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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HMGA2

Z-value: 1.77

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218598_662186780.653.5e-01Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_64014588 2.32 ENST00000371086.2
ENST00000340052.3
DLEU2L
deleted in lymphocytic leukemia 2-like
chr16_+_53483983 1.69 ENST00000544545.1
RBL2
retinoblastoma-like 2 (p130)
chr19_-_36297632 1.69 ENST00000588266.2
PRODH2
proline dehydrogenase (oxidase) 2
chr6_-_107230334 1.66 ENST00000607090.1
RP1-60O19.1
RP1-60O19.1
chr1_+_196621002 1.64 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr2_+_13677795 1.47 ENST00000434509.1
AC092635.1
AC092635.1
chr6_-_32908792 1.35 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr13_+_50656307 1.31 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr15_+_58702742 1.25 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr16_+_66442411 1.21 ENST00000499966.1
LINC00920
long intergenic non-protein coding RNA 920
chr1_+_196621156 1.08 ENST00000359637.2
CFH
complement factor H
chr6_-_32908765 0.98 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_117480036 0.98 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
WDR44
WD repeat domain 44
chr3_+_186501336 0.93 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr1_+_179263308 0.89 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr18_-_14132422 0.79 ENST00000589498.1
ENST00000590202.1
ZNF519
zinc finger protein 519
chr10_+_96305535 0.78 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS
helicase, lymphoid-specific
chr13_+_51483814 0.75 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr1_+_227751231 0.73 ENST00000343776.5
ENST00000608949.1
ENST00000397097.3
ZNF678
zinc finger protein 678
chr9_-_115480303 0.72 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INIP
INTS3 and NABP interacting protein
chr14_-_94759595 0.71 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_28836561 0.69 ENST00000419074.1
RCC1
regulator of chromosome condensation 1
chr1_-_226374373 0.69 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr1_+_104104379 0.66 ENST00000435302.1
AMY2B
amylase, alpha 2B (pancreatic)
chr3_-_123680246 0.62 ENST00000488653.2
CCDC14
coiled-coil domain containing 14
chr6_-_136571400 0.61 ENST00000418509.2
ENST00000420702.1
ENST00000451457.2
MTFR2
mitochondrial fission regulator 2
chrX_-_135962876 0.61 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr9_+_2157655 0.60 ENST00000452193.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_+_116892641 0.60 ENST00000487832.2
ENST00000518117.1
RWDD1
RWD domain containing 1
chr6_-_160209471 0.59 ENST00000539948.1
TCP1
t-complex 1
chr14_-_94759361 0.59 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.59 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_48884002 0.57 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr7_-_102985035 0.56 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr17_-_76220740 0.55 ENST00000600484.1
AC087645.1
Uncharacterized protein
chr2_+_177134201 0.54 ENST00000452865.1
MTX2
metaxin 2
chr10_+_86184676 0.51 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr5_-_102455801 0.50 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr1_+_2487631 0.50 ENST00000409119.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr12_-_122750957 0.49 ENST00000451053.2
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr14_-_65409502 0.48 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr3_+_106959530 0.48 ENST00000466734.1
ENST00000463143.1
ENST00000490441.1
LINC00883
long intergenic non-protein coding RNA 883
chr9_+_42704004 0.47 ENST00000457288.1
CBWD7
COBW domain containing 7
chr6_+_111580508 0.47 ENST00000368847.4
KIAA1919
KIAA1919
chr1_+_55464600 0.47 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr7_-_102985288 0.45 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr15_+_82722225 0.42 ENST00000300515.8
GOLGA6L9
golgin A6 family-like 9
chr19_-_38146289 0.42 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
ZFP30
ZFP30 zinc finger protein
chr2_-_216257849 0.41 ENST00000456923.1
FN1
fibronectin 1
chr14_-_65409438 0.40 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr15_+_83098710 0.38 ENST00000561062.1
ENST00000358583.3
GOLGA6L9
golgin A6 family-like 20
chr1_-_223988426 0.38 ENST00000391879.2
TP53BP2
tumor protein p53 binding protein, 2
chr10_-_101673782 0.37 ENST00000422692.1
DNMBP
dynamin binding protein
chr2_+_170683979 0.37 ENST00000418381.1
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr2_+_177134134 0.36 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr14_+_45553296 0.35 ENST00000355765.6
ENST00000553605.1
PRPF39
pre-mRNA processing factor 39
chr6_-_127664736 0.35 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
ECHDC1
enoyl CoA hydratase domain containing 1
chr2_+_172543967 0.35 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr15_-_32747835 0.32 ENST00000509311.2
ENST00000414865.2
GOLGA8O
golgin A8 family, member O
chrX_-_135962923 0.32 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr14_+_99947715 0.32 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
CCNK
cyclin K
chr14_+_88852059 0.31 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr15_+_84904525 0.31 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr18_+_11851383 0.30 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr2_+_120436733 0.29 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
TMEM177
transmembrane protein 177
chr15_+_28623784 0.29 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
GOLGA8F
golgin A8 family, member F
chr6_-_127664683 0.28 ENST00000528402.1
ENST00000454591.2
ECHDC1
enoyl CoA hydratase domain containing 1
chr2_+_172544011 0.27 ENST00000508530.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr15_-_70994612 0.27 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_172543919 0.26 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr12_+_65996599 0.25 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3
RP11-221N13.3
chr19_+_41882466 0.22 ENST00000436170.2
TMEM91
transmembrane protein 91
chr4_+_25378912 0.21 ENST00000510092.1
ENST00000505991.1
ANAPC4
anaphase promoting complex subunit 4
chr15_+_43885252 0.21 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr9_+_104296122 0.21 ENST00000389120.3
RNF20
ring finger protein 20, E3 ubiquitin protein ligase
chr12_-_8765446 0.21 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chrX_-_77150985 0.20 ENST00000358075.6
MAGT1
magnesium transporter 1
chr3_+_106959552 0.20 ENST00000473550.1
LINC00883
long intergenic non-protein coding RNA 883
chr6_+_106535455 0.19 ENST00000424894.1
PRDM1
PR domain containing 1, with ZNF domain
chr10_-_36813162 0.19 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr2_+_172544182 0.18 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr17_+_73230799 0.17 ENST00000579838.1
NUP85
nucleoporin 85kDa
chr6_+_88106840 0.17 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr19_-_1650666 0.15 ENST00000588136.1
TCF3
transcription factor 3
chr3_+_193853927 0.15 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr19_+_44455368 0.15 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
ZNF221
zinc finger protein 221
chr15_+_43985084 0.15 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr17_-_295730 0.14 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr21_+_38792602 0.14 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr15_-_74659978 0.10 ENST00000541301.1
ENST00000416978.1
ENST00000268053.6
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr6_+_123110302 0.10 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr12_+_59194154 0.09 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr11_-_130786400 0.09 ENST00000265909.4
SNX19
sorting nexin 19
chr12_+_113587558 0.09 ENST00000335621.6
CCDC42B
coiled-coil domain containing 42B
chr19_+_11457175 0.08 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr2_+_120436760 0.08 ENST00000445518.1
ENST00000409951.1
TMEM177
transmembrane protein 177
chr12_+_21207503 0.07 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr19_-_43099070 0.05 ENST00000244336.5
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr2_-_114461655 0.04 ENST00000424612.1
AC017074.2
AC017074.2
chrX_-_7895755 0.03 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4
patatin-like phospholipase domain containing 4
chr10_-_62332357 0.03 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_170683942 0.02 ENST00000272793.5
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr5_-_135290705 0.02 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr12_-_21757774 0.01 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:2001190 peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.4 1.9 GO:0008218 bioluminescence(GO:0008218)
0.3 0.8 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.2 1.7 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.2 1.0 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.2 0.8 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 2.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:0044417 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.9 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.4 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.1 1.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 1.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.6 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.1 0.3 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.2 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.2 GO:0060164 negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.5 GO:0015074 DNA integration(GO:0015074)
0.0 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.2 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.7 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.3 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.6 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 2.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.3 GO:0002945 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.1 0.7 GO:0070876 SOSS complex(GO:0070876)
0.0 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.3 0.9 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.2 0.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 0.6 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 2.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 2.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 1.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.0 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 3.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins