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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for DLX5

Z-value: 0.62

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 distal-less homeobox 5

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_63188009 0.61 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr4_-_8873531 0.56 ENST00000400677.3
HMX1
H6 family homeobox 1
chr7_+_100770328 0.49 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr1_-_21620877 0.33 ENST00000527991.1
ECE1
endothelin converting enzyme 1
chr12_+_52695617 0.31 ENST00000293525.5
KRT86
keratin 86
chr19_+_36605850 0.30 ENST00000221855.3
TBCB
tubulin folding cofactor B
chr1_-_201140673 0.29 ENST00000367333.2
TMEM9
transmembrane protein 9
chr19_+_54641444 0.28 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr14_+_32798462 0.28 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_27860956 0.26 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr6_-_33256664 0.25 ENST00000444176.1
WDR46
WD repeat domain 46
chr19_+_36606354 0.25 ENST00000589996.1
ENST00000591296.1
TBCB
tubulin folding cofactor B
chr8_-_124553437 0.24 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr2_+_228736335 0.24 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr15_+_89631647 0.23 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr14_+_32798547 0.22 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr17_+_36508826 0.22 ENST00000580660.1
SOCS7
suppressor of cytokine signaling 7
chr7_-_7575477 0.20 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr11_-_33913708 0.20 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_+_28268623 0.20 ENST00000394835.3
ENST00000320856.5
ENST00000394832.2
ENST00000378738.3
EFCAB5
EF-hand calcium binding domain 5
chrX_+_100645812 0.20 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr7_-_99717463 0.20 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_-_183387064 0.20 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr12_+_54378849 0.19 ENST00000515593.1
HOXC10
homeobox C10
chr1_+_54569968 0.19 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr7_-_99716952 0.18 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr12_+_64798826 0.18 ENST00000540203.1
XPOT
exportin, tRNA
chr6_-_112194484 0.17 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN
FYN oncogene related to SRC, FGR, YES
chr3_-_180397256 0.17 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr1_-_198906528 0.16 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr5_+_142286887 0.16 ENST00000451259.1
ARHGAP26
Rho GTPase activating protein 26
chr19_-_36606181 0.16 ENST00000221859.4
POLR2I
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr11_-_102651343 0.15 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr12_+_7014064 0.15 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr10_-_99205607 0.15 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr10_-_97200772 0.15 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr12_+_7013897 0.14 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr12_-_53171128 0.14 ENST00000332411.2
KRT76
keratin 76
chr6_+_123038689 0.13 ENST00000354275.2
ENST00000368446.1
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr17_-_37009882 0.13 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr3_+_11178779 0.13 ENST00000438284.2
HRH1
histamine receptor H1
chr18_+_55888767 0.12 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr9_+_34646651 0.12 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr13_-_36050819 0.12 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr8_-_22526597 0.11 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
BIN3
bridging integrator 3
chr11_+_818902 0.11 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr1_-_78444776 0.10 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr9_+_34646624 0.10 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr1_-_78444738 0.09 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr18_-_53255379 0.09 ENST00000565908.2
TCF4
transcription factor 4
chr17_-_47786375 0.09 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chr17_-_47785504 0.09 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
SLC35B1
solute carrier family 35, member B1
chr14_-_24711470 0.09 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr19_+_4007644 0.09 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chrX_+_100224676 0.08 ENST00000450049.2
ARL13A
ADP-ribosylation factor-like 13A
chr11_+_73498973 0.08 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr10_-_56561022 0.08 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr2_+_84542187 0.08 ENST00000440495.1
AC106874.1
AC106874.1
chr17_+_42264556 0.08 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr4_-_69111401 0.08 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr2_+_196313239 0.08 ENST00000413290.1
AC064834.1
AC064834.1
chr19_-_19302931 0.08 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr11_-_26593649 0.08 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr2_+_105050794 0.07 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr3_+_186560476 0.07 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr2_-_220118631 0.07 ENST00000248437.4
TUBA4A
tubulin, alpha 4a
chr4_-_7069760 0.07 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr12_-_57039739 0.07 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr5_-_20575959 0.07 ENST00000507958.1
CDH18
cadherin 18, type 2
chr2_+_228736321 0.07 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr2_-_183387283 0.06 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_+_186560462 0.06 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr12_-_95774672 0.06 ENST00000549961.1
RP11-167N24.6
Uncharacterized protein
chr14_-_68283291 0.06 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr2_-_183387430 0.06 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr11_-_71823266 0.06 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr6_-_78173490 0.06 ENST00000369947.2
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
chr14_-_24711806 0.06 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr7_+_97736197 0.06 ENST00000297293.5
LMTK2
lemur tyrosine kinase 2
chr4_-_66536196 0.05 ENST00000511294.1
EPHA5
EPH receptor A5
chr4_-_74853897 0.05 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr7_-_14028488 0.05 ENST00000405358.4
ETV1
ets variant 1
chr15_+_41913690 0.05 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr7_-_99716940 0.05 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr21_-_15918618 0.05 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_+_99717230 0.05 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr2_-_220117867 0.05 ENST00000456818.1
ENST00000447205.1
TUBA4A
tubulin, alpha 4a
chr4_-_66536057 0.04 ENST00000273854.3
EPHA5
EPH receptor A5
chr11_+_73498898 0.04 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr4_+_169575875 0.04 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr14_+_24540154 0.03 ENST00000559778.1
ENST00000560761.1
ENST00000557889.1
CPNE6
copine VI (neuronal)
chr12_+_51818749 0.03 ENST00000514353.3
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr14_-_95236551 0.03 ENST00000238558.3
GSC
goosecoid homeobox
chr4_-_105416039 0.02 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr3_-_186288097 0.02 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr2_+_228735763 0.02 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr3_-_105588231 0.02 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr8_+_92261516 0.02 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr10_-_128110441 0.01 ENST00000456514.1
LINC00601
long intergenic non-protein coding RNA 601
chr17_+_43238438 0.01 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr8_-_10512569 0.01 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr9_-_34329198 0.01 ENST00000379166.2
ENST00000345050.2
KIF24
kinesin family member 24
chr14_-_24711865 0.01 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr8_+_32579341 0.00 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr1_+_202317815 0.00 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001300 chronological cell aging(GO:0001300)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.3 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.2 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.1 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.1 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) negative regulation of dendritic spine maintenance(GO:1902951)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease