Motif ID: STAT2,4,6.p2

Z-value: 1.713


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT4chr2_-_192015934,
chr2_-_192016293,
chr2_-_192015706		-0.562.4e-02Click!
STAT2chr12_-_567539160.273.1e-01Click!
STAT6chr12_-_575051760.039.2e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_9268522 4.634 NM_000014
 A2M
alpha-2-macroglobulin
chr5_+_71502700 3.800 MAP1B
microtubule-associated protein 1B
chr14_+_95078713 3.799 NM_001085
 SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_-_187463227 3.661 BCL6
B-cell CLL/lymphoma 6
chr3_-_187463474 3.549 NM_001706
 BCL6
B-cell CLL/lymphoma 6
chr12_-_7245006 2.780 NM_001733
 C1R
complement component 1, r subcomponent
chr12_-_7245048 2.720 C1R
complement component 1, r subcomponent
chr12_-_9268440 2.638 A2M
alpha-2-macroglobulin
chr12_-_9268513 2.626 A2M
alpha-2-macroglobulin
chr3_+_186330859 2.061 AHSG
alpha-2-HS-glycoprotein
chr3_+_186330844 2.056 NM_001622
 AHSG
alpha-2-HS-glycoprotein
chr3_+_186330711 1.980 AHSG
alpha-2-HS-glycoprotein
chrX_+_106045880 1.954 NM_017752
NM_198881
 TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr12_-_9268475 1.878 A2M
alpha-2-macroglobulin
chr17_+_1646129 1.821 NM_000934
NM_001165921
 SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr11_+_57365026 1.772 NM_000062
 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_-_230849863 1.764 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230850335 1.752 NM_000029
 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr7_+_134464417 1.727 CALD1
caldesmon 1
chr12_+_7167979 1.655 NM_001734
NM_201442
 C1S

complement component 1, s subcomponent


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
Enrichment   P-value GO Accession GO Term
200.78 1.17e-02 GO:0001868 regulation of complement activation, lectin pathway
200.78 1.17e-02 GO:0001869 negative regulation of complement activation, lectin pathway
54.77 8.99e-03 GO:0031102 neuron projection regeneration
26.78 6.56e-03 GO:0006958 complement activation, classical pathway
24.50 7.96e-04 GO:0006956 complement activation
23.63 1.09e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
22.96 1.23e-02 GO:0006953 acute-phase response
21.53 1.48e-04 GO:0010951 negative regulation of endopeptidase activity
20.09 2.25e-04 GO:0072376 protein activation cascade
19.01 3.43e-05 GO:0002576 platelet degranulation
15.26 1.16e-03 GO:0006959 humoral immune response
14.19 1.79e-03 GO:0010466 negative regulation of peptidase activity
13.22 1.72e-02 GO:0031099 regeneration
10.97 7.96e-03 GO:0030162 regulation of proteolysis
10.31 1.13e-02 GO:0051346 negative regulation of hydrolase activity
8.80 6.39e-03 GO:0052548 regulation of endopeptidase activity
8.64 7.21e-03 GO:0006887 exocytosis
8.43 8.45e-03 GO:0052547 regulation of peptidase activity
7.10 1.98e-03 GO:0032940 secretion by cell
6.77 3.44e-02 GO:0030168 platelet activation

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
57.38 4.66e-02 GO:0005577 fibrinogen complex
25.65 9.78e-06 GO:0031093 platelet alpha granule lumen
25.11 1.11e-05 GO:0034774 secretory granule lumen
24.11 1.43e-05 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
23.18 1.82e-05 GO:0031983 vesicle lumen
21.53 2.86e-05 GO:0031091 platelet alpha granule
13.40 4.81e-04 GO:0005925 focal adhesion
12.83 6.19e-04 GO:0005924 cell-substrate adherens junction
12.31 7.88e-04 GO:0030055 cell-substrate junction
9.14 4.31e-03 GO:0005912 adherens junction
8.21 7.85e-03 GO:0070161 anchoring junction
7.82 2.64e-03 GO:0030141 stored secretory granule
6.87 6.05e-03 GO:0016323 basolateral plasma membrane
4.85 8.43e-06 GO:0005615 extracellular space
4.57 9.67e-07 GO:0044421 extracellular region part
4.10 2.82e-10 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
22.68 1.79e-06 GO:0004867 serine-type endopeptidase inhibitor activity
15.73 3.99e-07 GO:0030414 peptidase inhibitor activity
14.23 6.75e-06 GO:0004866 endopeptidase inhibitor activity
13.63 9.47e-06 GO:0061135 endopeptidase regulator activity
12.65 2.72e-06 GO:0061134 peptidase regulator activity
8.15 1.15e-04 GO:0004857 enzyme inhibitor activity
3.86 8.79e-04 GO:0030234 enzyme regulator activity