Motif ID: XBP1.p3

Z-value: 3.156


Transcription factors associated with XBP1.p3:

Gene SymbolEntrez IDGene Name
XBP1 7494 X-box binding protein 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
XBP1chr22_-_29196452-0.058.7e-01Click!


Activity profile for motif XBP1.p3.

activity profile for motif XBP1.p3


Sorted Z-values histogram for motif XBP1.p3

Sorted Z-values for motif XBP1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of XBP1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_94023872 19.656 NM_000089
COL1A2
collagen, type I, alpha 2
chr19_+_50031232 11.665 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr22_+_38864015 11.374 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr5_-_121414011 9.899 NM_002317
LOX
lysyl oxidase
chr10_+_89419352 9.081 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr7_+_94024201 8.824 COL1A2
collagen, type I, alpha 2
chr5_-_121413906 7.878 LOX
lysyl oxidase
chr12_-_106641675 7.050 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr4_+_38869346 6.979 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr19_+_50030874 5.419 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr3_-_57583153 5.392 NM_001660
ARF4
ADP-ribosylation factor 4
chr3_-_57583090 5.197 ARF4
ADP-ribosylation factor 4
chr11_+_32112607 5.033 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr5_+_119800004 4.784 NM_016644
PRR16
proline rich 16
chr11_+_32112414 4.520 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr3_-_57582866 4.353 ARF4
ADP-ribosylation factor 4
chr7_+_128379395 4.308 CALU
calumenin
chr7_+_128379428 4.259 CALU
calumenin
chr7_+_128379400 4.199 CALU
calumenin
chr7_-_6523689 4.117 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

chr5_+_119799898 4.102 PRR16
proline rich 16
chr7_-_30066124 4.033 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr7_+_128379452 3.907 CALU
calumenin
chr7_+_128379345 3.884 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr11_+_69455938 3.761 CCND1
cyclin D1
chr5_-_121413967 3.440 LOX
lysyl oxidase
chr5_-_93447237 3.338 NM_001163417
NM_001163418
NM_032042
FAM172A


family with sequence similarity 172, member A


chr3_-_57583080 3.325 ARF4
ADP-ribosylation factor 4
chr5_-_131563481 3.321 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr4_-_119757183 3.297 SEC24D
SEC24 family, member D (S. cerevisiae)
chr20_-_17662828 3.160 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr6_+_132129195 3.131 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr2_-_20251788 3.009 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr20_-_17662704 2.849 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr6_-_169653922 2.846 THBS2
thrombospondin 2
chr16_+_84328400 2.652 NM_021197
WFDC1
WAP four-disulfide core domain 1
chr4_-_119757288 2.623 NM_014822
SEC24D
SEC24 family, member D (S. cerevisiae)
chr12_-_133405197 2.591 NM_005895
GOLGA3
golgin A3
chr14_-_39572414 2.581 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr8_+_56015013 2.567 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr17_-_40575117 2.536 NM_012232
PTRF
polymerase I and transcript release factor
chr20_+_44044706 2.509 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr6_-_134496833 2.508 SGK1
serum/glucocorticoid regulated kinase 1
chr9_-_35689902 2.499 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr7_-_27183225 2.484 NM_019102
HOXA5
homeobox A5
chr10_-_128077072 2.481 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr2_-_20251400 2.444 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr2_+_242254722 2.409 NM_001008491
NM_006155
SEPT2

septin 2

chr6_+_132129154 2.334 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr14_+_102430767 2.321 NM_001376
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr3_+_171758289 2.313 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr3_+_127771287 2.310 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr3_-_49395751 2.243 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr14_-_39572278 2.135 SEC23A
Sec23 homolog A (S. cerevisiae)
chr5_-_9546157 2.116 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr6_-_83902921 2.089 NM_001199918
NM_001199919
NM_015599
PGM3


phosphoglucomutase 3


chr2_-_20251280 2.076 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr6_-_7910278 2.029 NM_001145549
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr9_-_113800243 1.988 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr3_-_73673978 1.962 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr9_+_35732498 1.933 CREB3
cAMP responsive element binding protein 3
chr3_+_33155559 1.894 CRTAP
cartilage associated protein
chr2_+_85132999 1.882 TMSB10
thymosin beta 10
chr4_+_169552752 1.859 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr3_+_33155447 1.829 NM_006371
CRTAP
cartilage associated protein
chr14_-_24664758 1.810 NM_001014842
NM_006405
TM9SF1

transmembrane 9 superfamily member 1

chr21_+_42539727 1.795 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr14_+_102430897 1.791 DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr11_+_17298278 1.748 NM_005013
NUCB2
nucleobindin 2
chr19_-_42463500 1.746 NM_006423
RABAC1
Rab acceptor 1 (prenylated)
chr20_+_61584094 1.731 SLC17A9
solute carrier family 17, member 9
chr9_+_35732629 1.723 CREB3
cAMP responsive element binding protein 3
chr3_+_122785855 1.716 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr11_-_66056455 1.713 YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr6_+_83903031 1.683 NM_033411
RWDD2A
RWD domain containing 2A
chr14_+_93260630 1.644 NM_005113
GOLGA5
golgin A5
chr17_-_767287 1.626 NM_001205319
NXN
nucleoredoxin
chr2_-_242254984 1.619 HDLBP
high density lipoprotein binding protein
chr14_-_24664606 1.559 TM9SF1
transmembrane 9 superfamily member 1
chr16_-_66959418 1.555 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr12_-_133404950 1.540 GOLGA3
golgin A3
chr10_-_128077011 1.529 ADAM12
ADAM metallopeptidase domain 12
chr15_-_60690115 1.528 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr3_+_128968470 1.479 COPG
coatomer protein complex, subunit gamma
chr19_+_50353942 1.465 PTOV1
prostate tumor overexpressed 1
chr15_-_75165595 1.457 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr2_-_33824294 1.442 NM_015475
FAM98A
family with sequence similarity 98, member A
chr3_+_128968429 1.439 NM_016128
COPG
coatomer protein complex, subunit gamma
chr1_+_21835915 1.433 ALPL
alkaline phosphatase, liver/bone/kidney
chr6_+_72892371 1.420 RIMS1
regulating synaptic membrane exocytosis 1
chr20_+_61583998 1.419 NM_022082
SLC17A9
solute carrier family 17, member 9
chr2_+_27255745 1.405 NM_001083590
NM_017727
TMEM214

transmembrane protein 214

chr9_+_35732207 1.403 NM_006368
CREB3
cAMP responsive element binding protein 3
chr1_+_21835841 1.386 NM_000478
NM_001127501
NM_001177520
ALPL


alkaline phosphatase, liver/bone/kidney


chr9_+_123963728 1.377 GSN
gelsolin
chr6_+_116692098 1.359 NM_013352
DSE
dermatan sulfate epimerase
chr17_+_64298844 1.343 NM_002737
PRKCA
protein kinase C, alpha
chr5_-_121412805 1.333 NM_001178102
LOX
lysyl oxidase
chr5_+_34656367 1.319 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr2_+_27255837 1.282 TMEM214
transmembrane protein 214
chr5_+_92920592 1.250 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr5_+_125759076 1.230 GRAMD3
GRAM domain containing 3
chr7_-_122526410 1.227 CADPS2
Ca++-dependent secretion activator 2
chr1_+_53068042 1.223 NM_015696
GPX6
GPX7
glutathione peroxidase 6 (olfactory)
glutathione peroxidase 7
chr6_-_7910716 1.178 NM_030810
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr11_-_66056607 1.170 NM_020470
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr3_-_145878775 1.166 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr17_+_8339135 1.155 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr2_+_85132762 1.135 NM_021103
TMSB10
thymosin beta 10
chr1_-_144931967 1.105 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_19030156 1.086 COPE
coatomer protein complex, subunit epsilon
chr1_+_110527399 1.073 AHCYL1
adenosylhomocysteinase-like 1
chr19_-_19030197 1.060 NM_007263
NM_199442
NM_199444
COPE


coatomer protein complex, subunit epsilon


chr11_-_62414063 1.059 GANAB
glucosidase, alpha; neutral AB
chr5_+_126853308 1.055 NM_130809
PRRC1
proline-rich coiled-coil 1
chr19_-_42463437 1.039 RABAC1
Rab acceptor 1 (prenylated)
chr1_+_145576011 1.004 PIAS3
protein inhibitor of activated STAT, 3
chr22_-_43253186 1.003 ARFGAP3
ADP-ribosylation factor GTPase activating protein 3
chr5_-_10761341 1.000 DAP
death-associated protein
chr12_+_124069099 0.987 TMED2
transmembrane emp24 domain trafficking protein 2
chr22_-_43253304 0.982 NM_001142293
NM_014570
ARFGAP3

ADP-ribosylation factor GTPase activating protein 3

chr19_-_19030196 0.981 COPE
coatomer protein complex, subunit epsilon
chr9_-_35072545 0.972 VCP
valosin containing protein
chr19_+_49468557 0.972 NM_000146
FTL
ferritin, light polypeptide
chr13_-_36920777 0.971 NM_001142295
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr3_-_49395697 0.969 GPX1
glutathione peroxidase 1
chr19_+_49468656 0.952 FTL
ferritin, light polypeptide
chr11_+_118443140 0.941 ARCN1
archain 1
chr5_-_10761179 0.904 DAP
death-associated protein
chr11_-_62414086 0.895 GANAB
glucosidase, alpha; neutral AB
chr19_-_19030178 0.894 COPE
coatomer protein complex, subunit epsilon
chrX_+_67718868 0.870 YIPF6
Yip1 domain family, member 6
chr14_+_100259445 0.867 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr7_-_19157262 0.866 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr9_+_114393543 0.857 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chrX_+_100805415 0.832 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr19_+_49468587 0.830 FTL
ferritin, light polypeptide
chr9_-_35732175 0.829 TLN1
talin 1
chr10_-_98346594 0.819 TM9SF3
transmembrane 9 superfamily member 3
chr1_+_32645647 0.803 TXLNA
taxilin alpha
chr5_-_108745569 0.798 NM_014819
PJA2
praja ring finger 2
chr9_-_35072596 0.790 VCP
valosin containing protein
chr2_-_227663454 0.782 NM_005544
IRS1
insulin receptor substrate 1
chr5_-_10761344 0.781 NM_004394
DAP
death-associated protein
chr2_-_69614321 0.777 NM_001244710
NM_002056
GFPT1

glutamine--fructose-6-phosphate transaminase 1

chr16_+_56966025 0.771 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr12_+_124069080 0.765 TMED2
transmembrane emp24 domain trafficking protein 2
chr19_-_19030195 0.763 COPE
coatomer protein complex, subunit epsilon
chr3_-_121468510 0.749 NM_004487
GOLGB1
golgin B1
chr16_-_22385596 0.742 NM_001802
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr3_-_187463227 0.738 BCL6
B-cell CLL/lymphoma 6
chr14_+_50087400 0.737 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr9_-_35072643 0.720 NM_007126
VCP
valosin containing protein
chr1_+_110527432 0.707 AHCYL1
adenosylhomocysteinase-like 1
chr12_+_124069053 0.705 NM_006815
TMED2
transmembrane emp24 domain trafficking protein 2
chr5_+_112196884 0.700 NM_001204193
NM_001204194
NM_001204196
NM_001204199
NM_003135
SRP19




signal recognition particle 19kDa




chr2_+_202899309 0.684 NM_003507
FZD7
frizzled family receptor 7
chr13_-_96705565 0.670 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr3_-_49761293 0.659 NM_013334
NM_021971
GMPPB

GDP-mannose pyrophosphorylase B

chr1_+_110527418 0.652 AHCYL1
adenosylhomocysteinase-like 1
chr9_-_35732115 0.651 TLN1
talin 1
chr6_-_43484701 0.643 NM_015388
YIPF3
Yip1 domain family, member 3
chr12_-_49318663 0.628 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr19_+_50354368 0.627 NM_017432
PTOV1
prostate tumor overexpressed 1
chr5_+_34656482 0.624 RAI14
retinoic acid induced 14
chr11_+_118443091 0.622 NM_001142281
NM_001655
ARCN1

archain 1

chr10_-_98346793 0.615 NM_020123
TM9SF3
transmembrane 9 superfamily member 3
chr15_-_83953465 0.615 NM_001717
BNC1
basonuclin 1
chr6_+_33168602 0.615 NM_001077516
NM_006979
SLC39A7

solute carrier family 39 (zinc transporter), member 7

chr6_-_134497069 0.613 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_99952779 0.608 NM_005783
TXNDC9
thioredoxin domain containing 9
chr4_+_26322184 0.596 NM_015874
NM_203284
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr10_-_16859336 0.590 RSU1
Ras suppressor protein 1
chr17_+_46048406 0.590 NM_176096
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr12_+_6937764 0.579 LEPREL2
leprecan-like 2
chr13_+_58207858 0.575 PCDH17
protocadherin 17
chr2_-_55276288 0.570 NM_207521
RTN4
reticulon 4
chr1_+_87170486 0.565 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr13_+_35516390 0.563 NM_015678
NBEA
neurobeachin
chr12_+_21654745 0.560 GOLT1B
golgi transport 1B
chr2_+_171785624 0.557 GORASP2
golgi reassembly stacking protein 2, 55kDa
chr4_-_111544206 0.557 NM_000325
PITX2
paired-like homeodomain 2
chr9_-_35732389 0.551 NM_006289
TLN1
talin 1
chr3_-_105587710 0.551 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr2_+_171785780 0.539 GORASP2
golgi reassembly stacking protein 2, 55kDa
chr11_-_62414096 0.535 NM_198334
NM_198335
GANAB

glucosidase, alpha; neutral AB

chr1_+_110527327 0.533 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chr4_+_8594521 0.530 CPZ
carboxypeptidase Z
chr11_-_126138736 0.516 SRPR
signal recognition particle receptor (docking protein)
chr12_-_56122748 0.505 CD63
CD63 molecule
chr13_-_36920491 0.502 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr19_+_1026627 0.491 CNN2
calponin 2
chr18_-_34408948 0.477 TPGS2
tubulin polyglutamylase complex subunit 2
chr10_-_71930185 0.476 NM_001142648
NM_020150
SAR1A

SAR1 homolog A (S. cerevisiae)

chr6_-_43484503 0.465 YIPF3
Yip1 domain family, member 3
chr17_-_79818514 0.456 NM_000918
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr14_+_74486049 0.455 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr17_+_46048467 0.454 CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr15_+_44038649 0.453 PDIA3
protein disulfide isomerase family A, member 3
chr12_+_59989847 0.447 SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.50 7.91e-05 GO:0016192 vesicle-mediated transport
11.11 3.15e-04 GO:0048193 Golgi vesicle transport
31.63 3.72e-03 GO:0048199 vesicle targeting, to, from or within Golgi
2.02 6.20e-03 GO:0051179 localization
26.36 8.00e-03 GO:0006901 vesicle coating
25.31 9.48e-03 GO:0006900 membrane budding
21.09 2.01e-02 GO:0006903 vesicle targeting
3.36 3.23e-02 GO:0015031 protein transport
3.30 3.93e-02 GO:0045184 establishment of protein localization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.20 1.09e-11 GO:0005783 endoplasmic reticulum
4.39 2.38e-07 GO:0005794 Golgi apparatus
1.88 2.88e-07 GO:0044444 cytoplasmic part
4.78 2.63e-06 GO:0044432 endoplasmic reticulum part
14.22 9.64e-06 GO:0005788 endoplasmic reticulum lumen
1.46 1.41e-03 GO:0005737 cytoplasm
43.13 4.58e-03 GO:0030663 COPI coated vesicle membrane
18.61 7.01e-03 GO:0030120 vesicle coat
36.50 7.87e-03 GO:0030137 COPI-coated vesicle
3.27 1.68e-02 GO:0031410 cytoplasmic vesicle
14.07 2.14e-02 GO:0005793 ER-Golgi intermediate compartment
2.44 2.28e-02 GO:0012505 endomembrane system
3.16 2.44e-02 GO:0031982 vesicle
79.06 2.79e-02 GO:0005797 Golgi medial cisterna
8.60 3.35e-02 GO:0030662 coated vesicle membrane
3.21 3.74e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
3.14 4.55e-02 GO:0031988 membrane-bounded vesicle

Nothing significant found in function category.