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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for NKX2-3

Z-value: 1.13

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_101292706-0.982.1e-02Click!

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_26027480 0.98 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr6_+_42123141 0.70 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr11_+_65266507 0.62 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr17_-_15469590 0.58 ENST00000312127.2
CDRT1
CMT duplicated region transcript 1; Uncharacterized protein
chr4_-_111536534 0.58 ENST00000503456.1
ENST00000513690.1
RP11-380D23.2
RP11-380D23.2
chr4_-_90758227 0.55 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_+_109602039 0.54 ENST00000520821.1
RGAG1
retrotransposon gag domain containing 1
chr19_-_44174330 0.49 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr6_-_26216872 0.46 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr3_-_167191814 0.45 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_-_182573514 0.41 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr19_+_45409011 0.39 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE
apolipoprotein E
chr19_+_13051206 0.39 ENST00000586760.1
CALR
calreticulin
chr15_-_36544450 0.38 ENST00000561394.1
RP11-184D12.1
RP11-184D12.1
chr20_-_1317555 0.38 ENST00000537552.1
AL136531.1
HCG2043693; Uncharacterized protein
chr12_-_102591604 0.37 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr10_+_35464513 0.37 ENST00000494479.1
ENST00000463314.1
ENST00000342105.3
ENST00000495301.1
ENST00000463960.1
CREM
cAMP responsive element modulator
chr3_+_98482175 0.36 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr16_+_32264040 0.36 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr14_+_45366518 0.36 ENST00000557112.1
C14orf28
chromosome 14 open reading frame 28
chr10_+_129785574 0.34 ENST00000430713.2
ENST00000471218.1
PTPRE
protein tyrosine phosphatase, receptor type, E
chr16_+_56969284 0.33 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr13_+_23993097 0.29 ENST00000443092.1
SACS-AS1
SACS antisense RNA 1
chr5_+_140213815 0.29 ENST00000525929.1
ENST00000378125.3
PCDHA7
protocadherin alpha 7
chr3_+_145782358 0.28 ENST00000422482.1
AC107021.1
HCG1786590; PRO2533; Uncharacterized protein
chr17_-_80797886 0.28 ENST00000572562.1
ZNF750
zinc finger protein 750
chr10_-_36813162 0.28 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr7_+_141463897 0.27 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr19_-_38743878 0.27 ENST00000587515.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr5_-_159846066 0.27 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr4_+_76439649 0.27 ENST00000507557.1
THAP6
THAP domain containing 6
chr2_-_37501692 0.26 ENST00000443977.1
PRKD3
protein kinase D3
chr16_+_8736232 0.26 ENST00000562973.1
METTL22
methyltransferase like 22
chr2_+_232135245 0.25 ENST00000446447.1
ARMC9
armadillo repeat containing 9
chr12_-_123201337 0.24 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr7_-_2883650 0.24 ENST00000544127.1
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr5_+_150404904 0.23 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr16_+_31225337 0.23 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr12_-_104531945 0.23 ENST00000551446.1
NFYB
nuclear transcription factor Y, beta
chr12_+_93963590 0.22 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr12_+_111051832 0.22 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr3_+_113775594 0.22 ENST00000479882.1
ENST00000493014.1
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr19_-_33182616 0.22 ENST00000592431.1
CTD-2538C1.2
CTD-2538C1.2
chr20_+_60962143 0.22 ENST00000343986.4
RPS21
ribosomal protein S21
chr1_+_225140372 0.21 ENST00000366848.1
ENST00000439375.2
DNAH14
dynein, axonemal, heavy chain 14
chr4_-_84035905 0.21 ENST00000311507.4
PLAC8
placenta-specific 8
chr1_+_35220613 0.21 ENST00000338513.1
GJB5
gap junction protein, beta 5, 31.1kDa
chr12_-_48119301 0.21 ENST00000545824.2
ENST00000422538.3
ENDOU
endonuclease, polyU-specific
chr1_-_35325400 0.21 ENST00000521580.2
SMIM12
small integral membrane protein 12
chr3_-_171527560 0.21 ENST00000331659.2
PP13439
PP13439
chr12_+_111051902 0.21 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chr4_+_80584903 0.20 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr4_-_75695366 0.20 ENST00000512743.1
BTC
betacellulin
chr5_-_132200477 0.20 ENST00000296875.2
GDF9
growth differentiation factor 9
chr1_+_43824669 0.20 ENST00000372462.1
CDC20
cell division cycle 20
chr13_-_50018140 0.20 ENST00000410043.1
ENST00000347776.5
CAB39L
calcium binding protein 39-like
chr4_-_140201333 0.20 ENST00000398955.1
MGARP
mitochondria-localized glutamic acid-rich protein
chr3_-_69062764 0.19 ENST00000295571.5
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr3_+_23851928 0.19 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr6_-_144329531 0.19 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr6_-_32160622 0.18 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr10_+_1120312 0.18 ENST00000436154.1
WDR37
WD repeat domain 37
chr20_+_57427765 0.18 ENST00000371100.4
GNAS
GNAS complex locus
chr19_-_46288917 0.18 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
DMWD
AC011530.4
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr3_-_49058479 0.18 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr12_+_48178706 0.17 ENST00000599515.1
AC004466.1
Uncharacterized protein
chr8_+_1919481 0.17 ENST00000518539.2
KBTBD11-OT1
KBTBD11 overlapping transcript 1 (non-protein coding)
chr11_+_35211429 0.17 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr8_-_101719159 0.17 ENST00000520868.1
ENST00000522658.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr19_-_39924349 0.17 ENST00000602153.1
RPS16
ribosomal protein S16
chr7_-_80548667 0.17 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_155278625 0.17 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr3_-_180397256 0.17 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr12_+_123464607 0.16 ENST00000543566.1
ENST00000315580.5
ENST00000542099.1
ENST00000392435.2
ENST00000413381.2
ENST00000426960.2
ENST00000453766.2
ARL6IP4
ADP-ribosylation-like factor 6 interacting protein 4
chr2_+_71357744 0.16 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr1_+_26147319 0.16 ENST00000374300.3
MTFR1L
mitochondrial fission regulator 1-like
chr1_-_232598163 0.16 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr19_+_36142147 0.16 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr19_+_33865218 0.16 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr3_+_23847432 0.16 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr20_+_57464200 0.16 ENST00000604005.1
GNAS
GNAS complex locus
chr9_+_131447342 0.16 ENST00000409104.3
SET
SET nuclear oncogene
chr8_+_91952750 0.16 ENST00000521366.1
NECAB1
N-terminal EF-hand calcium binding protein 1
chr2_-_201753980 0.16 ENST00000443398.1
ENST00000286175.8
ENST00000409449.1
PPIL3
peptidylprolyl isomerase (cyclophilin)-like 3
chr2_-_31440377 0.15 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr18_-_74839891 0.15 ENST00000581878.1
MBP
myelin basic protein
chr4_+_76439665 0.15 ENST00000508105.1
ENST00000311638.3
ENST00000380837.3
ENST00000507556.1
ENST00000504190.1
ENST00000507885.1
ENST00000502620.1
ENST00000514480.1
THAP6
THAP domain containing 6
chr11_+_118889142 0.15 ENST00000533632.1
TRAPPC4
trafficking protein particle complex 4
chr11_+_118889456 0.14 ENST00000528230.1
ENST00000525303.1
ENST00000434101.2
ENST00000359005.4
ENST00000533058.1
TRAPPC4
trafficking protein particle complex 4
chr17_+_53345080 0.14 ENST00000572002.1
HLF
hepatic leukemia factor
chr1_+_156561533 0.14 ENST00000368234.3
ENST00000368235.3
ENST00000368233.3
APOA1BP
apolipoprotein A-I binding protein
chr12_-_125398654 0.14 ENST00000541645.1
ENST00000540351.1
UBC
ubiquitin C
chr1_+_155278539 0.14 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr16_+_69458537 0.14 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr16_+_2255841 0.14 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr4_-_84035868 0.14 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chr4_+_81118647 0.13 ENST00000415738.2
PRDM8
PR domain containing 8
chr4_-_39033963 0.13 ENST00000381938.3
TMEM156
transmembrane protein 156
chr2_+_64068844 0.13 ENST00000337130.5
UGP2
UDP-glucose pyrophosphorylase 2
chr18_+_43684310 0.13 ENST00000592471.1
ENST00000585518.1
HAUS1
HAUS augmin-like complex, subunit 1
chr13_-_44735393 0.13 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr20_-_33539655 0.12 ENST00000451957.2
GSS
glutathione synthetase
chr8_+_11961898 0.12 ENST00000400085.3
ZNF705D
zinc finger protein 705D
chr6_-_116833500 0.12 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr5_-_110848189 0.12 ENST00000296632.3
ENST00000512160.1
ENST00000509887.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr4_+_146403912 0.12 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1
SMAD family member 1
chr12_+_71833550 0.12 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr16_+_2255710 0.12 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr4_+_48343339 0.12 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr9_-_25678856 0.12 ENST00000358022.3
TUSC1
tumor suppressor candidate 1
chr12_+_6309963 0.11 ENST00000382515.2
CD9
CD9 molecule
chr6_-_33239712 0.11 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr1_+_113217043 0.11 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr14_+_36295638 0.11 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr10_+_18041218 0.11 ENST00000480516.1
ENST00000457860.1
TMEM236
TMEM236
chr1_-_155990580 0.11 ENST00000531917.1
ENST00000480567.1
ENST00000526212.1
ENST00000529008.1
ENST00000496742.1
ENST00000295702.4
SSR2
signal sequence receptor, beta (translocon-associated protein beta)
chr10_+_116697946 0.11 ENST00000298746.3
TRUB1
TruB pseudouridine (psi) synthase family member 1
chr7_-_105221898 0.11 ENST00000486180.1
ENST00000485614.1
ENST00000480514.1
EFCAB10
EF-hand calcium binding domain 10
chrX_-_69509738 0.11 ENST00000374454.1
ENST00000239666.4
PDZD11
PDZ domain containing 11
chr19_+_39616410 0.11 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr1_-_33116128 0.11 ENST00000436661.1
ENST00000373501.2
ENST00000341885.5
ENST00000468695.1
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr3_+_183967409 0.11 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chr4_-_104020968 0.11 ENST00000504285.1
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr19_-_42746714 0.11 ENST00000222330.3
GSK3A
glycogen synthase kinase 3 alpha
chr6_-_137539651 0.11 ENST00000543628.1
IFNGR1
interferon gamma receptor 1
chrX_-_108976410 0.10 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr12_+_123465033 0.10 ENST00000454885.2
ARL6IP4
ADP-ribosylation-like factor 6 interacting protein 4
chr7_+_56032652 0.10 ENST00000437587.1
GBAS
glioblastoma amplified sequence
chr7_-_2883928 0.10 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr8_+_91803695 0.10 ENST00000417640.2
NECAB1
N-terminal EF-hand calcium binding protein 1
chr4_-_90757364 0.10 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr19_-_12946236 0.10 ENST00000589272.1
ENST00000393233.2
RTBDN
retbindin
chr11_-_10822029 0.10 ENST00000528839.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr1_+_174669653 0.10 ENST00000325589.5
RABGAP1L
RAB GTPase activating protein 1-like
chr4_+_144303093 0.10 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr1_+_41157671 0.10 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr11_+_6226782 0.10 ENST00000316375.2
C11orf42
chromosome 11 open reading frame 42
chr3_-_69062790 0.10 ENST00000540955.1
ENST00000456376.1
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr17_-_76870126 0.10 ENST00000586057.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr4_-_100212132 0.10 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr2_+_202125219 0.10 ENST00000323492.7
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr6_+_36562132 0.10 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr6_-_150212029 0.10 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr19_+_3178736 0.10 ENST00000246115.3
S1PR4
sphingosine-1-phosphate receptor 4
chr12_-_104532062 0.10 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr19_-_45579762 0.10 ENST00000303809.2
ZNF296
zinc finger protein 296
chr17_+_12569472 0.10 ENST00000343344.4
MYOCD
myocardin
chr10_+_17794251 0.09 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr6_-_33239612 0.09 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr1_+_174670143 0.09 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr16_+_23765948 0.09 ENST00000300113.2
CHP2
calcineurin-like EF-hand protein 2
chr1_+_113217073 0.09 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr15_+_69452959 0.09 ENST00000261858.2
GLCE
glucuronic acid epimerase
chr1_-_26147149 0.09 ENST00000536896.1
AL020996.1
Uncharacterized protein
chr19_-_49955096 0.09 ENST00000595550.1
PIH1D1
PIH1 domain containing 1
chr1_+_109632425 0.09 ENST00000338272.8
TMEM167B
transmembrane protein 167B
chr2_+_64069459 0.09 ENST00000445915.2
ENST00000475462.1
UGP2
UDP-glucose pyrophosphorylase 2
chr8_+_19674651 0.09 ENST00000397977.3
INTS10
integrator complex subunit 10
chrX_-_134049262 0.09 ENST00000370783.3
MOSPD1
motile sperm domain containing 1
chr15_-_101142401 0.09 ENST00000314742.8
LINS
lines homolog (Drosophila)
chr3_-_52002403 0.09 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4
poly(rC) binding protein 4
chr22_+_39101728 0.09 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr16_-_18911366 0.09 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr16_-_15474904 0.09 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr1_-_68962805 0.09 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr2_-_36825281 0.09 ENST00000405912.3
ENST00000379245.4
FEZ2
fasciculation and elongation protein zeta 2 (zygin II)
chr12_-_48119340 0.08 ENST00000229003.3
ENDOU
endonuclease, polyU-specific
chrX_-_108976449 0.08 ENST00000469857.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr4_-_90758118 0.08 ENST00000420646.2
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr7_+_7196565 0.08 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr6_+_83073334 0.08 ENST00000369750.3
TPBG
trophoblast glycoprotein
chr16_-_31076332 0.08 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr11_+_94277017 0.08 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr18_-_25616519 0.08 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr4_-_52883786 0.08 ENST00000343457.3
LRRC66
leucine rich repeat containing 66
chr10_+_103348031 0.08 ENST00000370151.4
ENST00000370147.1
ENST00000370148.2
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr17_-_76870222 0.08 ENST00000585421.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr5_+_49961727 0.08 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8
poly (ADP-ribose) polymerase family, member 8
chr9_+_131644398 0.08 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr8_-_99954788 0.08 ENST00000523601.1
STK3
serine/threonine kinase 3
chr2_+_132044330 0.08 ENST00000416266.1
CYP4F31P
cytochrome P450, family 4, subfamily F, polypeptide 31, pseudogene
chr2_+_234621551 0.08 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr14_+_100531738 0.08 ENST00000555706.1
EVL
Enah/Vasp-like
chr14_+_100531615 0.08 ENST00000392920.3
EVL
Enah/Vasp-like
chr22_+_45714301 0.08 ENST00000427777.1
FAM118A
family with sequence similarity 118, member A
chr2_+_64073187 0.07 ENST00000491621.1
UGP2
UDP-glucose pyrophosphorylase 2
chr14_+_55494323 0.07 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr6_-_2971494 0.07 ENST00000380539.1
SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr10_-_104262460 0.07 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr3_-_101039402 0.07 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr22_+_32439019 0.07 ENST00000266088.4
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr18_-_64271316 0.07 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr19_-_49955050 0.07 ENST00000262265.5
PIH1D1
PIH1 domain containing 1
chr11_+_7595136 0.07 ENST00000529575.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr14_+_67831576 0.07 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr15_+_43477455 0.07 ENST00000300213.4
CCNDBP1
cyclin D-type binding-protein 1
chr6_+_83072923 0.07 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr11_+_12399071 0.07 ENST00000539723.1
ENST00000550549.1
PARVA
parvin, alpha
chr1_+_65613340 0.07 ENST00000546702.1
AK4
adenylate kinase 4
chr15_-_101142362 0.07 ENST00000559577.1
ENST00000561308.1
ENST00000560133.1
ENST00000560941.1
ENST00000559736.1
ENST00000560272.1
LINS
lines homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0051621 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.4 GO:2000646 regulation of Cdc42 protein signal transduction(GO:0032489) positive regulation of receptor catabolic process(GO:2000646)
0.1 0.4 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.1 0.4 GO:0002501 MHC protein complex assembly(GO:0002396) peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 0.5 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 0.2 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.3 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 0.1 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.7 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.2 GO:1903939 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.0 0.2 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.2 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.3 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.1 GO:0052148 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.2 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.4 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.0 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.0 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.1 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.0 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.0 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.1 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 0.0 GO:0072534 perineuronal net(GO:0072534)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.7 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.4 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.5 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.1 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.3 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.3 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.1 0.3 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.3 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.0 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:1902444 riboflavin binding(GO:1902444)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.2 PID IL2 1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 2.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.4 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.3 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling