Motif ID: SPIB.p2

Z-value: 1.959


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPIBchr19_+_509221940.852.6e-05Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15114495 7.815 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_+_48542159 4.573 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr18_-_53068755 3.695 TCF4
transcription factor 4
chr2_-_175499275 3.128 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr17_+_34431219 2.884 NM_002984
 CCL4
chemokine (C-C motif) ligand 4
chr12_+_25205180 2.811 NM_001204126
NM_001204127
NM_006152
 LRMP


lymphoid-restricted membrane protein


chr12_+_25205488 2.769 LRMP
lymphoid-restricted membrane protein
chr17_+_34640030 2.695 NM_207007
NM_001001435
 CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr22_+_23222897 2.668 CYAT1
immunoglobulin lambda light chain-like
chr3_-_121379757 2.618 NM_005335
 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_+_49838673 2.462 NM_001040031
NM_001774
 CD37

CD37 molecule

chr19_+_49838700 2.406 CD37
CD37 molecule
chr6_-_32160289 2.391 GPSM3
G-protein signaling modulator 3
chr17_+_67410825 2.389 NM_002758
 MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_25256364 2.330 RUNX3
runt-related transcription factor 3
chr3_-_121379701 2.324 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_+_49838646 2.320 CD37
CD37 molecule
chr10_+_70847857 2.295 SRGN
serglycin
chr1_-_183560010 2.284 NM_001127651
 NCF2
neutrophil cytosolic factor 2
chr4_+_40198526 2.241 NM_004310
 RHOH
ras homolog gene family, member H

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 47 entries
Enrichment   P-value GO Accession GO Term
46.22 8.02e-04 GO:0043029 T cell homeostasis
31.52 4.17e-03 GO:0001776 leukocyte homeostasis
31.52 4.17e-03 GO:0002260 lymphocyte homeostasis
17.85 6.61e-05 GO:0007015 actin filament organization
13.49 4.62e-04 GO:0050851 antigen receptor-mediated signaling pathway
12.94 2.42e-02 GO:0050671 positive regulation of lymphocyte proliferation
12.75 2.60e-02 GO:0032946 positive regulation of mononuclear cell proliferation
12.57 2.79e-02 GO:0070665 positive regulation of leukocyte proliferation
12.39 8.25e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
12.02 1.01e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
11.79 4.58e-09 GO:0030036 actin cytoskeleton organization
11.72 3.91e-02 GO:0048872 homeostasis of number of cells
11.04 1.80e-03 GO:0042110 T cell activation
10.00 4.23e-08 GO:0030029 actin filament-based process
8.68 8.88e-03 GO:0002697 regulation of immune effector process
8.47 2.48e-03 GO:0002757 immune response-activating signal transduction
8.31 2.84e-03 GO:0002764 immune response-regulating signaling pathway
8.26 2.97e-03 GO:0050867 positive regulation of cell activation
7.89 1.65e-02 GO:0051251 positive regulation of lymphocyte activation
7.36 2.57e-02 GO:0002696 positive regulation of leukocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
57.77 4.06e-02 GO:0001891 phagocytic cup
27.09 7.81e-05 GO:0005884 actin filament
6.55 2.38e-02 GO:0031252 cell leading edge
3.19 2.38e-02 GO:0031982 vesicle
3.16 4.82e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
Enrichment   P-value GO Accession GO Term
5.91 4.91e-03 GO:0005083 small GTPase regulator activity
5.31 4.83e-04 GO:0030695 GTPase regulator activity
5.16 6.27e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.43 2.01e-02 GO:0005515 protein binding