Motif ID: SRF.p3

Z-value: 4.222


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFchr6_+_43139201-0.263.4e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_35169876 33.934 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_35169897 29.045 MYL9
myosin, light chain 9, regulatory
chr2_+_74120132 21.781 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 21.048 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr11_+_117070039 19.243 NM_001001522
NM_003186
TAGLN

transgelin

chr15_-_35087748 19.140 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr12_+_75874512 15.956 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr10_-_90712510 14.068 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_123339423 11.691 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_-_123339178 11.259 MYLK
myosin light chain kinase
chr14_-_53417808 11.050 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr7_-_94285372 10.653 SGCE
sarcoglycan, epsilon
chr7_-_94285477 10.555 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr6_+_151561094 10.511 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr7_-_94285426 10.443 SGCE
sarcoglycan, epsilon
chr1_-_89530890 10.277 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr11_-_119294242 8.246 NM_006288
THY1
Thy-1 cell surface antigen
chr3_-_99594915 7.899 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr1_-_229569839 7.613 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr9_-_79520878 7.364 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr6_+_151561508 7.084 AKAP12
A kinase (PRKA) anchor protein 12
chr9_+_116356199 6.709 NM_144489
RGS3
regulator of G-protein signaling 3
chr17_+_42634598 6.312 NM_001466
FZD2
frizzled family receptor 2
chr1_+_223889253 6.091 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr7_-_107643330 6.068 NM_002291
LAMB1
laminin, beta 1
chr17_-_10560625 6.019 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr19_+_16178170 5.814 NM_001145160
TPM4
tropomyosin 4
chr19_-_36247917 5.798 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr16_+_56966025 5.658 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr15_+_74218962 5.344 LOXL1
lysyl oxidase-like 1
chr12_+_26348488 5.224 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr12_-_50616425 5.204 NM_001113547
LIMA1
LIM domain and actin binding 1
chr17_-_46671043 5.069 NM_002147
HOXB5
homeobox B5
chr2_-_151344145 4.834 NM_005168
RND3
Rho family GTPase 3
chr11_-_119293848 4.809 THY1
Thy-1 cell surface antigen
chr19_-_45826131 4.664 CKM
creatine kinase, muscle
chr19_-_45826232 4.611 NM_001824
CKM
creatine kinase, muscle
chr10_+_31610063 4.076 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr7_+_134464161 3.971 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr1_-_86043932 3.831 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_+_187930720 3.810 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr19_+_2476122 3.785 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr6_-_109775423 3.726 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr7_+_143078399 3.667 ZYX
zyxin
chr12_-_91505541 3.658 NM_002345
LUM
lumican
chr2_-_231989755 3.626 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chrX_-_37706816 3.421 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr7_+_143078358 3.329 NM_001010972
NM_003461
ZYX

zyxin

chr2_-_106015423 3.321 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr7_+_94285676 3.258 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr7_+_143078444 3.234 ZYX
zyxin
chr9_+_116356407 3.146 RGS3
regulator of G-protein signaling 3
chr10_-_16859389 3.111 RSU1
Ras suppressor protein 1
chr5_+_140749830 3.111 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr10_-_16859408 3.086 NM_012425
NM_152724
RSU1

Ras suppressor protein 1

chr17_-_46671322 3.076 HOXB5
homeobox B5
chr7_+_143078447 3.011 ZYX
zyxin
chrX_-_10851808 3.005 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_137801178 2.994 NM_001964
EGR1
early growth response 1
chr5_+_92918924 2.942 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr10_-_16859336 2.888 RSU1
Ras suppressor protein 1
chr7_+_143078395 2.859 ZYX
zyxin
chr7_+_94285736 2.834 PEG10
paternally expressed 10
chr7_+_143078457 2.707 ZYX
zyxin
chr10_+_88428167 2.666 NM_001171610
LDB3
LIM domain binding 3
chr22_-_36784055 2.624 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr4_-_10118460 2.542 WDR1
WD repeat domain 1
chr16_+_31483066 2.464 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr17_+_80193649 2.370 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr17_-_79479780 2.357 ACTG1
actin, gamma 1
chr4_-_10118444 2.312 WDR1
WD repeat domain 1
chr7_-_27183225 2.227 NM_019102
HOXA5
homeobox A5
chr7_+_93551015 2.119 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr5_-_142000899 2.111 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr11_-_65667860 1.988 NM_005438
FOSL1
FOS-like antigen 1
chr19_+_16187306 1.973 TPM4
tropomyosin 4
chr11_-_65667858 1.926 FOSL1
FOS-like antigen 1
chr14_+_75745480 1.905 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_+_75273245 1.897 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr7_-_559479 1.896 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr9_+_92219926 1.869 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr2_-_128432642 1.850 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr22_+_31480981 1.815 NM_001207018
SMTN
smoothelin
chr10_+_75757847 1.811 NM_003373
NM_014000
VCL

vinculin

chr17_-_79479831 1.800 NM_001199954
NM_001614
ACTG1

actin, gamma 1

chr19_+_13135368 1.711 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_31845818 1.698 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr4_+_24797084 1.656 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr19_+_1026608 1.640 CNN2
calponin 2
chr12_-_6772252 1.606 NM_001127582
NM_001127583
NM_001127584
NM_001127585
NM_001127586
NM_016162
ING4





inhibitor of growth family, member 4





chr10_+_123922940 1.580 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_187871473 1.565 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_+_143078608 1.564 ZYX
zyxin
chr7_-_80548666 1.551 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_-_111093251 1.550 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr17_+_3379295 1.547 NM_000049
ASPA
aspartoacylase
chr1_-_89591685 1.505 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_11994710 1.488 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr10_+_112257624 1.468 NM_004419
DUSP5
dual specificity phosphatase 5
chr1_-_154164551 1.457 NM_152263
TPM3
tropomyosin 3
chr4_+_156680125 1.444 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr4_-_10118500 1.416 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr7_-_80548322 1.397 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_65667809 1.377 FOSL1
FOS-like antigen 1
chr1_+_28099682 1.329 NM_177424
STX12
syntaxin 12
chr3_+_62304667 1.305 C3orf14
chromosome 3 open reading frame 14
chr17_-_78450247 1.290 NM_002522
NPTX1
neuronal pentraxin I
chr19_+_1026627 1.287 CNN2
calponin 2
chr5_-_39425297 1.287 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr1_-_242162364 1.217 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr15_-_65360297 1.190 NM_016563
RASL12
RAS-like, family 12
chr10_+_88428263 1.176 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr3_+_49027281 1.146 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr15_-_45670624 1.144 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_181057835 1.131 IER5
immediate early response 5
chr6_-_16761600 1.117 NM_000332
NM_001128164
ATXN1

ataxin 1

chr6_-_75965845 1.106 TMEM30A
transmembrane protein 30A
chr17_-_74099855 1.044 NM_001013839
NM_001145297
NM_001145298
NM_001145299
NM_015219
EXOC7




exocyst complex component 7




chr19_+_16187047 1.008 NM_003290
TPM4
tropomyosin 4
chr1_+_151512760 0.989 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr21_-_28217272 0.986 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chrX_-_153602998 0.982 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr5_+_42565562 0.977 NM_001242406
GHR
growth hormone receptor
chr9_+_97521930 0.965 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr7_-_5569200 0.922 ACTB
actin, beta
chr17_-_1389013 0.921 NM_001080950
MYO1C
myosin IC
chr8_-_48650683 0.887 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chrX_-_153602928 0.872 FLNA
filamin A, alpha
chr2_+_85132762 0.862 NM_021103
TMSB10
thymosin beta 10
chr10_-_29923900 0.843 NM_021738
SVIL
supervillin
chr7_+_94285620 0.826 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr3_-_78666943 0.821 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_-_201346783 0.807 TNNT2
troponin T type 2 (cardiac)
chr15_-_59665069 0.805 NM_004998
MYO1E
myosin IE
chr10_+_6186903 0.799 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr7_-_5570188 0.790 NM_001101
ACTB
actin, beta
chr5_+_42565963 0.790 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr3_-_9834357 0.786 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr1_+_11994778 0.778 PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr10_+_11207053 0.731 CELF2
CUGBP, Elav-like family member 2
chr19_-_46283763 0.728 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr15_+_96873845 0.709 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr12_-_9268522 0.687 NM_000014
A2M
alpha-2-macroglobulin
chr10_+_6186758 0.634 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_-_168106535 0.632 GPR161
G protein-coupled receptor 161
chr11_-_2162167 0.632 IGF2
insulin-like growth factor 2 (somatomedin A)
chr15_-_59665053 0.628 MYO1E
myosin IE
chr8_+_24771268 0.617 NM_005382
NEFM
neurofilament, medium polypeptide
chr19_+_57874878 0.613 NM_173631
TRAPPC2P1
ZNF547
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
chr10_+_6186878 0.583 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr3_+_9834778 0.569 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr3_-_9834065 0.566 TADA3
transcriptional adaptor 3
chr8_-_62602285 0.553 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr12_+_53645369 0.523 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr1_-_168106810 0.492 GPR161
G protein-coupled receptor 161
chr19_+_1026271 0.490 NM_004368
NM_201277
CNN2

calponin 2

chrX_-_153599719 0.450 FLNA
filamin A, alpha
chr18_+_54318561 0.437 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr2_+_161993465 0.437 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr21_+_35190586 0.421 ITSN1
intersectin 1 (SH3 domain protein)
chr5_-_179050675 0.412 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr13_+_27825689 0.395 NM_000982
RPL21
ribosomal protein L21
chrX_+_150884506 0.387 NM_033085
FATE1
fetal and adult testis expressed 1
chr2_-_242254984 0.385 HDLBP
high density lipoprotein binding protein
chr1_+_19970674 0.385 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr8_-_101965096 0.381 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_+_24771276 0.377 NEFM
neurofilament, medium polypeptide
chr20_-_62258330 0.375 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr1_-_16344438 0.362 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr4_+_120056938 0.355 NM_016599
MYOZ2
myozenin 2
chr17_+_33914320 0.341 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chrX_+_70521627 0.338 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr4_-_88450243 0.334 SPARCL1
SPARC-like 1 (hevin)
chr6_-_73935174 0.330 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr17_-_4890664 0.312 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr15_+_96869156 0.301 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_+_43139201 0.290 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr12_-_11548485 0.248 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr17_-_74099603 0.248 EXOC7
exocyst complex component 7
chr20_+_44519924 0.241 CTSA
cathepsin A
chr2_+_207024614 0.238 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr6_+_43139190 0.234 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr10_-_45474210 0.233 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr21_-_35987144 0.232 NM_004414
RCAN1
regulator of calcineurin 1
chr17_+_16318848 0.231 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr3_-_12705329 0.230 RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
chr19_+_35849487 0.217 NM_005304
FFAR3
free fatty acid receptor 3
chr19_+_57901188 0.206 NM_001172773
NM_152909
ZNF548

zinc finger protein 548

chr18_+_3247527 0.204 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr12_-_11508509 0.200 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr10_+_88516340 0.199 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr3_+_9834201 0.190 NM_001198793
NM_005718
ARPC4-TTLL3
ARPC4
ARPC4-TTLL3 readthrough
actin related protein 2/3 complex, subunit 4, 20kDa
chr19_+_49376488 0.172 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr17_+_7517263 0.167 SHBG
sex hormone-binding globulin
chr19_+_56153417 0.161 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr5_-_179050635 0.158 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_+_43996478 0.157 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr4_+_155665150 0.155 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr1_+_244816434 0.140 PPPDE1
PPPDE peptidase domain containing 1
chr17_-_37350051 0.139 CACNB1
calcium channel, voltage-dependent, beta 1 subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
13.23 1.22e-09 GO:0006936 muscle contraction
12.13 4.02e-09 GO:0003012 muscle system process
3.08 4.22e-04 GO:0003008 system process
17.11 7.26e-04 GO:0030048 actin filament-based movement
19.66 2.93e-03 GO:0030049 muscle filament sliding
19.66 2.93e-03 GO:0033275 actin-myosin filament sliding
19.14 3.36e-03 GO:0070252 actin-mediated cell contraction
5.99 3.57e-03 GO:0030029 actin filament-based process
1.62 9.15e-03 GO:0050896 response to stimulus
5.68 1.66e-02 GO:0061061 muscle structure development
1.69 2.58e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
45.44 8.13e-13 GO:0042641 actomyosin
48.47 9.83e-12 GO:0001725 stress fiber
45.13 2.08e-11 GO:0032432 actin filament bundle
9.55 1.58e-10 GO:0015629 actin cytoskeleton
3.83 3.74e-09 GO:0005856 cytoskeleton
13.11 4.19e-07 GO:0043292 contractile fiber
14.55 1.04e-06 GO:0005925 focal adhesion
13.93 1.54e-06 GO:0005924 cell-substrate adherens junction
13.36 2.23e-06 GO:0030055 cell-substrate junction
11.03 2.26e-06 GO:0005912 adherens junction
12.59 3.76e-06 GO:0030016 myofibril
9.90 6.33e-06 GO:0070161 anchoring junction
11.53 4.50e-05 GO:0044449 contractile fiber part
3.41 3.82e-04 GO:0044430 cytoskeletal part
1.45 7.29e-04 GO:0005737 cytoplasm
2.17 1.09e-03 GO:0043228 non-membrane-bounded organelle
2.17 1.09e-03 GO:0043232 intracellular non-membrane-bounded organelle
6.39 1.15e-03 GO:0016323 basolateral plasma membrane
10.15 2.82e-03 GO:0030017 sarcomere
3.86 6.12e-03 GO:0030054 cell junction
33.56 9.05e-03 GO:0005865 striated muscle thin filament
1.25 1.68e-02 GO:0044424 intracellular part
2.08 2.19e-02 GO:0005829 cytosol
72.70 2.95e-02 GO:0005862 muscle thin filament tropomyosin
1.23 4.70e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.61 1.85e-04 GO:0008092 cytoskeletal protein binding
5.91 2.49e-04 GO:0003779 actin binding