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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for POU6F1

Z-value: 0.86

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_51611612-0.029.8e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_32767017 0.43 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr3_-_48659193 0.39 ENST00000330862.3
TMEM89
transmembrane protein 89
chr15_+_80351977 0.32 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr13_-_52027134 0.30 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr4_-_130692631 0.27 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
RP11-519M16.1
chr12_-_91546926 0.26 ENST00000550758.1
DCN
decorin
chr5_+_115177178 0.25 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr6_-_110501126 0.23 ENST00000368938.1
WASF1
WAS protein family, member 1
chrX_+_43515467 0.22 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr12_+_49297899 0.22 ENST00000552942.1
ENST00000320516.4
CCDC65
coiled-coil domain containing 65
chr15_+_80351910 0.20 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr4_+_78829479 0.19 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr1_+_171107241 0.19 ENST00000236166.3
FMO6P
flavin containing monooxygenase 6 pseudogene
chr11_+_71544246 0.19 ENST00000328698.1
DEFB108B
defensin, beta 108B
chr6_+_151646800 0.18 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chrX_-_100129320 0.17 ENST00000372966.3
NOX1
NADPH oxidase 1
chr3_-_108248169 0.17 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr1_+_225140372 0.17 ENST00000366848.1
ENST00000439375.2
DNAH14
dynein, axonemal, heavy chain 14
chr16_+_15744078 0.16 ENST00000396354.1
ENST00000570727.1
NDE1
nudE neurodevelopment protein 1
chr11_-_93583697 0.16 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr15_-_31283618 0.16 ENST00000563714.1
MTMR10
myotubularin related protein 10
chr14_+_39944025 0.16 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr11_+_2323236 0.15 ENST00000182290.4
TSPAN32
tetraspanin 32
chr12_-_95397442 0.15 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr2_+_202937972 0.15 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr19_-_58662139 0.14 ENST00000598312.1
ZNF329
zinc finger protein 329
chr18_+_52495426 0.14 ENST00000262094.5
RAB27B
RAB27B, member RAS oncogene family
chrY_+_14958970 0.14 ENST00000453031.1
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr5_+_67586465 0.13 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_76912070 0.13 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr15_-_85259294 0.12 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr15_-_85259384 0.12 ENST00000455959.3
SEC11A
SEC11 homolog A (S. cerevisiae)
chr20_+_58515417 0.12 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr14_+_24970800 0.12 ENST00000555109.1
RP11-80A15.1
Uncharacterized protein
chr9_+_128509624 0.11 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chr18_+_9475001 0.11 ENST00000019317.4
RALBP1
ralA binding protein 1
chr11_+_85339623 0.11 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B
chr15_-_44828838 0.10 ENST00000560750.1
EIF3J-AS1
EIF3J antisense RNA 1 (head to head)
chr2_+_191045562 0.10 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr15_-_85259330 0.10 ENST00000560266.1
SEC11A
SEC11 homolog A (S. cerevisiae)
chr17_-_39677971 0.09 ENST00000393976.2
KRT15
keratin 15
chr20_+_5987890 0.09 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr6_-_110501200 0.09 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WASF1
WAS protein family, member 1
chr12_+_102513950 0.09 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr13_+_98612446 0.09 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
IPO5
importin 5
chr4_-_83812157 0.08 ENST00000513323.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr15_+_45028520 0.08 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr11_-_4414880 0.08 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr7_-_83824169 0.08 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr22_+_31518938 0.08 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr11_-_107729887 0.08 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr9_+_131644398 0.08 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr6_-_74231444 0.07 ENST00000331523.2
ENST00000356303.2
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr12_-_30887948 0.07 ENST00000433722.2
CAPRIN2
caprin family member 2
chr7_+_157318477 0.07 ENST00000444154.1
AC006372.1
AC006372.1
chr6_-_111804905 0.07 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr10_+_97803151 0.07 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr15_+_59279851 0.07 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr19_-_3786354 0.07 ENST00000395040.2
ENST00000310132.6
MATK
megakaryocyte-associated tyrosine kinase
chr15_+_45028753 0.07 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr12_-_57443886 0.06 ENST00000300119.3
MYO1A
myosin IA
chr10_-_94257512 0.06 ENST00000371581.5
IDE
insulin-degrading enzyme
chr4_+_106631966 0.06 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
GSTCD
glutathione S-transferase, C-terminal domain containing
chr13_+_49551020 0.06 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr12_-_108954933 0.06 ENST00000431469.2
ENST00000546815.1
SART3
squamous cell carcinoma antigen recognized by T cells 3
chr15_+_45028719 0.06 ENST00000560442.1
ENST00000558329.1
ENST00000561043.1
TRIM69
tripartite motif containing 69
chr19_+_45116921 0.06 ENST00000402988.1
IGSF23
immunoglobulin superfamily, member 23
chr3_-_114343768 0.06 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_118398178 0.05 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr19_-_3786253 0.05 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr16_+_19422035 0.05 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr4_+_110749143 0.05 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr6_+_42123141 0.05 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr2_+_128403720 0.05 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr6_-_111136513 0.04 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr12_+_54892550 0.04 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr12_+_49297887 0.04 ENST00000266984.5
CCDC65
coiled-coil domain containing 65
chr7_-_83824449 0.04 ENST00000420047.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr10_-_43904235 0.03 ENST00000356053.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr19_+_42817527 0.03 ENST00000598766.1
TMEM145
transmembrane protein 145
chr1_+_176432298 0.03 ENST00000367661.3
ENST00000367662.3
PAPPA2
pappalysin 2
chr2_+_191045656 0.03 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr4_+_123161120 0.03 ENST00000446180.1
KIAA1109
KIAA1109
chr7_+_48494660 0.03 ENST00000411975.1
ENST00000544596.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr19_+_10959043 0.03 ENST00000397820.4
C19orf38
chromosome 19 open reading frame 38
chr6_+_110501344 0.03 ENST00000368932.1
CDC40
cell division cycle 40
chr4_+_40201954 0.03 ENST00000511121.1
RHOH
ras homolog family member H
chr17_-_26972126 0.03 ENST00000528896.2
KIAA0100
KIAA0100
chr11_-_107729504 0.03 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr9_+_131644388 0.03 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr9_-_86955598 0.03 ENST00000376238.4
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chr6_+_50786414 0.02 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr7_+_141490017 0.02 ENST00000247883.4
TAS2R5
taste receptor, type 2, member 5
chr1_-_197115818 0.02 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chrX_+_119737806 0.02 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr1_+_225117350 0.02 ENST00000413949.2
ENST00000430092.1
ENST00000366850.3
ENST00000400952.3
ENST00000366849.1
DNAH14
dynein, axonemal, heavy chain 14
chr8_+_92261516 0.02 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr11_-_107729287 0.02 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr2_-_166060382 0.02 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr5_+_162864575 0.02 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr12_+_102514019 0.02 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr15_+_74421961 0.02 ENST00000565159.1
ENST00000567206.1
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr1_-_151431909 0.02 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr9_+_103790991 0.01 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr20_+_34129770 0.01 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
ERGIC3
ERGIC and golgi 3
chr2_-_202563414 0.01 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr16_+_19421803 0.01 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr20_+_58203664 0.01 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr2_+_115219171 0.01 ENST00000409163.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr2_+_102721023 0.01 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr12_+_10460417 0.01 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr10_+_18041218 0.01 ENST00000480516.1
ENST00000457860.1
TMEM236
TMEM236
chr8_-_10512569 0.01 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr20_-_50418947 0.00 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr1_-_151431647 0.00 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr1_-_21377383 0.00 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr5_+_55147205 0.00 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr2_-_217560248 0.00 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr1_-_151431674 0.00 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.2 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.1 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.5 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.0 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation