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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)
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Results for ZBTB33_CHD2
Z-value: 3.15
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | 1.00 | 1.7e-03 | Click! |
| CHD2 | hg19_v2_chr15_+_93447675_93447703 | 0.79 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_111992064 Show fit | 2.19 |
ENST00000483994.1
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 |
|
| chr10_-_112064665 Show fit | 1.95 |
ENST00000369603.5
|
survival motor neuron domain containing 1 |
|
| chr5_-_176449586 Show fit | 1.82 |
ENST00000509236.1
|
ubiquitin interaction motif containing 1 |
|
| chr10_-_127408011 Show fit | 1.77 |
ENST00000531977.1
ENST00000527483.1 ENST00000525909.1 ENST00000528844.1 ENST00000423178.2 |
RP11-383C5.4 |
|
| chr10_+_127408110 Show fit | 1.48 |
ENST00000356792.4
|
erythroid differentiation regulatory factor 1 |
|
| chr2_-_232328867 Show fit | 1.39 |
ENST00000453992.1
ENST00000417652.1 ENST00000454824.1 |
nucleolin |
|
| chr5_+_169011033 Show fit | 1.29 |
ENST00000513795.1
|
spindle apparatus coiled-coil protein 1 |
|
| chr15_+_78730531 Show fit | 1.27 |
ENST00000258886.8
|
iron-responsive element binding protein 2 |
|
| chr10_+_127408263 Show fit | 1.23 |
ENST00000337623.3
|
erythroid differentiation regulatory factor 1 |
|
| chr9_+_26956474 Show fit | 1.22 |
ENST00000429045.2
|
intraflagellar transport 74 homolog (Chlamydomonas) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.2 | 3.2 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.2 | 2.9 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 2.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 2.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.8 | 2.3 | GO:0035508 | positive regulation of myosin-light-chain-phosphatase activity(GO:0035508) |
| 0.1 | 2.2 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.3 | 2.1 | GO:1905068 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.1 | 2.1 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.5 | 2.0 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 4.1 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.1 | 3.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 3.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 3.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 2.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 2.5 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.1 | 2.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 2.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.2 | 2.1 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 4.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 2.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 2.3 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 2.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 2.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 2.1 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 2.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 2.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.3 | 2.0 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 4.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 3.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| 0.1 | 2.3 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 2.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.9 | REACTOME CELL CYCLE CHECKPOINTS | Genes involved in Cell Cycle Checkpoints |
| 0.0 | 1.8 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.6 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.0 | 1.6 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 1.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |