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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for GATA6

Z-value: 0.79

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19750894_19750980-0.964.3e-02Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_2982869 1.02 ENST00000584915.1
LPIN2
lipin 2
chr17_+_19314432 0.93 ENST00000575165.2
RNF112
ring finger protein 112
chr17_+_74381343 0.63 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr11_+_10326918 0.61 ENST00000528544.1
ADM
adrenomedullin
chr19_-_13213954 0.61 ENST00000590974.1
LYL1
lymphoblastic leukemia derived sequence 1
chr15_-_64126084 0.58 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr2_-_219850277 0.48 ENST00000295727.1
FEV
FEV (ETS oncogene family)
chr3_+_137717571 0.37 ENST00000343735.4
CLDN18
claudin 18
chr19_-_13213662 0.37 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr19_+_36132631 0.37 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chr2_+_102928009 0.37 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr15_+_49715449 0.36 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr2_+_3642545 0.35 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
COLEC11
collectin sub-family member 11
chr6_-_86099898 0.35 ENST00000455071.1
RP11-30P6.6
RP11-30P6.6
chr19_+_10397621 0.34 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 0.34 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr11_+_118958689 0.29 ENST00000535253.1
ENST00000392841.1
HMBS
hydroxymethylbilane synthase
chr17_+_4835580 0.29 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr14_+_75988768 0.29 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr15_+_49715293 0.27 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr14_-_38036271 0.26 ENST00000556024.1
RP11-356O9.2
RP11-356O9.2
chr1_-_24469602 0.25 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr7_-_100239132 0.24 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr16_+_4475806 0.22 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
DNAJA3
DnaJ (Hsp40) homolog, subfamily A, member 3
chr11_+_10326612 0.21 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr10_+_71075552 0.21 ENST00000298649.3
HK1
hexokinase 1
chr20_-_60294804 0.20 ENST00000317652.1
RP11-429E11.3
Uncharacterized protein
chr12_+_111843749 0.20 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr5_+_131409476 0.19 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr13_-_46716969 0.19 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_23284703 0.18 ENST00000555911.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr8_-_95449155 0.18 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr12_+_122880045 0.17 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
RP11-450K4.1
chr17_-_4806369 0.17 ENST00000293780.4
CHRNE
cholinergic receptor, nicotinic, epsilon (muscle)
chr18_+_19749386 0.16 ENST00000269216.3
GATA6
GATA binding protein 6
chr22_-_20231207 0.16 ENST00000425986.1
RTN4R
reticulon 4 receptor
chr17_+_56833184 0.15 ENST00000308249.2
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr13_+_24144796 0.15 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_-_158656488 0.15 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr20_+_54967409 0.13 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr14_+_100204027 0.13 ENST00000554479.1
ENST00000555145.1
EML1
echinoderm microtubule associated protein like 1
chr10_-_127505167 0.13 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chrX_+_107288239 0.12 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_21928515 0.12 ENST00000537950.1
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr1_-_205912577 0.11 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr15_-_38852251 0.11 ENST00000558432.1
RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr14_-_38028689 0.11 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr9_-_114937543 0.11 ENST00000374264.2
ENST00000374263.3
SUSD1
sushi domain containing 1
chr8_-_38008783 0.10 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr14_+_21945335 0.10 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr20_-_54967187 0.10 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr3_-_47950745 0.10 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr14_-_23284675 0.09 ENST00000555959.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_+_38673270 0.09 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr22_-_29784519 0.09 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chrX_+_107288197 0.09 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr8_-_116681686 0.08 ENST00000519815.1
TRPS1
trichorhinophalangeal syndrome I
chr1_+_66999799 0.08 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr19_-_55549624 0.08 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chr1_+_12524965 0.08 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_94050668 0.07 ENST00000539242.1
BCAR3
breast cancer anti-estrogen resistance 3
chr14_+_105952648 0.07 ENST00000330233.7
CRIP1
cysteine-rich protein 1 (intestinal)
chr20_+_51588873 0.07 ENST00000371497.5
TSHZ2
teashirt zinc finger homeobox 2
chr9_+_33795533 0.07 ENST00000379405.3
PRSS3
protease, serine, 3
chr1_+_25598872 0.07 ENST00000328664.4
RHD
Rh blood group, D antigen
chr12_-_56221330 0.06 ENST00000546837.1
RP11-762I7.5
Uncharacterized protein
chr12_+_109785708 0.06 ENST00000310903.5
MYO1H
myosin IH
chr16_+_616995 0.06 ENST00000293874.2
ENST00000409527.2
ENST00000424439.2
ENST00000540585.1
PIGQ
NHLRC4
phosphatidylinositol glycan anchor biosynthesis, class Q
NHL repeat containing 4
chr10_-_21186144 0.06 ENST00000377119.1
NEBL
nebulette
chr17_+_75283973 0.06 ENST00000431235.2
ENST00000449803.2
SEPT9
septin 9
chr18_-_45663666 0.06 ENST00000535628.2
ZBTB7C
zinc finger and BTB domain containing 7C
chr19_-_11494975 0.06 ENST00000222139.6
ENST00000592375.2
EPOR
erythropoietin receptor
chr13_+_24144509 0.05 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_-_47374246 0.05 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr4_+_166794383 0.05 ENST00000061240.2
ENST00000507499.1
TLL1
tolloid-like 1
chr6_+_12290586 0.04 ENST00000379375.5
EDN1
endothelin 1
chr2_+_173792893 0.04 ENST00000535187.1
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr18_+_43304092 0.04 ENST00000321925.4
ENST00000587601.1
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr5_-_33984786 0.03 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr12_-_6233828 0.03 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr9_-_114937676 0.03 ENST00000374270.3
SUSD1
sushi domain containing 1
chr3_+_88188254 0.02 ENST00000309495.5
ZNF654
zinc finger protein 654
chr12_-_54689532 0.02 ENST00000540264.2
ENST00000312156.4
NFE2
nuclear factor, erythroid 2
chr11_-_66206260 0.02 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
MRPL11
mitochondrial ribosomal protein L11
chr7_+_150690857 0.02 ENST00000484524.1
ENST00000467517.1
NOS3
nitric oxide synthase 3 (endothelial cell)
chr18_+_43304137 0.02 ENST00000502059.2
ENST00000586951.1
ENST00000589322.2
ENST00000415427.3
ENST00000535474.1
ENST00000402943.2
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr1_+_161136180 0.02 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
PPOX
protoporphyrinogen oxidase
chr4_-_186697044 0.01 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr5_-_33984741 0.01 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr1_+_25598989 0.01 ENST00000454452.2
RHD
Rh blood group, D antigen
chr7_-_107880508 0.01 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr2_+_109237717 0.01 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_-_129691195 0.01 ENST00000368671.3
CLRN3
clarin 3
chr2_-_214015111 0.01 ENST00000433134.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr4_-_103266355 0.01 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_+_19314505 0.00 ENST00000461366.1
RNF112
ring finger protein 112
chr5_+_159848807 0.00 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr2_-_40739501 0.00 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.6 GO:0060437 lung growth(GO:0060437)
0.1 0.4 GO:0060796 regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796)
0.1 0.8 GO:0097647 dimeric G-protein coupled receptor signaling pathway(GO:0038042) calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.2 GO:0007493 endodermal cell fate determination(GO:0007493)
0.1 1.0 GO:0001955 blood vessel maturation(GO:0001955)
0.1 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.0 0.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.6 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0017143 insecticide metabolic process(GO:0017143) cellular response to luteinizing hormone stimulus(GO:0071373)
0.0 1.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 0.3 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.1 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.0 0.9 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 0.5 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.2 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.0 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.6 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.2 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.2 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.0 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis