164436
TMEM212
transmembrane protein 212
chr8_-_17752847 0.625 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chrX_-_50557019 0.623 NM_020717
SHROOM4
shroom family member 4
chr12_+_100867739 0.623 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr17_-_38821286 0.620 NM_152349
KRT222
keratin 222
chr13_-_46679143 0.619 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_+_46616044 0.619 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr6_-_135271206 0.619 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr14_-_95599794 0.618 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr19_-_41903226 0.614 NM_020158
EXOSC5
exosome component 5
chrX_-_78623006 0.613 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr17_+_58677603 0.612 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr7_+_116660263 0.611 ST7
suppression of tumorigenicity 7
chr5_+_36876899 0.611 NIPBL
Nipped-B homolog (Drosophila)
chr8_-_102803438 0.609 NM_032041
NCALD
neurocalcin delta
chr4_+_74281884 0.604 ALB
albumin
chr9_-_75567915 0.594 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_+_32940860 0.584 NM_001199456
BRD2
bromodomain containing 2
chr3_-_8693723 0.582 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr2_+_86668270 0.582 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr8_+_126442557 0.579 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr1_-_108231122 0.578 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr13_+_98795410 0.577 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr1_+_15272414 0.575 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr7_+_96745904 0.573 NM_020186
ACN9
ACN9 homolog (S. cerevisiae)
chr2_-_162930629 0.572 DPP4
dipeptidyl-peptidase 4
chr11_-_6817013 0.570 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr8_-_95449131 0.567 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr16_-_30934437 0.567 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chr10_+_5005453 0.566 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.61 3.28e-03 GO:0065007 biological regulation

Nothing significant found in compartment category.

Nothing significant found in function category.