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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for NKX2-2

Z-value: 0.91

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.5 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v2_chr20_-_21494654_214946780.927.6e-02Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_79165222 0.42 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chr8_+_22414182 0.37 ENST00000524057.1
SORBS3
sorbin and SH3 domain containing 3
chr10_-_112678692 0.34 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr10_+_32735030 0.32 ENST00000277657.6
ENST00000362006.5
CCDC7
coiled-coil domain containing 7
chr17_+_42015654 0.31 ENST00000565120.1
RP11-527L4.2
Uncharacterized protein
chr8_+_97597148 0.31 ENST00000521590.1
SDC2
syndecan 2
chr17_+_15604513 0.28 ENST00000481540.1
ZNF286A
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA.
chr7_-_120497178 0.27 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr3_-_121379739 0.27 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr15_+_79165296 0.27 ENST00000558746.1
ENST00000558830.1
ENST00000559345.1
MORF4L1
mortality factor 4 like 1
chr17_-_15469590 0.26 ENST00000312127.2
CDRT1
CMT duplicated region transcript 1; Uncharacterized protein
chr19_+_58193388 0.25 ENST00000596085.1
ENST00000594684.1
ZNF551
AC003006.7
zinc finger protein 551
Uncharacterized protein
chr15_+_79165372 0.25 ENST00000558502.1
MORF4L1
mortality factor 4 like 1
chr19_-_39881669 0.25 ENST00000221266.7
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr6_-_27440460 0.24 ENST00000377419.1
ZNF184
zinc finger protein 184
chr21_+_25801041 0.24 ENST00000453784.2
ENST00000423581.1
AP000476.1
AP000476.1
chr5_-_68339648 0.24 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr2_+_170655322 0.24 ENST00000260956.4
ENST00000417292.1
SSB
Sjogren syndrome antigen B (autoantigen La)
chrX_-_154033661 0.23 ENST00000393531.1
MPP1
membrane protein, palmitoylated 1, 55kDa
chr9_-_85882145 0.23 ENST00000328788.1
FRMD3
FERM domain containing 3
chr15_-_38519066 0.23 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr6_+_32937083 0.23 ENST00000456339.1
BRD2
bromodomain containing 2
chr2_+_39103103 0.23 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
MORN2
MORN repeat containing 2
chr1_-_160231451 0.22 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr1_+_104159999 0.22 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr6_-_150212029 0.21 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr4_+_160203650 0.21 ENST00000514565.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr10_+_90346519 0.21 ENST00000371939.3
LIPJ
lipase, family member J
chr5_+_75904918 0.21 ENST00000514001.1
ENST00000396234.3
ENST00000509074.1
IQGAP2
IQ motif containing GTPase activating protein 2
chr20_-_13765526 0.20 ENST00000202816.1
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr18_-_68004529 0.20 ENST00000578633.1
RP11-484N16.1
RP11-484N16.1
chr17_+_18647326 0.20 ENST00000395667.1
ENST00000395665.4
ENST00000308799.4
ENST00000301938.4
FBXW10
F-box and WD repeat domain containing 10
chrX_+_108779004 0.20 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_69004619 0.20 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr8_-_101962777 0.20 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr16_+_23194033 0.20 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr9_+_131447342 0.20 ENST00000409104.3
SET
SET nuclear oncogene
chr13_+_25875785 0.19 ENST00000381747.3
NUPL1
nucleoporin like 1
chr9_-_15510287 0.19 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chr19_-_51568324 0.19 ENST00000595547.1
ENST00000335422.3
ENST00000595793.1
ENST00000596955.1
KLK13
kallikrein-related peptidase 13
chr10_-_36813162 0.19 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr4_+_155484103 0.19 ENST00000302068.4
FGB
fibrinogen beta chain
chr3_-_196911002 0.19 ENST00000452595.1
DLG1
discs, large homolog 1 (Drosophila)
chr3_+_159943362 0.19 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr10_-_104913367 0.18 ENST00000423468.2
NT5C2
5'-nucleotidase, cytosolic II
chr2_+_162087577 0.18 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr8_+_71485681 0.18 ENST00000391684.1
AC120194.1
AC120194.1
chr11_-_7698453 0.18 ENST00000524608.1
CYB5R2
cytochrome b5 reductase 2
chr8_-_99954788 0.18 ENST00000523601.1
STK3
serine/threonine kinase 3
chr12_+_510742 0.17 ENST00000239830.4
CCDC77
coiled-coil domain containing 77
chr3_+_23847432 0.17 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr15_+_69365272 0.17 ENST00000559914.1
ENST00000558369.1
LINC00277
long intergenic non-protein coding RNA 277
chr1_+_171810606 0.17 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chrX_+_11777671 0.17 ENST00000380693.3
ENST00000380692.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr5_+_179135246 0.17 ENST00000508787.1
CANX
calnexin
chr8_-_82644562 0.17 ENST00000520604.1
ENST00000521742.1
ENST00000520635.1
ZFAND1
zinc finger, AN1-type domain 1
chrX_-_49121165 0.17 ENST00000376207.4
ENST00000376199.2
FOXP3
forkhead box P3
chr2_+_189157498 0.17 ENST00000359135.3
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr17_+_52978107 0.17 ENST00000445275.2
TOM1L1
target of myb1 (chicken)-like 1
chr10_-_61513146 0.17 ENST00000430431.1
LINC00948
long intergenic non-protein coding RNA 948
chr10_-_61513201 0.17 ENST00000414264.1
ENST00000594536.1
LINC00948
long intergenic non-protein coding RNA 948
chr10_-_4720301 0.16 ENST00000449712.1
LINC00704
long intergenic non-protein coding RNA 704
chr10_-_121296045 0.16 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr1_+_171810650 0.16 ENST00000520906.1
DNM3
dynamin 3
chr7_+_79765071 0.16 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr5_+_159656437 0.16 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chrX_-_30326445 0.16 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chrX_+_123095546 0.16 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr14_-_82000140 0.15 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr1_-_161046266 0.15 ENST00000453926.2
PVRL4
poliovirus receptor-related 4
chr7_-_102715263 0.15 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr1_-_197169672 0.15 ENST00000367405.4
ZBTB41
zinc finger and BTB domain containing 41
chr8_-_101718991 0.15 ENST00000517990.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr7_+_2393714 0.15 ENST00000431643.1
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr12_-_111926342 0.15 ENST00000389154.3
ATXN2
ataxin 2
chr2_-_160472052 0.15 ENST00000437839.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr12_+_510795 0.15 ENST00000412006.2
CCDC77
coiled-coil domain containing 77
chr5_+_154181816 0.15 ENST00000518677.1
LARP1
La ribonucleoprotein domain family, member 1
chr8_-_62559366 0.15 ENST00000522919.1
ASPH
aspartate beta-hydroxylase
chr2_-_55276320 0.15 ENST00000357376.3
RTN4
reticulon 4
chr2_+_208104497 0.15 ENST00000430494.1
AC007879.7
AC007879.7
chr12_-_8803128 0.15 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr15_-_93965805 0.15 ENST00000556708.1
RP11-164C12.2
RP11-164C12.2
chrM_+_12331 0.15 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chrX_-_130037198 0.15 ENST00000370935.1
ENST00000338144.3
ENST00000394363.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chrX_-_153363125 0.15 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr1_+_19967014 0.15 ENST00000428975.1
NBL1
neuroblastoma 1, DAN family BMP antagonist
chr13_-_41240717 0.14 ENST00000379561.5
FOXO1
forkhead box O1
chr2_-_38056538 0.14 ENST00000413792.1
LINC00211
long intergenic non-protein coding RNA 211
chr6_-_80247140 0.14 ENST00000392959.1
ENST00000467898.3
LCA5
Leber congenital amaurosis 5
chr2_+_192543694 0.14 ENST00000435931.1
NABP1
nucleic acid binding protein 1
chr8_+_26150628 0.14 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_-_154150651 0.14 ENST00000302206.5
TPM3
tropomyosin 3
chr14_+_96968707 0.14 ENST00000216277.8
ENST00000557320.1
ENST00000557471.1
PAPOLA
poly(A) polymerase alpha
chr4_-_99578776 0.14 ENST00000515287.1
TSPAN5
tetraspanin 5
chr14_-_38036271 0.14 ENST00000556024.1
RP11-356O9.2
RP11-356O9.2
chr3_+_101280677 0.14 ENST00000309922.6
ENST00000495642.1
TRMT10C
tRNA methyltransferase 10 homolog C (S. cerevisiae)
chr2_+_224822121 0.14 ENST00000258383.3
MRPL44
mitochondrial ribosomal protein L44
chr2_-_180871780 0.14 ENST00000410053.3
ENST00000295749.6
ENST00000404136.2
CWC22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr4_+_155484155 0.14 ENST00000509493.1
FGB
fibrinogen beta chain
chr12_-_112614506 0.13 ENST00000548588.2
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4
chr2_-_75937994 0.13 ENST00000409857.3
ENST00000470503.1
ENST00000541687.1
ENST00000442309.1
GCFC2
GC-rich sequence DNA-binding factor 2
chr16_+_53241854 0.13 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_227505289 0.13 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chrX_-_130037162 0.13 ENST00000432489.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chr10_+_13628933 0.13 ENST00000417658.1
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr14_-_38028689 0.13 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr7_-_17598506 0.13 ENST00000451792.1
AC017060.1
AC017060.1
chr15_-_60690163 0.13 ENST00000558998.1
ENST00000560165.1
ENST00000557986.1
ENST00000559780.1
ENST00000559467.1
ENST00000559956.1
ENST00000332680.4
ENST00000396024.3
ENST00000421017.2
ENST00000560466.1
ENST00000558132.1
ENST00000559113.1
ENST00000557906.1
ENST00000558558.1
ENST00000560468.1
ENST00000559370.1
ENST00000558169.1
ENST00000559725.1
ENST00000558985.1
ENST00000451270.2
ANXA2
annexin A2
chr13_-_36429763 0.13 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr11_-_11374904 0.13 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr10_+_35456444 0.13 ENST00000361599.4
CREM
cAMP responsive element modulator
chr6_-_80247105 0.13 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chrX_+_115567767 0.13 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr4_-_129491686 0.13 ENST00000514265.1
RP11-184M15.1
RP11-184M15.1
chr11_+_9406169 0.13 ENST00000379719.3
ENST00000527431.1
IPO7
importin 7
chr15_+_79165151 0.13 ENST00000331268.5
MORF4L1
mortality factor 4 like 1
chr15_-_42840961 0.13 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr1_+_104068562 0.13 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr12_+_51347705 0.12 ENST00000398455.3
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr14_-_100841794 0.12 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr13_+_25875662 0.12 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
NUPL1
nucleoporin like 1
chr8_+_91233744 0.12 ENST00000524361.1
LINC00534
long intergenic non-protein coding RNA 534
chr5_-_98262240 0.12 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr12_+_69202795 0.12 ENST00000539479.1
ENST00000393415.3
ENST00000523991.1
ENST00000543323.1
ENST00000393416.2
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr11_+_34654011 0.12 ENST00000531794.1
EHF
ets homologous factor
chr5_+_34757309 0.12 ENST00000397449.1
RAI14
retinoic acid induced 14
chr1_-_198906528 0.12 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr2_+_189157536 0.12 ENST00000409580.1
ENST00000409637.3
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr1_+_211433275 0.12 ENST00000367005.4
RCOR3
REST corepressor 3
chr1_+_171217622 0.12 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr1_-_150944411 0.12 ENST00000368949.4
CERS2
ceramide synthase 2
chr3_-_69101461 0.12 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chrX_-_19817869 0.12 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr8_-_102181718 0.12 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chr5_-_58652788 0.12 ENST00000405755.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_148593425 0.12 ENST00000367469.1
SASH1
SAM and SH3 domain containing 1
chr15_+_42841008 0.11 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr18_+_19668021 0.11 ENST00000579830.1
RP11-595B24.2
Uncharacterized protein
chr8_-_133637624 0.11 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr9_-_97356075 0.11 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr5_-_110848189 0.11 ENST00000296632.3
ENST00000512160.1
ENST00000509887.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr1_-_244006528 0.11 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr8_-_49833978 0.11 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr8_-_101719159 0.11 ENST00000520868.1
ENST00000522658.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr17_+_66511224 0.11 ENST00000588178.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr14_-_50154921 0.11 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr5_+_148206156 0.11 ENST00000305988.4
ADRB2
adrenoceptor beta 2, surface
chr1_+_67395922 0.11 ENST00000401042.3
ENST00000355356.3
MIER1
mesoderm induction early response 1, transcriptional regulator
chr12_-_68696652 0.11 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr13_+_111855414 0.11 ENST00000375737.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_75198940 0.10 ENST00000417775.1
CRYZ
crystallin, zeta (quinone reductase)
chr5_-_179047881 0.10 ENST00000521173.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_-_115259337 0.10 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr8_+_94767109 0.10 ENST00000409623.3
ENST00000453906.1
ENST00000521517.1
TMEM67
transmembrane protein 67
chr5_+_56205878 0.10 ENST00000423328.1
SETD9
SET domain containing 9
chr19_-_2427536 0.10 ENST00000591871.1
TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr3_+_151591422 0.10 ENST00000362032.5
SUCNR1
succinate receptor 1
chr9_+_123884038 0.10 ENST00000373847.1
CNTRL
centriolin
chr2_+_152266604 0.10 ENST00000430328.2
RIF1
RAP1 interacting factor homolog (yeast)
chr6_+_151561506 0.10 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr9_-_20622478 0.10 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr20_+_13765596 0.10 ENST00000378106.5
ENST00000463598.1
NDUFAF5
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr8_-_49834299 0.10 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr12_-_4488872 0.10 ENST00000237837.1
FGF23
fibroblast growth factor 23
chr8_-_22526597 0.10 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
BIN3
bridging integrator 3
chr3_-_150920979 0.10 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chr15_+_81391740 0.10 ENST00000561216.1
C15orf26
chromosome 15 open reading frame 26
chr13_+_113863858 0.10 ENST00000375440.4
CUL4A
cullin 4A
chr2_-_151344172 0.10 ENST00000375734.2
ENST00000263895.4
ENST00000454202.1
RND3
Rho family GTPase 3
chr4_+_139230865 0.10 ENST00000502757.1
ENST00000507145.1
ENST00000515282.1
ENST00000510736.1
LINC00499
long intergenic non-protein coding RNA 499
chr3_+_158991025 0.10 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr9_+_129097479 0.10 ENST00000402437.2
MVB12B
multivesicular body subunit 12B
chr9_+_17135016 0.09 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr1_-_207095324 0.09 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr2_+_192543153 0.09 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chr1_+_84630367 0.09 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_36812323 0.09 ENST00000543053.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr14_-_100841930 0.09 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr8_+_110552831 0.09 ENST00000530629.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr12_+_69202975 0.09 ENST00000544561.1
ENST00000393410.1
ENST00000299252.4
ENST00000360430.2
ENST00000517852.1
ENST00000545204.1
ENST00000393413.3
ENST00000350057.5
ENST00000348801.2
ENST00000478070.1
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr1_+_104068312 0.09 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr17_-_74351010 0.09 ENST00000435555.2
PRPSAP1
phosphoribosyl pyrophosphate synthetase-associated protein 1
chr5_+_169011033 0.09 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr10_-_27529486 0.09 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr14_-_73360796 0.08 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr2_-_75938115 0.08 ENST00000321027.3
GCFC2
GC-rich sequence DNA-binding factor 2
chr5_-_43557791 0.08 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
PAIP1
poly(A) binding protein interacting protein 1
chr10_+_73156664 0.08 ENST00000398809.4
ENST00000398842.3
ENST00000461841.3
ENST00000299366.7
CDH23
cadherin-related 23
chr18_-_64271316 0.08 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr6_-_72129806 0.08 ENST00000413945.1
ENST00000602878.1
ENST00000436803.1
ENST00000421704.1
ENST00000441570.1
LINC00472
long intergenic non-protein coding RNA 472
chr19_-_44174330 0.08 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr6_+_151561085 0.08 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_156887027 0.08 ENST00000435489.2
ENST00000311946.7
NIPAL4
NIPA-like domain containing 4
chr6_+_44355257 0.08 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr15_+_67835517 0.08 ENST00000395476.2
MAP2K5
mitogen-activated protein kinase kinase 5
chr14_-_100841670 0.08 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr18_+_9103957 0.08 ENST00000400033.1
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr12_+_32552451 0.08 ENST00000534526.2
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_+_91233711 0.08 ENST00000523283.1
ENST00000517400.1
LINC00534
long intergenic non-protein coding RNA 534

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 0.2 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.2 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.1 0.2 GO:0032714 regulation of tolerance induction dependent upon immune response(GO:0002652) positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) negative regulation of interleukin-5 production(GO:0032714) positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 0.2 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.0 0.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.3 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 1.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0044035 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:0035936 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.0 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:1905044 Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045)
0.0 0.1 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.2 GO:0072752 cellular response to rapamycin(GO:0072752)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0010979 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369)
0.0 0.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.2 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.0 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.0 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.2 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843) postsynaptic endocytic zone membrane(GO:0098844)
0.1 0.2 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.3 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0001939 female pronucleus(GO:0001939)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.2 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.1 0.2 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 0.2 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.5 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0004583 alpha-1,3-mannosyltransferase activity(GO:0000033) dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate