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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for IRX6_IRX4

Z-value: 0.51

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.955.1e-02Click!
IRX6hg19_v2_chr16_+_55357672_55357672-0.752.5e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_141264597 1.59 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr1_+_63989004 0.72 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr7_-_16844611 0.64 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr15_-_63448973 0.45 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr3_-_27498235 0.35 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chrX_-_135962923 0.30 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr4_-_104119528 0.28 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr7_+_23210760 0.27 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr3_+_53528659 0.26 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr12_-_76462713 0.24 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr18_-_47376197 0.22 ENST00000592688.1
MYO5B
myosin VB
chr1_+_212475148 0.20 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr3_+_186158169 0.20 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr8_-_17555164 0.18 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr8_+_27631903 0.18 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr4_-_153303658 0.17 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_113558612 0.15 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr13_-_41768654 0.15 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr9_+_26746951 0.15 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr15_+_66585555 0.13 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr15_+_66585879 0.12 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr18_-_28622774 0.11 ENST00000434452.1
DSC3
desmocollin 3
chr10_-_115904361 0.11 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr22_-_24096562 0.11 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr8_+_67976593 0.11 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr14_+_56127960 0.10 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr16_+_777118 0.10 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr8_-_101724989 0.10 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr2_-_231989808 0.10 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr1_+_220267429 0.09 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr1_+_53308398 0.09 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr11_+_110225855 0.08 ENST00000526605.1
ENST00000526703.1
RP11-347E10.1
RP11-347E10.1
chr20_+_43990576 0.08 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr2_+_160590469 0.08 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr12_+_53848549 0.08 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr14_+_56127989 0.07 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr6_+_149887377 0.07 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr5_+_169758393 0.06 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr7_-_55583740 0.06 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr8_-_67976509 0.06 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr10_+_86184676 0.06 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr5_+_59783540 0.06 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr17_-_47723943 0.05 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr11_+_61891445 0.05 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP
inner centromere protein antigens 135/155kDa
chr12_-_124118151 0.05 ENST00000534960.1
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr3_-_9994021 0.04 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr9_-_27573651 0.04 ENST00000379995.1
ENST00000379997.3
C9orf72
chromosome 9 open reading frame 72
chr2_+_58655520 0.04 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chr4_-_104119488 0.04 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr8_+_84824920 0.04 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr4_-_143481822 0.04 ENST00000510812.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chrX_-_19988382 0.03 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr12_+_32655110 0.03 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr15_-_64665911 0.02 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr7_+_6121296 0.02 ENST00000428901.1
AC004895.4
AC004895.4
chrX_+_99899180 0.02 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr18_-_56985776 0.01 ENST00000587244.1
CPLX4
complexin 4
chr12_+_32655048 0.01 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_+_123653882 0.01 ENST00000433287.1
BBS12
Bardet-Biedl syndrome 12
chr1_-_201438282 0.01 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr3_-_168865522 0.00 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.6 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.2 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.0 0.2 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.5 GO:0008494 translation activator activity(GO:0008494)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)