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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HAND1

Z-value: 0.86

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Transcription factors associated with HAND1

Gene Symbol Gene ID Gene Info
ENSG00000113196.2 heart and neural crest derivatives expressed 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAND1hg19_v2_chr5_-_153857819_153857824-0.257.5e-01Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_64216748 1.19 ENST00000585162.1
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_36304201 0.76 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr2_+_13677795 0.59 ENST00000434509.1
AC092635.1
chr7_+_76139833 0.58 ENST00000257632.5
uroplakin 3B
chr3_-_114035026 0.58 ENST00000570269.1
RP11-553L6.5
chr3_-_20227619 0.57 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
shugoshin-like 1 (S. pombe)
chr1_+_28261492 0.55 ENST00000373894.3
sphingomyelin phosphodiesterase, acid-like 3B
chr16_-_28621353 0.53 ENST00000567512.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr14_+_93673574 0.51 ENST00000554232.1
ENST00000556871.1
ENST00000555113.1
ubiquitin protein ligase E3 component n-recognin 7 (putative)
chr6_+_80341000 0.50 ENST00000369838.4
SH3 domain binding glutamic acid-rich protein like 2
chr1_+_28261621 0.50 ENST00000549094.1
sphingomyelin phosphodiesterase, acid-like 3B
chr16_-_10652993 0.50 ENST00000536829.1
epithelial membrane protein 2
chr10_+_99344071 0.50 ENST00000370647.4
ENST00000370646.4
4-hydroxy-2-oxoglutarate aldolase 1
chr12_+_52450298 0.48 ENST00000550582.2
nuclear receptor subfamily 4, group A, member 1
chr11_+_101785727 0.45 ENST00000263468.8
KIAA1377
chr17_+_6347761 0.45 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr14_-_65409502 0.41 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr14_-_65409438 0.39 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr10_-_118032697 0.38 ENST00000439649.3
GDNF family receptor alpha 1
chr1_+_28261533 0.38 ENST00000411604.1
ENST00000373888.4
sphingomyelin phosphodiesterase, acid-like 3B
chr3_-_15382875 0.36 ENST00000408919.3
SH3-domain binding protein 5 (BTK-associated)
chr6_-_133119668 0.35 ENST00000275227.4
ENST00000538764.1
solute carrier family 18, subfamily B, member 1
chr19_+_47421933 0.34 ENST00000404338.3
Rho GTPase activating protein 35
chr12_+_49717019 0.33 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
trophinin associated protein
chr11_+_124933191 0.32 ENST00000532000.1
ENST00000308074.4
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr5_-_41870621 0.31 ENST00000196371.5
3-oxoacid CoA transferase 1
chr16_-_4303767 0.30 ENST00000573268.1
ENST00000573042.1
RP11-95P2.1
chr20_+_3713314 0.30 ENST00000254963.2
ENST00000542646.1
ENST00000399701.1
heat shock 70kD protein 12B
chr1_+_155911480 0.30 ENST00000368318.3
relaxin/insulin-like family peptide receptor 4
chr11_+_124932986 0.30 ENST00000407458.1
ENST00000298280.5
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr3_-_20227720 0.30 ENST00000412997.1
shugoshin-like 1 (S. pombe)
chr6_+_44191507 0.29 ENST00000371724.1
ENST00000371713.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr15_-_33447055 0.27 ENST00000559047.1
ENST00000561249.1
formin 1
chr17_-_43025005 0.27 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
kinesin family member 18B
chr1_-_205601064 0.27 ENST00000357992.4
ENST00000289703.4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr12_+_53848505 0.25 ENST00000552819.1
ENST00000455667.3
poly(rC) binding protein 2
chr1_+_27719148 0.25 ENST00000374024.3
G protein-coupled receptor 3
chr3_+_148415571 0.24 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
angiotensin II receptor, type 1
chr4_-_25161996 0.23 ENST00000513285.1
ENST00000382103.2
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr17_+_6347729 0.23 ENST00000572447.1
family with sequence similarity 64, member A
chr9_-_115095229 0.22 ENST00000210227.4
polypyrimidine tract binding protein 3
chr1_-_155904161 0.21 ENST00000368319.3
KIAA0907
chr11_+_124932955 0.21 ENST00000403796.2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr19_-_55866061 0.20 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr19_+_39647271 0.20 ENST00000599657.1
p21 protein (Cdc42/Rac)-activated kinase 4
chr2_-_228582709 0.20 ENST00000541617.1
ENST00000409456.2
ENST00000409287.1
ENST00000258403.3
solute carrier family 19 (thiamine transporter), member 3
chr2_-_197791441 0.20 ENST00000409475.1
ENST00000354764.4
ENST00000374738.3
post-GPI attachment to proteins 1
chr1_-_155904187 0.20 ENST00000368321.3
ENST00000368320.3
KIAA0907
chr12_-_7261772 0.19 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
complement component 1, r subcomponent-like
chr22_+_31518938 0.19 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
inositol polyphosphate-5-phosphatase J
chr12_+_53848549 0.19 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
poly(rC) binding protein 2
chr17_+_46133307 0.19 ENST00000580037.1
nuclear factor, erythroid 2-like 1
chr18_+_55712915 0.18 ENST00000592846.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr16_-_28621298 0.18 ENST00000566189.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr10_-_118032979 0.17 ENST00000355422.6
GDNF family receptor alpha 1
chr1_+_215747118 0.17 ENST00000448333.1
potassium channel tetramerization domain containing 3
chr17_+_45908974 0.17 ENST00000269025.4
leucine rich repeat containing 46
chr18_+_12407895 0.17 ENST00000590956.1
ENST00000336990.4
ENST00000440960.1
ENST00000588729.1
slowmo homolog 1 (Drosophila)
chr4_-_25162188 0.16 ENST00000302922.3
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr1_+_164528866 0.16 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chrX_-_34675391 0.16 ENST00000275954.3
transmembrane protein 47
chr20_+_816695 0.16 ENST00000246100.3
family with sequence similarity 110, member A
chr15_-_76304731 0.14 ENST00000394907.3
neuregulin 4
chr20_+_34020827 0.14 ENST00000374375.1
growth differentiation factor 5 opposite strand
chr2_-_42588338 0.13 ENST00000234301.2
cytochrome c oxidase subunit VIIa polypeptide 2 like
chr6_-_117923610 0.13 ENST00000535237.1
ENST00000052569.6
golgi-associated PDZ and coiled-coil motif containing
chr1_-_223988426 0.13 ENST00000391879.2
tumor protein p53 binding protein, 2
chr9_-_115095123 0.13 ENST00000458258.1
polypyrimidine tract binding protein 3
chr16_-_28621312 0.13 ENST00000314752.7
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr4_-_40631859 0.12 ENST00000295971.7
ENST00000319592.4
RNA binding motif protein 47
chr6_-_39282221 0.12 ENST00000453413.2
potassium channel, subfamily K, member 17
chr3_-_9811595 0.12 ENST00000256460.3
calcium/calmodulin-dependent protein kinase I
chr16_-_28608364 0.12 ENST00000533150.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr12_+_98909260 0.11 ENST00000556029.1
thymopoietin
chr16_+_56969284 0.11 ENST00000568358.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr9_-_35828576 0.11 ENST00000377984.2
ENST00000423537.2
ENST00000472182.1
family with sequence similarity 221, member B
chr22_-_24093267 0.11 ENST00000341976.3
zinc finger protein 70
chr17_+_53342311 0.11 ENST00000226067.5
hepatic leukemia factor
chr12_+_68042495 0.10 ENST00000344096.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr11_+_67171358 0.10 ENST00000526387.1
TBC1 domain family, member 10C
chr11_-_72432950 0.10 ENST00000426523.1
ENST00000429686.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr1_-_52344416 0.10 ENST00000544028.1
nardilysin (N-arginine dibasic convertase)
chr6_-_53013620 0.10 ENST00000259803.7
glial cells missing homolog 1 (Drosophila)
chr5_+_167913450 0.10 ENST00000231572.3
ENST00000538719.1
arginyl-tRNA synthetase
chr1_+_110036699 0.10 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
cytochrome b561 family, member D1
chr11_-_62476694 0.10 ENST00000524862.1
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr2_+_3642545 0.10 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
collectin sub-family member 11
chr16_-_28608424 0.10 ENST00000335715.4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr7_-_140714430 0.10 ENST00000393008.3
mitochondrial ribosomal protein S33
chr17_+_75452447 0.09 ENST00000591472.2
septin 9
chr21_+_34602377 0.09 ENST00000342101.3
ENST00000413881.1
ENST00000443073.1
interferon (alpha, beta and omega) receptor 2
chr4_-_40632605 0.09 ENST00000514014.1
RNA binding motif protein 47
chr7_-_142583506 0.08 ENST00000359396.3
transient receptor potential cation channel, subfamily V, member 6
chr4_+_76481258 0.08 ENST00000311623.4
ENST00000435974.2
chromosome 4 open reading frame 26
chrX_-_133930285 0.08 ENST00000486347.1
ENST00000343004.5
family with sequence similarity 122B
chr19_+_45165545 0.08 ENST00000592472.1
ENST00000587729.1
ENST00000585657.1
ENST00000592789.1
ENST00000591979.1
carcinoembryonic antigen-related cell adhesion molecule 19
chr12_+_68042517 0.07 ENST00000393555.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr2_-_159237472 0.07 ENST00000409187.1
coiled-coil domain containing 148
chr7_+_141490017 0.07 ENST00000247883.4
taste receptor, type 2, member 5
chr4_+_22999152 0.07 ENST00000511453.1
RP11-412P11.1
chr10_+_99344104 0.07 ENST00000555577.1
ENST00000370649.3
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein
chr11_+_67171548 0.07 ENST00000542590.1
TBC1 domain family, member 10C
chr17_-_45908875 0.06 ENST00000351111.2
ENST00000414011.1
mitochondrial ribosomal protein L10
chr7_-_140714739 0.06 ENST00000467334.1
ENST00000324787.5
mitochondrial ribosomal protein S33
chr1_+_174846570 0.06 ENST00000392064.2
RAB GTPase activating protein 1-like
chr1_+_110036728 0.05 ENST00000369868.3
ENST00000430195.2
cytochrome b561 family, member D1
chr4_+_41614909 0.05 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIM and calponin homology domains 1
chr12_+_67663056 0.05 ENST00000545606.1
cullin-associated and neddylation-dissociated 1
chr12_+_54379569 0.05 ENST00000513209.1
RP11-834C11.12
chr19_-_37701386 0.05 ENST00000527838.1
ENST00000591492.1
ENST00000532828.2
zinc finger protein 585B
chr4_-_40632757 0.04 ENST00000511902.1
ENST00000505220.1
RNA binding motif protein 47
chr17_+_66624280 0.04 ENST00000585484.1
RP11-118B18.1
chr3_-_43147431 0.04 ENST00000441964.1
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
chr14_+_24422795 0.04 ENST00000313250.5
ENST00000558263.1
ENST00000543741.2
ENST00000421831.1
ENST00000397073.2
ENST00000308178.8
ENST00000382761.3
ENST00000397075.3
ENST00000397074.3
ENST00000559632.1
ENST00000558581.1
dehydrogenase/reductase (SDR family) member 4
chrX_+_149531606 0.04 ENST00000432680.2
mastermind-like domain containing 1
chr7_+_140378955 0.04 ENST00000473512.1
aarF domain containing kinase 2
chr19_+_12862604 0.03 ENST00000553030.1
bestrophin 2
chr12_-_110271178 0.03 ENST00000261740.2
ENST00000392719.2
ENST00000346520.2
transient receptor potential cation channel, subfamily V, member 4
chr12_+_26111823 0.03 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr11_+_67171391 0.03 ENST00000312390.5
TBC1 domain family, member 10C
chr17_-_40337470 0.03 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr3_+_46919235 0.03 ENST00000449590.1
parathyroid hormone 1 receptor
chr17_-_34890037 0.03 ENST00000589404.1
myosin XIX
chr3_-_43147549 0.02 ENST00000344697.2
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
chr3_+_141103634 0.02 ENST00000507722.1
zinc finger and BTB domain containing 38
chr7_-_81399355 0.02 ENST00000457544.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399411 0.02 ENST00000423064.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399329 0.01 ENST00000453411.1
ENST00000444829.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_+_202091980 0.01 ENST00000367282.5
G protein-coupled receptor 37 like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 1.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 1.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.8 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.4 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.1 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.3 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 0.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.5 GO:0070836 caveola assembly(GO:0070836)
0.0 1.0 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0010360 negative regulation of anion channel activity(GO:0010360) Golgi to plasma membrane CFTR protein transport(GO:0043000)
0.0 0.6 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.3 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.0 GO:2000338 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) positive regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000340)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.2 0.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 1.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 1.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.8 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.3 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.1 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.0 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.0 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels