Motif ID: TP53.p2

Z-value: 1.235


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP53chr17_-_75907310.523.9e-02Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_47746919 3.738 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr10_-_47173917 3.715 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr6_+_116692098 2.389 NM_013352
DSE
dermatan sulfate epimerase
chr6_+_36644236 2.304 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr18_-_28622624 2.236 NM_001941
NM_024423
DSC3

desmocollin 3

chr2_-_110874142 1.918 NM_005434
MALL
mal, T-cell differentiation protein-like
chr5_+_17217474 1.832 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr18_+_57567191 1.734 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr10_+_5566923 1.691 NM_005185
CALML3
calmodulin-like 3
chr13_+_37006628 1.356 CCNA1
cyclin A1
chr2_-_24307179 1.349 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr6_-_138428477 1.309 NM_022121
PERP
PERP, TP53 apoptosis effector
chrX_+_152086408 1.259 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr4_-_10118358 1.258 WDR1
WD repeat domain 1
chr7_+_116166346 1.238 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr4_-_10118286 1.137


chr16_+_57653909 1.095 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr4_-_10118378 1.078 WDR1
WD repeat domain 1
chr10_+_90751044 1.072 FAS
Fas (TNF receptor superfamily, member 6)
chr10_+_90750384 0.997 FAS
Fas (TNF receptor superfamily, member 6)
chr8_-_22926406 0.884 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr13_+_37006408 0.852 NM_001111045
NM_003914
CCNA1

cyclin A1

chr1_+_223900212 0.851 CAPN2
calpain 2, (m/II) large subunit
chr19_-_6591082 0.822 CD70
CD70 molecule
chr12_-_76424474 0.814 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr16_+_57653649 0.813 GPR56
G protein-coupled receptor 56
chr1_-_209825673 0.812 NM_001127641
LAMB3
laminin, beta 3
chr10_-_95241943 0.808 NM_013451
NM_133337
MYOF

myoferlin

chr1_-_153508495 0.796 S100A6
S100 calcium binding protein A6
chr1_-_153508463 0.756 S100A6
S100 calcium binding protein A6
chr4_+_103422479 0.747 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chrX_+_154611748 0.746 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr1_-_209825797 0.739 NM_000228
LAMB3
laminin, beta 3
chrX_-_154688260 0.736 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr10_+_124134206 0.733 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr8_-_22926490 0.713 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr1_+_223900226 0.706 CAPN2
calpain 2, (m/II) large subunit
chr4_-_10118444 0.701 WDR1
WD repeat domain 1
chr1_-_6453362 0.694 ACOT7
acyl-CoA thioesterase 7
chr1_+_13910251 0.683 NM_006474
NM_198389
PDPN

podoplanin

chrX_+_154114609 0.683 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr4_-_10118296 0.675 WDR1
WD repeat domain 1
chr4_+_103422553 0.660 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr7_+_48128225 0.646 NM_181597
UPP1
uridine phosphorylase 1
chr20_-_1373571 0.645 FKBP1A
FK506 binding protein 1A, 12kDa
chr6_-_101329197 0.642 NM_006828
NM_022091
ASCC3

activating signal cointegrator 1 complex subunit 3

chr1_+_156052330 0.622 LMNA
lamin A/C
chr10_+_124134093 0.618 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_+_43622638 0.604 NM_004760
STK17A
serine/threonine kinase 17a
chr11_+_9685624 0.590 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr11_+_9685650 0.584 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr3_-_12800739 0.577 NM_018306
TMEM40
transmembrane protein 40
chr10_+_134000335 0.568 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr5_+_52284903 0.562 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr2_-_26205327 0.560 KIF3C
kinesin family member 3C
chr2_-_24307529 0.553 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr2_-_38303307 0.552 NM_000104
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr18_-_34408699 0.550 TPGS2
tubulin polyglutamylase complex subunit 2
chr3_-_182880463 0.534 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr19_+_49458129 0.528 BAX
BCL2-associated X protein
chr3_+_52529351 0.526 NM_015136
STAB1
stabilin 1
chr20_-_1373702 0.522 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr10_-_105212022 0.517 CALHM2
calcium homeostasis modulator 2
chr7_+_48128738 0.509 NM_003364
UPP1
uridine phosphorylase 1
chr3_+_52529370 0.507 STAB1
stabilin 1
chrX_-_106960028 0.506 TSC22D3
TSC22 domain family, member 3
chr4_+_148653452 0.505 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr11_-_108464344 0.504 NM_015065
EXPH5
exophilin 5
chr22_-_18257194 0.503 BID
BH3 interacting domain death agonist
chrX_-_154114431 0.502 NM_019863
F8
coagulation factor VIII, procoagulant component
chr16_-_15149827 0.497 NM_173474
NTAN1
N-terminal asparagine amidase
chr8_+_94929991 0.495 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr19_+_49458151 0.494 BAX
BCL2-associated X protein
chr19_+_49458031 0.493 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr2_-_26205437 0.492 NM_002254
KIF3C
kinesin family member 3C
chr17_-_61523544 0.492 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr5_+_121647773 0.489 NM_001242935
NM_005460
SNCAIP

synuclein, alpha interacting protein

chr10_-_105212149 0.485 NM_015916
CALHM2
calcium homeostasis modulator 2
chr1_-_10532603 0.484 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr1_+_41444968 0.473 NM_001905
CTPS
CTP synthase
chr22_-_18257221 0.471 BID
BH3 interacting domain death agonist
chr18_-_34409084 0.470 NM_015476
TPGS2
tubulin polyglutamylase complex subunit 2
chr2_-_38303265 0.467 CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr1_-_202936333 0.465 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr9_+_119449573 0.465 NM_001099679
NM_012210
TRIM32

tripartite motif containing 32

chr20_-_1373744 0.463 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr1_-_156710902 0.453 NM_024540
NM_145729
MRPL24

mitochondrial ribosomal protein L24

chr19_-_4817502 0.449 TICAM1
toll-like receptor adaptor molecule 1
chr4_-_57976355 0.449 IGFBP7
insulin-like growth factor binding protein 7
chr3_-_113465101 0.448 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr5_+_121647385 0.445 SNCAIP
synuclein, alpha interacting protein
chr7_+_140396463 0.435 NM_004546
NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr18_-_34408948 0.429 TPGS2
tubulin polyglutamylase complex subunit 2
chr6_-_30712294 0.427 NM_003897
IER3
immediate early response 3
chr4_-_186347037 0.418 NM_018359
UFSP2
UFM1-specific peptidase 2
chr6_+_76458888 0.418 NM_004999
MYO6
myosin VI
chr4_-_57976550 0.415 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr1_-_10532513 0.412 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr3_-_113464991 0.406 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr5_-_141061798 0.400 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr15_+_40532034 0.395 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr4_-_10118500 0.393 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr14_-_64970319 0.391 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr14_+_64971226 0.390 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr4_+_52709165 0.389 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chrX_+_48368063 0.377 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr6_-_46922533 0.366 NM_015234
GPR116
G protein-coupled receptor 116
chrX_-_106959597 0.365 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr9_-_126692184 0.363 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr1_+_224544550 0.362 CNIH4
cornichon homolog 4 (Drosophila)
chr10_-_104262404 0.362 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr7_+_98972326 0.361 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr18_-_34408845 0.358 TPGS2
tubulin polyglutamylase complex subunit 2
chr7_+_98972351 0.357 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr4_-_57976516 0.351 IGFBP7
insulin-like growth factor binding protein 7
chr8_+_95732101 0.350 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr4_-_55991746 0.348 NM_002253
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr11_+_125439370 0.348 EI24
etoposide induced 2.4 mRNA
chr20_+_4666796 0.345 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr1_+_224544590 0.343 NM_014184
CNIH4
cornichon homolog 4 (Drosophila)
chr11_-_59383616 0.343 NM_002556
OSBP
oxysterol binding protein
chr5_+_141348692 0.341 NM_183401
RNF14
ring finger protein 14
chr12_+_12966249 0.339 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr5_-_141061749 0.327 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_+_35606731 0.327 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr7_+_48128939 0.325 UPP1
uridine phosphorylase 1
chr16_+_30194730 0.323 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr15_-_52821004 0.316 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr6_+_76458970 0.310 MYO6
myosin VI
chr6_-_109775423 0.308 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_-_150738232 0.305 CTSS
cathepsin S
chr19_-_42746678 0.305 GSK3A
glycogen synthase kinase 3 alpha
chr5_-_176831385 0.297 F12
coagulation factor XII (Hageman factor)
chr5_-_112824526 0.294 NM_001085377
MCC
mutated in colorectal cancers
chrX_+_129305553 0.293 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr16_-_3930713 0.292 CREBBP
CREB binding protein
chr19_+_35607218 0.289 FXYD3
FXYD domain containing ion transport regulator 3
chr11_+_125439363 0.288 EI24
etoposide induced 2.4 mRNA
chr13_+_115000357 0.287 NM_001078645
NM_003903
CDC16

cell division cycle 16 homolog (S. cerevisiae)

chr1_-_153508597 0.287 NM_014624
S100A6
S100 calcium binding protein A6
chr2_+_169312793 0.283 NM_203463
CERS6
ceramide synthase 6
chr12_+_22778085 0.282 ETNK1
ethanolamine kinase 1
chr4_+_85504056 0.280 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr2_-_220118610 0.280 NM_006000
TUBA4A
tubulin, alpha 4a
chr1_+_86889768 0.279 NM_006536
CLCA2
chloride channel accessory 2
chr1_+_224544597 0.278 CNIH4
cornichon homolog 4 (Drosophila)
chr11_-_64570621 0.277 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr5_-_137071462 0.277 KLHL3
kelch-like 3 (Drosophila)
chr8_+_94929082 0.274 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr12_+_56498347 0.271 PA2G4
proliferation-associated 2G4, 38kDa
chr5_+_141348646 0.271 RNF14
ring finger protein 14
chr1_-_117210301 0.266 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr12_+_56498324 0.265 PA2G4
proliferation-associated 2G4, 38kDa
chr19_+_44080951 0.264 NM_001193621
LOC390940
uncharacterized protein ENSP00000244321
chr6_-_33547833 0.261 BAK1
BCL2-antagonist/killer 1
chr22_-_18257238 0.258 NM_001196
NM_001244569
NM_001244570
NM_197967
NM_001244567
BID




BH3 interacting domain death agonist




chr12_+_27485767 0.258 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr22_-_18257160 0.256 BID
BH3 interacting domain death agonist
chr2_+_113403433 0.256 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr7_+_65670256 0.254 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr6_-_32163299 0.254 NM_022107
GPSM3
G-protein signaling modulator 3
chr19_-_6591012 0.253 CD70
CD70 molecule
chr1_-_54518790 0.250 TMEM59
transmembrane protein 59
chr19_-_42746723 0.246 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr22_+_40766563 0.246 NM_015705
SGSM3
small G protein signaling modulator 3
chr6_+_36098261 0.243 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr10_-_30348433 0.242 NM_020848
KIAA1462
KIAA1462
chr1_-_54518886 0.242 TMEM59
transmembrane protein 59
chr22_+_40766636 0.241 SGSM3
small G protein signaling modulator 3
chr14_-_75078669 0.240 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr4_+_48988264 0.239 NM_025087
CWH43
cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
chr7_-_42971779 0.239 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr14_+_77787229 0.235 NM_145870
NM_145871
GSTZ1

glutathione transferase zeta 1

chr11_-_77122877 0.235 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr13_-_50367027 0.234 NM_002267
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr4_-_68566847 0.233 NM_018227
UBA6
ubiquitin-like modifier activating enzyme 6
chr18_+_33877630 0.232 NM_025135
FHOD3
formin homology 2 domain containing 3
chr2_+_69969250 0.225 ANXA4
annexin A4
chr11_+_64949149 0.223 NM_001198869
CAPN1
calpain 1, (mu/I) large subunit
chr20_-_5100443 0.223 NM_182649
PCNA
proliferating cell nuclear antigen
chr11_-_82996898 0.222 CCDC90B
coiled-coil domain containing 90B
chr2_+_203776930 0.219 NM_001104586
NM_024744
ALS2CR8

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

chr22_-_18111400 0.218 ATP6V1E1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
chr3_+_16926451 0.216 NM_001144382
PLCL2
phospholipase C-like 2
chr11_+_19138639 0.215 NM_001001483
NM_019028
ZDHHC13

zinc finger, DHHC-type containing 13

chr22_+_37447615 0.214 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr1_+_43824598 0.213 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr11_-_89322778 0.212 NM_001143837
NOX4
NADPH oxidase 4
chr11_-_64545933 0.212 NM_001178030
SF1
splicing factor 1
chr19_+_3572903 0.212 NM_006339
HMG20B
high mobility group 20B
chr5_+_141348450 0.211 NM_004290
NM_183398
NM_183400
RNF14


ring finger protein 14


chr21_+_42792441 0.209 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr19_-_14228560 0.208 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr19_+_38865424 0.206 PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr11_+_45826640 0.206 NM_018389
SLC35C1
solute carrier family 35, member C1
chr14_-_106610338 0.206 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_104850986 0.206 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_150738292 0.205 NM_001199739
NM_004079
CTSS

cathepsin S

chr11_+_64948685 0.205 NM_001198868
CAPN1
calpain 1, (mu/I) large subunit
chr11_+_64126616 0.204 NM_001006944
NM_003942
RPS6KA4

ribosomal protein S6 kinase, 90kDa, polypeptide 4


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
89.34 5.00e-05 GO:0005544 calcium-dependent phospholipid binding