ISMARA results: IRF2_STAT2_IRF8

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 16.83

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol	Gene ID	Gene Info
IRF2 Ensembl NCBI GeneCards UniProt	ENSG00000168310.6	interferon regulatory factor 2
STAT2 Ensembl NCBI GeneCards UniProt	ENSG00000170581.9	signal transducer and activator of transcription 2
IRF8 Ensembl NCBI GeneCards UniProt	ENSG00000140968.6	interferon regulatory factor 8
IRF1 Ensembl NCBI GeneCards UniProt	ENSG00000125347.9	interferon regulatory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT2	hg19_v2_chr12_-_56753858_56753930	1.00	4.5e-03	Click!
IRF1	hg19_v2_chr5_-_131826457_131826514	0.99	8.7e-03	Click!
IRF2	hg19_v2_chr4_-_185395672_185395734	0.96	3.6e-02	Click!
IRF8	hg19_v2_chr16_+_85942594_85942635	-0.59	4.1e-01	Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_91152303 Show fit	88.81	ENST00000371804.3	IFIT1 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr10_+_91087651 Show fit	79.72	ENST00000371818.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr1_+_948803 Show fit	77.51	ENST00000379389.4	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin-like modifier
chr10_+_91092241 Show fit	72.82	ENST00000371811.4	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr12_+_113416191 Show fit	67.42	ENST00000342315.4 ENST00000392583.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr2_-_7005785 Show fit	59.02	ENST00000256722.5 ENST00000404168.1 ENST00000458098.1	CMPK2 Ensembl NCBI GeneCards UniProt Show fit	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_79086088 Show fit	56.54	ENST00000370751.5 ENST00000342282.3	IFI44L Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 44-like
chr21_+_42792442 Show fit	54.02	ENST00000398600.2	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr22_+_18632666 Show fit	53.31	ENST00000215794.7	USP18 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin specific peptidase 18
chr11_-_64764435 Show fit	51.17	ENST00000534177.1 ENST00000301887.4	BATF2 Ensembl NCBI GeneCards UniProt Show fit	basic leucine zipper transcription factor, ATF-like 2
chr10_+_91061712 Show fit	50.05	ENST00000371826.3	IFIT2 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 2
chr11_-_615942 Show fit	48.97	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr12_+_113416265 Show fit	47.75	ENST00000449768.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr19_+_39759154 Show fit	44.72	ENST00000331982.5	IFNL2 Ensembl NCBI GeneCards UniProt Show fit	interferon, lambda 2
chr1_+_79115503 Show fit	44.32	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 44
chr14_+_94577074 Show fit	41.69	ENST00000444961.1 ENST00000448882.1 ENST00000557098.1 ENST00000554800.1 ENST00000556544.1 ENST00000298902.5 ENST00000555819.1 ENST00000557634.1 ENST00000555744.1	IFI27 Ensembl NCBI GeneCards UniProt Show fit	interferon, alpha-inducible protein 27
chr8_-_145060593 Show fit	41.33	ENST00000313059.5 ENST00000524918.1 ENST00000313028.7 ENST00000525773.1	PARP10 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 10
chr12_+_113376249 Show fit	39.04	ENST00000551007.1 ENST00000548514.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3, 100kDa
chr16_-_11350036 Show fit	38.94	ENST00000332029.2	SOCS1 Ensembl NCBI GeneCards UniProt Show fit	suppressor of cytokine signaling 1
chr11_-_615570 Show fit	37.85	ENST00000525445.1 ENST00000348655.6 ENST00000397566.1	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr6_+_32821924 Show fit	33.37	ENST00000374859.2 ENST00000453265.2	PSMB9 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr2_+_7017796 Show fit	33.28	ENST00000382040.3	RSAD2 Ensembl NCBI GeneCards UniProt Show fit	radical S-adenosyl methionine domain containing 2
chr17_+_6659153 Show fit	32.84	ENST00000441631.1 ENST00000438512.1 ENST00000346752.4 ENST00000361842.3	XAF1 Ensembl NCBI GeneCards UniProt Show fit	XIAP associated factor 1
chr16_+_57023406 Show fit	31.35	ENST00000262510.6 ENST00000308149.7 ENST00000436936.1	NLRC5 Ensembl NCBI GeneCards UniProt Show fit	NLR family, CARD domain containing 5
chr7_-_92777606 Show fit	31.25	ENST00000437805.1 ENST00000446959.1 ENST00000439952.1 ENST00000414791.1 ENST00000446033.1 ENST00000411955.1 ENST00000318238.4	SAMD9L Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9-like
chr12_+_113376157 Show fit	30.68	ENST00000228928.7	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_-_231084820 Show fit	30.52	ENST00000258382.5 ENST00000338556.3	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr9_-_32526299 Show fit	29.85	ENST00000379882.1 ENST00000379883.2	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_163175133 Show fit	29.44	ENST00000421365.2 ENST00000263642.2	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr2_+_7005959 Show fit	29.13	ENST00000442639.1	RSAD2 Ensembl NCBI GeneCards UniProt Show fit	radical S-adenosyl methionine domain containing 2
chr3_-_49851313 Show fit	29.02	ENST00000333486.3	UBA7 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin-like modifier activating enzyme 7
chr3_+_187086120 Show fit	28.87	ENST00000259030.2	RTP4 Ensembl NCBI GeneCards UniProt Show fit	receptor (chemosensory) transporter protein 4
chr1_+_158979680 Show fit	28.69	ENST00000368131.4 ENST00000340979.6	IFI16 Ensembl NCBI GeneCards UniProt Show fit	interferon, gamma-inducible protein 16
chr4_+_89378261 Show fit	28.56	ENST00000264350.3	HERC5 Ensembl NCBI GeneCards UniProt Show fit	HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr2_-_231084659 Show fit	28.53	ENST00000258381.6 ENST00000358662.4 ENST00000455674.1 ENST00000392048.3	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr2_-_191878874 Show fit	28.24	ENST00000392322.3 ENST00000392323.2 ENST00000424722.1 ENST00000361099.3	STAT1 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 1, 91kDa
chr2_-_191878681 Show fit	28.05	ENST00000409465.1	STAT1 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 1, 91kDa
chr1_+_158979686 Show fit	27.70	ENST00000368132.3 ENST00000295809.7	IFI16 Ensembl NCBI GeneCards UniProt Show fit	interferon, gamma-inducible protein 16
chr1_+_158979792 Show fit	27.62	ENST00000359709.3 ENST00000430894.2	IFI16 Ensembl NCBI GeneCards UniProt Show fit	interferon, gamma-inducible protein 16
chr1_-_27998689 Show fit	27.60	ENST00000339145.4 ENST00000362020.4 ENST00000361157.6	IFI6 Ensembl NCBI GeneCards UniProt Show fit	interferon, alpha-inducible protein 6
chr4_-_169401628 Show fit	27.29	ENST00000514748.1 ENST00000512371.1 ENST00000260184.7 ENST00000505890.1 ENST00000511577.1	DDX60L Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr9_-_32526184 Show fit	26.64	ENST00000545044.1 ENST00000379868.1	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr21_+_42733870 Show fit	25.90	ENST00000330714.3 ENST00000436410.1 ENST00000435611.1	MX2 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 2 (mouse)
chr11_+_5710919 Show fit	25.52	ENST00000379965.3 ENST00000425490.1	TRIM22 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 22
chr3_-_122283424 Show fit	24.12	ENST00000477522.2 ENST00000360356.2	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr1_-_89531041 Show fit	23.85	ENST00000370473.4	GBP1 Ensembl NCBI GeneCards UniProt Show fit	guanylate binding protein 1, interferon-inducible
chr9_-_100881466 Show fit	23.81	ENST00000341469.2 ENST00000342043.3 ENST00000375098.3	TRIM14 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 14
chr3_-_122283100 Show fit	23.68	ENST00000492382.1 ENST00000462315.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr21_+_42798094 Show fit	23.40	ENST00000398598.3 ENST00000455164.2 ENST00000424365.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr6_-_32821599 Show fit	23.34	ENST00000354258.4	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_+_91174486 Show fit	22.90	ENST00000416601.1	IFIT5 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 5
chr3_-_122283079 Show fit	22.64	ENST00000471785.1 ENST00000466126.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr10_+_91174314 Show fit	22.19	ENST00000371795.4	IFIT5 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 5
chr19_-_49371711 Show fit	22.14	ENST00000355496.5 ENST00000263265.6	PLEKHA4 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr2_-_55920952 Show fit	21.75	ENST00000447944.2	PNPT1 Ensembl NCBI GeneCards UniProt Show fit	polyribonucleotide nucleotidyltransferase 1
chr19_+_10196781 Show fit	21.47	ENST00000253110.11	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr11_+_5711010 Show fit	21.09	ENST00000454828.1	TRIM22 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 22
chr11_-_4414880 Show fit	21.03	ENST00000254436.7 ENST00000543625.1	TRIM21 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 21
chr9_+_100174232 Show fit	20.43	ENST00000355295.4	TDRD7 Ensembl NCBI GeneCards UniProt Show fit	tudor domain containing 7
chr9_+_100174344 Show fit	20.27	ENST00000422139.2	TDRD7 Ensembl NCBI GeneCards UniProt Show fit	tudor domain containing 7
chr12_+_113344811 Show fit	19.83	ENST00000551241.1 ENST00000553185.1 ENST00000550689.1	OAS1 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr19_-_39735646 Show fit	19.82	ENST00000413851.2	IFNL3 Ensembl NCBI GeneCards UniProt Show fit	interferon, lambda 3
chr22_-_36635684 Show fit	19.75	ENST00000358502.5	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 2
chr9_+_5450503 Show fit	19.72	ENST00000381573.4 ENST00000381577.3	CD274 Ensembl NCBI GeneCards UniProt Show fit	CD274 molecule
chr6_+_32811885 Show fit	19.59	ENST00000458296.1 ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1	TAPSAR1 Ensembl NCBI GeneCards UniProt Show fit PSMB9 Ensembl NCBI GeneCards UniProt Show fit	TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9
chr22_+_36649056 Show fit	19.53	ENST00000397278.3 ENST00000422706.1 ENST00000426053.1 ENST00000319136.4	APOL1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 1
chr11_-_321050 Show fit	18.51	ENST00000399808.4	IFITM3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced transmembrane protein 3
chr2_-_231084617 Show fit	18.32	ENST00000409815.2	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr3_+_122399444 Show fit	18.29	ENST00000474629.2	PARP14 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 14
chr22_-_36635563 Show fit	18.17	ENST00000451256.2	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 2
chr11_-_104905840 Show fit	18.03	ENST00000526568.1 ENST00000393136.4 ENST00000531166.1 ENST00000534497.1 ENST00000527979.1 ENST00000446369.1 ENST00000353247.5 ENST00000528974.1 ENST00000533400.1 ENST00000525825.1 ENST00000436863.3	CASP1 Ensembl NCBI GeneCards UniProt Show fit	caspase 1, apoptosis-related cysteine peptidase
chr11_-_57334732 Show fit	18.03	ENST00000526659.1 ENST00000527022.1	UBE2L6 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin-conjugating enzyme E2L 6
chr22_-_36635225 Show fit	17.65	ENST00000529194.1	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 2
chr22_-_36635598 Show fit	17.20	ENST00000454728.1	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 2
chr22_+_36649170 Show fit	17.02	ENST00000438034.1 ENST00000427990.1 ENST00000347595.7 ENST00000397279.4 ENST00000433768.1 ENST00000440669.2	APOL1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 1
chr11_-_104916034 Show fit	16.98	ENST00000528513.1 ENST00000375706.2 ENST00000375704.3	CARD16 Ensembl NCBI GeneCards UniProt Show fit	caspase recruitment domain family, member 16
chr6_+_32811861 Show fit	16.91	ENST00000453426.1	TAPSAR1 Ensembl NCBI GeneCards UniProt Show fit	TAP1 and PSMB8 antisense RNA 1
chr4_-_169239921 Show fit	16.75	ENST00000514995.1 ENST00000393743.3	DDX60 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr19_-_17516449 Show fit	16.70	ENST00000252593.6	BST2 Ensembl NCBI GeneCards UniProt Show fit	bone marrow stromal cell antigen 2
chr12_-_121477039 Show fit	16.47	ENST00000257570.5	OASL Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase-like
chr11_-_60719213 Show fit	15.67	ENST00000227880.3	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 (oligopeptide transporter), member 3
chr20_-_47894569 Show fit	15.46	ENST00000371744.1 ENST00000371752.1 ENST00000396105.1	ZNFX1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger, NFX1-type containing 1
chr9_-_21077939 Show fit	15.33	ENST00000380232.2	IFNB1 Ensembl NCBI GeneCards UniProt Show fit	interferon, beta 1, fibroblast
chr12_-_121476959 Show fit	14.87	ENST00000339275.5	OASL Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase-like
chr12_+_113416340 Show fit	14.85	ENST00000552756.1	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr8_+_39770803 Show fit	14.79	ENST00000518237.1	IDO1 Ensembl NCBI GeneCards UniProt Show fit	indoleamine 2,3-dioxygenase 1
chr11_+_5646213 Show fit	14.66	ENST00000429814.2	TRIM34 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 34
chr3_+_122283064 Show fit	14.47	ENST00000296161.4	DTX3L Ensembl NCBI GeneCards UniProt Show fit	deltex 3-like (Drosophila)
chr3_+_48507210 Show fit	14.36	ENST00000433541.1 ENST00000422277.2 ENST00000436480.2 ENST00000444177.1	TREX1 Ensembl NCBI GeneCards UniProt Show fit	three prime repair exonuclease 1
chr21_+_42798124 Show fit	14.29	ENST00000417963.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_+_231280954 Show fit	14.08	ENST00000409824.1 ENST00000409341.1 ENST00000409112.1 ENST00000340126.4 ENST00000341950.4	SP100 Ensembl NCBI GeneCards UniProt Show fit	SP100 nuclear antigen
chr15_+_74287035 Show fit	14.01	ENST00000395132.2 ENST00000268059.6 ENST00000354026.6 ENST00000268058.3 ENST00000565898.1 ENST00000569477.1 ENST00000569965.1 ENST00000567543.1 ENST00000436891.3 ENST00000435786.2 ENST00000564428.1 ENST00000359928.4	PML Ensembl NCBI GeneCards UniProt Show fit	promyelocytic leukemia
chr19_+_10196981 Show fit	13.45	ENST00000591813.1	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr12_-_56753858 Show fit	13.23	ENST00000314128.4 ENST00000557235.1 ENST00000418572.2	STAT2 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 2, 113kDa
chr5_+_131746575 Show fit	13.22	ENST00000337752.2 ENST00000378947.3 ENST00000407797.1	C5orf56 Ensembl NCBI GeneCards UniProt Show fit	chromosome 5 open reading frame 56
chr7_+_134832808 Show fit	13.17	ENST00000275767.3	TMEM140 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 140
chr11_-_57335280 Show fit	13.03	ENST00000287156.4	UBE2L6 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin-conjugating enzyme E2L 6
chr1_-_89488510 Show fit	12.93	ENST00000564665.1 ENST00000370481.4	GBP3 Ensembl NCBI GeneCards UniProt Show fit	guanylate binding protein 3
chr3_-_172241250 Show fit	12.71	ENST00000420541.2 ENST00000241261.2	TNFSF10 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 10
chr15_+_89182156 Show fit	12.48	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr6_+_37400974 Show fit	12.48	ENST00000455891.1 ENST00000373451.4	CMTR1 Ensembl NCBI GeneCards UniProt Show fit	cap methyltransferase 1
chr21_+_42798158 Show fit	12.42	ENST00000441677.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_+_231280908 Show fit	12.41	ENST00000427101.2 ENST00000432979.1	SP100 Ensembl NCBI GeneCards UniProt Show fit	SP100 nuclear antigen
chr17_-_40264692 Show fit	12.40	ENST00000591220.1 ENST00000251642.3	DHX58 Ensembl NCBI GeneCards UniProt Show fit	DEXH (Asp-Glu-X-His) box polypeptide 58
chr12_+_113344582 Show fit	12.37	ENST00000202917.5 ENST00000445409.2 ENST00000452357.2	OAS1 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr19_+_39786962 Show fit	12.32	ENST00000333625.2	IFNL1 Ensembl NCBI GeneCards UniProt Show fit	interferon, lambda 1
chr22_-_36556821 Show fit	12.15	ENST00000531095.1 ENST00000397293.2 ENST00000349314.2	APOL3 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 3
chr7_-_92747269 Show fit	12.14	ENST00000446617.1 ENST00000379958.2	SAMD9 Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9
chr15_+_89182178 Show fit	12.13	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr22_+_39436862 Show fit	12.08	ENST00000381565.2 ENST00000452957.2	APOBEC3F Ensembl NCBI GeneCards UniProt Show fit APOBEC3G Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr21_+_42797958 Show fit	12.01	ENST00000419044.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_+_69455855 Show fit	11.62	ENST00000227507.2 ENST00000536559.1	CCND1 Ensembl NCBI GeneCards UniProt Show fit	cyclin D1
chr8_-_23540402 Show fit	11.44	ENST00000523261.1 ENST00000380871.4	NKX3-1 Ensembl NCBI GeneCards UniProt Show fit	NK3 homeobox 1
chr2_+_231191875 Show fit	11.30	ENST00000444636.1 ENST00000415673.2 ENST00000243810.6 ENST00000396563.4	SP140L Ensembl NCBI GeneCards UniProt Show fit	SP140 nuclear body protein-like
chr22_+_36044411 Show fit	11.27	ENST00000409652.4	APOL6 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 6
chr11_-_104972158 Show fit	11.00	ENST00000598974.1 ENST00000593315.1 ENST00000594519.1 ENST00000415981.2 ENST00000525374.1 ENST00000375707.1	CASP1 Ensembl NCBI GeneCards UniProt Show fit CARD16 Ensembl NCBI GeneCards UniProt Show fit CARD17 Ensembl NCBI GeneCards UniProt Show fit	caspase 1, apoptosis-related cysteine peptidase caspase recruitment domain family, member 16 caspase recruitment domain family, member 17
chr17_+_6659354 Show fit	10.77	ENST00000574907.1	XAF1 Ensembl NCBI GeneCards UniProt Show fit	XIAP associated factor 1
chr17_+_78234625 Show fit	10.74	ENST00000508628.2 ENST00000582970.1 ENST00000456466.1 ENST00000319921.4	RNF213 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 213
chr15_+_74287118 Show fit	10.64	ENST00000563500.1	PML Ensembl NCBI GeneCards UniProt Show fit	promyelocytic leukemia
chr12_+_113344755 Show fit	10.62	ENST00000550883.1	OAS1 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr20_+_388791 Show fit	10.62	ENST00000441733.1 ENST00000353660.3	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_63330842 Show fit	10.41	ENST00000255695.1	HRASLS2 Ensembl NCBI GeneCards UniProt Show fit	HRAS-like suppressor 2
chr12_+_43086018 Show fit	10.07	ENST00000550177.1	RP11-25I15.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-25I15.3
chr15_+_89181974 Show fit	9.85	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20kDa
chr20_+_388935 Show fit	9.80	ENST00000382181.2 ENST00000400247.3	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RanBP-type and C3HC4-type zinc finger containing 1
chr11_+_71710973 Show fit	9.76	ENST00000393707.4	IL18BP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 binding protein
chr6_-_32806506 Show fit	9.60	ENST00000374897.2 ENST00000452392.2	TAP2 Ensembl NCBI GeneCards UniProt Show fit TAP2 Ensembl NCBI GeneCards UniProt Show fit	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Uncharacterized protein
chr6_-_32811771 Show fit	9.43	ENST00000395339.3 ENST00000374882.3	PSMB8 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) subunit, beta type, 8
chr17_-_54991369 Show fit	9.37	ENST00000537230.1	TRIM25 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 25
chr2_-_37384175 Show fit	9.06	ENST00000411537.2 ENST00000233057.4 ENST00000395127.2 ENST00000390013.3	EIF2AK2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2-alpha kinase 2
chr3_+_48507621 Show fit	9.02	ENST00000456089.1	TREX1 Ensembl NCBI GeneCards UniProt Show fit	three prime repair exonuclease 1
chr20_+_388679 Show fit	8.97	ENST00000356286.5 ENST00000475269.1	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RanBP-type and C3HC4-type zinc finger containing 1
chr11_+_71710648 Show fit	8.91	ENST00000260049.5	IL18BP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 binding protein
chr12_-_121476750 Show fit	8.89	ENST00000543677.1	OASL Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase-like
chr17_-_54991395 Show fit	8.77	ENST00000316881.4	TRIM25 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 25
chr11_+_57308979 Show fit	8.71	ENST00000457912.1	SMTNL1 Ensembl NCBI GeneCards UniProt Show fit	smoothelin-like 1
chr11_+_71709938 Show fit	8.58	ENST00000393705.4 ENST00000337131.5 ENST00000531053.1 ENST00000404792.1	IL18BP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 binding protein
chr11_+_313503 Show fit	8.55	ENST00000528780.1 ENST00000328221.5	IFITM1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced transmembrane protein 1
chr6_-_31324943 Show fit	8.33	ENST00000412585.2 ENST00000434333.1	HLA-B Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, B
chr13_+_50070077 Show fit	8.23	ENST00000378319.3 ENST00000426879.1	PHF11 Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 11
chr6_-_26027480 Show fit	8.21	ENST00000377364.3	HIST1H4B Ensembl NCBI GeneCards UniProt Show fit	histone cluster 1, H4b
chr12_+_14369524 Show fit	7.97	ENST00000538329.1	RP11-134N1.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-134N1.2
chr1_-_60392452 Show fit	7.88	ENST00000371204.3	CYP2J2 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450, family 2, subfamily J, polypeptide 2
chr17_-_76975925 Show fit	7.88	ENST00000591274.1 ENST00000589906.1 ENST00000591778.1 ENST00000589775.2 ENST00000585407.1 ENST00000262776.3	LGALS3BP Ensembl NCBI GeneCards UniProt Show fit	lectin, galactoside-binding, soluble, 3 binding protein
chr6_+_25963020 Show fit	7.84	ENST00000357085.3	TRIM38 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 38
chr11_+_63304273 Show fit	7.74	ENST00000439013.2 ENST00000255688.3	RARRES3 Ensembl NCBI GeneCards UniProt Show fit	retinoic acid receptor responder (tazarotene induced) 3
chr19_+_16254488 Show fit	7.68	ENST00000588246.1 ENST00000593031.1	HSH2D Ensembl NCBI GeneCards UniProt Show fit	hematopoietic SH2 domain containing
chr15_-_80263506 Show fit	7.66	ENST00000335661.6	BCL2A1 Ensembl NCBI GeneCards UniProt Show fit	BCL2-related protein A1
chr11_-_14358620 Show fit	7.43	ENST00000531421.1	RRAS2 Ensembl NCBI GeneCards UniProt Show fit	related RAS viral (r-ras) oncogene homolog 2
chr13_+_50070491 Show fit	7.39	ENST00000496612.1 ENST00000357596.3 ENST00000485919.1 ENST00000442195.1	PHF11 Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 11
chr6_-_32806483 Show fit	6.98	ENST00000374899.4	TAP2 Ensembl NCBI GeneCards UniProt Show fit	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_152146385 Show fit	6.96	ENST00000414946.1 ENST00000243346.5	NMI Ensembl NCBI GeneCards UniProt Show fit	N-myc (and STAT) interactor
chr1_-_24469602 Show fit	6.93	ENST00000270800.1	IL22RA1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 22 receptor, alpha 1
chr17_+_25958174 Show fit	6.71	ENST00000313648.6 ENST00000577392.1 ENST00000584661.1 ENST00000413914.2	LGALS9 Ensembl NCBI GeneCards UniProt Show fit	lectin, galactoside-binding, soluble, 9
chr17_+_41158742 Show fit	6.55	ENST00000415816.2 ENST00000438323.2	IFI35 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein 35
chr20_-_47894936 Show fit	6.54	ENST00000371754.4	ZNFX1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger, NFX1-type containing 1
chr6_+_53659746 Show fit	6.32	ENST00000370888.1	LRRC1 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 1
chr22_-_30695471 Show fit	6.10	ENST00000434291.1	RP1-130H16.18 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr11_-_321340 Show fit	5.98	ENST00000526811.1	IFITM3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced transmembrane protein 3
chr1_+_113217309 Show fit	5.92	ENST00000544796.1 ENST00000369644.1	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr3_-_146262365 Show fit	5.90	ENST00000448787.2	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chr1_+_113217345 Show fit	5.78	ENST00000357443.2	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_-_54778471 Show fit	5.73	ENST00000550120.1 ENST00000394313.2 ENST00000547210.1	ZNF385A Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 385A
chr3_-_146262352 Show fit	5.73	ENST00000462666.1	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chr12_-_54778444 Show fit	5.70	ENST00000551771.1	ZNF385A Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 385A
chr12_-_10022735 Show fit	5.69	ENST00000228438.2	CLEC2B Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 2, member B
chr14_+_101295948 Show fit	5.66	ENST00000452514.2	MEG3 Ensembl NCBI GeneCards UniProt Show fit	maternally expressed 3 (non-protein coding)
chr1_+_113217073 Show fit	5.63	ENST00000369645.1	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr3_-_178865747 Show fit	5.52	ENST00000435560.1	RP11-360P21.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-360P21.2
chr3_-_146262428 Show fit	5.50	ENST00000486631.1	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chr1_+_113217043 Show fit	5.47	ENST00000413052.2	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr17_-_43339474 Show fit	5.43	ENST00000331780.4	SPATA32 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated 32
chr6_+_26402465 Show fit	5.38	ENST00000476549.2 ENST00000289361.6 ENST00000450085.2 ENST00000425234.2 ENST00000427334.1 ENST00000506698.1	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A1
chr3_-_146262637 Show fit	5.30	ENST00000472349.1 ENST00000342435.4	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chr6_+_29691056 Show fit	5.25	ENST00000414333.1 ENST00000334668.4 ENST00000259951.7	HLA-F Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, F
chr3_+_122399697 Show fit	5.14	ENST00000494811.1	PARP14 Ensembl NCBI GeneCards UniProt Show fit	poly (ADP-ribose) polymerase family, member 14
chr6_+_29691198 Show fit	5.08	ENST00000440587.2 ENST00000434407.2	HLA-F Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, F
chr22_-_36600727 Show fit	5.04	ENST00000397275.2 ENST00000328429.4	APOL4 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L, 4
chr3_-_28390415 Show fit	5.02	ENST00000414162.1 ENST00000420543.2	AZI2 Ensembl NCBI GeneCards UniProt Show fit	5-azacytidine induced 2
chr17_-_43339453 Show fit	4.97	ENST00000543122.1	SPATA32 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated 32
chr3_+_122283175 Show fit	4.88	ENST00000383661.3	DTX3L Ensembl NCBI GeneCards UniProt Show fit	deltex 3-like (Drosophila)
chr17_+_7358889 Show fit	4.85	ENST00000575379.1	CHRNB1 Ensembl NCBI GeneCards UniProt Show fit	cholinergic receptor, nicotinic, beta 1 (muscle)
chr4_-_185395672 Show fit	4.79	ENST00000393593.3	IRF2 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 2
chr6_+_126240442 Show fit	4.77	ENST00000448104.1 ENST00000438495.1 ENST00000444128.1	NCOA7 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor coactivator 7
chr6_-_170599561 Show fit	4.71	ENST00000366756.3	DLL1 Ensembl NCBI GeneCards UniProt Show fit	delta-like 1 (Drosophila)
chr1_-_151319654 Show fit	4.68	ENST00000430227.1 ENST00000412774.1	RFX5 Ensembl NCBI GeneCards UniProt Show fit	regulatory factor X, 5 (influences HLA class II expression)
chr9_-_21368075 Show fit	4.68	ENST00000449498.1	IFNA13 Ensembl NCBI GeneCards UniProt Show fit	interferon, alpha 13
chr17_-_4167142 Show fit	4.60	ENST00000570535.1 ENST00000574367.1 ENST00000341657.4 ENST00000433651.1	ANKFY1 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and FYVE domain containing 1
chr15_+_74287009 Show fit	4.33	ENST00000395135.3	PML Ensembl NCBI GeneCards UniProt Show fit	promyelocytic leukemia
chr3_-_146262488 Show fit	4.28	ENST00000487389.1	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chr11_-_47270341 Show fit	4.27	ENST00000529444.1 ENST00000530453.1 ENST00000537863.1 ENST00000529788.1 ENST00000444355.2 ENST00000527256.1 ENST00000529663.1 ENST00000256997.3	ACP2 Ensembl NCBI GeneCards UniProt Show fit	acid phosphatase 2, lysosomal
chr14_-_69445968 Show fit	4.21	ENST00000438964.2	ACTN1 Ensembl NCBI GeneCards UniProt Show fit	actinin, alpha 1
chr12_+_75874460 Show fit	4.20	ENST00000266659.3	GLIPR1 Ensembl NCBI GeneCards UniProt Show fit	GLI pathogenesis-related 1
chr1_+_901847 Show fit	4.17	ENST00000379410.3 ENST00000379409.2 ENST00000379407.3	PLEKHN1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family N member 1
chr4_+_185395947 Show fit	4.17	ENST00000605834.1	RP11-326I11.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-326I11.3
chr7_+_150382781 Show fit	4.07	ENST00000223293.5 ENST00000474605.1	GIMAP2 Ensembl NCBI GeneCards UniProt Show fit	GTPase, IMAP family member 2
chr2_+_210288760 Show fit	4.05	ENST00000199940.6	MAP2 Ensembl NCBI GeneCards UniProt Show fit	microtubule-associated protein 2
chr21_+_43933946 Show fit	4.03	ENST00000352133.2	SLC37A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr7_-_134143841 Show fit	4.00	ENST00000285930.4	AKR1B1 Ensembl NCBI GeneCards UniProt Show fit	aldo-keto reductase family 1, member B1 (aldose reductase)
chr1_-_154580616 Show fit	3.96	ENST00000368474.4	ADAR Ensembl NCBI GeneCards UniProt Show fit	adenosine deaminase, RNA-specific

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
22.6	90.5	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
22.3	89.3	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
22.2	88.8	GO:0051097	negative regulation of helicase activity(GO:0051097)
14.8	59.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
14.5	202.6	GO:0035457	cellular response to interferon-alpha(GO:0035457)
14.1	56.3	GO:0072308	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
13.8	166.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
13.5	40.5	GO:0010847	regulation of chromatin assembly(GO:0010847)
11.8	130.0	GO:0018377	protein myristoylation(GO:0018377)
10.6	63.5	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
10.0	39.9	GO:0046967	cytosol to ER transport(GO:0046967)
8.1	73.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
8.0	88.4	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
7.3	21.8	GO:2000625	rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
6.9	34.5	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
6.8	142.0	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
6.7	26.9	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
5.9	70.7	GO:0060700	regulation of ribonuclease activity(GO:0060700)
5.6	16.7	GO:0002731	negative regulation of dendritic cell cytokine production(GO:0002731)
5.2	20.9	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
4.9	14.8	GO:0036269	swimming behavior(GO:0036269)
4.7	37.6	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533)
4.6	27.7	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
4.2	12.5	GO:0036451	cap mRNA methylation(GO:0036451)
3.8	379.8	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
3.7	18.4	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
3.2	48.0	GO:0034058	endosomal vesicle fusion(GO:0034058)
2.9	29.4	GO:0097039	protein linear polyubiquitination(GO:0097039)
2.9	192.4	GO:0045071	negative regulation of viral genome replication(GO:0045071)
2.7	10.7	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.5	49.1	GO:0042832	defense response to protozoan(GO:0042832)
2.4	28.9	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
2.3	7.0	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
2.1	23.0	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
2.0	14.2	GO:1902164	mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
2.0	15.9	GO:0071494	cellular response to UV-C(GO:0071494)
1.9	11.4	GO:0060664	androgen secretion(GO:0035935) epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
1.8	10.6	GO:0030421	defecation(GO:0030421)
1.6	4.8	GO:0006624	vacuolar protein processing(GO:0006624)
1.6	1.6	GO:0061209	BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) cell-cell signaling involved in cell fate commitment(GO:0045168) cell proliferation involved in mesonephros development(GO:0061209) mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
1.6	4.7	GO:0048633	negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) positive regulation of skeletal muscle tissue growth(GO:0048633) negative regulation of inner ear receptor cell differentiation(GO:2000981)
1.5	40.1	GO:0002385	mucosal immune response(GO:0002385)
1.4	2.8	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
1.3	4.0	GO:0006059	hexitol metabolic process(GO:0006059)
1.3	1.3	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
1.2	12.3	GO:0070141	response to UV-A(GO:0070141)
1.2	12.9	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
1.1	40.8	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
1.1	26.7	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
1.0	27.0	GO:1900115	extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
1.0	3.0	GO:0061537	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.0	8.7	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
1.0	37.2	GO:0044364	killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.9	2.7	GO:0044830	modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.9	4.6	GO:0060611	mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.9	23.8	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.9	67.6	GO:0070206	protein trimerization(GO:0070206)
0.8	0.8	GO:0002428	antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.8	4.0	GO:0002636	positive regulation of germinal center formation(GO:0002636)
0.8	71.6	GO:0060135	maternal process involved in female pregnancy(GO:0060135)
0.8	7.7	GO:1904180	negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.7	2.8	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.7	2.1	GO:0070859	lipid transport involved in lipid storage(GO:0010877) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.7	8.4	GO:1903943	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.7	1.4	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.7	2.0	GO:0033037	polysaccharide localization(GO:0033037)
0.7	2.6	GO:0071348	cellular response to interleukin-11(GO:0071348)
0.7	19.1	GO:0036152	phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.6	1.9	GO:0009443	pyridoxal 5'-phosphate salvage(GO:0009443)
0.6	1.8	GO:0072300	vestibulocochlear nerve formation(GO:0021650) negative regulation of cytolysis(GO:0045918) positive regulation of metanephric glomerulus development(GO:0072300)
0.5	56.7	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.5	4.1	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.5	3.8	GO:0044565	dendritic cell proliferation(GO:0044565)
0.5	1.4	GO:0035989	tendon development(GO:0035989)
0.5	2.7	GO:0044111	development involved in symbiotic interaction(GO:0044111)
0.4	5.8	GO:0072643	interferon-gamma secretion(GO:0072643)
0.4	2.6	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.4	2.2	GO:1904582	cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.4	1.3	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.4	1.2	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.4	1.2	GO:0050822	peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.4	4.8	GO:0035095	behavioral response to nicotine(GO:0035095)
0.4	2.7	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.4	3.8	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.4	1.8	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.4	8.4	GO:0036344	platelet morphogenesis(GO:0036344)
0.4	2.8	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.4	1.4	GO:0010793	regulation of mRNA export from nucleus(GO:0010793)
0.3	2.8	GO:1903976	negative regulation of glial cell migration(GO:1903976)
0.3	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.3	1.0	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.3	1.9	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3	0.9	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.3	5.8	GO:2000404	regulation of T cell migration(GO:2000404)
0.3	0.6	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3	15.0	GO:0010390	histone monoubiquitination(GO:0010390)
0.3	7.3	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.3	1.2	GO:0003051	brain renin-angiotensin system(GO:0002035) angiotensin-mediated drinking behavior(GO:0003051)
0.3	1.1	GO:1904117	response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.3	2.6	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.3	1.7	GO:0051271	negative regulation of cellular component movement(GO:0051271)
0.3	0.3	GO:1903383	neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.3	1.6	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.3	2.1	GO:0007296	vitellogenesis(GO:0007296)
0.3	7.9	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.3	1.8	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.3	2.3	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.3	7.7	GO:0008053	mitochondrial fusion(GO:0008053)
0.2	0.2	GO:0052199	negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.2	0.5	GO:0051899	membrane depolarization(GO:0051899)
0.2	0.9	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2	1.4	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2	0.2	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
0.2	1.7	GO:2000402	negative regulation of lymphocyte migration(GO:2000402)
0.2	13.9	GO:0006298	mismatch repair(GO:0006298)
0.2	0.6	GO:0070894	transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
0.2	0.4	GO:0032661	regulation of interleukin-18 production(GO:0032661)
0.2	1.9	GO:0048286	lung alveolus development(GO:0048286)
0.2	1.0	GO:0007520	myoblast fusion(GO:0007520)
0.2	1.2	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.2	1.6	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.2	0.2	GO:0060594	mammary gland specification(GO:0060594)
0.2	1.5	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2	1.5	GO:0048625	myoblast fate commitment(GO:0048625)
0.2	0.5	GO:0061074	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) regulation of neural retina development(GO:0061074) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) regulation of amacrine cell differentiation(GO:1902869) positive regulation of amacrine cell differentiation(GO:1902871)
0.2	1.6	GO:0071763	nuclear membrane organization(GO:0071763)
0.2	1.2	GO:0061458	reproductive system development(GO:0061458)
0.2	2.4	GO:0006968	cellular defense response(GO:0006968)
0.2	1.5	GO:0043473	pigmentation(GO:0043473)
0.2	0.3	GO:0035669	TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.2	0.5	GO:1990108	protein linear deubiquitination(GO:1990108)
0.2	1.3	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.2	1.0	GO:0098886	modification of dendritic spine(GO:0098886)
0.2	2.7	GO:0048706	embryonic skeletal system development(GO:0048706)
0.2	0.6	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.2	0.8	GO:0071609	chemokine (C-C motif) ligand 5 production(GO:0071609) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.2	1.3	GO:1901295	arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.2	0.9	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2	0.5	GO:0006481	C-terminal protein methylation(GO:0006481)
0.2	2.6	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2	0.8	GO:0036496	regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.2	5.7	GO:0045907	positive regulation of vasoconstriction(GO:0045907)
0.2	0.5	GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1	2.2	GO:0046085	adenosine metabolic process(GO:0046085)
0.1	0.6	GO:0003363	lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1	1.2	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	0.9	GO:0007320	insemination(GO:0007320)
0.1	2.1	GO:0033227	dsRNA transport(GO:0033227)
0.1	48.8	GO:0009615	response to virus(GO:0009615)
0.1	0.4	GO:0015882	L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.1	1.1	GO:0070269	pyroptosis(GO:0070269)
0.1	0.4	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1	1.4	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.1	0.5	GO:0042264	peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1	0.9	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) positive regulation of transcription by glucose(GO:0046016)
0.1	0.5	GO:1904217	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1	0.9	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1	4.2	GO:0034389	lipid particle organization(GO:0034389)
0.1	0.5	GO:1903236	regulation of leukocyte tethering or rolling(GO:1903236) negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1	0.9	GO:0098704	fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1	0.3	GO:0036369	transcription factor catabolic process(GO:0036369)
0.1	0.5	GO:0060032	notochord regression(GO:0060032)
0.1	3.5	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.1	0.1	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.1	2.3	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1	1.0	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.1	0.9	GO:1900038	negative regulation of cellular response to hypoxia(GO:1900038)
0.1	0.8	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.9	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.1	3.4	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1	0.3	GO:0035881	amacrine cell differentiation(GO:0035881)
0.1	0.7	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1	0.6	GO:0010225	response to UV-C(GO:0010225)
0.1	2.5	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.1	0.5	GO:0051174	regulation of phosphate metabolic process(GO:0019220) regulation of phosphorus metabolic process(GO:0051174)
0.1	0.6	GO:0015692	lead ion transport(GO:0015692)
0.1	1.8	GO:0014894	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1	0.3	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.1	0.4	GO:0046909	intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1	0.5	GO:0048839	ear development(GO:0043583) inner ear development(GO:0048839)
0.1	0.2	GO:0035655	interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.1	0.8	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.1	0.7	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1	0.6	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.1	0.3	GO:0060012	synaptic transmission, glycinergic(GO:0060012)
0.1	1.0	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004)
0.1	1.2	GO:1902222	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1	1.6	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.6	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.1	0.4	GO:0090383	phagosome acidification(GO:0090383)
0.1	0.2	GO:0048627	myoblast development(GO:0048627)
0.1	1.5	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1	1.0	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1	1.1	GO:0007351	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.1	1.4	GO:0097264	self proteolysis(GO:0097264)
0.1	1.9	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.1	1.2	GO:1990118	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1	3.5	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1	0.8	GO:0003341	cilium movement(GO:0003341)
0.1	0.4	GO:0033489	cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1	16.3	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.1	1.7	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.1	0.2	GO:0042335	cuticle development(GO:0042335)
0.1	2.3	GO:0008217	regulation of blood pressure(GO:0008217)
0.1	0.7	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	0.5	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1	2.2	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1	2.0	GO:0030890	positive regulation of B cell proliferation(GO:0030890)
0.1	0.5	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1	0.9	GO:1904896	ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1	0.3	GO:1904751	positive regulation of protein localization to nucleolus(GO:1904751)
0.1	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1	0.2	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.1	0.3	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.1	0.2	GO:0000270	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1	3.1	GO:0006536	glutamate metabolic process(GO:0006536)
0.1	1.1	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.1	0.2	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.1	1.0	GO:0015671	oxygen transport(GO:0015671)
0.1	0.7	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.1	1.1	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1	1.4	GO:0045687	positive regulation of glial cell differentiation(GO:0045687)
0.1	0.5	GO:0002223	innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1	10.8	GO:0006818	hydrogen transport(GO:0006818) proton transport(GO:0015992)
0.1	1.6	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.1	0.4	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0	7.8	GO:0006661	phosphatidylinositol biosynthetic process(GO:0006661)
0.0	0.1	GO:0071418	cellular response to amine stimulus(GO:0071418)
0.0	0.5	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0	6.7	GO:0042742	defense response to bacterium(GO:0042742)
0.0	0.5	GO:0021759	globus pallidus development(GO:0021759)
0.0	0.8	GO:0051931	regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0	1.0	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	1.8	GO:0046326	positive regulation of glucose import(GO:0046326)
0.0	0.2	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.4	GO:0003360	brainstem development(GO:0003360)
0.0	0.8	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0	1.2	GO:2000144	positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.4	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	1.8	GO:0001953	negative regulation of cell-matrix adhesion(GO:0001953)
0.0	0.6	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.7	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.8	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.0	0.2	GO:0042357	thiamine metabolic process(GO:0006772) thiamine diphosphate metabolic process(GO:0042357)
0.0	0.4	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0	1.6	GO:0060997	dendritic spine morphogenesis(GO:0060997)
0.0	0.9	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.3	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.3	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0	0.8	GO:0052695	cellular glucuronidation(GO:0052695)
0.0	4.4	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	0.1	GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.8	GO:0030865	cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866)
0.0	1.5	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0	0.8	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0	0.6	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.0	2.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.5	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.4	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	1.1	GO:0046627	negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0	0.4	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.6	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	1.5	GO:0001649	osteoblast differentiation(GO:0001649)
0.0	0.2	GO:0038042	dimeric G-protein coupled receptor signaling pathway(GO:0038042) calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.2	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.4	GO:0001696	gastric acid secretion(GO:0001696)
0.0	0.4	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.1	GO:0015942	formate metabolic process(GO:0015942)
0.0	0.2	GO:0071799	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.8	GO:0000132	establishment of mitotic spindle orientation(GO:0000132)
0.0	0.1	GO:0035026	leading edge cell differentiation(GO:0035026)
0.0	1.1	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.4	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0051971	positive regulation of transmission of nerve impulse(GO:0051971)
0.0	3.6	GO:0002576	platelet degranulation(GO:0002576)
0.0	0.4	GO:0048147	negative regulation of fibroblast proliferation(GO:0048147)
0.0	0.3	GO:0015886	heme transport(GO:0015886)
0.0	0.3	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.2	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	2.5	GO:0031929	TOR signaling(GO:0031929)
0.0	0.3	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.0	0.4	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0	0.9	GO:0050918	positive chemotaxis(GO:0050918)
0.0	0.3	GO:0006839	mitochondrial transport(GO:0006839)
0.0	0.3	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.3	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.3	GO:0006024	aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0	0.9	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.2	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.2	GO:0002456	T cell mediated immunity(GO:0002456)
0.0	0.1	GO:0051012	microtubule sliding(GO:0051012)
0.0	0.2	GO:0016048	detection of temperature stimulus(GO:0016048)
0.0	0.7	GO:0090109	regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0	0.5	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.0	GO:0060823	canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0	0.2	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.5	60.2	GO:1990111	spermatoproteasome complex(GO:1990111)
6.6	46.0	GO:0097179	protease inhibitor complex(GO:0097179)
5.9	41.2	GO:0042825	TAP complex(GO:0042825)
4.9	29.4	GO:0071797	LUBAC complex(GO:0071797)
4.1	29.0	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
4.1	12.3	GO:0032002	interleukin-28 receptor complex(GO:0032002)
4.0	12.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
2.3	40.7	GO:0033391	chromatoid body(GO:0033391)
2.1	49.3	GO:0008385	IkappaB kinase complex(GO:0008385)
1.9	24.5	GO:0042788	polysomal ribosome(GO:0042788)
1.8	24.0	GO:0030870	Mre11 complex(GO:0030870)
1.3	7.6	GO:0008537	proteasome activator complex(GO:0008537)
1.2	36.1	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
1.0	14.6	GO:0031089	platelet dense granule lumen(GO:0031089)
1.0	80.4	GO:0015030	Cajal body(GO:0015030)
0.9	6.4	GO:0036021	endolysosome lumen(GO:0036021)
0.8	21.6	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.8	4.6	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.7	2.2	GO:0060076	excitatory synapse(GO:0060076)
0.7	4.0	GO:0044530	supraspliceosomal complex(GO:0044530)
0.7	4.6	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.6	2.4	GO:0005600	collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.6	4.1	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.6	1.1	GO:1990723	cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.6	68.5	GO:0005811	lipid particle(GO:0005811)
0.6	70.5	GO:0043657	host(GO:0018995) host cell(GO:0043657)
0.5	4.1	GO:0097422	tubular endosome(GO:0097422)
0.4	0.4	GO:0032437	cuticular plate(GO:0032437)
0.4	74.1	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.4	1.5	GO:0031084	BLOC-2 complex(GO:0031084)
0.4	9.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.4	20.7	GO:0005643	nuclear pore(GO:0005643)
0.3	2.4	GO:1902560	GMP reductase complex(GO:1902560)
0.3	1.7	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.3	1.0	GO:0097444	spine apparatus(GO:0097444)
0.3	1.5	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.3	33.1	GO:0005637	nuclear inner membrane(GO:0005637)
0.3	0.9	GO:0005674	transcription factor TFIIF complex(GO:0005674)
0.3	1.4	GO:0031905	early endosome lumen(GO:0031905)
0.3	4.0	GO:0033010	paranodal junction(GO:0033010)
0.3	0.8	GO:0001534	radial spoke(GO:0001534)
0.3	9.1	GO:0031143	pseudopodium(GO:0031143)
0.3	106.8	GO:0031965	nuclear membrane(GO:0031965)
0.2	49.8	GO:0032587	ruffle membrane(GO:0032587)
0.2	0.7	GO:0070703	inner mucus layer(GO:0070702) outer mucus layer(GO:0070703)
0.2	15.8	GO:0005771	multivesicular body(GO:0005771)
0.2	1.6	GO:0005899	insulin receptor complex(GO:0005899)
0.2	14.8	GO:0032421	stereocilium bundle(GO:0032421)
0.2	4.8	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.2	0.4	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
0.2	1.6	GO:0030896	checkpoint clamp complex(GO:0030896)
0.2	7.8	GO:0031430	M band(GO:0031430)
0.2	31.5	GO:0005769	early endosome(GO:0005769)
0.2	1.4	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.1	0.9	GO:0016035	zeta DNA polymerase complex(GO:0016035)
0.1	1.0	GO:0005833	hemoglobin complex(GO:0005833)
0.1	157.2	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.1	3.7	GO:0098793	presynapse(GO:0098793)
0.1	0.4	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1	0.8	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	1.1	GO:0032009	early phagosome(GO:0032009)
0.1	7.0	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	1.3	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	3.3	GO:0036020	endolysosome(GO:0036019) endolysosome membrane(GO:0036020)
0.1	4.2	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	64.4	GO:0010008	endosome membrane(GO:0010008)
0.1	2.3	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	2.4	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	148.9	GO:0005730	nucleolus(GO:0005730)
0.1	0.9	GO:0016589	NURF complex(GO:0016589)
0.1	0.8	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.1	1.8	GO:0070938	contractile ring(GO:0070938)
0.1	269.6	GO:0005739	mitochondrion(GO:0005739)
0.1	1.9	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	0.9	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	1.1	GO:0072546	ER membrane protein complex(GO:0072546)
0.1	3.4	GO:0070822	Sin3-type complex(GO:0070822)
0.1	0.6	GO:0044327	dendritic spine head(GO:0044327)
0.1	0.4	GO:0005879	axonemal microtubule(GO:0005879)
0.1	14.6	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	12.3	GO:0031975	organelle envelope(GO:0031967) envelope(GO:0031975)
0.1	0.8	GO:0034706	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1	1.5	GO:0000124	SAGA complex(GO:0000124)
0.1	0.5	GO:0043196	varicosity(GO:0043196)
0.1	1.1	GO:0001673	male germ cell nucleus(GO:0001673)
0.1	1.0	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	0.8	GO:0005610	laminin-5 complex(GO:0005610)
0.1	0.7	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	0.7	GO:0031209	SCAR complex(GO:0031209)
0.1	75.2	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.7	GO:0019774	proteasome core complex, beta-subunit complex(GO:0019774)
0.1	0.6	GO:0016461	unconventional myosin complex(GO:0016461)
0.1	1.5	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.7	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	0.1	GO:0045202	synapse(GO:0045202)
0.1	9.3	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1	0.5	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	1.0	GO:0005802	trans-Golgi network(GO:0005802)
0.1	3.4	GO:0055037	recycling endosome(GO:0055037)
0.1	1.8	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	0.6	GO:0097427	microtubule bundle(GO:0097427)
0.1	1.9	GO:0016235	aggresome(GO:0016235)
0.1	1.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	3.1	GO:0035580	specific granule lumen(GO:0035580)
0.0	9.0	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	0.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.6	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.3	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	4.0	GO:0070821	tertiary granule membrane(GO:0070821)
0.0	0.4	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	61.4	GO:0005615	extracellular space(GO:0005615)
0.0	1.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.6	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.7	GO:0005581	collagen trimer(GO:0005581)
0.0	0.4	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.7	GO:0030057	desmosome(GO:0030057)
0.0	1.3	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.6	GO:0043209	myelin sheath(GO:0043209)
0.0	1.8	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.4	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.5	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	1.1	GO:0005925	cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.0	157.8	GO:0005634	nucleus(GO:0005634)
0.0	1.7	GO:0015934	large ribosomal subunit(GO:0015934)
0.0	11.5	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	1.0	GO:0016592	mediator complex(GO:0016592)
0.0	0.8	GO:0008180	COP9 signalosome(GO:0008180)
0.0	13.1	GO:0000139	Golgi membrane(GO:0000139)
0.0	0.4	GO:0009925	basal plasma membrane(GO:0009925)
0.0	1.4	GO:0043197	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0	0.6	GO:0030424	axon(GO:0030424)
0.0	0.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.8	GO:0034707	chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
23.6	282.8	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
14.8	59.0	GO:0009041	uridylate kinase activity(GO:0009041)
11.5	34.5	GO:0008859	exoribonuclease II activity(GO:0008859)
9.1	27.3	GO:0042007	interleukin-18 binding(GO:0042007)
7.2	28.9	GO:0031849	olfactory receptor binding(GO:0031849)
6.0	77.5	GO:0031386	protein tag(GO:0031386)
6.0	59.6	GO:0042296	ISG15 transferase activity(GO:0042296)
5.7	51.5	GO:0046977	TAP binding(GO:0046977) TAP1 binding(GO:0046978)
4.2	25.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
4.2	12.5	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
4.1	73.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
3.7	15.0	GO:0033754	indoleamine 2,3-dioxygenase activity(GO:0033754)
3.5	24.5	GO:0034046	poly(G) binding(GO:0034046)
3.1	15.6	GO:0005132	type I interferon receptor binding(GO:0005132)
2.9	26.5	GO:0070087	chromo shadow domain binding(GO:0070087)
2.9	29.0	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
2.9	17.3	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
2.9	137.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
2.2	28.0	GO:0089720	caspase binding(GO:0089720)
2.0	59.7	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.9	9.6	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
1.9	11.4	GO:0004882	androgen receptor activity(GO:0004882)
1.7	6.7	GO:0048030	disaccharide binding(GO:0048030)
1.5	8.8	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.4	44.4	GO:0008266	poly(U) RNA binding(GO:0008266)
1.4	69.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
1.3	29.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
1.1	6.8	GO:0042015	interleukin-20 binding(GO:0042015)
1.1	6.8	GO:0005134	interleukin-2 receptor binding(GO:0005134)
1.1	2.1	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
1.0	40.9	GO:0005521	lamin binding(GO:0005521)
1.0	126.6	GO:0003725	double-stranded RNA binding(GO:0003725)
1.0	62.9	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
1.0	18.0	GO:0050700	CARD domain binding(GO:0050700)
1.0	3.0	GO:0015375	glycine:sodium symporter activity(GO:0015375)
1.0	7.6	GO:0061133	endopeptidase activator activity(GO:0061133)
0.8	2.5	GO:0032090	Pyrin domain binding(GO:0032090)
0.8	18.6	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.7	3.7	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.7	96.4	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.7	36.3	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.6	18.0	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.6	1.9	GO:0008478	pyridoxal kinase activity(GO:0008478)
0.6	1.2	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
0.6	1.2	GO:0035877	death effector domain binding(GO:0035877) cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.6	3.4	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.5	5.0	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.5	1.5	GO:0004531	deoxyribonuclease II activity(GO:0004531)
0.5	2.4	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.5	12.9	GO:0032183	SUMO binding(GO:0032183)
0.5	83.7	GO:0001047	core promoter binding(GO:0001047)
0.5	24.3	GO:0051879	Hsp90 protein binding(GO:0051879)
0.5	1.9	GO:0004967	glucagon receptor activity(GO:0004967)
0.5	3.7	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4	3.1	GO:0047820	D-glutamate cyclase activity(GO:0047820)
0.4	1.3	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.4	2.0	GO:0050659	chondroitin 4-sulfotransferase activity(GO:0047756) N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.4	0.8	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.4	22.9	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4	52.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.4	7.7	GO:0051400	BH domain binding(GO:0051400)
0.4	4.7	GO:0030957	Tat protein binding(GO:0030957)
0.4	1.1	GO:0005019	platelet-derived growth factor beta-receptor activity(GO:0005019)
0.4	1.4	GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.3	2.4	GO:0016657	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.3	2.7	GO:0050815	phosphoserine binding(GO:0050815)
0.3	7.9	GO:0070330	aromatase activity(GO:0070330)
0.3	37.9	GO:0005254	chloride channel activity(GO:0005254)
0.3	1.8	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.3	184.2	GO:0005525	GTP binding(GO:0005525)
0.3	4.1	GO:0034452	dynactin binding(GO:0034452)
0.3	8.4	GO:0032813	tumor necrosis factor receptor superfamily binding(GO:0032813)
0.3	0.3	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.3	3.8	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3	2.3	GO:0004985	opioid receptor activity(GO:0004985)
0.3	4.8	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.2	40.6	GO:0047485	protein N-terminus binding(GO:0047485)
0.2	2.4	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.2	7.8	GO:0070064	proline-rich region binding(GO:0070064)
0.2	1.4	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.2	2.8	GO:0004969	histamine receptor activity(GO:0004969)
0.2	45.2	GO:0004386	helicase activity(GO:0004386)
0.2	0.4	GO:0050692	DBD domain binding(GO:0050692)
0.2	1.0	GO:0030492	hemoglobin binding(GO:0030492)
0.2	0.6	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.2	0.8	GO:1902379	receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.2	4.3	GO:0003993	acid phosphatase activity(GO:0003993)
0.2	7.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2	1.1	GO:0016402	pristanoyl-CoA oxidase activity(GO:0016402)
0.2	2.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.2	1.2	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.2	1.6	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2	34.9	GO:0005125	cytokine activity(GO:0005125)
0.2	0.3	GO:0035276	ethanol binding(GO:0035276)
0.2	1.2	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.2	0.7	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.2	0.5	GO:0003880	protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.1	0.4	GO:0015229	L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1	1.1	GO:1901612	cardiolipin binding(GO:1901612)
0.1	2.6	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) TFIIB-class transcription factor binding(GO:0001093)
0.1	1.5	GO:0035325	Toll-like receptor binding(GO:0035325)
0.1	6.8	GO:0004623	phospholipase A2 activity(GO:0004623)
0.1	1.7	GO:0045159	myosin II binding(GO:0045159)
0.1	0.9	GO:0016403	dimethylargininase activity(GO:0016403)
0.1	16.5	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.1	0.9	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.1	7.8	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1	0.9	GO:0005353	fructose transmembrane transporter activity(GO:0005353)
0.1	8.7	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	2.3	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.1	34.8	GO:0030674	protein binding, bridging(GO:0030674)
0.1	0.9	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.1	0.8	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.1	1.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1	3.5	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	0.9	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.1	1.0	GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1	0.7	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	0.4	GO:0016435	rRNA (guanine) methyltransferase activity(GO:0016435)
0.1	0.9	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.1	2.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.1	0.4	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1	14.5	GO:0043130	ubiquitin binding(GO:0043130)
0.1	1.4	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1	0.6	GO:0015086	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1	0.5	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1	1.2	GO:0015386	potassium:proton antiporter activity(GO:0015386)
0.1	1.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.1	1.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.1	2.4	GO:0042056	chemoattractant activity(GO:0042056)
0.1	12.7	GO:0005319	lipid transporter activity(GO:0005319)
0.1	2.5	GO:0003924	GTPase activity(GO:0003924)
0.1	0.8	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	0.2	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.1	0.8	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.5	GO:0071532	ankyrin repeat binding(GO:0071532)
0.1	0.7	GO:0019211	phosphatase activator activity(GO:0019211)
0.1	0.7	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.9	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	13.8	GO:0042393	histone binding(GO:0042393)
0.1	1.7	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.3	GO:1990460	leptin receptor binding(GO:1990460)
0.1	0.3	GO:0102008	cytosolic dipeptidase activity(GO:0102008)
0.1	60.6	GO:0008270	zinc ion binding(GO:0008270)
0.1	1.6	GO:0001948	glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1	0.7	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.2	GO:0047374	methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1	0.3	GO:0050115	myosin-light-chain-phosphatase activity(GO:0050115)
0.1	0.7	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.9	GO:0008179	adenylate cyclase binding(GO:0008179)
0.1	0.2	GO:0016495	C-X3-C chemokine receptor activity(GO:0016495)
0.1	1.3	GO:0070888	E-box binding(GO:0070888)
0.0	0.3	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	1.5	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0004852	uroporphyrinogen-III synthase activity(GO:0004852)
0.0	0.2	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	1.1	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.3	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.9	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	4.9	GO:0008083	growth factor activity(GO:0008083)
0.0	1.0	GO:0031005	filamin binding(GO:0031005)
0.0	0.3	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.7	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	73.8	GO:0042802	identical protein binding(GO:0042802)
0.0	0.9	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.7	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	1.4	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.6	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.2	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.5	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	2.0	GO:0019212	protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0	0.1	GO:0060001	minus-end directed microfilament motor activity(GO:0060001)
0.0	0.5	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	8.7	GO:0030246	carbohydrate binding(GO:0030246)
0.0	0.5	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.1	GO:0033612	receptor serine/threonine kinase binding(GO:0033612) transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	1.6	GO:0050136	NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.5	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.3	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.5	GO:0101005	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.5	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	1.2	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	43.4	GO:0003723	RNA binding(GO:0003723)
0.0	0.6	GO:0070840	dynein complex binding(GO:0070840)
0.0	53.4	GO:0003677	DNA binding(GO:0003677)
0.0	0.1	GO:0004977	melanocortin receptor activity(GO:0004977)
0.0	5.4	GO:0016746	transferase activity, transferring acyl groups(GO:0016746)
0.0	0.3	GO:0015232	heme transporter activity(GO:0015232)
0.0	1.3	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	1.6	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.4	GO:0005539	glycosaminoglycan binding(GO:0005539)
0.0	0.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	3.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.1	GO:0002114	interleukin-33 receptor activity(GO:0002114)
0.0	0.4	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.0	0.8	GO:0051213	dioxygenase activity(GO:0051213)
0.0	0.6	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.4	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	1.5	GO:0003676	nucleic acid binding(GO:0003676)
0.0	0.2	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.3	88.5	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.8	28.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.7	11.8	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.6	33.6	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.5	38.3	PID AURORA A PATHWAY	Aurora A signaling
0.5	23.2	PID MYC PATHWAY	C-MYC pathway
0.5	14.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.4	70.6	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.4	40.8	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.4	23.5	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.4	17.9	PID TRAIL PATHWAY	TRAIL signaling pathway
0.3	14.9	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.2	19.5	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.2	2.6	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	12.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	13.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	28.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	4.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	2.2	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	2.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	7.5	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.1	1.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	4.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	0.6	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	3.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	1.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.1	6.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	13.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	0.8	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	0.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.4	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	1.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	2.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	1.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	1.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.4	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	1.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	ST ADRENERGIC	Adrenergic Pathway
0.0	0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.1	PID BMP PATHWAY	BMP receptor signaling
0.0	0.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.3	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	1.1	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
13.5	1291.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
6.5	104.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
2.2	116.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
1.3	12.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
1.3	78.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
1.3	27.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
1.3	37.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.9	34.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.8	57.9	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.8	9.3	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.8	10.8	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.7	4.7	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5	17.9	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.4	3.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.4	2.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3	2.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	0.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.3	9.9	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.3	2.8	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.2	63.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	8.0	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	1.0	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.2	4.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.2	14.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	6.9	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.1	3.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	4.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	1.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	5.5	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	0.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	10.1	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	0.6	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	2.2	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	1.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1	2.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	0.6	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1	1.9	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.1	2.0	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	0.5	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1	1.4	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.1	1.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	0.4	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	1.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	1.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.9	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0	1.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	1.0	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	1.7	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.8	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	1.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.3	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	3.2	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.0	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	1.9	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.4	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.7	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.4	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	1.1	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.8	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.5	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	1.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.3	REACTOME ION CHANNEL TRANSPORT	Genes involved in Ion channel transport

Results for IRF2_STAT2_IRF8_IRF1

Z-value: 16.83

Motif logo

Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Activity-expression correlation:

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: