Motif ID: TBP.p2

Z-value: 3.338


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBPchr6_+_170863420-0.601.4e-02Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_56685810 10.655 NM_005947
 MT1B
metallothionein 1B
chr1_-_59042827 10.392 TACSTD2
tumor-associated calcium signal transducer 2
chr16_+_56659584 10.315 NM_175617
 MT1E
metallothionein 1E
chr17_-_39780762 10.267 NM_000422
 KRT17
keratin 17
chr16_+_56659679 10.133 MT1E
metallothionein 1E
chr4_+_75310852 10.017 NM_001657
 AREG
amphiregulin
chr1_+_153003677 9.673 NM_003125
 SPRR1B
small proline-rich protein 1B
chr12_-_52886971 9.636 NM_005554
 KRT6A
keratin 6A
chr2_-_151344145 9.570 NM_005168
 RND3
Rho family GTPase 3
chr12_-_52867521 9.326 NM_173086
 KRT6C
keratin 6C
chr2_-_216300770 8.922 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr21_-_28217692 8.371 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_-_53012332 8.301 NM_175068
 KRT73
keratin 73
chr11_-_2950593 8.136 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr1_-_153363544 7.998 NM_002964
 S100A8
S100 calcium binding protein A8
chr7_+_100770378 7.970 NM_000602
NM_001165413
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr21_-_28217272 7.918 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_+_54074037 7.885 NM_012242
 DKK1
dickkopf 1 homolog (Xenopus laevis)
chr16_+_56716378 7.555 NM_005952
 MT1X
metallothionein 1X
chr15_-_63674074 7.305 NM_001218
NM_206925
 CA12

carbonic anhydrase XII


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
26.75 5.54e-05 GO:0031424 keratinization
20.65 3.06e-02 GO:0045103 intermediate filament-based process
18.68 4.66e-02 GO:0018149 peptide cross-linking
15.49 1.79e-03 GO:0030193 regulation of blood coagulation
14.36 2.85e-03 GO:0050818 regulation of coagulation
13.38 4.37e-03 GO:0030216 keratinocyte differentiation
12.58 3.81e-02 GO:0034614 cellular response to reactive oxygen species
12.52 6.48e-03 GO:0061041 regulation of wound healing
11.32 1.18e-02 GO:0009913 epidermal cell differentiation
9.44 4.15e-08 GO:0008544 epidermis development
7.99 2.26e-02 GO:0000302 response to reactive oxygen species
5.91 2.73e-05 GO:0010035 response to inorganic substance
5.78 7.58e-03 GO:0006979 response to oxidative stress
4.81 6.15e-03 GO:0006954 inflammatory response
4.55 4.39e-10 GO:0009888 tissue development
3.50 3.82e-02 GO:0007010 cytoskeleton organization
3.47 4.15e-02 GO:0072358 cardiovascular system development
3.47 4.15e-02 GO:0072359 circulatory system development
3.42 2.62e-02 GO:0006935 chemotaxis
3.42 2.62e-02 GO:0042330 taxis

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
Enrichment   P-value GO Accession GO Term
98.05 1.37e-02 GO:0005584 collagen type I
34.61 1.45e-06 GO:0001533 cornified envelope
23.78 1.33e-07 GO:0045095 keratin filament
19.62 9.68e-15 GO:0005882 intermediate filament
15.54 4.82e-13 GO:0045111 intermediate filament cytoskeleton
10.44 1.44e-02 GO:0031093 platelet alpha granule lumen
10.22 1.60e-02 GO:0034774 secretory granule lumen
9.81 1.95e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
9.44 2.35e-02 GO:0031983 vesicle lumen
8.76 3.34e-02 GO:0031091 platelet alpha granule
4.14 1.07e-08 GO:0005615 extracellular space
3.98 6.13e-03 GO:0031012 extracellular matrix
3.79 4.00e-02 GO:0015629 actin cytoskeleton
3.52 9.95e-08 GO:0044421 extracellular region part
3.36 5.45e-10 GO:0005856 cytoskeleton
3.20 2.26e-05 GO:0044430 cytoskeletal part
2.69 4.20e-07 GO:0005576 extracellular region
2.03 2.03e-04 GO:0043228 non-membrane-bounded organelle
2.03 2.03e-04 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
78.44 6.99e-06 GO:0046870 cadmium ion binding
29.42 1.63e-02 GO:0001968 fibronectin binding
26.75 2.22e-02 GO:0048407 platelet-derived growth factor binding
16.82 6.21e-10 GO:0005200 structural constituent of cytoskeleton
12.80 9.04e-04 GO:0005507 copper ion binding
6.21 4.03e-15 GO:0005198 structural molecule activity
3.58 3.44e-02 GO:0030246 carbohydrate binding
1.37 5.56e-03 GO:0005515 protein binding