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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for HOXD1

Z-value: 1.61

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.11 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_1770534020.663.4e-01Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_113568207 1.15 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr4_-_19458597 0.97 ENST00000505347.1
RP11-3J1.1
RP11-3J1.1
chr7_-_73256838 0.92 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr11_-_102651343 0.72 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_201140673 0.71 ENST00000367333.2
TMEM9
transmembrane protein 9
chr12_-_52761262 0.71 ENST00000257901.3
KRT85
keratin 85
chr12_-_118796910 0.66 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr7_+_37723336 0.64 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr7_-_55620433 0.62 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr7_+_99717230 0.62 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr4_+_144354644 0.62 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr11_-_71823266 0.59 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr1_+_117544366 0.58 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr19_+_50016610 0.56 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_126327398 0.54 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr2_+_135596180 0.52 ENST00000283054.4
ENST00000392928.1
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr14_+_32798547 0.48 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr11_-_71823796 0.48 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr20_-_50418972 0.48 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr7_+_37723420 0.47 ENST00000476620.1
EPDR1
ependymin related 1
chr1_-_190446759 0.45 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr4_+_71019903 0.45 ENST00000344526.5
C4orf40
chromosome 4 open reading frame 40
chr12_-_118796971 0.44 ENST00000542902.1
TAOK3
TAO kinase 3
chr10_+_99205959 0.43 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_+_86749045 0.42 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr15_-_37393406 0.37 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr9_-_5339873 0.37 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr5_+_67535647 0.37 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_27418537 0.36 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr5_-_96478466 0.33 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr14_+_74034310 0.31 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr11_+_47293795 0.30 ENST00000422579.1
MADD
MAP-kinase activating death domain
chr7_-_99717463 0.29 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chrX_+_77154935 0.29 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr17_+_57233087 0.28 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr10_+_99205894 0.28 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr20_-_50418947 0.28 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr13_+_78315348 0.28 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr3_-_101039402 0.27 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr4_+_158493642 0.27 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
RP11-364P22.1
RP11-364P22.1
chr16_+_53133070 0.25 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr5_+_148737562 0.25 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr4_-_25865159 0.25 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr12_-_22063787 0.24 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr12_+_64798826 0.24 ENST00000540203.1
XPOT
exportin, tRNA
chr15_-_55562479 0.23 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55563072 0.23 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_+_63050785 0.22 ENST00000472902.1
TLN2
talin 2
chr12_-_118797475 0.22 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr8_+_55528627 0.21 ENST00000220676.1
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr17_+_18086392 0.21 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr11_-_62521614 0.20 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr10_-_99205607 0.20 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chrX_+_43515467 0.20 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr11_+_101918153 0.20 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70
chr14_+_32798462 0.19 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr11_+_65554493 0.19 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr13_+_36050881 0.19 ENST00000537702.1
NBEA
neurobeachin
chrX_+_77166172 0.19 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr20_+_43990576 0.18 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr9_+_124329336 0.18 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr10_-_72142345 0.18 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
LRRC20
leucine rich repeat containing 20
chr12_+_109577202 0.17 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr7_-_99716952 0.17 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr11_-_26593649 0.17 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr22_-_24951888 0.17 ENST00000404664.3
GUCD1
guanylyl cyclase domain containing 1
chr3_-_99569821 0.16 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr13_+_78315295 0.16 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr11_+_71900572 0.15 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr11_+_71900703 0.14 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr5_-_20575959 0.14 ENST00000507958.1
CDH18
cadherin 18, type 2
chr7_-_81399438 0.14 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_-_74800799 0.13 ENST00000305159.3
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr2_+_135596106 0.12 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr4_-_69111401 0.12 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr12_-_53171128 0.11 ENST00000332411.2
KRT76
keratin 76
chr12_+_29376592 0.11 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr1_-_232651312 0.10 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr8_-_49833978 0.10 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr12_+_29376673 0.10 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr4_-_74486347 0.10 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr2_-_99871570 0.09 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr15_+_58702742 0.09 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr12_+_10163231 0.09 ENST00000396502.1
ENST00000338896.5
CLEC12B
C-type lectin domain family 12, member B
chr7_-_81399355 0.08 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr14_+_56584414 0.08 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr7_-_81399329 0.08 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr15_-_55562582 0.07 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr8_-_49834299 0.07 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr13_-_36050819 0.06 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr22_+_24951949 0.06 ENST00000402849.1
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr10_-_4285923 0.06 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr4_+_86748898 0.06 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr10_+_18549645 0.05 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr11_-_71823715 0.04 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chrX_-_19504642 0.04 ENST00000469203.2
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr7_-_99716940 0.04 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_81399287 0.03 ENST00000354224.6
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399411 0.02 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_+_118398178 0.02 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr4_+_144312659 0.01 ENST00000509992.1
GAB1
GRB2-associated binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.3 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 0.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 1.1 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 1.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.6 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990032 parallel fiber(GO:1990032)
0.1 0.7 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093) melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.8 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.3 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.6 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.2 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.6 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing