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A549 cells infected with IAV Analysis Results (GEO series: GSE147507)

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Results for ZNF423

Z-value: 0.80

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49890016_498900460.297.1e-01Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_30675654 0.83 ENST00000287468.5
ENST00000395073.2
fibrosin
chr9_-_131486367 0.82 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
zinc finger, DHHC-type containing 12
chr11_-_44972418 0.82 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
tumor protein p53 inducible protein 11
chr9_+_135037334 0.62 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
netrin G2
chr17_-_79212825 0.47 ENST00000374769.2
ENTH domain containing 2
chr15_-_75660919 0.42 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
mannosidase, alpha, class 2C, member 1
chr11_-_44972299 0.41 ENST00000528473.1
tumor protein p53 inducible protein 11
chr16_-_11681023 0.41 ENST00000570904.1
ENST00000574701.1
lipopolysaccharide-induced TNF factor
chr11_+_60691924 0.40 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
transmembrane protein 132A
chr19_-_56110859 0.39 ENST00000221665.3
ENST00000592585.1
FLT3-interacting zinc finger 1
chr2_-_206950996 0.39 ENST00000414320.1
INO80 complex subunit D
chr19_+_14544099 0.39 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
protein kinase N1
chr11_-_44972390 0.38 ENST00000395648.3
ENST00000531928.2
tumor protein p53 inducible protein 11
chr9_+_130160440 0.37 ENST00000439597.1
ENST00000423934.1
solute carrier family 2 (facilitated glucose transporter), member 8
chr20_-_36794902 0.36 ENST00000373403.3
transglutaminase 2
chr20_-_36794938 0.34 ENST00000453095.1
transglutaminase 2
chr11_-_44971702 0.34 ENST00000533940.1
ENST00000533937.1
tumor protein p53 inducible protein 11
chr9_-_130742792 0.33 ENST00000373095.1
family with sequence similarity 102, member A
chr11_-_44972476 0.33 ENST00000527685.1
ENST00000308212.5
tumor protein p53 inducible protein 11
chr6_-_32160622 0.32 ENST00000487761.1
ENST00000375040.3
G-protein signaling modulator 3
chr17_+_6347761 0.31 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr11_-_504489 0.30 ENST00000529368.1
ribonuclease/angiogenin inhibitor 1
chr19_-_4066890 0.30 ENST00000322357.4
zinc finger and BTB domain containing 7A
chr17_+_77020224 0.30 ENST00000339142.2
C1q and tumor necrosis factor related protein 1
chr19_-_15311713 0.29 ENST00000601011.1
ENST00000263388.2
notch 3
chr17_+_77020146 0.28 ENST00000579760.1
C1q and tumor necrosis factor related protein 1
chr8_+_22423168 0.28 ENST00000518912.1
ENST00000428103.1
sorbin and SH3 domain containing 3
chr22_-_37823468 0.27 ENST00000402918.2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr17_-_27230035 0.27 ENST00000378895.4
ENST00000394901.3
dehydrogenase/reductase (SDR family) member 13
chr19_-_4043154 0.27 ENST00000535853.1
AC016586.1
chr20_+_44462430 0.26 ENST00000462307.1
sorting nexin family member 21
chr9_+_131549610 0.26 ENST00000223865.8
TBC1 domain family, member 13
chr19_-_10679644 0.26 ENST00000393599.2
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr17_+_77020325 0.25 ENST00000311661.4
C1q and tumor necrosis factor related protein 1
chr3_+_9958758 0.25 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
interleukin 17 receptor C
chr11_-_67120974 0.24 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr11_-_61659006 0.23 ENST00000278829.2
fatty acid desaturase 3
chr9_-_35619539 0.23 ENST00000396757.1
CD72 molecule
chr16_+_3014269 0.23 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
kringle containing transmembrane protein 2
chr20_+_44462749 0.22 ENST00000372541.1
sorting nexin family member 21
chr12_+_7342178 0.22 ENST00000266563.5
ENST00000543974.1
peroxisomal biogenesis factor 5
chr3_+_9958870 0.20 ENST00000413608.1
interleukin 17 receptor C
chr3_-_52931557 0.20 ENST00000504329.1
ENST00000355083.5
TMEM110-MUSTN1 readthrough
transmembrane protein 110
chr5_+_150400124 0.20 ENST00000388825.4
ENST00000521650.1
ENST00000517973.1
glutathione peroxidase 3 (plasma)
chr19_-_36391434 0.20 ENST00000396901.1
ENST00000585925.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr17_+_6347729 0.20 ENST00000572447.1
family with sequence similarity 64, member A
chr1_-_204121102 0.19 ENST00000367202.4
ethanolamine kinase 2
chr16_+_27324983 0.18 ENST00000566117.1
interleukin 4 receptor
chr12_+_7342271 0.18 ENST00000434354.2
ENST00000544456.1
ENST00000545574.1
ENST00000420616.2
peroxisomal biogenesis factor 5
chr1_-_33366931 0.17 ENST00000373463.3
ENST00000329151.5
transmembrane protein 54
chr20_+_44462481 0.17 ENST00000491381.1
ENST00000342644.5
ENST00000372542.1
sorting nexin family member 21
chr1_-_204121298 0.17 ENST00000367199.2
ethanolamine kinase 2
chr9_+_139249228 0.17 ENST00000392944.1
G-protein signaling modulator 1
chr8_+_22422749 0.16 ENST00000523900.1
sorbin and SH3 domain containing 3
chr8_+_22423219 0.16 ENST00000523965.1
ENST00000521554.1
sorbin and SH3 domain containing 3
chr14_-_93582214 0.16 ENST00000556603.2
ENST00000354313.3
inositol-tetrakisphosphate 1-kinase
chr1_+_1222489 0.15 ENST00000379099.3
sodium channel, non-voltage-gated 1, delta subunit
chr1_-_204121013 0.15 ENST00000367201.3
ethanolamine kinase 2
chr12_+_7342441 0.15 ENST00000412720.2
ENST00000396637.3
peroxisomal biogenesis factor 5
chr12_-_54779511 0.14 ENST00000551109.1
ENST00000546970.1
zinc finger protein 385A
chr11_+_73019282 0.14 ENST00000263674.3
Rho guanine nucleotide exchange factor (GEF) 17
chr11_-_61062762 0.13 ENST00000335613.5
von Willebrand factor C and EGF domains
chr1_+_24118452 0.13 ENST00000421070.1
lysophospholipase II
chr5_+_141303373 0.12 ENST00000432126.2
ENST00000194118.4
KIAA0141
chr19_+_45582453 0.12 ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
ENST00000587566.1
gem (nuclear organelle) associated protein 7
MAP/microtubule affinity-regulating kinase 4
chr17_+_36584662 0.12 ENST00000431231.2
ENST00000437668.3
Rho GTPase activating protein 23
chr13_+_21277482 0.11 ENST00000304920.3
interleukin 17D
chr20_+_43029911 0.11 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
hepatocyte nuclear factor 4, alpha
chr22_-_43045574 0.11 ENST00000352397.5
cytochrome b5 reductase 3
chr8_+_22022800 0.10 ENST00000397814.3
bone morphogenetic protein 1
chr6_-_33663474 0.10 ENST00000594414.1
SBP1; Uncharacterized protein
chr13_-_46626820 0.10 ENST00000428921.1
zinc finger CCCH-type containing 13
chr19_-_5292781 0.09 ENST00000586065.1
protein tyrosine phosphatase, receptor type, S
chr12_+_7037461 0.09 ENST00000396684.2
atrophin 1
chr7_+_20370746 0.09 ENST00000222573.4
integrin, beta 8
chr1_+_17914907 0.08 ENST00000375420.3
Rho guanine nucleotide exchange factor (GEF) 10-like
chr22_-_31742218 0.08 ENST00000266269.5
ENST00000405309.3
ENST00000351933.4
POZ (BTB) and AT hook containing zinc finger 1
chrX_+_152760397 0.07 ENST00000331595.4
ENST00000431891.1
biglycan
chr18_-_60985914 0.07 ENST00000589955.1
B-cell CLL/lymphoma 2
chr19_+_41770349 0.07 ENST00000602130.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr8_+_22022653 0.07 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
bone morphogenetic protein 1
chr16_-_2162831 0.07 ENST00000483024.1
polycystic kidney disease 1 (autosomal dominant)
chr1_-_155177677 0.07 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
thrombospondin 3
chr8_+_22022223 0.07 ENST00000306385.5
bone morphogenetic protein 1
chr5_-_176057518 0.07 ENST00000393693.2
synuclein, beta
chr19_+_10531150 0.07 ENST00000352831.6
phosphodiesterase 4A, cAMP-specific
chr15_+_41523417 0.06 ENST00000560397.1
calcineurin-like EF-hand protein 1
chr7_-_27219632 0.06 ENST00000470747.4
Uncharacterized protein
chr5_+_141303461 0.06 ENST00000508751.1
KIAA0141
chr9_-_130659679 0.06 ENST00000373141.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr12_-_125348329 0.06 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
scavenger receptor class B, member 1
chr12_-_125348448 0.06 ENST00000339570.5
scavenger receptor class B, member 1
chr19_-_11689752 0.06 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
acid phosphatase 5, tartrate resistant
chr19_+_41770236 0.06 ENST00000392006.3
heterogeneous nuclear ribonucleoprotein U-like 1
chr17_-_48227877 0.06 ENST00000316878.6
protein phosphatase 1, regulatory subunit 9B
chr2_-_120980939 0.06 ENST00000426077.2
transmembrane protein 185B
chr14_-_93582148 0.06 ENST00000267615.6
ENST00000553452.1
inositol-tetrakisphosphate 1-kinase
chr20_-_25062767 0.05 ENST00000429762.3
ENST00000444511.2
ENST00000376707.3
visual system homeobox 1
chr7_-_44265492 0.05 ENST00000425809.1
calcium/calmodulin-dependent protein kinase II beta
chr12_-_57522813 0.05 ENST00000556155.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr12_-_50101165 0.05 ENST00000352151.5
ENST00000335154.5
ENST00000293590.5
formin-like 3
chr8_+_145065705 0.05 ENST00000533044.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr8_+_145065521 0.04 ENST00000534791.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chrX_+_106163626 0.04 ENST00000336803.1
claudin 2
chr11_-_61658853 0.04 ENST00000525588.1
ENST00000540820.1
fatty acid desaturase 3
chr16_-_11681316 0.04 ENST00000571688.1
lipopolysaccharide-induced TNF factor
chr16_+_27325202 0.04 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
interleukin 4 receptor
chr11_-_47207950 0.04 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
protein kinase C and casein kinase substrate in neurons 3
chr7_-_27219849 0.04 ENST00000396344.4
homeobox A10
chr9_-_99382065 0.03 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
cell division cycle 14B
chr9_-_130659569 0.03 ENST00000542456.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr9_-_39239171 0.03 ENST00000358144.2
contactin associated protein-like 3
chr11_-_6495082 0.03 ENST00000536344.1
tripartite motif containing 3
chr15_+_41523335 0.03 ENST00000334660.5
calcineurin-like EF-hand protein 1
chr11_+_61595572 0.03 ENST00000517312.1
fatty acid desaturase 2
chr17_+_7341586 0.02 ENST00000575235.1
fibroblast growth factor 11
chr10_-_118032979 0.02 ENST00000355422.6
GDNF family receptor alpha 1
chr19_-_38714847 0.02 ENST00000420980.2
ENST00000355526.4
D4, zinc and double PHD fingers family 1
chr12_-_50101003 0.01 ENST00000550488.1
formin-like 3
chr19_+_41770269 0.01 ENST00000378215.4
heterogeneous nuclear ribonucleoprotein U-like 1
chr6_+_33589161 0.01 ENST00000605930.1
inositol 1,4,5-trisphosphate receptor, type 3
chr9_+_116638562 0.01 ENST00000374126.5
ENST00000288466.7
zinc finger protein 618
chr22_-_38484922 0.01 ENST00000428572.1
BAI1-associated protein 2-like 2
chr4_-_20985632 0.01 ENST00000359001.5
Kv channel interacting protein 4
chr3_-_114173530 0.01 ENST00000470311.1
zinc finger and BTB domain containing 20
chr16_+_70148230 0.00 ENST00000398122.3
ENST00000568530.1
pyruvate dehydrogenase phosphatase regulatory subunit
chr7_+_20370300 0.00 ENST00000537992.1
integrin, beta 8
chr11_-_107729504 0.00 ENST00000265836.7
solute carrier family 35, member F2
chr7_-_5570229 0.00 ENST00000331789.5
actin, beta
chr6_+_42896865 0.00 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr6_-_91296737 0.00 ENST00000369332.3
ENST00000369329.3
mitogen-activated protein kinase kinase kinase 7
chr5_-_176057365 0.00 ENST00000310112.3
synuclein, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.5 GO:1901091 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.1 0.8 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.5 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0 0.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.1 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.3 GO:0072104 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 0.2 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.3 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.2 GO:0070245 negative regulation of T cell differentiation in thymus(GO:0033085) positive regulation of thymocyte apoptotic process(GO:0070245) negative regulation of thymocyte aggregation(GO:2000399)
0.0 0.1 GO:0032848 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.4 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.0 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.1 GO:0002133 polycystin complex(GO:0002133)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.2 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.1 0.2 GO:0052825 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.1 0.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.3 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters