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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for IRX6_IRX4

Z-value: 0.39

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.336.7e-01Click!
IRX6hg19_v2_chr16_+_55357672_553576720.198.1e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_201438282 0.44 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr16_+_776936 0.25 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr19_-_54974894 0.20 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr7_-_55583740 0.16 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr16_+_777739 0.16 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr16_+_777246 0.13 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr3_-_9994021 0.13 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr1_-_3566627 0.10 ENST00000419924.2
ENST00000270708.7
WRAP73
WD repeat containing, antisense to TP73
chr3_+_186158169 0.10 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr16_+_777118 0.09 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr20_+_43990576 0.09 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr1_-_3566590 0.08 ENST00000424367.1
ENST00000378322.3
WRAP73
WD repeat containing, antisense to TP73
chr3_-_124606502 0.08 ENST00000483168.1
ITGB5
integrin, beta 5
chr13_-_46716969 0.08 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_871559 0.07 ENST00000421580.1
SUN1
Sad1 and UNC84 domain containing 1
chr15_+_41057818 0.07 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr2_-_231989808 0.07 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr2_+_58655461 0.06 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr11_+_114166536 0.06 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr6_-_33679452 0.06 ENST00000374231.4
ENST00000607484.1
ENST00000374214.3
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr11_+_110225855 0.05 ENST00000526605.1
ENST00000526703.1
RP11-347E10.1
RP11-347E10.1
chr18_-_56985776 0.05 ENST00000587244.1
CPLX4
complexin 4
chr3_+_53528659 0.05 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr1_-_149859466 0.05 ENST00000331128.3
HIST2H2AB
histone cluster 2, H2ab
chr18_-_46784778 0.05 ENST00000582399.1
DYM
dymeclin
chr18_+_616672 0.05 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr8_+_84824920 0.04 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr17_-_42327236 0.04 ENST00000399246.2
AC003102.1
AC003102.1
chr1_-_89641680 0.04 ENST00000294671.2
GBP7
guanylate binding protein 7
chr7_+_23210760 0.04 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr4_+_144312659 0.04 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chrX_-_15333736 0.04 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr4_-_153303658 0.03 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr2_-_183106641 0.03 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chrX_+_15767971 0.03 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr8_+_12803176 0.03 ENST00000524591.2
KIAA1456
KIAA1456
chr5_-_177207634 0.03 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr1_-_152086556 0.03 ENST00000368804.1
TCHH
trichohyalin
chr12_+_53848549 0.02 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr5_+_59783540 0.02 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr6_-_117747015 0.02 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr11_+_61891445 0.02 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP
inner centromere protein antigens 135/155kDa
chrX_+_99899180 0.02 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr1_+_67673297 0.02 ENST00000425614.1
ENST00000395227.1
IL23R
interleukin 23 receptor
chr7_-_16844611 0.02 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr10_+_118349920 0.02 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr7_-_92855762 0.02 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr17_-_47723943 0.01 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr12_-_10282836 0.01 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr5_+_175490540 0.01 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr3_+_111758553 0.01 ENST00000419127.1
TMPRSS7
transmembrane protease, serine 7
chr12_+_32655110 0.01 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr14_-_68159152 0.01 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr1_+_170904612 0.01 ENST00000367759.4
ENST00000367758.3
MROH9
maestro heat-like repeat family member 9
chr3_-_168865522 0.01 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr16_+_21689835 0.01 ENST00000286149.4
ENST00000388958.3
OTOA
otoancorin
chr1_-_110284384 0.01 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr12_-_10282742 0.01 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr4_+_123653882 0.01 ENST00000433287.1
BBS12
Bardet-Biedl syndrome 12
chr17_-_6524159 0.01 ENST00000589033.1
KIAA0753
KIAA0753
chr4_+_40194609 0.01 ENST00000508513.1
RHOH
ras homolog family member H
chr4_+_40194570 0.00 ENST00000507851.1
RHOH
ras homolog family member H
chr17_-_29641084 0.00 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chrX_-_135962923 0.00 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr1_-_8763278 0.00 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr8_-_101724989 0.00 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr19_+_50691437 0.00 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr21_-_48024986 0.00 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr8_-_74495065 0.00 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr12_-_124118151 0.00 ENST00000534960.1
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr1_+_212475148 0.00 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)