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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRX5

Z-value: 1.38

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Transcription factors associated with IRX5

Gene Symbol Gene ID Gene Info
IRX5
ENSG00000176842.10 iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX5hg19_v2_chr16_+_54964740_549647890.316.9e-01Click!

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_141264597 3.93 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr2_+_38177575 1.60 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr12_+_56114151 1.48 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr7_-_16844611 1.19 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr12_+_56114189 1.18 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr17_+_14277419 1.14 ENST00000436469.1
AC022816.2
AC022816.2
chr1_+_63989004 1.07 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr10_-_18944123 1.06 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr6_+_26204825 1.06 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr7_+_23210760 1.04 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr1_-_197115818 1.02 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr4_-_104119528 0.91 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr8_+_27631903 0.91 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr11_-_31014214 0.90 ENST00000406071.2
ENST00000339794.5
DCDC1
doublecortin domain containing 1
chr7_-_99573677 0.85 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr5_-_156390230 0.82 ENST00000407087.3
ENST00000274532.2
TIMD4
T-cell immunoglobulin and mucin domain containing 4
chr1_+_53480598 0.81 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
SCP2
sterol carrier protein 2
chr1_+_196912902 0.80 ENST00000476712.2
ENST00000367415.5
CFHR2
complement factor H-related 2
chr1_+_97188188 0.79 ENST00000541987.1
PTBP2
polypyrimidine tract binding protein 2
chr3_+_186158169 0.79 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr15_+_66585555 0.79 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr1_+_212475148 0.77 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_+_196788887 0.74 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
CFHR1
CFHR2
complement factor H-related 1
complement factor H-related 2
chr4_+_113558612 0.72 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr20_-_3762087 0.72 ENST00000379756.3
SPEF1
sperm flagellar 1
chr12_+_21679220 0.71 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr15_-_63448973 0.69 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chrX_-_15353629 0.64 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr12_-_76462713 0.63 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr14_+_73563735 0.61 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr15_-_56757329 0.60 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr1_-_115124257 0.59 ENST00000369541.3
BCAS2
breast carcinoma amplified sequence 2
chr3_+_180586536 0.57 ENST00000465551.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr8_-_17555164 0.55 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr3_-_27498235 0.55 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_+_58335360 0.53 ENST00000300145.3
XRCC6BP1
XRCC6 binding protein 1
chr5_-_93447333 0.53 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A
family with sequence similarity 172, member A
chr9_-_19065082 0.52 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr7_+_116502527 0.50 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr2_+_113299990 0.50 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr2_-_32236002 0.49 ENST00000404530.1
MEMO1
mediator of cell motility 1
chr8_+_9009296 0.49 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chr8_+_101349823 0.49 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chrX_-_135962923 0.47 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr10_-_115904361 0.46 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr14_+_56127960 0.46 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr1_+_145524891 0.46 ENST00000369304.3
ITGA10
integrin, alpha 10
chr11_+_31531291 0.45 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr11_+_110225855 0.45 ENST00000526605.1
ENST00000526703.1
RP11-347E10.1
RP11-347E10.1
chr15_+_21145765 0.44 ENST00000553416.1
CT60
cancer/testis antigen 60 (non-protein coding)
chr13_-_41768654 0.43 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr8_+_120885949 0.43 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr5_+_140566 0.43 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr15_+_49170083 0.43 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr1_-_62190793 0.42 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr18_-_28622774 0.42 ENST00000434452.1
DSC3
desmocollin 3
chr18_-_69246167 0.42 ENST00000566582.1
RP11-510D19.1
RP11-510D19.1
chr5_+_96079240 0.41 ENST00000515663.1
CAST
calpastatin
chr15_+_66585879 0.41 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr10_-_15130767 0.41 ENST00000356189.5
ACBD7
acyl-CoA binding domain containing 7
chr15_+_65204075 0.40 ENST00000380230.3
ENST00000357698.3
ENST00000395720.1
ENST00000496660.1
ENST00000319580.8
ANKDD1A
ankyrin repeat and death domain containing 1A
chr12_-_100486668 0.40 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L
UHRF1 binding protein 1-like
chr12_-_120315074 0.40 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr20_+_43990576 0.39 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr3_-_127541194 0.38 ENST00000453507.2
MGLL
monoglyceride lipase
chr1_+_81106951 0.38 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr14_+_56127989 0.36 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr3_+_101659682 0.36 ENST00000465215.1
RP11-221J22.1
RP11-221J22.1
chr3_+_53528659 0.35 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr1_+_87458692 0.35 ENST00000370548.2
ENST00000356813.4
RP5-1052I5.2
HS2ST1
Heparan sulfate 2-O-sulfotransferase 1
heparan sulfate 2-O-sulfotransferase 1
chr7_-_99573640 0.35 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr20_+_54933971 0.35 ENST00000371384.3
ENST00000437418.1
FAM210B
family with sequence similarity 210, member B
chr2_-_242041607 0.35 ENST00000434791.1
ENST00000401626.2
ENST00000439144.1
ENST00000406593.1
ENST00000495694.1
ENST00000407095.3
ENST00000391980.2
MTERFD2
MTERF domain containing 2
chr1_+_53308398 0.34 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr11_-_22647350 0.34 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chr11_-_1619524 0.34 ENST00000412090.1
KRTAP5-2
keratin associated protein 5-2
chr1_+_145525015 0.34 ENST00000539363.1
ENST00000538811.1
ITGA10
integrin, alpha 10
chr8_+_84824920 0.33 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chrX_+_108779004 0.33 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr8_-_101724989 0.33 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr22_-_24096562 0.33 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr1_-_145826450 0.33 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr6_+_27925019 0.33 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr2_+_160590469 0.33 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr8_+_22225041 0.33 ENST00000289952.5
ENST00000524285.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr13_+_96085847 0.32 ENST00000376873.3
CLDN10
claudin 10
chr13_+_97928395 0.32 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr4_+_189376725 0.32 ENST00000510832.1
ENST00000510005.1
ENST00000503458.1
LINC01060
long intergenic non-protein coding RNA 1060
chr12_-_58329819 0.31 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr12_+_53848549 0.31 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr8_+_67976593 0.31 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr11_+_34999328 0.31 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex, component X
chr18_+_22006580 0.30 ENST00000284202.4
IMPACT
impact RWD domain protein
chr16_+_19467772 0.30 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr8_-_101962777 0.28 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr1_-_114355083 0.28 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr1_+_240408560 0.27 ENST00000441342.1
ENST00000545751.1
FMN2
formin 2
chr4_+_80584903 0.27 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr18_+_52258390 0.27 ENST00000321600.1
DYNAP
dynactin associated protein
chr5_+_169758393 0.26 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr22_+_18721427 0.26 ENST00000342888.3
AC008132.1
Uncharacterized protein
chr9_+_26746951 0.26 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr1_+_196743943 0.26 ENST00000471440.2
ENST00000391985.3
CFHR3
complement factor H-related 3
chr3_-_3221358 0.26 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr18_-_69246186 0.26 ENST00000568095.1
RP11-510D19.1
RP11-510D19.1
chr17_-_47723943 0.25 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr9_-_3489428 0.25 ENST00000451859.1
RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr11_-_118305921 0.25 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr9_+_42704004 0.25 ENST00000457288.1
CBWD7
COBW domain containing 7
chr10_-_96829246 0.24 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr1_+_10509971 0.24 ENST00000320498.4
CORT
cortistatin
chr4_+_169842707 0.23 ENST00000503290.1
PALLD
palladin, cytoskeletal associated protein
chr2_-_32490801 0.23 ENST00000360906.5
ENST00000342905.6
NLRC4
NLR family, CARD domain containing 4
chrX_+_12809463 0.23 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr12_-_102224704 0.23 ENST00000299314.7
GNPTAB
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr1_+_220267429 0.23 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr3_-_46068969 0.23 ENST00000542109.1
ENST00000395946.2
XCR1
chemokine (C motif) receptor 1
chr1_-_244006528 0.22 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr13_-_88323218 0.22 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr3_+_158787041 0.22 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr6_-_111804905 0.21 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr10_+_86184676 0.21 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr5_+_54455946 0.21 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr1_-_160492994 0.20 ENST00000368055.1
ENST00000368057.3
ENST00000368059.3
SLAMF6
SLAM family member 6
chr12_-_58329888 0.20 ENST00000546580.1
RP11-620J15.3
RP11-620J15.3
chr18_-_56985776 0.20 ENST00000587244.1
CPLX4
complexin 4
chr10_-_35379524 0.20 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr7_-_112430427 0.18 ENST00000449743.1
ENST00000441474.1
ENST00000454074.1
ENST00000447395.1
TMEM168
transmembrane protein 168
chr16_+_87636474 0.18 ENST00000284262.2
JPH3
junctophilin 3
chr13_-_20110902 0.18 ENST00000390680.2
ENST00000382977.4
ENST00000382975.4
ENST00000457266.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr2_+_191792376 0.18 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr2_-_231989808 0.17 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr1_-_241683001 0.17 ENST00000366560.3
FH
fumarate hydratase
chr8_+_95558771 0.17 ENST00000391679.1
AC023632.1
HCG2009141; PRO2397; Uncharacterized protein
chr7_+_133615169 0.17 ENST00000541309.1
EXOC4
exocyst complex component 4
chr7_-_55583740 0.17 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr4_-_143481822 0.16 ENST00000510812.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr6_+_149887377 0.16 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr4_+_159131596 0.16 ENST00000512481.1
TMEM144
transmembrane protein 144
chr18_+_33709834 0.16 ENST00000358232.6
ENST00000351393.6
ENST00000442325.2
ENST00000423854.2
ENST00000350494.6
ENST00000542824.1
ELP2
elongator acetyltransferase complex subunit 2
chr9_+_71820057 0.16 ENST00000539225.1
TJP2
tight junction protein 2
chr9_+_71819927 0.15 ENST00000535702.1
TJP2
tight junction protein 2
chr1_-_179457805 0.15 ENST00000600581.1
AL160286.1
Uncharacterized protein
chr3_-_52713729 0.15 ENST00000296302.7
ENST00000356770.4
ENST00000337303.4
ENST00000409057.1
ENST00000410007.1
ENST00000409114.3
ENST00000409767.1
ENST00000423351.1
PBRM1
polybromo 1
chr8_-_67976509 0.15 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr3_-_81792780 0.15 ENST00000489715.1
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr8_+_27947746 0.15 ENST00000521015.1
ENST00000521570.1
ELP3
elongator acetyltransferase complex subunit 3
chr2_+_173686303 0.15 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr16_+_19535133 0.14 ENST00000396212.2
ENST00000381396.5
CCP110
centriolar coiled coil protein 110kDa
chr7_+_66386204 0.14 ENST00000341567.4
ENST00000607045.1
TMEM248
transmembrane protein 248
chr4_-_104119488 0.14 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr1_+_196743912 0.14 ENST00000367425.4
CFHR3
complement factor H-related 3
chr14_-_95624227 0.14 ENST00000526495.1
DICER1
dicer 1, ribonuclease type III
chr16_+_56969284 0.13 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_+_95326416 0.13 ENST00000371481.4
ENST00000371483.4
ENST00000604414.1
FFAR4
free fatty acid receptor 4
chr3_-_9994021 0.13 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr10_+_127661942 0.13 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr10_+_96698406 0.13 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr18_-_32924372 0.13 ENST00000261332.6
ENST00000399061.3
ZNF24
zinc finger protein 24
chr3_+_12392971 0.12 ENST00000287820.6
PPARG
peroxisome proliferator-activated receptor gamma
chr11_-_74408739 0.12 ENST00000529912.1
CHRDL2
chordin-like 2
chr11_+_114310237 0.12 ENST00000539119.1
REXO2
RNA exonuclease 2
chr4_+_110769258 0.11 ENST00000594814.1
LRIT3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr8_+_125463048 0.10 ENST00000328599.3
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chrX_-_19988382 0.10 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr17_+_12859080 0.10 ENST00000583608.1
ARHGAP44
Rho GTPase activating protein 44
chr11_+_61891445 0.10 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP
inner centromere protein antigens 135/155kDa
chr16_+_76668895 0.09 ENST00000512279.1
RP11-96P7.1
RP11-96P7.1
chr3_+_155838337 0.09 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr12_+_106751436 0.09 ENST00000228347.4
POLR3B
polymerase (RNA) III (DNA directed) polypeptide B
chr16_+_31539183 0.09 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr7_+_13141097 0.08 ENST00000411542.1
AC011288.2
AC011288.2
chr12_-_123728548 0.08 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr17_-_7108436 0.07 ENST00000493294.1
DLG4
discs, large homolog 4 (Drosophila)
chr2_+_58655520 0.07 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chr21_+_38792602 0.07 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr18_-_44702668 0.07 ENST00000256433.3
IER3IP1
immediate early response 3 interacting protein 1
chr3_+_81043000 0.07 ENST00000482617.1
RP11-6B4.1
RP11-6B4.1
chr17_+_3379284 0.07 ENST00000263080.2
ASPA
aspartoacylase
chr8_-_108510224 0.07 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr9_-_37465396 0.07 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr15_+_41057818 0.07 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr7_-_111424462 0.07 ENST00000437129.1
DOCK4
dedicator of cytokinesis 4
chr13_-_20080080 0.06 ENST00000400103.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr4_+_159131630 0.06 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
TMEM144
transmembrane protein 144
chr9_-_100707116 0.06 ENST00000259456.3
HEMGN
hemogen
chr5_+_136070614 0.06 ENST00000502421.1
CTB-1I21.1
CTB-1I21.1
chr4_+_123653882 0.06 ENST00000433287.1
BBS12
Bardet-Biedl syndrome 12
chr2_-_206950996 0.06 ENST00000414320.1
INO80D
INO80 complex subunit D
chr6_-_52774464 0.06 ENST00000370968.1
ENST00000211122.3
GSTA3
glutathione S-transferase alpha 3
chr22_+_20877924 0.05 ENST00000445189.1
MED15
mediator complex subunit 15
chr1_+_46152886 0.05 ENST00000372025.4
TMEM69
transmembrane protein 69
chrX_+_99899180 0.04 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr7_+_77469439 0.04 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr1_-_227505289 0.04 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr16_-_58585513 0.04 ENST00000245138.4
ENST00000567285.1
CNOT1
CCR4-NOT transcription complex, subunit 1
chr7_+_13141010 0.03 ENST00000443947.1
AC011288.2
AC011288.2
chr18_+_22006646 0.03 ENST00000585067.1
ENST00000578221.1
IMPACT
impact RWD domain protein
chr2_-_228579305 0.03 ENST00000456524.1
SLC19A3
solute carrier family 19 (thiamine transporter), member 3
chr4_+_113739244 0.03 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 3.9 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 1.2 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.2 0.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.5 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.8 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.3 GO:0071264 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.1 0.8 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 0.3 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1 0.2 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.3 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 1.1 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.0 0.1 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0097267 omega-hydroxylase P450 pathway(GO:0097267)
0.0 2.0 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:2001205 TNFSF11-mediated signaling pathway(GO:0071847) negative regulation of osteoclast development(GO:2001205)
0.0 0.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0072343 regulation of cholesterol transporter activity(GO:0060694) pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.6 GO:0070986 left/right axis specification(GO:0070986)
0.0 1.3 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 0.4 GO:2000674 regulation of type B pancreatic cell apoptotic process(GO:2000674)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.5 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0015684 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.2 GO:0016045 detection of bacterium(GO:0016045)
0.0 0.1 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.6 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.3 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:1903894 regulation of IRE1-mediated unfolded protein response(GO:1903894)
0.0 0.2 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0032053 ciliary basal body organization(GO:0032053)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.0 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.8 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.1 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.9 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.5 GO:0070652 HAUS complex(GO:0070652)
0.0 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.8 GO:0043234 macromolecular complex(GO:0032991) protein complex(GO:0043234)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.4 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.1 0.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 2.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.4 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.2 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.0 GO:0008494 translation activator activity(GO:0008494)
0.0 0.6 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.3 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.4 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.2 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.1 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.8 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis