Motif ID: SRF.p3

Z-value: 4.222


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRFchr6_+_43139201-0.263.4e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_35169876 33.934 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr20_+_35169897 29.045 MYL9
myosin, light chain 9, regulatory
chr2_+_74120132 21.781 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 21.048 NM_001199893
NM_001615
 ACTG2

actin, gamma 2, smooth muscle, enteric

chr11_+_117070039 19.243 NM_001001522
NM_003186
 TAGLN

transgelin

chr15_-_35087748 19.140 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr12_+_75874512 15.956 NM_006851
 GLIPR1
GLI pathogenesis-related 1
chr10_-_90712510 14.068 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_123339423 11.691 NM_053031
NM_053032
 MYLK

myosin light chain kinase

chr3_-_123339178 11.259 MYLK
myosin light chain kinase
chr14_-_53417808 11.050 NM_001134999
NM_001135000
NM_006832
 FERMT2


fermitin family member 2


chr7_-_94285372 10.653 SGCE
sarcoglycan, epsilon
chr7_-_94285477 10.555 NM_001099400
NM_001099401
NM_003919
 SGCE


sarcoglycan, epsilon


chr6_+_151561094 10.511 NM_005100
 AKAP12
A kinase (PRKA) anchor protein 12
chr7_-_94285426 10.443 SGCE
sarcoglycan, epsilon
chr1_-_89530890 10.277 NM_002053
 GBP1
guanylate binding protein 1, interferon-inducible
chr11_-_119294242 8.246 NM_006288
 THY1
Thy-1 cell surface antigen
chr3_-_99594915 7.899 NM_014890
 FILIP1L
filamin A interacting protein 1-like
chr1_-_229569839 7.613 NM_001100
 ACTA1
actin, alpha 1, skeletal muscle
chr9_-_79520878 7.364 NM_015225
 PRUNE2
prune homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
19.66 2.93e-03 GO:0030049 muscle filament sliding
19.66 2.93e-03 GO:0033275 actin-myosin filament sliding
19.14 3.36e-03 GO:0070252 actin-mediated cell contraction
17.11 7.26e-04 GO:0030048 actin filament-based movement
13.23 1.22e-09 GO:0006936 muscle contraction
12.13 4.02e-09 GO:0003012 muscle system process
5.99 3.57e-03 GO:0030029 actin filament-based process
5.68 1.66e-02 GO:0061061 muscle structure development
3.08 4.22e-04 GO:0003008 system process
1.69 2.58e-02 GO:0032501 multicellular organismal process
1.62 9.15e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
72.70 2.95e-02 GO:0005862 muscle thin filament tropomyosin
48.47 9.83e-12 GO:0001725 stress fiber
45.44 8.13e-13 GO:0042641 actomyosin
45.13 2.08e-11 GO:0032432 actin filament bundle
33.56 9.05e-03 GO:0005865 striated muscle thin filament
14.55 1.04e-06 GO:0005925 focal adhesion
13.93 1.54e-06 GO:0005924 cell-substrate adherens junction
13.36 2.23e-06 GO:0030055 cell-substrate junction
13.11 4.19e-07 GO:0043292 contractile fiber
12.59 3.76e-06 GO:0030016 myofibril
11.53 4.50e-05 GO:0044449 contractile fiber part
11.03 2.26e-06 GO:0005912 adherens junction
10.15 2.82e-03 GO:0030017 sarcomere
9.90 6.33e-06 GO:0070161 anchoring junction
9.55 1.58e-10 GO:0015629 actin cytoskeleton
6.39 1.15e-03 GO:0016323 basolateral plasma membrane
3.86 6.12e-03 GO:0030054 cell junction
3.83 3.74e-09 GO:0005856 cytoskeleton
3.41 3.82e-04 GO:0044430 cytoskeletal part
2.17 1.09e-03 GO:0043228 non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
5.91 2.49e-04 GO:0003779 actin binding
4.61 1.85e-04 GO:0008092 cytoskeletal protein binding