Motif ID: SPI1.p2

Z-value: 2.853


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPI1chr11_-_474000960.693.4e-03Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_26644458 5.016 CD52
CD52 molecule
chr1_-_111743297 4.854 DENND2D
DENN/MADD domain containing 2D
chr1_-_31230673 4.784 NM_006762
 LAPTM5
lysosomal protein transmembrane 5
chr12_+_25205488 4.686 LRMP
lymphoid-restricted membrane protein
chr5_-_88179278 4.504 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr22_+_37257004 4.018 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chrX_+_48542159 3.914 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_29641094 3.899 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr12_+_25205180 3.853 NM_001204126
NM_001204127
NM_006152
 LRMP


lymphoid-restricted membrane protein


chr11_+_65190272 3.756


chr17_-_29641087 3.709 EVI2B
ecotropic viral integration site 2B
chr19_-_7764283 3.606 NM_001207019
 FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr14_-_23288912 3.506 NM_001126106
 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_-_53600999 3.465 NM_000889
 ITGB7
integrin, beta 7
chr1_+_111415791 3.463 CD53
CD53 molecule
chr17_-_29641068 3.452 EVI2B
ecotropic viral integration site 2B
chr5_+_118691692 3.447 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_23285011 3.360 NM_001126105
 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_+_111415721 3.350 NM_000560
 CD53
CD53 molecule
chr2_+_143886969 3.311 ARHGAP15
Rho GTPase activating protein 15

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 74 entries
Enrichment   P-value GO Accession GO Term
59.81 1.72e-04 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
51.27 3.98e-04 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
44.86 2.10e-02 GO:0045586 regulation of gamma-delta T cell differentiation
44.86 2.10e-02 GO:0045588 positive regulation of gamma-delta T cell differentiation
39.87 1.41e-03 GO:0002922 positive regulation of humoral immune response
38.45 3.64e-02 GO:0046643 regulation of gamma-delta T cell activation
38.45 3.64e-02 GO:0046645 positive regulation of gamma-delta T cell activation
35.89 2.32e-03 GO:0002714 positive regulation of B cell mediated immunity
35.89 2.32e-03 GO:0002891 positive regulation of immunoglobulin mediated immune response
29.91 3.44e-04 GO:0002920 regulation of humoral immune response
29.91 5.39e-03 GO:0045730 respiratory burst
26.39 6.97e-04 GO:0050853 B cell receptor signaling pathway
18.89 3.97e-02 GO:0008154 actin polymerization or depolymerization
13.20 2.69e-02 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
12.82 3.12e-02 GO:0002821 positive regulation of adaptive immune response
11.97 2.24e-07 GO:0050851 antigen receptor-mediated signaling pathway
11.81 4.69e-02 GO:0002705 positive regulation of leukocyte mediated immunity
11.81 4.69e-02 GO:0002708 positive regulation of lymphocyte mediated immunity
11.81 4.69e-02 GO:0030183 B cell differentiation
10.99 6.15e-07 GO:0002429 immune response-activating cell surface receptor signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
51.27 6.78e-05 GO:0043020 NADPH oxidase complex
44.86 3.58e-03 GO:0001891 phagocytic cup
14.02 3.39e-03 GO:0005884 actin filament
1.60 1.38e-02 GO:0071944 cell periphery
1.60 1.88e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
Enrichment   P-value GO Accession GO Term
44.86 1.53e-04 GO:0016175 superoxide-generating NADPH oxidase activity
27.61 1.50e-03 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
13.46 7.32e-04 GO:0003823 antigen binding
12.38 4.33e-02 GO:0032813 tumor necrosis factor receptor superfamily binding
4.84 1.55e-02 GO:0005125 cytokine activity
1.33 2.08e-02 GO:0005515 protein binding