Motif ID: TCF4_dimer.p2

Z-value: 2.144


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF4chr18_-_530712250.411.2e-01Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_74218962 6.887 LOXL1
lysyl oxidase-like 1
chr9_-_35689799 4.825 TPM2
tropomyosin 2 (beta)
chr9_-_35689902 4.746 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr2_+_220283098 4.632 NM_001927
DES
desmin
chr4_-_80994183 4.587


chr15_+_74218786 4.435 NM_005576
LOXL1
lysyl oxidase-like 1
chr15_+_74218794 4.372 LOXL1
lysyl oxidase-like 1
chr15_-_48937795 3.928 NM_000138
FBN1
fibrillin 1
chr9_-_75567915 3.771 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_+_170366211 3.659 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr7_+_94023872 3.418 NM_000089
COL1A2
collagen, type I, alpha 2
chr9_-_75568232 3.200 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr7_+_94024201 3.143 COL1A2
collagen, type I, alpha 2
chr10_+_124220990 2.978 NM_002775
HTRA1
HtrA serine peptidase 1
chr2_-_175629140 2.835 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr3_-_87040246 2.748 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr11_-_47470687 2.728 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr6_-_139695349 2.565 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chrX_-_135863502 2.539 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_-_107018889 2.518 TSC22D3
TSC22 domain family, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 36 entries
Enrichment   P-value GO Accession GO Term
118.21 4.80e-02 GO:0001765 membrane raft assembly
118.21 4.80e-02 GO:0070836 caveola assembly
59.11 7.82e-03 GO:0031579 membrane raft organization
39.41 3.22e-02 GO:0045214 sarcomere organization
35.47 4.58e-02 GO:0032781 positive regulation of ATPase activity
35.15 4.44e-12 GO:0030049 muscle filament sliding
35.15 4.44e-12 GO:0033275 actin-myosin filament sliding
34.23 6.21e-12 GO:0070252 actin-mediated cell contraction
31.53 4.15e-03 GO:0043462 regulation of ATPase activity
31.53 4.15e-03 GO:0060048 cardiac muscle contraction
26.28 3.35e-07 GO:0006941 striated muscle contraction
25.50 2.24e-10 GO:0030048 actin filament-based movement
24.89 1.15e-02 GO:0003015 heart process
24.89 1.15e-02 GO:0030239 myofibril assembly
24.89 1.15e-02 GO:0060047 heart contraction
23.65 1.23e-03 GO:0031032 actomyosin structure organization
16.56 1.26e-04 GO:0055001 muscle cell development
15.77 1.33e-03 GO:0055002 striated muscle cell development
11.66 1.46e-03 GO:0051146 striated muscle cell differentiation
11.61 2.85e-10 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
45.47 6.43e-06 GO:0005865 striated muscle thin filament
32.25 1.24e-02 GO:0005583 fibrillar collagen
23.07 2.03e-07 GO:0031674 I band
22.17 3.22e-05 GO:0030018 Z disc
22.00 1.67e-15 GO:0030017 sarcomere
19.33 1.52e-15 GO:0030016 myofibril
18.73 2.49e-14 GO:0044449 contractile fiber part
18.11 4.81e-15 GO:0043292 contractile fiber
10.95 1.20e-02 GO:0016459 myosin complex
7.77 6.75e-09 GO:0015629 actin cytoskeleton
7.25 2.38e-02 GO:0044420 extracellular matrix part
4.00 2.67e-02 GO:0031012 extracellular matrix
2.78 9.61e-03 GO:0044430 cytoskeletal part
2.60 9.22e-04 GO:0005856 cytoskeleton
1.82 4.90e-02 GO:0043228 non-membrane-bounded organelle
1.82 4.90e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
Enrichment   P-value GO Accession GO Term
23.07 2.07e-07 GO:0008307 structural constituent of muscle
8.70 3.68e-02 GO:0005201 extracellular matrix structural constituent
5.68 6.10e-05 GO:0003779 actin binding
4.92 1.55e-07 GO:0005198 structural molecule activity
4.81 3.89e-06 GO:0008092 cytoskeletal protein binding