Motif ID: STAT2,4,6.p2

Z-value: 1.713


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT4chr2_-_192015934,
chr2_-_192016293,
chr2_-_192015706
-0.562.4e-02Click!
STAT2chr12_-_567539160.273.1e-01Click!
STAT6chr12_-_575051760.039.2e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_9268522 4.634 NM_000014
A2M
alpha-2-macroglobulin
chr5_+_71502700 3.800 MAP1B
microtubule-associated protein 1B
chr14_+_95078713 3.799 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_-_187463227 3.661 BCL6
B-cell CLL/lymphoma 6
chr3_-_187463474 3.549 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr12_-_7245006 2.780 NM_001733
C1R
complement component 1, r subcomponent
chr12_-_7245048 2.720 C1R
complement component 1, r subcomponent
chr12_-_9268440 2.638 A2M
alpha-2-macroglobulin
chr12_-_9268513 2.626 A2M
alpha-2-macroglobulin
chr3_+_186330859 2.061 AHSG
alpha-2-HS-glycoprotein
chr3_+_186330844 2.056 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr3_+_186330711 1.980 AHSG
alpha-2-HS-glycoprotein
chrX_+_106045880 1.954 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr12_-_9268475 1.878 A2M
alpha-2-macroglobulin
chr17_+_1646129 1.821 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr11_+_57365026 1.772 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_-_230849863 1.764 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230850335 1.752 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr7_+_134464417 1.727 CALD1
caldesmon 1
chr12_+_7167979 1.655 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr1_-_230849847 1.652 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_-_44860798 1.608 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr17_+_1646290 1.606 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr5_-_121414011 1.603 NM_002317
LOX
lysyl oxidase
chr11_+_57365577 1.569 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_+_53443834 1.558 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr14_-_53417272 1.550 FERMT2
fermitin family member 2
chrX_-_133119475 1.542 GPC3
glypican 3
chrX_-_133119624 1.524 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr5_-_111092918 1.521 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr17_+_32582295 1.483 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr11_-_27681195 1.471 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr4_-_155511838 1.453 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr8_-_48650703 1.451 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_-_48650683 1.395 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_17906941 1.379 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_-_90750955 1.369 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_+_14166632 1.334 TMEM43
transmembrane protein 43
chr3_+_14166543 1.317 TMEM43
transmembrane protein 43
chr3_+_14166582 1.310 TMEM43
transmembrane protein 43
chr4_-_155533882 1.291 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr3_-_148939784 1.275 NM_000096
CP
ceruloplasmin (ferroxidase)
chr11_+_10326618 1.273 NM_001124
ADM
adrenomedullin
chr3_+_133495925 1.270 TF
transferrin
chr4_-_155533850 1.267 FGG
fibrinogen gamma chain
chr4_-_155533757 1.267 FGG
fibrinogen gamma chain
chr4_+_88896899 1.262 SPP1
secreted phosphoprotein 1
chr5_-_111092865 1.258 C5orf13
chromosome 5 open reading frame 13
chr4_-_155533800 1.248 FGG
fibrinogen gamma chain
chr3_+_14166439 1.248 NM_024334
TMEM43
transmembrane protein 43
chr19_-_44123732 1.245 ZNF428
zinc finger protein 428
chr8_+_26435920 1.241 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr12_-_7261788 1.234 NM_016546
C1RL
complement component 1, r subcomponent-like
chr19_+_15218141 1.224 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr9_-_117880411 1.221 NM_002160
TNC
tenascin C
chr19_+_35773409 1.220 NM_021175
HAMP
hepcidin antimicrobial peptide
chr22_+_38598065 1.213 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_+_52828783 1.195 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chrX_-_106243442 1.189 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr4_+_88896868 1.184 SPP1
secreted phosphoprotein 1
chr19_+_44556163 1.179 NM_013361
ZNF223
zinc finger protein 223
chr4_+_88896838 1.175 SPP1
secreted phosphoprotein 1
chr3_+_187871473 1.172 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_+_88896801 1.169 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr16_+_31483066 1.168 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr2_+_201450730 1.149 NM_001159
AOX1
aldehyde oxidase 1
chr8_+_26371461 1.145 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr2_-_167232464 1.129 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chrX_+_115567746 1.121 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr5_-_121413967 1.116 LOX
lysyl oxidase
chr22_+_21128378 1.109 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr5_-_121413906 1.106 LOX
lysyl oxidase
chr14_-_69446038 1.101 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr10_-_52645384 1.101 A1CF
APOBEC1 complementation factor
chrX_-_99891690 1.099 NM_003270
TSPAN6
tetraspanin 6
chr6_-_83903632 1.098 NM_001199917
PGM3
phosphoglucomutase 3
chr14_-_69445978 1.095 ACTN1
actinin, alpha 1
chr14_-_69446008 1.083 ACTN1
actinin, alpha 1
chr1_-_68299047 1.083 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr2_-_190044330 1.082 NM_000393
COL5A2
collagen, type V, alpha 2
chr14_+_21538339 1.064 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr19_-_44124013 1.061 NM_182498
ZNF428
zinc finger protein 428
chr3_-_123603144 1.059 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr14_-_69445974 1.056 ACTN1
actinin, alpha 1
chr17_-_80291639 1.052 SECTM1
secreted and transmembrane 1
chr17_-_7082559 1.051 ASGR1
asialoglycoprotein receptor 1
chrX_+_102632108 1.046 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_+_31913763 1.044 CFB
complement factor B
chr15_+_71184781 1.042 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr14_-_69445989 1.037 ACTN1
actinin, alpha 1
chr7_-_150038689 1.027 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr16_-_28550324 1.023 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr9_-_107690526 1.008 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr11_+_114167168 0.999 NNMT
nicotinamide N-methyltransferase
chr15_+_33010174 0.997 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr14_-_69445948 0.996 ACTN1
actinin, alpha 1
chr6_+_151561094 0.995 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr6_+_31913852 0.992 CFB
complement factor B
chr17_-_80291610 0.991 SECTM1
secreted and transmembrane 1
chr19_+_44669214 0.985 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr16_-_52581713 0.984 NM_001146188
TOX3
TOX high mobility group box family member 3
chr17_-_7082654 0.982 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr2_+_235860616 0.981 NM_014521
SH3BP4
SH3-domain binding protein 4
chr8_-_120651019 0.979 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr6_+_30130982 0.977 NM_033229
TRIM15
tripartite motif containing 15
chr1_+_201979747 0.973 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_-_76975932 0.970 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr16_-_28550227 0.970 NUPR1
nuclear protein, transcriptional regulator, 1
chr11_+_114167197 0.965 NNMT
nicotinamide N-methyltransferase
chr17_-_1619473 0.951 MIR22HG
MIR22 host gene (non-protein coding)
chr20_+_44036940 0.943 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_-_12030128 0.941 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr5_-_111312522 0.934 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr2_-_218808705 0.931 NM_022648
TNS1
tensin 1
chr1_+_169075869 0.931 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr1_+_207262583 0.928 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr17_+_4675175 0.923 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr6_+_31913708 0.920 NM_001710
CFB
complement factor B
chr5_-_111091947 0.905 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr16_+_72088507 0.898 NM_001126102
NM_005143
HP

haptoglobin

chrX_+_54835492 0.888 NM_201222
MAGED2
melanoma antigen family D, 2
chr22_+_38597938 0.888 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr1_+_207262211 0.886 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr2_-_44065888 0.885 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr14_-_54423448 0.881 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr10_-_52645430 0.881 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr9_+_103791030 0.879 NM_207299
LPPR1
lipid phosphate phosphatase-related protein type 1
chr1_-_173174611 0.879 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_55095263 0.876 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_-_111093030 0.876 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr5_-_111093251 0.874 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr10_-_95241943 0.871 NM_013451
NM_133337
MYOF

myoferlin

chr19_+_54024176 0.870 NM_018555
ZNF331
zinc finger protein 331
chr8_+_70405080 0.868 SULF1
sulfatase 1
chr12_+_133656984 0.867 NM_003440
ZNF140
zinc finger protein 140
chr3_+_45067750 0.867 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chrX_-_48931645 0.866 NM_007213
PRAF2
PRA1 domain family, member 2
chr3_-_158450230 0.864 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_+_159557745 0.853 SCHIP1
schwannomin interacting protein 1
chr3_-_158450205 0.853 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr2_-_151344145 0.852 NM_005168
RND3
Rho family GTPase 3
chr3_-_158450271 0.850 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr1_+_201979689 0.842 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr8_-_27472298 0.834 NM_001831
CLU
clusterin
chr5_-_55290601 0.834 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr12_+_53491417 0.832 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr16_+_53738044 0.831 FTO
fat mass and obesity associated
chr3_+_110790460 0.829 NM_001243286
NM_015480
PVRL3

poliovirus receptor-related 3

chr8_-_27472188 0.823 CLU
clusterin
chr1_+_155099935 0.818 EFNA1
ephrin-A1
chr6_-_35464716 0.806 NM_003214
TEAD3
TEA domain family member 3
chr6_+_31895401 0.800 C2
complement component 2
chr3_+_133464883 0.792 NM_001063
TF
transferrin
chr13_+_113777112 0.783 NM_000504
F10
coagulation factor X
chr14_+_75745480 0.781 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr14_-_94759594 0.777 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_+_171757432 0.777 FNDC3B
fibronectin type III domain containing 3B
chr17_-_26697293 0.771 VTN
vitronectin
chr10_-_126716452 0.767 NM_022802
CTBP2
C-terminal binding protein 2
chr16_+_69220940 0.753 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr11_+_7506599 0.743 NM_198474
OLFML1
olfactomedin-like 1
chr12_+_53491448 0.743 IGFBP6
insulin-like growth factor binding protein 6
chr17_-_26697310 0.742 VTN
vitronectin
chr16_+_53737874 0.727 NM_001080432
FTO
fat mass and obesity associated
chr16_+_69726751 0.718 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr4_+_4861371 0.716 NM_002448
MSX1
msh homeobox 1
chr11_+_73357222 0.716 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chrX_-_10544852 0.708 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr14_-_69445772 0.703 ACTN1
actinin, alpha 1
chr18_+_66382490 0.701 NM_001093729
CCDC102B
coiled-coil domain containing 102B
chr14_-_30396811 0.700 NM_002742
PRKD1
protein kinase D1
chr8_-_13134028 0.700 DLC1
deleted in liver cancer 1
chr22_-_36236421 0.697 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr18_+_29171729 0.691 NM_000371
TTR
transthyretin
chr19_+_45418063 0.689 APOC1
apolipoprotein C-I
chr17_-_26697224 0.686 VTN
vitronectin
chr17_+_75315632 0.685 SEPT9
septin 9
chr15_-_71184611 0.684 NM_020147
THAP10
THAP domain containing 10
chr19_+_3094266 0.678 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr20_+_44036628 0.675 NM_001048225
NM_001048226
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr11_+_844445 0.664 NM_001025237
TSPAN4
tetraspanin 4
chr10_+_75673346 0.656 PLAU
plasminogen activator, urokinase
chr17_-_41623652 0.655 NM_001079675
ETV4
ets variant 4
chr16_-_69760367 0.653 NQO1
NAD(P)H dehydrogenase, quinone 1
chr16_+_56659584 0.653 NM_175617
MT1E
metallothionein 1E
chr20_+_30945988 0.652 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr10_+_71812356 0.651 NM_018649
H2AFY2
H2A histone family, member Y2
chr6_-_31830551 0.651 NEU1
sialidase 1 (lysosomal sialidase)
chr3_+_179370779 0.651 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr1_+_205473768 0.648 CDK18
cyclin-dependent kinase 18
chr10_+_123754141 0.646 TACC2
transforming, acidic coiled-coil containing protein 2
chr22_-_36236330 0.645 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_-_186697065 0.645 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr6_+_31895201 0.640 NM_000063
NM_001145903
C2

complement component 2

chr14_-_51135021 0.634 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr4_+_169418167 0.634 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr11_+_844111 0.632 TSPAN4
tetraspanin 4
chr7_+_134464372 0.632 CALD1
caldesmon 1
chr17_+_75315590 0.629 NM_006640
SEPT9
septin 9
chr22_+_36044412 0.628 NM_030641
APOL6
apolipoprotein L, 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.78 6.80e-06 GO:0009611 response to wounding
19.01 3.43e-05 GO:0002576 platelet degranulation
21.53 1.48e-04 GO:0010951 negative regulation of endopeptidase activity
20.09 2.25e-04 GO:0072376 protein activation cascade
24.50 7.96e-04 GO:0006956 complement activation
15.26 1.16e-03 GO:0006959 humoral immune response
2.57 1.25e-03 GO:0006950 response to stress
14.19 1.79e-03 GO:0010466 negative regulation of peptidase activity
7.10 1.98e-03 GO:0032940 secretion by cell
8.80 6.39e-03 GO:0052548 regulation of endopeptidase activity
26.78 6.56e-03 GO:0006958 complement activation, classical pathway
8.64 7.21e-03 GO:0006887 exocytosis
10.97 7.96e-03 GO:0030162 regulation of proteolysis
2.73 8.13e-03 GO:0048583 regulation of response to stimulus
2.53 8.43e-03 GO:0065008 regulation of biological quality
8.43 8.45e-03 GO:0052547 regulation of peptidase activity
54.77 8.99e-03 GO:0031102 neuron projection regeneration
23.63 1.09e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
1.72 1.13e-02 GO:0050896 response to stimulus
10.31 1.13e-02 GO:0051346 negative regulation of hydrolase activity
200.78 1.17e-02 GO:0001868 regulation of complement activation, lectin pathway
200.78 1.17e-02 GO:0001869 negative regulation of complement activation, lectin pathway
22.96 1.23e-02 GO:0006953 acute-phase response
1.54 1.41e-02 GO:0065007 biological regulation
4.04 1.47e-02 GO:0016192 vesicle-mediated transport
13.22 1.72e-02 GO:0031099 regeneration
5.05 3.01e-02 GO:0046903 secretion
6.77 3.44e-02 GO:0030168 platelet activation
3.67 3.78e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.10 2.82e-10 GO:0005576 extracellular region
4.57 9.67e-07 GO:0044421 extracellular region part
4.85 8.43e-06 GO:0005615 extracellular space
25.65 9.78e-06 GO:0031093 platelet alpha granule lumen
25.11 1.11e-05 GO:0034774 secretory granule lumen
24.11 1.43e-05 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
23.18 1.82e-05 GO:0031983 vesicle lumen
21.53 2.86e-05 GO:0031091 platelet alpha granule
13.40 4.81e-04 GO:0005925 focal adhesion
12.83 6.19e-04 GO:0005924 cell-substrate adherens junction
12.31 7.88e-04 GO:0030055 cell-substrate junction
7.82 2.64e-03 GO:0030141 stored secretory granule
9.14 4.31e-03 GO:0005912 adherens junction
6.87 6.05e-03 GO:0016323 basolateral plasma membrane
8.21 7.85e-03 GO:0070161 anchoring junction
57.38 4.66e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
15.73 3.99e-07 GO:0030414 peptidase inhibitor activity
22.68 1.79e-06 GO:0004867 serine-type endopeptidase inhibitor activity
12.65 2.72e-06 GO:0061134 peptidase regulator activity
14.23 6.75e-06 GO:0004866 endopeptidase inhibitor activity
13.63 9.47e-06 GO:0061135 endopeptidase regulator activity
8.15 1.15e-04 GO:0004857 enzyme inhibitor activity
3.86 8.79e-04 GO:0030234 enzyme regulator activity