Motif ID: UCCAGUU

Z-value: 2.244


Mature miRNA associated with seed UCCAGUU:

NamemiRBase Accession
hsa-miR-145 MIMAT0000437



Activity profile for motif UCCAGUU.

activity profile for motif UCCAGUU


Sorted Z-values histogram for motif UCCAGUU

Sorted Z-values for motif UCCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of UCCAGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_151646634 8.096 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr6_+_151561094 7.775 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_39425297 7.512 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr12_-_106533810 6.946 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr7_+_130126035 6.591 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr5_-_121412805 6.424 NM_001178102
LOX
lysyl oxidase
chr1_+_86046434 6.237 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr8_-_12973752 6.168 NM_001164271
DLC1
deleted in liver cancer 1
chr8_-_12990731 6.051 NM_006094
DLC1
deleted in liver cancer 1
chr7_+_130131172 5.710 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr7_+_130131921 5.487 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr1_-_94703252 5.335 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chrX_-_99891690 4.921 NM_003270
TSPAN6
tetraspanin 6
chr12_+_78225068 4.781 NM_014903
NAV3
neuron navigator 3
chr5_-_121414011 4.736 NM_002317
LOX
lysyl oxidase
chr7_+_100770378 4.459 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr2_+_9346876 4.345 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr7_-_131241321 4.078 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr3_+_30647901 3.491 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr12_-_89746244 3.367 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr8_+_26435339 3.296 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr18_-_25757351 3.296 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr8_-_119964059 3.234 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr17_-_46682333 3.152 NM_018952
HOXB6
homeobox B6
chr3_-_129325175 3.152 NM_015103
PLXND1
plexin D1
chr8_+_70405027 3.133 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr8_+_70378858 3.132 NM_001128204
NM_015170
SULF1

sulfatase 1

chr17_-_15165873 3.118 NM_153321
PMP22
peripheral myelin protein 22
chr8_+_26371461 3.023 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr21_-_28339405 3.006 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr3_-_134093235 2.970 NM_016201
AMOTL2
angiomotin like 2
chr17_-_15168590 2.945 NM_000304
PMP22
peripheral myelin protein 22
chr11_-_86666211 2.860 NM_012193
FZD4
frizzled family receptor 4
chr17_-_15164043 2.763 NM_153322
PMP22
peripheral myelin protein 22
chr2_+_36583369 2.763 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_-_11382501 2.720 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_227663454 2.680 NM_005544
IRS1
insulin receptor substrate 1
chr9_-_14398981 2.620 NM_001190738
NFIB
nuclear factor I/B
chr11_+_12399024 2.436 NM_018222
PARVA
parvin, alpha
chr16_+_69220940 2.435 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr7_-_27183225 2.379 NM_019102
HOXA5
homeobox A5
chr6_+_76458888 2.351 NM_004999
MYO6
myosin VI
chr9_-_14314036 2.220 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr8_-_18871163 2.185 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr7_+_116140097 2.071 NM_001206748
CAV2
caveolin 2
chr15_+_67458492 2.056 NM_001145104
SMAD3
SMAD family member 3
chr9_-_107690526 1.953 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_+_116139619 1.894 NM_001206747
NM_001233
NM_198212
CAV2


caveolin 2


chr20_+_19867075 1.871 NM_001242581
RIN2
Ras and Rab interactor 2
chr6_+_143929316 1.867 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr2_-_216300770 1.858 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr4_-_102268626 1.845 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr6_+_143999058 1.843 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr3_-_51996855 1.841 NM_033010
PCBP4
poly(rC) binding protein 4
chr8_-_18666295 1.840 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr12_+_10365415 1.810 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr10_-_101945787 1.755 NM_001100626
ERLIN1
ER lipid raft associated 1
chr2_+_66662516 1.751 NM_002398
MEIS1
Meis homeobox 1
chr2_+_102314162 1.744 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr1_-_21616648 1.723 NM_001113349
ECE1
endothelin converting enzyme 1
chr20_+_19870209 1.720 NM_018993
RIN2
Ras and Rab interactor 2
chr15_+_67358194 1.684 NM_005902
SMAD3
SMAD family member 3
chr2_+_5832778 1.641 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr10_-_101945686 1.639 NM_006459
ERLIN1
ER lipid raft associated 1
chr15_+_68924326 1.581 NM_001190457
CORO2B
coronin, actin binding protein, 2B
chr11_-_9025531 1.562 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr3_-_15900928 1.547 NM_015199
ANKRD28
ankyrin repeat domain 28
chr15_+_68908878 1.535 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chrX_-_10588458 1.518 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr3_-_15798057 1.499 NM_001195099
ANKRD28
ankyrin repeat domain 28
chr8_-_121824287 1.494 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr4_+_86851425 1.492 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr1_-_21605984 1.491 NM_001113347
ECE1
endothelin converting enzyme 1
chr4_+_86699846 1.477 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr19_-_11308184 1.464 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr6_-_139695349 1.461 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr3_+_57994087 1.460 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr1_+_160313061 1.449 NM_015331
NCSTN
nicastrin
chrX_-_10544852 1.448 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr15_+_67418053 1.419 NM_001145102
SMAD3
SMAD family member 3
chr4_+_86396251 1.408 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr7_-_50800018 1.400 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chr2_+_148602569 1.386 NM_001616
ACVR2A
activin A receptor, type IIA
chr6_-_11232901 1.381 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr17_+_72983723 1.375 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr6_-_139695784 1.370 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr20_-_25566137 1.369 NM_025176
NINL
ninein-like
chr8_+_30241943 1.366 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr9_-_139940595 1.365 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chrX_-_108976509 1.363 NM_004458
NM_022977
ACSL4

acyl-CoA synthetase long-chain family member 4

chr15_+_67430358 1.362 NM_001145103
SMAD3
SMAD family member 3
chr16_+_84853585 1.360 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr4_+_154074269 1.352 NM_001130067
TRIM2
tripartite motif containing 2
chr8_-_6420454 1.347 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr7_-_50861114 1.345 NM_001001555
GRB10
growth factor receptor-bound protein 10
chrX_-_10851808 1.341 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_10645726 1.333 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_21671905 1.333 NM_001113348
ECE1
endothelin converting enzyme 1
chr1_-_21616888 1.298 NM_001397
ECE1
endothelin converting enzyme 1
chr15_-_52821004 1.264 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr4_+_184020343 1.259 NM_024949
WWC2
WW and C2 domain containing 2
chr19_-_11305186 1.255 NM_015493
KANK2
KN motif and ankyrin repeat domains 2
chr19_+_16178170 1.235 NM_001145160
TPM4
tropomyosin 4
chr12_+_58087737 1.229 NM_001017956
NM_001017957
NM_001017958
NM_006812
OS9



osteosarcoma amplified 9, endoplasmic reticulum lectin



chr3_+_49506079 1.199 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr6_-_83903632 1.164 NM_001199917
PGM3
phosphoglucomutase 3
chr8_+_95732101 1.157 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr19_+_16187047 1.139 NM_003290
TPM4
tropomyosin 4
chr17_+_46125675 1.126 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr3_+_135684463 1.114 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr10_+_96162185 1.102 NM_015188
TBC1D12
TBC1 domain family, member 12
chr3_+_171757413 1.101 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr2_-_242255114 1.099 NM_005336
HDLBP
high density lipoprotein binding protein
chr14_+_67707825 1.093 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr4_+_154125589 1.092 NM_015271
TRIM2
tripartite motif containing 2
chr2_+_202899309 1.088 NM_003507
FZD7
frizzled family receptor 7
chr7_-_50772997 1.082 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr2_+_70485204 1.071 NM_016297
PCYOX1
prenylcysteine oxidase 1
chrX_+_48432740 1.060 NM_006743
RBM3
RNA binding motif (RNP1, RRM) protein 3
chr3_+_135741576 1.060 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr21_-_39870303 1.039 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr3_-_52001388 1.022 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr1_+_89149836 1.019 NM_006256
PKN2
protein kinase N2
chr13_-_72441312 1.002 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr15_+_99192696 0.972 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr9_+_112542496 0.964 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr11_+_576482 0.956 NM_020901
PHRF1
PHD and ring finger domains 1
chr12_-_120703549 0.948 NM_001080855
NM_001243756
NM_002859
PXN


paxillin


chr6_+_158733691 0.900 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr12_+_52345437 0.888 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr11_+_61447816 0.870 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr7_+_872137 0.861 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr2_-_106810781 0.853 NM_025076
UXS1
UDP-glucuronate decarboxylase 1
chr1_-_208417635 0.850 NM_025179
PLXNA2
plexin A2
chr10_-_118032717 0.847 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr19_+_34745452 0.824 NM_014686
KIAA0355
KIAA0355
chrX_+_73641084 0.812 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr3_+_49507470 0.808 NM_001165928
NM_001177634
NM_001177635
NM_001177636
NM_001177637
NM_001177638
NM_001177639
NM_001177640
NM_001177641
NM_001177642
NM_001177644
NM_004393
DAG1











dystroglycan 1 (dystrophin-associated glycoprotein 1)











chr19_+_18794391 0.804 NM_001098482
NM_015321
CRTC1

CREB regulated transcription coactivator 1

chr5_+_86564727 0.802 NM_022650
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr16_-_49860917 0.797 NM_015069
ZNF423
zinc finger protein 423
chr7_+_94285620 0.796 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr9_+_116226006 0.796 NM_017790
RGS3
regulator of G-protein signaling 3
chr11_-_118966175 0.776 NM_002105
H2AFX
H2A histone family, member X
chr5_-_179233772 0.767 NM_014275
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr10_-_118032975 0.760 NM_005264
GFRA1
GDNF family receptor alpha 1
chr10_-_118031542 0.759 NM_145793
GFRA1
GDNF family receptor alpha 1
chr11_+_9406123 0.758 NM_006391
IPO7
importin 7
chr12_+_13043955 0.753 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr14_-_75179739 0.752 NM_001039479
KIAA0317
KIAA0317
chr1_+_186798031 0.748 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_-_53522756 0.732 NM_001134223
USP46
ubiquitin specific peptidase 46
chr5_-_77944341 0.717 NM_005779
LHFPL2
lipoma HMGIC fusion partner-like 2
chr5_+_86564044 0.704 NM_002890
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr18_+_33234532 0.699 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr4_+_78078332 0.694 NM_004354
CCNG2
cyclin G2
chr7_+_94285676 0.690 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr11_-_82611358 0.688 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr13_-_30424795 0.688 NM_007106
UBL3
ubiquitin-like 3
chr4_+_72204769 0.686 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr6_-_116575170 0.678 NM_021648
TSPYL4
TSPY-like 4
chr12_+_72233486 0.666 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr1_+_218518675 0.662 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr18_-_812268 0.657 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr15_+_63569748 0.653 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr12_-_112037360 0.648 NM_002973
ATXN2
ataxin 2
chr21_-_40033617 0.630 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr4_+_81187741 0.628 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr3_+_23987514 0.616 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr17_-_1090562 0.616 NM_001159746
ABR
active BCR-related gene
chr17_-_1359410 0.597 NM_005206
NM_016823
CRK

v-crk sarcoma virus CT10 oncogene homolog (avian)

chr15_+_68871285 0.583 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr3_+_69134057 0.583 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr13_+_73633097 0.579 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr12_+_52347163 0.574 NM_020327
ACVR1B
activin A receptor, type IB
chr5_-_179229874 0.561 NM_054013
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr6_-_111804413 0.558 NM_002912
REV3L
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
chrX_-_77041678 0.552 NM_000489
NM_138270
ATRX

alpha thalassemia/mental retardation syndrome X-linked

chr17_-_58603492 0.550 NM_006380
APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chrX_-_83442906 0.538 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr11_-_104035023 0.533 NM_025208
NM_033135
PDGFD

platelet derived growth factor D

chr13_-_29069215 0.524 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr12_-_120687956 0.519 NM_025157
PXN
paxillin
chr19_-_58662144 0.516 NM_024620
ZNF329
zinc finger protein 329
chr6_-_83902921 0.516 NM_001199918
NM_001199919
NM_015599
PGM3


phosphoglucomutase 3


chr17_-_1012257 0.513 NM_001092
ABR
active BCR-related gene
chr3_+_179370779 0.511 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr11_-_8985955 0.508 NM_020644
TMEM9B
TMEM9 domain family, member B
chr4_-_156298094 0.502 NM_001039580
MAP9
microtubule-associated protein 9
chr17_-_40307015 0.501 NM_001252039
NM_004583
NM_201434
RAB5C


RAB5C, member RAS oncogene family


chr17_-_5389480 0.494 NM_016041
DERL2
Der1-like domain family, member 2
chr18_+_3247527 0.491 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr3_-_11761946 0.487 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr19_+_1269244 0.486 NM_001280
CIRBP
cold inducible RNA binding protein
chr20_-_4795768 0.484 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr8_-_17658385 0.480 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr3_+_171758289 0.469 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr12_+_49760679 0.463 NM_023071
SPATS2
spermatogenesis associated, serine-rich 2
chr8_-_17555158 0.458 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr12_-_25102281 0.450 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.47 2.11e-05 GO:0009966 regulation of signal transduction
3.13 7.35e-05 GO:0023051 regulation of signaling
7.00 2.62e-04 GO:0001944 vasculature development
5.20 6.38e-04 GO:0072358 cardiovascular system development
5.20 6.38e-04 GO:0072359 circulatory system development
6.83 1.15e-03 GO:0001568 blood vessel development
2.68 1.43e-03 GO:0048583 regulation of response to stimulus
7.46 1.89e-03 GO:0048514 blood vessel morphogenesis
2.12 3.70e-03 GO:0048856 anatomical structure development
2.84 5.02e-03 GO:0009653 anatomical structure morphogenesis
4.66 5.36e-03 GO:0009967 positive regulation of signal transduction
4.43 8.88e-03 GO:0010647 positive regulation of cell communication
4.41 9.30e-03 GO:0023056 positive regulation of signaling
3.17 1.06e-02 GO:0010646 regulation of cell communication
47.44 1.77e-02 GO:0034446 substrate adhesion-dependent cell spreading
1.91 1.84e-02 GO:0032502 developmental process
7.59 2.28e-02 GO:0001525 angiogenesis
43.13 2.42e-02 GO:0048009 insulin-like growth factor receptor signaling pathway
3.34 3.84e-02 GO:0048584 positive regulation of response to stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
7.97 9.61e-04 GO:0031252 cell leading edge
10.84 1.33e-02 GO:0030027 lamellipodium
31.63 1.47e-02 GO:0016010 dystrophin-associated glycoprotein complex
6.94 3.11e-02 GO:0045121 membrane raft

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.85 9.34e-04 GO:0003779 actin binding
3.94 1.25e-02 GO:0008092 cytoskeletal protein binding
1.41 4.68e-02 GO:0005515 protein binding