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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for ATF4

Z-value: 0.95

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.871.3e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_41245160 1.28 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr1_+_149804218 0.89 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr17_-_40828969 0.58 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr16_-_87812735 0.56 ENST00000570159.1
RP4-536B24.4
RP4-536B24.4
chr17_+_73089382 0.51 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr19_-_47288162 0.45 ENST00000594991.1
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_-_40829026 0.42 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr12_-_117318788 0.42 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr19_-_47287990 0.41 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr12_+_57914481 0.40 ENST00000548887.1
MBD6
methyl-CpG binding domain protein 6
chr8_-_38008783 0.39 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr5_+_174151536 0.38 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr1_-_149832704 0.38 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
HIST2H4B
histone cluster 2, H4b
chr15_+_89182156 0.37 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr16_-_67694597 0.32 ENST00000393919.4
ENST00000219251.8
ACD
adrenocortical dysplasia homolog (mouse)
chr17_-_79895154 0.31 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
PYCR1
pyrroline-5-carboxylate reductase 1
chr16_+_56970567 0.30 ENST00000563911.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_-_51014460 0.30 ENST00000595669.1
JOSD2
Josephin domain containing 2
chr2_-_98280383 0.30 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr16_+_67694849 0.30 ENST00000602551.1
ENST00000458121.2
ENST00000219255.3
PARD6A
par-6 family cell polarity regulator alpha
chr11_+_62649158 0.29 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr14_+_24563262 0.27 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr19_-_51014588 0.27 ENST00000598418.1
JOSD2
Josephin domain containing 2
chr17_-_79895097 0.27 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
PYCR1
pyrroline-5-carboxylate reductase 1
chr19_-_51014345 0.25 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr7_-_56101826 0.23 ENST00000421626.1
PSPH
phosphoserine phosphatase
chr12_-_25102252 0.23 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr14_+_24563510 0.21 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr12_+_57623477 0.21 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr5_+_44809027 0.20 ENST00000507110.1
MRPS30
mitochondrial ribosomal protein S30
chr12_+_57624085 0.20 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr22_+_50919995 0.20 ENST00000362068.2
ENST00000395737.1
ADM2
adrenomedullin 2
chr1_-_44497118 0.19 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_-_28550320 0.18 ENST00000395641.2
NUPR1
nuclear protein, transcriptional regulator, 1
chr22_+_42229100 0.17 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr12_+_57623869 0.17 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr17_-_77967433 0.17 ENST00000571872.1
TBC1D16
TBC1 domain family, member 16
chr12_+_57624119 0.16 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chrX_+_48398053 0.15 ENST00000537536.1
ENST00000418627.1
TBC1D25
TBC1 domain family, member 25
chr12_-_92539614 0.15 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr3_+_11314099 0.15 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr12_+_56862301 0.15 ENST00000338146.5
SPRYD4
SPRY domain containing 4
chr12_+_57914742 0.14 ENST00000551351.1
MBD6
methyl-CpG binding domain protein 6
chr14_+_75894714 0.14 ENST00000559060.1
JDP2
Jun dimerization protein 2
chr19_-_49258606 0.14 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr10_-_101190202 0.13 ENST00000543866.1
ENST00000370508.5
GOT1
glutamic-oxaloacetic transaminase 1, soluble
chr7_-_48068699 0.13 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr14_-_88282595 0.13 ENST00000554519.1
RP11-1152H15.1
RP11-1152H15.1
chr12_+_57623907 0.13 ENST00000553529.1
ENST00000554310.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr17_+_39846114 0.12 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr1_-_204380919 0.12 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr10_+_63661053 0.12 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_-_44497024 0.12 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_154244987 0.12 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr1_+_33283043 0.12 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
S100PBP
S100P binding protein
chr11_-_57092381 0.11 ENST00000358252.3
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr12_-_57914275 0.11 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr21_-_44495964 0.10 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr12_+_93963590 0.09 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr16_-_18908196 0.09 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr12_+_57624059 0.09 ENST00000557427.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_+_151187074 0.09 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chrX_+_9431324 0.08 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chrX_+_77359726 0.08 ENST00000442431.1
PGK1
phosphoglycerate kinase 1
chrX_+_77359671 0.08 ENST00000373316.4
PGK1
phosphoglycerate kinase 1
chr1_+_162602244 0.07 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chr7_+_48211048 0.07 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr1_+_52521797 0.07 ENST00000313334.8
BTF3L4
basic transcription factor 3-like 4
chr21_-_44495919 0.07 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr22_+_50919944 0.07 ENST00000395738.2
ADM2
adrenomedullin 2
chr3_-_99594948 0.06 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr5_-_76935513 0.06 ENST00000306422.3
OTP
orthopedia homeobox
chr8_-_116680833 0.06 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr12_-_12674032 0.06 ENST00000298573.4
DUSP16
dual specificity phosphatase 16
chr7_-_48068643 0.05 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr1_-_167883353 0.05 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr17_-_46703826 0.05 ENST00000550387.1
ENST00000311177.5
HOXB9
homeobox B9
chr4_-_70725856 0.05 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr11_-_77185094 0.05 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr17_+_46133307 0.05 ENST00000580037.1
NFE2L1
nuclear factor, erythroid 2-like 1
chr11_-_3078616 0.05 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chr11_-_8680383 0.04 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr7_-_50860565 0.04 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr12_+_50135588 0.04 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr15_+_89182178 0.04 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr3_-_99595037 0.04 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr16_+_46918235 0.04 ENST00000340124.4
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr1_+_228353495 0.04 ENST00000366711.3
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr12_-_25101920 0.04 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr16_-_70323422 0.03 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chrX_-_80457385 0.03 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr12_+_57849048 0.03 ENST00000266646.2
INHBE
inhibin, beta E
chr5_+_143584814 0.03 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr1_+_52521928 0.02 ENST00000489308.2
BTF3L4
basic transcription factor 3-like 4
chr1_-_52521831 0.02 ENST00000371626.4
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr7_+_30634297 0.02 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr14_-_92413727 0.02 ENST00000267620.10
FBLN5
fibulin 5
chr1_+_162351503 0.02 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr14_-_92413353 0.02 ENST00000556154.1
FBLN5
fibulin 5
chr20_+_8112824 0.02 ENST00000378641.3
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific)
chr16_+_56965960 0.02 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_-_76836963 0.02 ENST00000312010.6
USP36
ubiquitin specific peptidase 36
chr1_+_241815577 0.02 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr2_-_46769694 0.01 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr11_-_17555421 0.01 ENST00000526181.1
USH1C
Usher syndrome 1C (autosomal recessive, severe)
chr11_-_3078838 0.01 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr4_+_95128748 0.01 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr6_+_151187615 0.00 ENST00000441122.1
ENST00000423867.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr17_-_77813186 0.00 ENST00000448310.1
ENST00000269397.4
CBX4
chromobox homolog 4

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.4 GO:0090427 activation of meiosis(GO:0090427)
0.1 0.4 GO:0017143 insecticide metabolic process(GO:0017143) cellular response to luteinizing hormone stimulus(GO:0071373)
0.1 0.3 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 1.0 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.1 0.6 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 1.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.5 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.3 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
0.0 0.2 GO:0006565 cysteine biosynthetic process from serine(GO:0006535) L-serine catabolic process(GO:0006565)
0.0 0.3 GO:0060356 leucine import(GO:0060356)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.3 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.1 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.4 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:1903912 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:1901096 regulation of autophagosome maturation(GO:1901096)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.5 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.0 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.2 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.3 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 0.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4