Motif ID: SREBF1,2.p2

Z-value: 1.524


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF2chr22_+_422291070.629.8e-03Click!
SREBF1chr17_-_17740288,
chr17_-_17740309
-0.476.5e-02Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_44519965 4.688 CTSA
cathepsin A
chr20_+_44520021 4.512 CTSA
cathepsin A
chr17_+_78075299 3.655 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr17_-_46688362 3.515 NM_004502
HOXB7
homeobox B7
chr20_+_44519924 3.493 CTSA
cathepsin A
chr20_+_44520203 3.404 CTSA
cathepsin A
chr1_+_11866240 3.343 CLCN6
chloride channel 6
chr1_+_183605207 3.332 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr1_-_161193375 3.218 NM_001643
APOA2
apolipoprotein A-II
chr15_-_72668301 3.205 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr17_+_78075390 3.070 GAA
glucosidase, alpha; acid
chr7_+_150065859 3.019 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr6_+_160390128 2.922 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr19_+_10765106 2.846 ILF3
interleukin enhancer binding factor 3, 90kDa
chr20_+_44519590 2.667 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chrY_+_15016698 2.663 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr16_-_5083933 2.595 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr22_+_35777087 2.538 HMOX1
heme oxygenase (decycling) 1
chr17_-_46688279 2.531 HOXB7
homeobox B7
chr17_+_79935493 2.519 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr12_-_49318663 2.518 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr5_-_150537306 2.507 ANXA6
annexin A6
chr16_-_5083913 2.467 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr12_-_63328857 2.447 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr6_+_31982538 2.398 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr9_-_19127494 2.280 NM_001122
PLIN2
perilipin 2
chr18_+_9136742 2.247 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr9_-_19127462 2.239 PLIN2
perilipin 2
chr12_-_65153182 2.207 GNS
glucosamine (N-acetyl)-6-sulfatase
chr17_-_42201009 2.196 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr17_-_42200957 2.165 HDAC5
histone deacetylase 5
chr5_-_150537261 2.152 ANXA6
annexin A6
chr6_+_87865261 2.114 NM_015021
ZNF292
zinc finger protein 292
chr19_-_41256371 2.105 C19orf54
chromosome 19 open reading frame 54
chr19_+_14544100 2.101 NM_002741
PKN1
protein kinase N1
chr17_-_35969401 2.096 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr1_+_11866206 2.071 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr17_-_46687925 2.066 HOXB7
homeobox B7
chr15_-_72668184 2.017 HEXA
hexosaminidase A (alpha polypeptide)
chr7_+_150065968 1.957 REPIN1
replication initiator 1
chr19_+_1067293 1.935 HMHA1
histocompatibility (minor) HA-1
chr12_-_63328663 1.862 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr5_-_150537335 1.771 NM_001155
ANXA6
annexin A6
chrX_-_102319080 1.666 BEX1
brain expressed, X-linked 1
chr14_-_35591439 1.651 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr17_-_73975443 1.626 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr18_+_32556891 1.606 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr12_+_12869818 1.589 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr17_+_25621105 1.578 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr2_+_220042986 1.572 FAM134A
family with sequence similarity 134, member A
chr19_+_14544216 1.550 PKN1
protein kinase N1
chr8_+_74903563 1.550 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr6_-_31830551 1.518 NEU1
sialidase 1 (lysosomal sialidase)
chr12_-_103311053 1.514 PAH
phenylalanine hydroxylase
chr10_+_51827710 1.500 FAM21A
family with sequence similarity 21, member A
chrX_-_102319096 1.499 NM_018476
BEX1
brain expressed, X-linked 1
chr2_+_177053306 1.495 NM_024501
HOXD1
homeobox D1
chr10_+_69644341 1.489 NM_012238
SIRT1
sirtuin 1
chr12_-_65153189 1.468 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr17_-_7137722 1.463 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr2_+_220042948 1.453 FAM134A
family with sequence similarity 134, member A
chrY_+_15016018 1.410 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_+_220042901 1.405 NM_024293
FAM134A
family with sequence similarity 134, member A
chr19_+_1067536 1.395 HMHA1
histocompatibility (minor) HA-1
chr22_+_35777051 1.384 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr17_-_7137675 1.377 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr10_+_69644708 1.371 SIRT1
sirtuin 1
chr19_+_49458151 1.354 BAX
BCL2-associated X protein
chr16_-_30134582 1.348 NM_001040056
NM_001109891
NM_002746
MAPK3


mitogen-activated protein kinase 3


chr2_+_46926049 1.304 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr17_-_7137580 1.291 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr10_+_46222647 1.286 NM_001169106
NM_001169107
NM_015262
FAM21C


family with sequence similarity 21, member C


chr6_+_151646634 1.275 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chrY_+_2709630 1.272 RPS4Y1
ribosomal protein S4, Y-linked 1
chr5_-_121414011 1.255 NM_002317
LOX
lysyl oxidase
chr12_+_112451151 1.242 NM_001034025
NM_006817
ERP29

endoplasmic reticulum protein 29

chr19_+_50016500 1.235 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_+_75526211 1.234 NM_003369
UVRAG
UV radiation resistance associated gene
chr8_-_13134028 1.230 DLC1
deleted in liver cancer 1
chr12_+_112451261 1.229 ERP29
endoplasmic reticulum protein 29
chrX_-_15872882 1.225 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr14_-_35591151 1.217 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr19_+_49458129 1.216 BAX
BCL2-associated X protein
chr1_-_40562917 1.203 PPT1
palmitoyl-protein thioesterase 1
chr1_-_40562909 1.192 PPT1
palmitoyl-protein thioesterase 1
chr19_+_50016490 1.188 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_49458031 1.183 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chrX_-_15872938 1.171 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr7_-_30029284 1.168 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr17_+_25621141 1.168 WSB1
WD repeat and SOCS box containing 1
chr12_+_7023490 1.165 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr16_-_1877140 1.146 NM_001040427
NM_005326
HAGH

hydroxyacylglutathione hydrolase

chrX_-_15873094 1.131 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr10_+_51827654 1.131 NM_001005751
FAM21C
FAM21A
family with sequence similarity 21, member C
family with sequence similarity 21, member A
chr15_-_72668740 1.127 HEXA
hexosaminidase A (alpha polypeptide)
chr7_-_1595746 1.126 NM_001097620
TMEM184A
transmembrane protein 184A
chr22_-_36903033 1.123 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr4_-_23891608 1.123 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_-_154928564 1.121 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr19_+_40854529 1.120 PLD3
phospholipase D family, member 3
chr2_-_220083658 1.112 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr17_-_73975507 1.111 NM_001185039
NM_004035
NM_007292
ACOX1


acyl-CoA oxidase 1, palmitoyl


chr7_+_102074002 1.110 ORAI2
ORAI calcium release-activated calcium modulator 2
chr1_+_150255228 1.109 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr17_+_79935410 1.095 NM_001251888
NM_024083
ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1

chr2_-_220083699 1.093 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr11_+_75526236 1.092 UVRAG
UV radiation resistance associated gene
chr19_+_1067114 1.065 NM_012292
HMHA1
histocompatibility (minor) HA-1
chr12_-_65153148 1.061 GNS
glucosamine (N-acetyl)-6-sulfatase
chr11_-_57283145 1.053 NM_003627
SLC43A1
solute carrier family 43, member 1
chr6_+_151561094 1.053 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_6640644 1.052 TPP1
tripeptidyl peptidase I
chr3_-_4508939 1.048 SUMF1
sulfatase modifying factor 1
chr1_-_161193190 1.047 APOA2
apolipoprotein A-II
chr12_+_53400245 1.046 EIF4B
eukaryotic translation initiation factor 4B
chr20_-_4795768 1.045 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr5_-_121413967 1.037 LOX
lysyl oxidase
chr5_-_121413906 1.036 LOX
lysyl oxidase
chr17_-_76124767 1.033 TMC6
transmembrane channel-like 6
chr19_+_10764896 1.030 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr16_+_69796237 1.028 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr22_+_35695872 1.024 TOM1
target of myb1 (chicken)
chr6_-_109703661 1.014 CD164
CD164 molecule, sialomucin
chr11_+_118938473 1.005 NM_021729
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr20_+_37590969 1.003 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr13_-_33002218 0.998 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr8_-_82395401 0.996 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr14_+_105953531 0.992 CRIP1
cysteine-rich protein 1 (intestinal)
chr15_+_89182038 0.986 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr3_-_11610264 0.984 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chrY_+_2709596 0.974 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr14_-_89883306 0.973 NM_005197
FOXN3
forkhead box N3
chr19_+_50922194 0.969 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chrX_+_30671456 0.958 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr16_+_2570322 0.953 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr11_+_118938515 0.952 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr2_-_220083394 0.950 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr1_-_1167421 0.943 NM_016176
NM_016547
SDF4

stromal cell derived factor 4

chr5_-_133706717 0.939 CDKL3
cyclin-dependent kinase-like 3
chr7_-_47621635 0.936 TNS3
tensin 3
chr11_+_118938528 0.928 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr19_+_40854331 0.920 NM_001031696
NM_012268
PLD3

phospholipase D family, member 3

chr22_+_38599026 0.909 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr14_-_74551159 0.908 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr1_+_110162427 0.903 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chr7_-_47621741 0.900 NM_022748
TNS3
tensin 3
chr17_+_80416047 0.893 NM_001038618
NARF
nuclear prelamin A recognition factor
chr17_-_78194085 0.889 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr11_+_118938530 0.883 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr15_+_44084493 0.879 SERF2
small EDRK-rich factor 2
chr1_+_110162459 0.878 AMPD2
adenosine monophosphate deaminase 2
chrY_+_15016775 0.877 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr1_-_212873306 0.868 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chrX_-_15872871 0.867 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_99797536 0.860 NM_145212
MRPL30
mitochondrial ribosomal protein L30
chr22_-_36903086 0.858 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr9_+_6757636 0.845 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr7_+_149570004 0.842 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr1_-_154193044 0.837 C1orf43
chromosome 1 open reading frame 43
chr22_-_39636906 0.835 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide
chr14_-_94849552 0.829 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_-_133427624 0.827 LYPD1
LY6/PLAUR domain containing 1
chr10_+_101542554 0.827 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr20_+_47538211 0.822 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr11_+_7535213 0.822 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_-_109703703 0.816 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr10_+_101542460 0.813 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr11_+_9685624 0.812 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr2_+_99797632 0.812 MRPL30
mitochondrial ribosomal protein L30
chr19_-_3985343 0.811 EEF2
eukaryotic translation elongation factor 2
chr3_-_187463474 0.801 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr1_+_226016428 0.794 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr18_+_32621299 0.791 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chrX_+_77166178 0.790 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr16_-_431822 0.789 NM_021259
TMEM8A
transmembrane protein 8A
chr6_+_31949800 0.781 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr7_+_106685007 0.779 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr12_-_65153055 0.778 GNS
glucosamine (N-acetyl)-6-sulfatase
chr6_-_151773168 0.773 NM_017909
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr4_-_89978117 0.768 NM_014883
FAM13A
family with sequence similarity 13, member A
chrX_-_15872921 0.766 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr16_-_30134529 0.765 MAPK3
mitogen-activated protein kinase 3
chr16_-_28503079 0.765 NM_000086
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_-_241520467 0.760 NM_002924
RGS7
regulator of G-protein signaling 7
chr1_-_241520384 0.754 RGS7
regulator of G-protein signaling 7
chr22_+_35695792 0.753 NM_001135730
NM_001135732
NM_005488
TOM1


target of myb1 (chicken)


chr8_-_8750739 0.752 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr6_+_64345726 0.751 PHF3
PHD finger protein 3
chr19_-_5720158 0.743 NM_004793
LONP1
lon peptidase 1, mitochondrial
chr16_-_30134266 0.742 MAPK3
mitogen-activated protein kinase 3
chr19_-_3985460 0.739 NM_001961
EEF2
eukaryotic translation elongation factor 2
chr12_+_53400061 0.738 NM_001417
EIF4B
eukaryotic translation initiation factor 4B
chr6_-_109703617 0.737 CD164
CD164 molecule, sialomucin
chr1_-_115259381 0.737 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr6_-_31830593 0.735 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr19_+_1071208 0.734 HMHA1
histocompatibility (minor) HA-1
chr11_+_7535000 0.734 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_50016606 0.734 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_90121911 0.734 RRAGD
Ras-related GTP binding D
chr2_-_176032850 0.732 NM_001880
ATF2
activating transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
31.09 4.21e-03 GO:0007040 lysosome organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
7.78 3.78e-06 GO:0005773 vacuole
8.48 6.19e-06 GO:0000323 lytic vacuole
8.48 6.19e-06 GO:0005764 lysosome
9.90 6.88e-04 GO:0005774 vacuolar membrane
9.51 8.99e-04 GO:0044437 vacuolar part
11.28 1.56e-03 GO:0005765 lysosomal membrane
1.63 3.40e-03 GO:0044444 cytoplasmic part
4.60 6.14e-03 GO:0005768 endosome
1.40 3.18e-02 GO:0005737 cytoplasm
1.38 3.43e-02 GO:0043227 membrane-bounded organelle

Nothing significant found in function category.