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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for CBFB

Z-value: 0.82

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67063036_67063088-0.982.2e-02Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_34417479 2.54 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr1_+_209859510 0.84 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr20_+_43343886 0.61 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr12_-_54778444 0.50 ENST00000551771.1
ZNF385A
zinc finger protein 385A
chr17_-_39183452 0.49 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr12_-_54778471 0.48 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A
zinc finger protein 385A
chr14_-_61116168 0.43 ENST00000247182.6
SIX1
SIX homeobox 1
chr2_-_127977654 0.42 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr17_+_32582293 0.40 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr11_+_114310164 0.39 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2
RNA exonuclease 2
chr15_+_67390920 0.38 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chrX_+_115567767 0.38 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_+_68048803 0.35 ENST00000204961.4
EFNB1
ephrin-B1
chr11_+_114310102 0.32 ENST00000265881.5
REXO2
RNA exonuclease 2
chr4_+_71091786 0.31 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr14_-_59951112 0.29 ENST00000247194.4
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr4_+_74347400 0.28 ENST00000226355.3
AFM
afamin
chr9_-_130541017 0.28 ENST00000314830.8
SH2D3C
SH2 domain containing 3C
chr1_+_66796401 0.26 ENST00000528771.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr11_-_64885111 0.26 ENST00000528598.1
ENST00000310597.4
ZNHIT2
zinc finger, HIT-type containing 2
chrX_-_49041242 0.25 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr2_+_234826016 0.24 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr1_-_179112173 0.23 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr11_-_66103867 0.22 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr11_-_66103932 0.22 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chrX_-_19688475 0.21 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr12_-_54778244 0.21 ENST00000549937.1
ZNF385A
zinc finger protein 385A
chr5_+_131409476 0.20 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr13_+_76210448 0.19 ENST00000377499.5
LMO7
LIM domain 7
chr5_-_39203093 0.19 ENST00000515010.1
FYB
FYN binding protein
chr11_-_66104237 0.16 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr1_-_179112189 0.16 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr6_+_30908747 0.15 ENST00000462446.1
ENST00000304311.2
DPCR1
diffuse panbronchiolitis critical region 1
chr8_+_28747884 0.14 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1
homeobox containing 1
chr3_+_98482159 0.14 ENST00000468553.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr6_+_45296391 0.13 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr6_-_152623231 0.13 ENST00000540663.1
ENST00000537033.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_+_156799587 0.12 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr2_-_87248975 0.12 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr3_-_99569821 0.12 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr19_-_14048804 0.11 ENST00000254320.3
ENST00000586075.1
PODNL1
podocan-like 1
chr12_-_4754339 0.11 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_89246647 0.10 ENST00000544045.1
PKN2
protein kinase N2
chr4_+_88896819 0.10 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr15_-_64385981 0.10 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chr2_-_158300556 0.10 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr3_+_98482175 0.09 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr1_-_157014865 0.08 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr2_+_68592305 0.08 ENST00000234313.7
PLEK
pleckstrin
chr8_-_134072593 0.07 ENST00000427060.2
SLA
Src-like-adaptor
chr8_-_60031762 0.07 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr3_+_157154578 0.06 ENST00000295927.3
PTX3
pentraxin 3, long
chr12_-_14849470 0.06 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr15_-_64386120 0.06 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr2_+_103035102 0.06 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_47264711 0.06 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
chr2_+_207024306 0.06 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr11_+_114310237 0.05 ENST00000539119.1
REXO2
RNA exonuclease 2
chr19_-_14049184 0.05 ENST00000339560.5
PODNL1
podocan-like 1
chr8_-_28747717 0.05 ENST00000416984.2
INTS9
integrator complex subunit 9
chr15_+_64386261 0.04 ENST00000560829.1
SNX1
sorting nexin 1
chr20_+_54987168 0.04 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr9_+_123884038 0.04 ENST00000373847.1
CNTRL
centriolin
chr14_+_72064945 0.04 ENST00000537413.1
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr15_-_64665911 0.04 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr9_-_123342415 0.03 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr8_-_28747424 0.03 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9
chr19_+_10541462 0.03 ENST00000293683.5
PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_+_173955327 0.03 ENST00000422149.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr5_-_137878887 0.03 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr14_+_85996507 0.03 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr2_-_207024233 0.02 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr5_+_67576109 0.02 ENST00000522084.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_159770292 0.02 ENST00000536257.1
ENST00000321935.6
FCRL6
Fc receptor-like 6
chr8_+_67624653 0.02 ENST00000521198.2
SGK3
serum/glucocorticoid regulated kinase family, member 3
chrX_-_70838306 0.01 ENST00000373691.4
ENST00000373693.3
CXCR3
chemokine (C-X-C motif) receptor 3
chr1_+_39876151 0.00 ENST00000530275.1
KIAA0754
KIAA0754
chr12_-_52585765 0.00 ENST00000313234.5
ENST00000394815.2
KRT80
keratin 80

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 1.2 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.4 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.8 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0035938 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.0 0.3 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.1 GO:0044793 negative regulation by host of viral process(GO:0044793)
0.0 0.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.1 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698) CCR1 chemokine receptor binding(GO:0031726)
0.3 0.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.3 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.2 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.1 0.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.2 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.4 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL