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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for DMC1

Z-value: 0.40

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_389662910.891.1e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_190044480 0.19 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr6_-_150067632 0.19 ENST00000460354.2
ENST00000367404.4
ENST00000543637.1
NUP43
nucleoporin 43kDa
chr17_+_57297807 0.19 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr18_+_11857439 0.18 ENST00000602628.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr4_-_76944621 0.14 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr10_+_62538248 0.12 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr10_+_62538089 0.12 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr11_-_85779971 0.11 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_-_31637560 0.11 ENST00000379416.3
XDH
xanthine dehydrogenase
chr3_+_148457585 0.11 ENST00000402260.1
AGTR1
angiotensin II receptor, type 1
chr12_-_50677255 0.11 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr14_+_74318611 0.09 ENST00000555976.1
ENST00000267568.4
PTGR2
prostaglandin reductase 2
chr2_+_171640291 0.09 ENST00000409885.1
ERICH2
glutamate-rich 2
chr19_+_1041187 0.08 ENST00000531467.1
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr10_-_74856608 0.08 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr2_+_187454749 0.08 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr20_+_2796948 0.08 ENST00000361033.1
ENST00000380585.1
TMEM239
transmembrane protein 239
chr11_-_85780086 0.08 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_47131521 0.08 ENST00000542495.1
ENST00000532925.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr7_-_22539771 0.07 ENST00000406890.2
ENST00000424363.1
STEAP1B
STEAP family member 1B
chr19_+_44617511 0.07 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr7_-_15601595 0.07 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr11_+_71846764 0.06 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr2_-_18741882 0.06 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr6_-_150067696 0.06 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr3_+_9834758 0.06 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr3_+_9944303 0.05 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr11_+_101785727 0.05 ENST00000263468.8
KIAA1377
KIAA1377
chr14_+_74318513 0.05 ENST00000555228.1
ENST00000555661.1
PTGR2
prostaglandin reductase 2
chr2_-_21022818 0.05 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
C2orf43
chromosome 2 open reading frame 43
chr15_-_49103235 0.05 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr17_+_77019030 0.05 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr2_+_219247021 0.05 ENST00000539932.1
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr14_+_21492331 0.05 ENST00000533984.1
ENST00000532213.2
AL161668.5
AL161668.5
chr19_+_11466062 0.05 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr2_+_48667983 0.05 ENST00000449090.2
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr14_+_21525981 0.05 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr3_-_156840776 0.04 ENST00000471357.1
LINC00880
long intergenic non-protein coding RNA 880
chr2_-_61244550 0.04 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr4_+_2800722 0.04 ENST00000508385.1
SH3BP2
SH3-domain binding protein 2
chr1_+_12290121 0.04 ENST00000358136.3
ENST00000356315.4
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr19_-_3600549 0.04 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr14_-_68157084 0.04 ENST00000557564.1
RP11-1012A1.4
RP11-1012A1.4
chr19_-_42947121 0.03 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr12_-_9268707 0.03 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr3_+_9944492 0.03 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr17_+_77018896 0.03 ENST00000578229.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_-_104597286 0.02 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr4_+_15471489 0.02 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr1_-_11863571 0.02 ENST00000376583.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_+_71846748 0.02 ENST00000445078.2
FOLR3
folate receptor 3 (gamma)
chr8_-_101734907 0.02 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chrX_-_134305322 0.02 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr2_+_61244697 0.02 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr2_+_120187465 0.02 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr17_+_38333263 0.02 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr2_-_85641162 0.01 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr21_-_46348694 0.01 ENST00000355153.4
ENST00000397850.2
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr10_+_74870206 0.01 ENST00000357321.4
ENST00000349051.5
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr10_-_98031310 0.01 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr1_+_18958008 0.01 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr7_+_150758304 0.01 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr7_+_47694842 0.01 ENST00000408988.2
C7orf65
chromosome 7 open reading frame 65
chr11_-_73720276 0.01 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr6_-_62996066 0.01 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_-_61244308 0.01 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr14_-_21492251 0.01 ENST00000554398.1
NDRG2
NDRG family member 2
chr3_-_141747459 0.00 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_+_150758642 0.00 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr12_-_120805872 0.00 ENST00000546985.1
MSI1
musashi RNA-binding protein 1
chr7_+_107332334 0.00 ENST00000541474.1
ENST00000544569.1
SLC26A4
solute carrier family 26 (anion exchanger), member 4
chr3_-_141747950 0.00 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.0 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.0 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.0 0.0 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.1 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.0 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.0 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.1 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade