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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 0.89

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_501691320.742.6e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_28223229 0.89 ENST00000566073.1
XPO6
exportin 6
chr9_-_14322319 0.76 ENST00000606230.1
NFIB
nuclear factor I/B
chr12_+_113416265 0.53 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr12_+_113416340 0.50 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr1_+_948803 0.47 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr12_+_113416191 0.44 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr3_-_172241250 0.41 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr15_-_55611306 0.39 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr19_-_17516449 0.36 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr3_+_122399697 0.34 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr4_-_169239921 0.30 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr1_-_146644036 0.29 ENST00000425272.2
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr5_-_60139347 0.29 ENST00000511799.1
ELOVL7
ELOVL fatty acid elongase 7
chr19_+_39926791 0.27 ENST00000594990.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr2_-_163175133 0.27 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr16_-_11350036 0.27 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chr19_-_47735918 0.26 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr12_+_113376249 0.26 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr1_+_110577229 0.25 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr20_+_61436146 0.25 ENST00000290291.6
OGFR
opioid growth factor receptor
chr7_+_142829162 0.24 ENST00000291009.3
PIP
prolactin-induced protein
chr7_-_92777606 0.23 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr2_+_201981527 0.23 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr4_-_156875003 0.23 ENST00000433477.3
CTSO
cathepsin O
chr9_-_90589586 0.22 ENST00000325303.8
ENST00000375883.3
CDK20
cyclin-dependent kinase 20
chr1_+_59486129 0.22 ENST00000438195.1
ENST00000424308.1
RP4-794H19.4
RP4-794H19.4
chr11_-_615942 0.22 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr1_+_210502238 0.21 ENST00000545154.1
ENST00000537898.1
ENST00000391905.3
ENST00000545781.1
ENST00000261458.3
ENST00000308852.6
HHAT
hedgehog acyltransferase
chr11_-_57334732 0.21 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr8_+_109455830 0.21 ENST00000524143.1
EMC2
ER membrane protein complex subunit 2
chr1_-_161015663 0.20 ENST00000534633.1
USF1
upstream transcription factor 1
chr16_-_67970990 0.19 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr20_+_388791 0.19 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr19_+_10196981 0.19 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr11_-_615570 0.18 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr21_+_42792442 0.18 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr22_-_36635598 0.18 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr17_-_61517572 0.17 ENST00000582997.1
CYB561
cytochrome b561
chr1_+_79115503 0.17 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr7_+_100728720 0.17 ENST00000306085.6
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr15_+_55611401 0.16 ENST00000566999.1
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr8_+_22446763 0.16 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr22_+_36649056 0.16 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr7_-_139756791 0.16 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr10_-_22292675 0.16 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr15_-_88799948 0.15 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr12_+_6561190 0.15 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr19_+_50431959 0.15 ENST00000595125.1
ATF5
activating transcription factor 5
chr6_+_32821924 0.15 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr22_-_36635225 0.15 ENST00000529194.1
APOL2
apolipoprotein L, 2
chr14_+_35451880 0.15 ENST00000554803.1
ENST00000555746.1
SRP54
signal recognition particle 54kDa
chr6_+_26087509 0.14 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr6_+_26087646 0.13 ENST00000309234.6
HFE
hemochromatosis
chr4_-_169401628 0.13 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr17_+_6659153 0.13 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr3_-_53079281 0.13 ENST00000394750.1
SFMBT1
Scm-like with four mbt domains 1
chr2_-_231989808 0.12 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr11_+_66008698 0.12 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr5_-_95158375 0.12 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr3_-_125802765 0.12 ENST00000514891.1
ENST00000512470.1
ENST00000504035.1
ENST00000360370.4
ENST00000513723.1
ENST00000510651.1
ENST00000514333.1
SLC41A3
solute carrier family 41, member 3
chr6_+_26402517 0.12 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr1_+_236557569 0.12 ENST00000334232.4
EDARADD
EDAR-associated death domain
chr10_+_91087651 0.12 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_125802998 0.11 ENST00000514677.1
SLC41A3
solute carrier family 41, member 3
chr12_+_14369524 0.11 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr2_+_201980961 0.11 ENST00000342795.5
CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_+_36861735 0.11 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr17_+_21730180 0.10 ENST00000584398.1
UBBP4
ubiquitin B pseudogene 4
chr19_+_50432400 0.10 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
ATF5
activating transcription factor 5
chr2_-_190044480 0.10 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr20_-_25038804 0.10 ENST00000323482.4
ACSS1
acyl-CoA synthetase short-chain family member 1
chr15_+_64428529 0.10 ENST00000560861.1
SNX1
sorting nexin 1
chr12_+_133614062 0.09 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chr9_-_90589402 0.09 ENST00000375871.4
ENST00000605159.1
ENST00000336654.5
CDK20
cyclin-dependent kinase 20
chr6_+_26440700 0.09 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chrX_+_154610428 0.09 ENST00000354514.4
H2AFB2
H2A histone family, member B2
chr20_+_388679 0.09 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_+_21729899 0.09 ENST00000583708.1
UBBP4
ubiquitin B pseudogene 4
chrX_+_10031499 0.09 ENST00000454666.1
WWC3
WWC family member 3
chr2_+_239756671 0.08 ENST00000448943.2
TWIST2
twist family bHLH transcription factor 2
chr11_-_796197 0.08 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr1_-_177939041 0.08 ENST00000308284.6
SEC16B
SEC16 homolog B (S. cerevisiae)
chr12_-_10022735 0.08 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr12_+_97300995 0.08 ENST00000266742.4
ENST00000429527.2
ENST00000554226.1
ENST00000557478.1
ENST00000557092.1
ENST00000411739.2
ENST00000553609.1
NEDD1
neural precursor cell expressed, developmentally down-regulated 1
chr16_+_66968343 0.08 ENST00000417689.1
ENST00000561697.1
ENST00000317091.4
ENST00000566182.1
CES2
carboxylesterase 2
chr11_+_124735282 0.07 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr2_+_99771527 0.07 ENST00000415142.1
ENST00000436234.1
LIPT1
lipoyltransferase 1
chr12_-_54582655 0.07 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr2_-_152118276 0.07 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr5_+_131746575 0.07 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr10_+_91092241 0.07 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr9_-_95640218 0.07 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr2_+_201980827 0.07 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_+_79373540 0.07 ENST00000307745.7
RP11-1055B8.7
BAH and coiled-coil domain-containing protein 1
chr12_+_133613937 0.07 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
ZNF84
zinc finger protein 84
chr3_+_63898275 0.07 ENST00000538065.1
ATXN7
ataxin 7
chr1_+_25598872 0.06 ENST00000328664.4
RHD
Rh blood group, D antigen
chr22_+_36044411 0.06 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr7_-_32931387 0.06 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr1_+_112298514 0.06 ENST00000536167.1
DDX20
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
chr20_-_47894936 0.06 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr2_-_119605253 0.06 ENST00000295206.6
EN1
engrailed homeobox 1
chr17_+_8316442 0.06 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr12_-_133613794 0.06 ENST00000443154.3
RP11-386I8.6
RP11-386I8.6
chr1_-_161014731 0.06 ENST00000368020.1
USF1
upstream transcription factor 1
chr5_+_140071178 0.06 ENST00000508522.1
ENST00000448069.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr11_+_5646213 0.05 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr16_-_29875057 0.05 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr11_-_57335280 0.05 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr3_-_123339343 0.05 ENST00000578202.1
MYLK
myosin light chain kinase
chr9_-_100954910 0.05 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr19_+_10196781 0.05 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr20_+_388935 0.05 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_87856129 0.05 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr10_+_48355024 0.05 ENST00000395702.2
ENST00000442001.1
ENST00000433077.1
ENST00000436850.1
ENST00000494156.1
ENST00000586537.1
ZNF488
zinc finger protein 488
chr19_+_50887585 0.04 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr5_-_77656175 0.04 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
CTD-2037K23.2
chr4_+_118955500 0.04 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr8_+_27238147 0.04 ENST00000412793.1
PTK2B
protein tyrosine kinase 2 beta
chr6_-_90529418 0.04 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr6_+_41748500 0.04 ENST00000458694.1
ENST00000359201.5
PRICKLE4
prickle homolog 4 (Drosophila)
chr19_+_49977466 0.04 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr14_+_73525144 0.04 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr3_-_71114066 0.04 ENST00000485326.2
FOXP1
forkhead box P1
chr4_+_124320665 0.03 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_151129103 0.03 ENST00000368910.3
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr20_+_20033158 0.03 ENST00000340348.6
ENST00000377309.2
ENST00000389656.3
ENST00000377306.1
ENST00000245957.5
ENST00000377303.2
ENST00000475466.1
C20orf26
chromosome 20 open reading frame 26
chrX_+_57313113 0.03 ENST00000374900.4
FAAH2
fatty acid amide hydrolase 2
chr20_-_33872518 0.03 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr15_-_62352570 0.03 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr2_+_99771418 0.03 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
LIPT1
MRPL30
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr20_-_61847455 0.03 ENST00000370334.4
YTHDF1
YTH domain family, member 1
chr1_-_177939348 0.03 ENST00000464631.2
SEC16B
SEC16 homolog B (S. cerevisiae)
chr10_-_102046417 0.03 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr1_-_161015752 0.03 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chr9_+_140083099 0.03 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr1_+_200011711 0.03 ENST00000544748.1
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr10_+_115439630 0.03 ENST00000369318.3
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr17_+_6658878 0.03 ENST00000574394.1
XAF1
XIAP associated factor 1
chr1_-_182558374 0.03 ENST00000367559.3
ENST00000539397.1
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr14_-_70883708 0.02 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr4_+_130017268 0.02 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr3_+_63897605 0.02 ENST00000487717.1
ATXN7
ataxin 7
chr14_+_73525229 0.02 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr17_-_7166500 0.02 ENST00000575313.1
ENST00000397317.4
CLDN7
claudin 7
chr3_-_125803105 0.02 ENST00000346785.5
ENST00000315891.6
SLC41A3
solute carrier family 41, member 3
chr7_-_37382360 0.02 ENST00000455119.1
ELMO1
engulfment and cell motility 1
chr22_+_18632666 0.02 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr9_-_140082983 0.02 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr11_-_60720002 0.02 ENST00000538739.1
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr2_-_231084820 0.02 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr5_+_140749803 0.02 ENST00000576222.1
PCDHGB3
protocadherin gamma subfamily B, 3
chr3_+_122399444 0.02 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr11_+_125461607 0.02 ENST00000527606.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr3_+_187957646 0.02 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr22_+_31892261 0.02 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr6_+_42018614 0.02 ENST00000465926.1
ENST00000482432.1
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr14_-_75518129 0.02 ENST00000556257.1
ENST00000557648.1
ENST00000553263.1
ENST00000355774.2
ENST00000380968.2
ENST00000238662.7
MLH3
mutL homolog 3
chr1_+_76190357 0.01 ENST00000370834.5
ENST00000541113.1
ENST00000543667.1
ENST00000420607.2
ACADM
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr14_-_91976794 0.01 ENST00000555462.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr14_-_24615523 0.01 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_-_41039567 0.01 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr6_-_110964453 0.01 ENST00000413605.2
CDK19
cyclin-dependent kinase 19
chr6_-_32821599 0.01 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_-_180288248 0.01 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62
ZFP62 zinc finger protein
chr22_+_36649170 0.01 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr22_+_39436862 0.01 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr1_-_146644122 0.01 ENST00000254101.3
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr6_+_26402465 0.01 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr9_+_74764278 0.01 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chr6_+_42018251 0.01 ENST00000372978.3
ENST00000494547.1
ENST00000456846.2
ENST00000372982.4
ENST00000472818.1
ENST00000372977.3
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr17_+_6659354 0.01 ENST00000574907.1
XAF1
XIAP associated factor 1
chr2_-_231084659 0.01 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr7_+_134832808 0.00 ENST00000275767.3
TMEM140
transmembrane protein 140
chr4_+_87928140 0.00 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr9_+_77112244 0.00 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr4_-_85771168 0.00 ENST00000514071.1
WDFY3
WD repeat and FYVE domain containing 3
chr20_-_56195449 0.00 ENST00000541799.1
ZBP1
Z-DNA binding protein 1
chr3_+_51977294 0.00 ENST00000498510.1
PARP3
poly (ADP-ribose) polymerase family, member 3
chr3_+_122283175 0.00 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr6_-_32806506 0.00 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr4_-_87855851 0.00 ENST00000473559.1
C4orf36
chromosome 4 open reading frame 36

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.1 1.5 GO:0018377 protein myristoylation(GO:0018377)
0.1 0.4 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
0.1 0.4 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.2 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.3 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.0 0.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.3 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.3 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 0.1 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0 0.2 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 0.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.3 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.3 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0 0.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0032044 DSIF complex(GO:0032044)
0.0 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093) melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.3 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 2.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing