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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for GRHL1

Z-value: 0.67

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091815_10091864-0.435.7e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_110736505 0.59 ENST00000609440.1
RP11-602N24.3
RP11-602N24.3
chr9_+_140122018 0.54 ENST00000445101.2
RNF224
ring finger protein 224
chr19_-_35981358 0.48 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr6_+_168227552 0.45 ENST00000400825.4
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr7_-_29152509 0.40 ENST00000448959.1
CPVL
carboxypeptidase, vitellogenic-like
chr9_+_5450503 0.39 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr20_-_25320367 0.36 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chr6_-_31107127 0.33 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr8_-_130799134 0.32 ENST00000276708.4
GSDMC
gasdermin C
chr3_-_129513259 0.31 ENST00000329333.5
TMCC1
transmembrane and coiled-coil domain family 1
chr1_-_16539094 0.30 ENST00000270747.3
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr3_-_172241250 0.29 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr10_-_94301107 0.27 ENST00000436178.1
IDE
insulin-degrading enzyme
chr1_+_206643806 0.24 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr4_-_69083720 0.24 ENST00000432593.3
TMPRSS11BNL
TMPRSS11B N-terminal like
chr1_-_24469602 0.23 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr1_+_44440575 0.21 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr21_+_33671160 0.21 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr19_-_12146483 0.20 ENST00000455504.2
ENST00000547560.1
ENST00000552904.1
ENST00000419886.2
ENST00000550507.1
ENST00000344980.6
ENST00000550745.1
ENST00000411841.1
ZNF433
zinc finger protein 433
chr9_+_130565568 0.20 ENST00000423577.1
FPGS
folylpolyglutamate synthase
chr1_-_51425902 0.20 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr19_-_291133 0.20 ENST00000327790.3
PPAP2C
phosphatidic acid phosphatase type 2C
chr6_-_43027105 0.19 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr14_-_62217779 0.19 ENST00000554254.1
HIF1A-AS2
HIF1A antisense RNA 2
chr17_-_60883993 0.19 ENST00000583803.1
ENST00000456609.2
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr5_-_132299290 0.19 ENST00000378595.3
AFF4
AF4/FMR2 family, member 4
chr2_+_95940186 0.18 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr1_+_206643787 0.16 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr11_+_119039069 0.16 ENST00000422249.1
NLRX1
NLR family member X1
chr1_-_51425772 0.16 ENST00000371778.4
FAF1
Fas (TNFRSF6) associated factor 1
chr11_+_119038897 0.16 ENST00000454811.1
ENST00000449394.1
NLRX1
NLR family member X1
chr3_+_101568349 0.15 ENST00000326151.5
ENST00000326172.5
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr12_+_49687425 0.14 ENST00000257860.4
PRPH
peripherin
chr1_-_36863481 0.14 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr9_+_130565487 0.14 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr17_+_9728828 0.13 ENST00000262441.5
GLP2R
glucagon-like peptide 2 receptor
chr9_+_77703414 0.13 ENST00000346234.6
OSTF1
osteoclast stimulating factor 1
chr19_+_10736183 0.13 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr1_-_234667504 0.12 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr4_+_110736659 0.12 ENST00000394631.3
ENST00000226796.6
GAR1
GAR1 ribonucleoprotein
chr11_+_15095108 0.11 ENST00000324229.6
ENST00000533448.1
CALCB
calcitonin-related polypeptide beta
chr21_+_33671264 0.11 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr3_-_113415441 0.10 ENST00000491165.1
ENST00000316407.4
KIAA2018
KIAA2018
chr14_+_23938891 0.10 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
NGDN
neuroguidin, EIF4E binding protein
chr19_+_12035878 0.10 ENST00000254321.5
ENST00000538752.1
ENST00000590798.1
ZNF700
ZNF763
ZNF763
zinc finger protein 700
zinc finger protein 763
Uncharacterized protein; Zinc finger protein 763
chr14_-_23540747 0.09 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
ACIN1
apoptotic chromatin condensation inducer 1
chr7_-_102184083 0.09 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr19_-_4043154 0.08 ENST00000535853.1
AC016586.1
AC016586.1
chr12_+_123874589 0.08 ENST00000437502.1
SETD8
SET domain containing (lysine methyltransferase) 8
chr18_+_44497455 0.07 ENST00000592005.1
KATNAL2
katanin p60 subunit A-like 2
chr5_+_125759140 0.07 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr8_+_27950619 0.06 ENST00000542181.1
ENST00000524103.1
ENST00000537665.1
ENST00000380353.4
ENST00000520288.1
ELP3
elongator acetyltransferase complex subunit 3
chr11_+_119039414 0.06 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
NLRX1
NLR family member X1
chr20_-_54967187 0.05 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr11_-_111636772 0.05 ENST00000531373.1
PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
chr2_-_190446738 0.05 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr2_-_85641162 0.05 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr16_+_2564254 0.04 ENST00000565223.1
ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr3_-_49142178 0.04 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
QARS
glutaminyl-tRNA synthetase
chr22_+_18560743 0.04 ENST00000399744.3
PEX26
peroxisomal biogenesis factor 26
chr19_-_40596767 0.04 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
ZNF780A
zinc finger protein 780A
chr2_+_113299990 0.03 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr7_-_102283238 0.03 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr3_-_49142504 0.03 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr19_+_1491144 0.03 ENST00000233596.3
REEP6
receptor accessory protein 6
chr3_+_161214596 0.03 ENST00000327928.4
OTOL1
otolin 1
chr5_+_125758813 0.03 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr10_+_105036909 0.02 ENST00000369849.4
INA
internexin neuronal intermediate filament protein, alpha
chr16_-_23568651 0.02 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
EARS2
glutamyl-tRNA synthetase 2, mitochondrial
chr19_+_19496728 0.02 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr14_-_23540826 0.02 ENST00000357481.2
ACIN1
apoptotic chromatin condensation inducer 1
chr19_-_12405606 0.01 ENST00000356109.5
ZNF44
zinc finger protein 44
chr18_+_9475001 0.01 ENST00000019317.4
RALBP1
ralA binding protein 1
chr11_-_67442079 0.01 ENST00000349015.3
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr1_-_28384598 0.01 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr12_+_56498312 0.01 ENST00000552766.1
PA2G4
proliferation-associated 2G4, 38kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.4 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.3 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.2 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.0 0.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0070839 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
0.0 0.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0044393 microspike(GO:0044393)
0.0 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.1 0.3 GO:0070996 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996)
0.1 0.3 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 0.4 GO:0008384 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling