Motif ID: ZIC1..3.p2

Z-value: 1.042


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZIC1chr3_+_1471271510.572.2e-02Click!
ZIC3chrX_+_136648313-0.381.5e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_39873276 2.413 NM_003246
THBS1
thrombospondin 1
chr11_-_65640199 2.354 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr11_-_12030539 2.079 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr7_+_130131921 1.952 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr11_-_111782447 1.931 NM_001885
CRYAB
crystallin, alpha B
chr11_+_111783459 1.838 NM_001541
HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr3_-_73673978 1.782 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr11_+_111783476 1.750 HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr9_-_113800243 1.687 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr2_+_235860616 1.669 NM_014521
SH3BP4
SH3-domain binding protein 4
chr11_-_12030128 1.668 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_-_85930610 1.653 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr16_+_31483066 1.620 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr11_-_12030622 1.609 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr7_-_150946031 1.580 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr10_-_90712510 1.528 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_+_130131172 1.515 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr5_-_121412805 1.473 NM_001178102
LOX
lysyl oxidase
chrX_-_51812249 1.457 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr16_+_55512801 1.409 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr5_+_52776408 1.358 FST
follistatin
chr16_+_70502824 1.347 FUK
fucokinase
chr10_+_75673346 1.327 PLAU
plasminogen activator, urokinase
chr19_-_50143350 1.151 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr5_+_71403040 1.137 NM_005909
MAP1B
microtubule-associated protein 1B
chrX_+_51927918 1.106 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr3_+_110790460 1.104 NM_001243286
NM_015480
PVRL3

poliovirus receptor-related 3

chr5_+_52776479 1.092 FST
follistatin
chrX_+_134166318 1.069 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr21_-_28217272 1.030 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_19734821 1.028 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chrX_-_48931645 1.026 NM_007213
PRAF2
PRA1 domain family, member 2
chr5_+_52776263 1.025 NM_006350
NM_013409
FST

follistatin

chr21_-_28217692 1.010 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr19_+_16435632 1.006 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr8_+_22436641 0.976 PDLIM2
PDZ and LIM domain 2 (mystique)
chr17_+_60705051 0.971 MRC2
mannose receptor, C type 2
chr7_-_150945731 0.961 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr12_+_6309475 0.936 NM_001769
CD9
CD9 molecule
chr2_+_217498205 0.924 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chrX_-_128657453 0.906 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr2_+_220283098 0.884 NM_001927
DES
desmin
chr6_+_151561508 0.883 AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_123476578 0.882 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr1_-_153508463 0.852 S100A6
S100 calcium binding protein A6
chr8_-_122653493 0.849 NM_005328
HAS2
hyaluronan synthase 2
chr5_-_87564615 0.849 NM_153354
TMEM161B
transmembrane protein 161B
chr9_+_124061880 0.848 NM_000177
GSN
gelsolin
chr2_+_217498082 0.837 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr16_+_31044881 0.834 NM_004604
STX4
syntaxin 4
chr7_-_80548666 0.828 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_61658853 0.807 NM_021727
FADS3
fatty acid desaturase 3
chr11_-_117186918 0.800 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr4_-_102267952 0.793 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chrX_-_128657440 0.789 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr1_-_33168356 0.780 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr19_+_16435734 0.779 KLF2
Kruppel-like factor 2 (lung)
chrX_+_51636608 0.775 NM_001005333
NM_006986
MAGED1

melanoma antigen family D, 1

chr4_-_102268333 0.771 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr9_+_124062105 0.767 GSN
gelsolin
chr11_+_19372270 0.761 NM_001111018
NAV2
neuron navigator 2
chr9_-_35689799 0.757 TPM2
tropomyosin 2 (beta)
chrX_-_128657381 0.744 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr17_+_39968961 0.736 NM_021939
FKBP10
FK506 binding protein 10, 65 kDa
chr16_+_31044414 0.719 STX4
syntaxin 4
chr16_+_31044849 0.710 STX4
syntaxin 4
chr17_-_5404304 0.685 NM_001162371
LOC728392
uncharacterized LOC728392
chr14_-_103988829 0.675 CKB
creatine kinase, brain
chr7_-_27224762 0.674 NM_005523
HOXA11
homeobox A11
chr8_-_67525426 0.670 NM_001080416
NM_001144755
MYBL1

LOC645895
v-myb myeloblastosis viral oncogene homolog (avian)-like 1

uncharacterized LOC645895
chr14_-_30396811 0.667 NM_002742
PRKD1
protein kinase D1
chr16_+_56672577 0.664 NM_005946
MT1A
metallothionein 1A
chr20_-_36758362 0.663 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chrX_-_134185978 0.650 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr3_-_149688638 0.643 NM_002628
NM_053024
PFN2

profilin 2

chr2_-_26205327 0.639 KIF3C
kinesin family member 3C
chr11_-_2158510 0.635 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_53491448 0.631 IGFBP6
insulin-like growth factor binding protein 6
chrX_+_54835492 0.629 NM_201222
MAGED2
melanoma antigen family D, 2
chr9_+_112810877 0.628 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr14_+_101292483 0.620


chr8_-_12990731 0.617 NM_006094
DLC1
deleted in liver cancer 1
chr1_+_203595929 0.616 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr3_-_185542807 0.613 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr3_-_149688886 0.613 PFN2
profilin 2
chr14_+_105941061 0.608 NM_001312
CRIP2
cysteine-rich protein 2
chr1_+_182992694 0.597


chr1_+_99730067 0.596 LPPR4
lipid phosphate phosphatase-related protein type 4
chr5_-_168271852 0.594


chrX_-_140271275 0.593 LDOC1
leucine zipper, down-regulated in cancer 1
chr6_-_128841432 0.592 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chrX_-_17879355 0.588 NM_001172732
NM_001172739
NM_001172743
NM_021785
RAI2



retinoic acid induced 2



chr2_+_202899309 0.588 NM_003507
FZD7
frizzled family receptor 7
chr17_-_26989176 0.587 NM_006923
SDF2
stromal cell-derived factor 2
chr1_+_203595897 0.585 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr7_-_45960738 0.578 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr21_-_27543134 0.570 NM_000484
NM_001136129
NM_001136130
NM_001204301
NM_001204302
NM_001204303
NM_201413
NM_201414
APP







amyloid beta (A4) precursor protein







chr17_-_15168590 0.568 NM_000304
PMP22
peripheral myelin protein 22
chrX_-_37706816 0.567 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr1_+_156084541 0.564 LMNA
lamin A/C
chr11_+_131780537 0.560 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr4_+_123747815 0.551 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr6_-_139695349 0.549 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr9_-_113800980 0.548 LPAR1
lysophosphatidic acid receptor 1
chr1_+_78444922 0.548 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr9_-_35689902 0.543 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr12_+_79258588 0.539 SYT1
synaptotagmin I
chr11_+_44117746 0.536 NM_000401
EXT2
exostosin 2
chr3_+_49449753 0.533 TCTA
T-cell leukemia translocation altered gene
chr12_+_2999994 0.529 NM_001160408
NM_003324
TULP3

tubby like protein 3

chr14_-_105444693 0.529 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr19_-_12886421 0.528 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr21_-_27543445 0.527 NM_001136131
APP
amyloid beta (A4) precursor protein
chr3_-_55515361 0.526 WNT5A
wingless-type MMTV integration site family, member 5A
chr1_+_182992329 0.521 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr7_+_44144002 0.520 AEBP1
AE binding protein 1
chr4_+_72052354 0.520 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chrX_-_15872882 0.517 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr7_+_79764087 0.515 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr14_+_101292451 0.512 MEG3
maternally expressed 3 (non-protein coding)
chr12_+_122150638 0.510 NM_001080825
TMEM120B
transmembrane protein 120B
chr11_+_114310107 0.509 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr12_-_50616425 0.505 NM_001113547
LIMA1
LIM domain and actin binding 1
chrX_-_15872938 0.504 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chrX_-_134156488 0.502 NM_001078173
FAM127C
family with sequence similarity 127, member C
chr1_-_27930360 0.497 AHDC1
AT hook, DNA binding motif, containing 1
chr11_-_27681195 0.494 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr4_-_5021095 0.484 NM_018659
CYTL1
cytokine-like 1
chr10_+_180404 0.482 NM_006624
NM_001202465
NM_001202466
NM_212479
ZMYND11



zinc finger, MYND-type containing 11



chr14_-_51411118 0.479 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr10_+_124134206 0.479 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_-_6798419 0.472 ZNF384
zinc finger protein 384
chr14_+_65007418 0.463 HSPA2
heat shock 70kDa protein 2
chr4_-_149363498 0.463 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr10_+_124134093 0.462 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_+_26348488 0.462 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_+_203596222 0.458 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr5_-_176924601 0.457 NM_005451
NM_203352
NM_213636
PDLIM7


PDZ and LIM domain 7 (enigma)


chr9_-_88714486 0.454 NM_016548
GOLM1
golgi membrane protein 1
chr7_+_94024201 0.452 COL1A2
collagen, type I, alpha 2
chr21_-_27543044 0.449 APP
amyloid beta (A4) precursor protein
chr1_-_94147201 0.448 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr10_+_124220990 0.448 NM_002775
HTRA1
HtrA serine peptidase 1
chr12_+_111051831 0.447 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr9_-_88714395 0.447 GOLM1
golgi membrane protein 1
chr19_-_12886263 0.445 HOOK2
hook homolog 2 (Drosophila)
chr11_-_66084501 0.445 NM_020404
CD248
CD248 molecule, endosialin
chr6_-_112575708 0.442 LAMA4
laminin, alpha 4
chr12_-_106641675 0.442 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr7_+_106809405 0.442 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr5_+_131593388 0.437 PDLIM4
PDZ and LIM domain 4
chr4_-_177713664 0.437 NM_005429
VEGFC
vascular endothelial growth factor C
chr9_-_88714460 0.436 GOLM1
golgi membrane protein 1
chr12_+_79258517 0.435 SYT1
synaptotagmin I
chr14_-_103989195 0.435 NM_001823
CKB
creatine kinase, brain
chr1_+_156084579 0.434 LMNA
lamin A/C
chr16_-_47494981 0.429 NM_030790
ITFG1
integrin alpha FG-GAP repeat containing 1
chr5_-_39424930 0.426 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_-_26988886 0.426 SDF2
stromal cell-derived factor 2
chr8_-_98290072 0.425 TSPYL5
TSPY-like 5
chrX_-_140271293 0.425 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr3_-_129325175 0.422 NM_015103
PLXND1
plexin D1
chrX_+_102000906 0.422 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chr11_-_119187811 0.421 NM_006500
MCAM
melanoma cell adhesion molecule
chrX_-_15872921 0.419 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_+_46403302 0.419 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr6_+_148664124 0.418 SASH1
SAM and SH3 domain containing 1
chr2_-_175869910 0.412 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr14_+_65007163 0.411 NM_021979
HSPA2
heat shock 70kDa protein 2
chr6_+_148663953 0.410 SASH1
SAM and SH3 domain containing 1
chr10_+_52751114 0.408 PRKG1
protein kinase, cGMP-dependent, type I
chr4_+_123747939 0.407 FGF2
fibroblast growth factor 2 (basic)
chr6_+_151561653 0.405 AKAP12
A kinase (PRKA) anchor protein 12
chr22_-_19511777 0.404 CLDN5
claudin 5
chr11_+_46403279 0.404 MDK
midkine (neurite growth-promoting factor 2)
chrX_-_119603068 0.403 LAMP2
lysosomal-associated membrane protein 2
chr4_-_54930706 0.402 CHIC2
cysteine-rich hydrophobic domain 2
chr4_-_54930466 0.401 CHIC2
cysteine-rich hydrophobic domain 2
chr1_+_155829259 0.400 NM_152280
SYT11
synaptotagmin XI
chrX_+_118370205 0.399 NM_006667
PGRMC1
progesterone receptor membrane component 1
chr5_+_76011780 0.399 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr1_+_170633312 0.394 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr1_+_156084458 0.393 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr11_+_46403260 0.390 MDK
midkine (neurite growth-promoting factor 2)
chr1_+_167905921 0.390 DCAF6
DDB1 and CUL4 associated factor 6
chr1_+_7831326 0.389 NM_004781
VAMP3
vesicle-associated membrane protein 3 (cellubrevin)
chr7_+_134464417 0.389 CALD1
caldesmon 1
chr7_+_44143945 0.388 NM_001129
AEBP1
AE binding protein 1
chr2_+_20646831 0.388 NM_004040
RHOB
ras homolog gene family, member B
chr5_+_86563594 0.387 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr9_-_131872907 0.386 NM_000755
CRAT
carnitine O-acetyltransferase
chr12_-_15942350 0.383 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr11_-_27741192 0.383 NM_001143807
BDNF
brain-derived neurotrophic factor
chr11_+_46403205 0.380 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr17_-_39968450 0.380 NM_006455
LEPREL4
leprecan-like 4
chr12_+_13044352 0.379 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr18_+_8717368 0.378 NM_015210
CCDC165
coiled-coil domain containing 165
chr15_-_48937795 0.377 NM_000138
FBN1
fibrillin 1
chr3_+_170136652 0.375 NM_005602
CLDN11
claudin 11
chr14_-_103989112 0.373 CKB
creatine kinase, brain

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.53 1.19e-03 GO:0031012 extracellular matrix
4.51 9.43e-03 GO:0044421 extracellular region part
14.38 4.95e-02 GO:0044420 extracellular matrix part

Nothing significant found in function category.