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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for SIX6

Z-value: 0.55

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.6 SIX homeobox 6

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_9203855 0.93 ENST00000429566.3
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr12_-_71512027 0.55 ENST00000549357.1
CTD-2021H9.3
Uncharacterized protein
chr6_+_37012607 0.33 ENST00000423336.1
COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr4_-_6694189 0.30 ENST00000596858.1
AC093323.1
Uncharacterized protein
chr6_-_8102279 0.28 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr9_-_100707116 0.27 ENST00000259456.3
HEMGN
hemogen
chr12_-_14849470 0.21 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr15_+_63414760 0.20 ENST00000557972.1
LACTB
lactamase, beta
chr10_+_52094298 0.19 ENST00000595931.1
AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr12_-_121477039 0.19 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_121476959 0.19 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_32579271 0.17 ENST00000518084.1
NRG1
neuregulin 1
chr16_+_22524379 0.15 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr13_+_73629107 0.15 ENST00000539231.1
KLF5
Kruppel-like factor 5 (intestinal)
chr12_+_133614062 0.15 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chr3_+_151531859 0.15 ENST00000488869.1
AADAC
arylacetamide deacetylase
chr3_-_107596910 0.14 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr22_+_24666763 0.13 ENST00000437398.1
ENST00000421374.1
ENST00000314328.9
ENST00000541492.1
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1-like
chr12_-_10978957 0.12 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr1_+_112016414 0.12 ENST00000343534.5
ENST00000369718.3
C1orf162
chromosome 1 open reading frame 162
chr8_+_101170134 0.12 ENST00000520643.1
SPAG1
sperm associated antigen 1
chr8_+_32579321 0.12 ENST00000522402.1
NRG1
neuregulin 1
chr19_-_14628645 0.12 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_-_65468148 0.11 ENST00000415842.1
RP11-182I10.3
RP11-182I10.3
chr13_+_34392200 0.11 ENST00000434425.1
RFC3
replication factor C (activator 1) 3, 38kDa
chr7_-_123198284 0.11 ENST00000355749.2
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr12_+_19282643 0.11 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr12_-_46385811 0.10 ENST00000419565.2
SCAF11
SR-related CTD-associated factor 11
chr8_+_101170257 0.10 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr11_-_104916034 0.09 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
CARD16
caspase recruitment domain family, member 16
chr15_-_80263506 0.09 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr12_-_121476750 0.09 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_107593198 0.09 ENST00000517686.1
OXR1
oxidation resistance 1
chr1_-_150669604 0.08 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr10_-_14614311 0.08 ENST00000479731.1
ENST00000468492.1
FAM107B
family with sequence similarity 107, member B
chr4_+_189321881 0.08 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chr8_+_32579341 0.07 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr1_+_179263308 0.07 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr3_+_186742464 0.07 ENST00000416235.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_160709055 0.07 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr9_-_135230336 0.07 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
SETX
senataxin
chr7_+_107332334 0.07 ENST00000541474.1
ENST00000544569.1
SLC26A4
solute carrier family 26 (anion exchanger), member 4
chr19_-_16008880 0.07 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr22_+_18043133 0.06 ENST00000327451.6
ENST00000399813.1
SLC25A18
solute carrier family 25 (glutamate carrier), member 18
chr10_-_75008620 0.06 ENST00000372950.4
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr4_-_184241927 0.06 ENST00000323319.5
CLDN22
claudin 22
chr2_+_177134201 0.06 ENST00000452865.1
MTX2
metaxin 2
chr7_+_6121296 0.06 ENST00000428901.1
AC004895.4
AC004895.4
chr2_-_100925967 0.06 ENST00000409647.1
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr1_-_20446020 0.06 ENST00000375105.3
PLA2G2D
phospholipase A2, group IID
chr10_+_91061712 0.06 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr12_-_15374328 0.05 ENST00000537647.1
RERG
RAS-like, estrogen-regulated, growth inhibitor
chr6_+_80816342 0.05 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
BCKDHB
branched chain keto acid dehydrogenase E1, beta polypeptide
chr17_-_67057047 0.05 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_-_36235559 0.05 ENST00000251195.5
CLSPN
claspin
chr19_+_46000479 0.05 ENST00000456399.2
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr12_-_28123206 0.05 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr6_+_127898312 0.05 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr17_-_6524159 0.05 ENST00000589033.1
KIAA0753
KIAA0753
chr17_-_67224812 0.05 ENST00000423818.2
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr8_+_67104323 0.05 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
LINC00967
long intergenic non-protein coding RNA 967
chr12_-_11091862 0.05 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr15_-_51397473 0.05 ENST00000327536.5
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr9_-_100684845 0.04 ENST00000375119.3
C9orf156
chromosome 9 open reading frame 156
chr1_+_212738676 0.04 ENST00000366981.4
ENST00000366987.2
ATF3
activating transcription factor 3
chr2_-_62081148 0.04 ENST00000404929.1
FAM161A
family with sequence similarity 161, member A
chr4_+_57396766 0.04 ENST00000512175.2
THEGL
theg spermatid protein-like
chrX_-_99665262 0.04 ENST00000373034.4
ENST00000255531.7
PCDH19
protocadherin 19
chr4_+_74301880 0.04 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr17_-_5342380 0.04 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr7_-_81635106 0.04 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chrX_+_128674213 0.04 ENST00000371113.4
ENST00000357121.5
OCRL
oculocerebrorenal syndrome of Lowe
chr8_+_84824920 0.03 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr2_-_100939195 0.03 ENST00000393437.3
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr2_+_177134134 0.03 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr16_+_72090053 0.03 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
HP
haptoglobin
chr10_+_45495898 0.03 ENST00000298299.3
ZNF22
zinc finger protein 22
chr20_+_34802295 0.03 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr9_-_7800067 0.02 ENST00000358227.4
TMEM261
transmembrane protein 261
chrX_-_118699325 0.02 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
CXorf56
chromosome X open reading frame 56
chr18_+_158327 0.02 ENST00000582707.1
USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr22_-_17702729 0.02 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
CECR1
cat eye syndrome chromosome region, candidate 1
chr9_-_99382065 0.02 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr13_-_20080080 0.02 ENST00000400103.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr16_+_19467772 0.02 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr13_-_46679185 0.02 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr5_+_115420688 0.02 ENST00000274458.4
COMMD10
COMM domain containing 10
chr9_+_109685630 0.02 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr13_-_46679144 0.02 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chrX_-_20236970 0.02 ENST00000379548.4
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr1_+_40942887 0.02 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr16_-_21436459 0.02 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chrX_+_38660704 0.02 ENST00000378474.3
MID1IP1
MID1 interacting protein 1
chr11_-_45307817 0.02 ENST00000020926.3
SYT13
synaptotagmin XIII
chr12_+_117348742 0.01 ENST00000309909.5
ENST00000455858.2
FBXW8
F-box and WD repeat domain containing 8
chr1_-_182369751 0.01 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr1_-_67142710 0.01 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr10_-_79397479 0.01 ENST00000404771.3
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr12_-_498620 0.01 ENST00000399788.2
ENST00000382815.4
KDM5A
lysine (K)-specific demethylase 5A
chr3_-_196242233 0.01 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr1_+_160709029 0.01 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr2_-_58468437 0.01 ENST00000403676.1
ENST00000427708.2
ENST00000403295.3
ENST00000446381.1
ENST00000417361.1
ENST00000233741.4
ENST00000402135.3
ENST00000540646.1
ENST00000449070.1
FANCL
Fanconi anemia, complementation group L
chr17_+_61271355 0.01 ENST00000583356.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr18_+_42260059 0.01 ENST00000426838.4
SETBP1
SET binding protein 1
chr17_+_7788104 0.01 ENST00000380358.4
CHD3
chromodomain helicase DNA binding protein 3
chr14_+_21152259 0.01 ENST00000555835.1
ENST00000336811.6
RNASE4
ANG
ribonuclease, RNase A family, 4
angiogenin, ribonuclease, RNase A family, 5
chr2_+_85822857 0.01 ENST00000306368.4
ENST00000414390.1
ENST00000456023.1
RNF181
ring finger protein 181
chr1_+_160709076 0.01 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr1_+_234509186 0.00 ENST00000366615.4
COA6
cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chr11_-_104972158 0.00 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr4_-_155511887 0.00 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr5_+_55147205 0.00 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr8_+_26247878 0.00 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr11_+_126262027 0.00 ENST00000526311.1
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr1_-_10003372 0.00 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr20_-_4990931 0.00 ENST00000379333.1
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr1_-_13673511 0.00 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chrX_-_53350522 0.00 ENST00000396435.3
ENST00000375368.5
IQSEC2
IQ motif and Sec7 domain 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.0 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0071494 cellular response to UV-C(GO:0071494)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.0 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.1 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.1 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)
0.0 0.0 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway