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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for LHX3

Z-value: 0.71

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
ENSG00000107187.11 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139094988_1390950120.415.9e-01Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_50016411 0.52 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
Fc fragment of IgG, receptor, transporter, alpha
chr14_-_21566731 0.50 ENST00000360947.3
zinc finger protein 219
chr19_+_50016610 0.39 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr18_-_53303123 0.38 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
transcription factor 4
chr8_-_124741451 0.34 ENST00000520519.1
annexin A13
chr9_-_128246769 0.34 ENST00000444226.1
mitogen-activated protein kinase associated protein 1
chr6_+_26104104 0.32 ENST00000377803.2
histone cluster 1, H4c
chr19_+_48949030 0.31 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr14_-_21567009 0.25 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
zinc finger protein 219
chr17_-_72772462 0.24 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
N-acetyltransferase 9 (GCN5-related, putative)
chr12_-_52761262 0.24 ENST00000257901.3
keratin 85
chr10_+_18549645 0.23 ENST00000396576.2
calcium channel, voltage-dependent, beta 2 subunit
chr12_+_49740700 0.23 ENST00000549441.2
ENST00000395069.3
DnaJ (Hsp40) homolog, subfamily C, member 22
chr17_-_39093672 0.22 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chr9_-_100000957 0.22 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
chr22_+_23487513 0.21 ENST00000263116.2
ENST00000341989.4
RAB36, member RAS oncogene family
chr5_+_140529630 0.20 ENST00000543635.1
protocadherin beta 6
chr3_-_47517302 0.20 ENST00000441517.2
ENST00000545718.1
SREBF chaperone
chr16_+_89334512 0.20 ENST00000602042.1
AC137932.1
chr18_+_61616510 0.20 ENST00000408945.3
histocompatibility (minor) serpin domain containing
chr16_-_28634874 0.20 ENST00000395609.1
ENST00000350842.4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr14_+_29241910 0.19 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
chromosome 14 open reading frame 23
chr19_+_11457175 0.19 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
coiled-coil domain containing 159
chr6_+_114178512 0.19 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr17_+_61151306 0.18 ENST00000580068.1
ENST00000580466.1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr10_+_104263743 0.17 ENST00000369902.3
ENST00000369899.2
ENST00000423559.2
suppressor of fused homolog (Drosophila)
chr3_-_167191814 0.17 ENST00000466903.1
ENST00000264677.4
serpin peptidase inhibitor, clade I (pancpin), member 2
chr9_-_215744 0.16 ENST00000382387.2
chromosome 9 open reading frame 66
chr16_-_28937027 0.16 ENST00000358201.4
rabaptin, RAB GTPase binding effector protein 2
chrM_-_14670 0.15 ENST00000361681.2
mitochondrially encoded NADH dehydrogenase 6
chr11_-_559377 0.15 ENST00000486629.1
chromosome 11 open reading frame 35
chr1_-_150208291 0.14 ENST00000533654.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr19_-_11457162 0.14 ENST00000590482.1
transmembrane protein 205
chrM_+_10053 0.14 ENST00000361227.2
mitochondrially encoded NADH dehydrogenase 3
chr1_-_24126051 0.14 ENST00000445705.1
UDP-galactose-4-epimerase
chr2_-_166930131 0.14 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr4_-_120243545 0.14 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr17_-_4938712 0.13 ENST00000254853.5
ENST00000424747.1
solute carrier family 52 (riboflavin transporter), member 1
chr1_-_24126023 0.13 ENST00000429356.1
UDP-galactose-4-epimerase
chr8_-_66750978 0.12 ENST00000523253.1
phosphodiesterase 7A
chr1_-_150208320 0.11 ENST00000534220.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chrX_+_107288197 0.11 ENST00000415430.3
V-set and immunoglobulin domain containing 1
chr17_-_71223839 0.11 ENST00000579872.1
ENST00000580032.1
family with sequence similarity 104, member A
chr14_-_54425475 0.11 ENST00000559642.1
bone morphogenetic protein 4
chr19_-_43969796 0.10 ENST00000244333.3
LY6/PLAUR domain containing 3
chr12_-_42631529 0.10 ENST00000548917.1
YY1 associated factor 2
chr17_-_27418537 0.10 ENST00000408971.2
TGFB1-induced anti-apoptotic factor 1
chr4_-_41884620 0.10 ENST00000504870.1
long intergenic non-protein coding RNA 682
chr5_+_59783941 0.10 ENST00000506884.1
ENST00000504876.2
prostate androgen-regulated transcript 1 (non-protein coding)
chrX_+_107288239 0.10 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr3_+_186692745 0.10 ENST00000438590.1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_+_48949087 0.10 ENST00000598711.1
glutamate-rich WD repeat containing 1
chr17_+_35851570 0.10 ENST00000394386.1
dual specificity phosphatase 14
chr7_-_84122033 0.10 ENST00000424555.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr15_+_75970672 0.10 ENST00000435356.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr3_+_41236325 0.10 ENST00000426215.1
ENST00000405570.1
catenin (cadherin-associated protein), beta 1, 88kDa
chr1_-_160549235 0.09 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84 molecule
chr19_-_49149553 0.09 ENST00000084798.4
carbonic anhydrase XI
chr4_-_103940791 0.09 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chrM_+_10464 0.09 ENST00000361335.1
mitochondrially encoded NADH dehydrogenase 4L
chr3_-_20053741 0.09 ENST00000389050.4
protein phosphatase 2C-like domain containing 1
chr12_-_11287243 0.09 ENST00000539585.1
taste receptor, type 2, member 30
chr9_-_21482312 0.09 ENST00000448696.3
interferon, epsilon
chr7_-_22862406 0.09 ENST00000372879.4
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr16_+_15489629 0.08 ENST00000396385.3
MPV17 mitochondrial membrane protein-like
chr12_-_86650077 0.08 ENST00000552808.2
ENST00000547225.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr18_+_72201829 0.08 ENST00000582365.1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr1_+_244214577 0.08 ENST00000358704.4
zinc finger and BTB domain containing 18
chr11_-_128894053 0.07 ENST00000392657.3
Rho GTPase activating protein 32
chr5_-_88120151 0.07 ENST00000506716.1
myocyte enhancer factor 2C
chr10_+_696000 0.07 ENST00000381489.5
proline rich 26
chr18_+_616672 0.07 ENST00000338387.7
clusterin-like 1 (retinal)
chr18_+_616711 0.07 ENST00000579494.1
clusterin-like 1 (retinal)
chr16_+_15489603 0.07 ENST00000568766.1
ENST00000287594.7
Uncharacterized protein
MPV17 mitochondrial membrane protein-like
chr12_-_53994805 0.07 ENST00000328463.7
activating transcription factor 7
chr17_-_64225508 0.07 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_86595190 0.06 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
KIAA1324-like
chr1_-_231005310 0.06 ENST00000470540.1
chromosome 1 open reading frame 198
chr7_-_122840015 0.06 ENST00000194130.2
solute carrier family 13 (sodium/sulfate symporter), member 1
chr7_+_138915102 0.06 ENST00000486663.1
ubinuclein 2
chrX_-_110655306 0.06 ENST00000371993.2
doublecortin
chr6_+_83072923 0.06 ENST00000535040.1
trophoblast glycoprotein
chrX_+_24167746 0.06 ENST00000428571.1
ENST00000539115.1
zinc finger protein, X-linked
chr2_-_99871570 0.06 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
lysozyme G-like 2
chr9_+_35042205 0.06 ENST00000312292.5
ENST00000378745.3
chromosome 9 open reading frame 131
chr1_+_197237352 0.06 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
crumbs homolog 1 (Drosophila)
chr7_+_39017504 0.06 ENST00000403058.1
POU class 6 homeobox 2
chr3_+_69812877 0.06 ENST00000457080.1
ENST00000328528.6
microphthalmia-associated transcription factor
chrX_+_9431324 0.05 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr2_-_14541060 0.05 ENST00000418420.1
ENST00000417751.1
long intergenic non-protein coding RNA 276
chr12_-_118628315 0.05 ENST00000540561.1
TAO kinase 3
chr12_-_10282742 0.05 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr11_-_327537 0.05 ENST00000602735.1
interferon induced transmembrane protein 3
chr12_-_10282836 0.05 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr17_-_72772425 0.05 ENST00000578822.1
N-acetyltransferase 9 (GCN5-related, putative)
chr2_-_228582709 0.04 ENST00000541617.1
ENST00000409456.2
ENST00000409287.1
ENST00000258403.3
solute carrier family 19 (thiamine transporter), member 3
chr1_+_15668240 0.04 ENST00000444385.1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr8_-_25281747 0.04 ENST00000421054.2
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr7_-_87342564 0.04 ENST00000265724.3
ENST00000416177.1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_+_123317116 0.04 ENST00000275162.5
clavesin 2
chr1_+_168250194 0.04 ENST00000367821.3
T-box 19
chr2_+_234826016 0.04 ENST00000324695.4
ENST00000433712.2
transient receptor potential cation channel, subfamily M, member 8
chr8_+_119294456 0.04 ENST00000366457.2
Uncharacterized protein
chr15_-_99057551 0.04 ENST00000558256.1
family with sequence similarity 169, member B
chr4_-_185275104 0.04 ENST00000317596.3
RP11-290F5.2
chr12_+_40787194 0.04 ENST00000425730.2
ENST00000454784.4
mucin 19, oligomeric
chrX_-_19504642 0.03 ENST00000469203.2
mitogen-activated protein kinase kinase kinase 15
chr17_+_68071389 0.03 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr13_+_24144796 0.03 ENST00000403372.2
tumor necrosis factor receptor superfamily, member 19
chr20_-_656823 0.03 ENST00000246104.6
scratch family zinc finger 2
chr5_+_59783540 0.03 ENST00000515734.2
prostate androgen-regulated transcript 1 (non-protein coding)
chr14_+_39583427 0.03 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
gem (nuclear organelle) associated protein 2
chr15_+_65843130 0.03 ENST00000569894.1
protein tyrosine phosphatase-like A domain containing 1
chr4_-_23891658 0.02 ENST00000507380.1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr17_+_68071458 0.02 ENST00000589377.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr14_+_20215587 0.02 ENST00000331723.1
olfactory receptor, family 4, subfamily Q, member 3
chr2_-_99279928 0.02 ENST00000414521.2
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr4_+_3344141 0.02 ENST00000306648.7
regulator of G-protein signaling 12
chr8_+_11961898 0.02 ENST00000400085.3
zinc finger protein 705D
chr1_-_92952433 0.02 ENST00000294702.5
growth factor independent 1 transcription repressor
chr4_-_23891693 0.02 ENST00000264867.2
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_+_125133315 0.02 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_9296279 0.02 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chr1_-_94147385 0.02 ENST00000260502.6
breast cancer anti-estrogen resistance 3
chr4_+_41937131 0.02 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chrX_-_55057403 0.02 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
aminolevulinate, delta-, synthase 2
chr9_+_125132803 0.02 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_48130707 0.02 ENST00000360240.6
ENST00000383737.4
microtubule-associated protein 4
chr5_+_140557371 0.02 ENST00000239444.2
protocadherin beta 8
chr10_-_74283694 0.01 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
mitochondrial calcium uptake 1
chr8_+_92261516 0.01 ENST00000276609.3
ENST00000309536.2
solute carrier family 26 (anion exchanger), member 7
chr3_+_167582561 0.01 ENST00000463642.1
ENST00000464514.1
RP11-298O21.6
RP11-298O21.7
chr6_+_153019069 0.01 ENST00000532295.1
myc target 1
chr6_-_66417107 0.00 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
eyes shut homolog (Drosophila)
chr7_+_30185496 0.00 ENST00000455738.1
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr14_-_57197224 0.00 ENST00000554597.1
ENST00000556696.1
Uncharacterized protein
chr14_-_36990354 0.00 ENST00000518149.1
NK2 homeobox 1

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.2 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.2 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0 0.1 GO:0007403 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.0 0.1 GO:0061151 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637) regulation of ovarian follicle development(GO:2000354)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:1990907 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.8 GO:0004969 histamine receptor activity(GO:0004969)
0.1 0.3 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.0 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine