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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NKX2-1

Z-value: 0.67

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36989336_369893540.891.1e-01Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_101591314 0.56 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr15_+_89182178 0.50 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_180165672 0.50 ENST00000443059.1
QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr15_+_89182156 0.49 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr10_-_79397547 0.47 ENST00000481070.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_-_139195350 0.44 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr1_+_15736359 0.44 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr15_+_89181974 0.43 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_-_108976410 0.35 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr22_+_50986462 0.33 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr17_+_61086917 0.33 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr8_-_16859690 0.33 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr1_+_206643806 0.33 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr13_-_41240717 0.32 ENST00000379561.5
FOXO1
forkhead box O1
chr16_-_67190152 0.31 ENST00000486556.1
TRADD
TNFRSF1A-associated via death domain
chr20_-_56285595 0.30 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr6_-_117747015 0.30 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr22_-_30968839 0.29 ENST00000445645.1
ENST00000416358.1
ENST00000423371.1
ENST00000411821.1
ENST00000448604.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr11_-_62313090 0.29 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr19_-_36231437 0.29 ENST00000591748.1
IGFLR1
IGF-like family receptor 1
chr1_+_206643787 0.28 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr3_-_114790179 0.25 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr20_-_36793663 0.25 ENST00000536701.1
ENST00000536724.1
TGM2
transglutaminase 2
chr18_+_33877654 0.24 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr12_-_719573 0.24 ENST00000397265.3
NINJ2
ninjurin 2
chr22_-_30968813 0.22 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr2_+_220299547 0.22 ENST00000312358.7
SPEG
SPEG complex locus
chr14_+_74353320 0.22 ENST00000540593.1
ENST00000555730.1
ZNF410
zinc finger protein 410
chr2_+_119699864 0.21 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr17_-_76778339 0.21 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr8_-_38326119 0.21 ENST00000356207.5
ENST00000326324.6
FGFR1
fibroblast growth factor receptor 1
chr5_-_171615315 0.21 ENST00000176763.5
STK10
serine/threonine kinase 10
chr2_+_119699742 0.20 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr9_-_34397800 0.20 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr11_-_104827425 0.20 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr21_+_33671264 0.19 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr17_-_1508379 0.19 ENST00000412517.3
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr6_+_32121218 0.18 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr10_-_7708918 0.18 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr19_-_46234119 0.18 ENST00000317683.3
FBXO46
F-box protein 46
chr8_-_62602327 0.18 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr8_+_94752349 0.18 ENST00000391680.1
RBM12B-AS1
RBM12B antisense RNA 1
chr8_+_145203548 0.17 ENST00000534366.1
MROH1
maestro heat-like repeat family member 1
chrX_-_83442915 0.17 ENST00000262752.2
ENST00000543399.1
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr1_-_17338386 0.17 ENST00000341676.5
ENST00000452699.1
ATP13A2
ATPase type 13A2
chr1_-_228604328 0.16 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17
tripartite motif containing 17
chr5_-_58571935 0.16 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_127881325 0.16 ENST00000308868.4
LEP
leptin
chr21_+_45432174 0.16 ENST00000380221.3
ENST00000291574.4
TRAPPC10
trafficking protein particle complex 10
chr1_-_92952433 0.15 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chrX_+_136648297 0.15 ENST00000287538.5
ZIC3
Zic family member 3
chr6_+_32121789 0.15 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr9_-_4299874 0.15 ENST00000381971.3
ENST00000477901.1
GLIS3
GLIS family zinc finger 3
chr2_-_176033066 0.14 ENST00000437522.1
ATF2
activating transcription factor 2
chr8_-_80680078 0.14 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr19_+_39903185 0.14 ENST00000409794.3
PLEKHG2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr8_+_145065521 0.14 ENST00000534791.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr17_+_46048471 0.13 ENST00000578018.1
ENST00000579175.1
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr17_+_46048497 0.13 ENST00000583352.1
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr12_+_7941989 0.13 ENST00000229307.4
NANOG
Nanog homeobox
chr2_+_220379052 0.13 ENST00000347842.3
ENST00000358078.4
ASIC4
acid-sensing (proton-gated) ion channel family member 4
chrX_-_108976449 0.13 ENST00000469857.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr5_+_96077888 0.13 ENST00000509259.1
ENST00000503828.1
CAST
calpastatin
chr7_+_99156249 0.13 ENST00000449244.1
ZNF655
zinc finger protein 655
chr1_-_41487383 0.13 ENST00000302946.8
ENST00000372613.2
ENST00000439569.2
ENST00000397197.2
SLFNL1
schlafen-like 1
chr5_-_146889619 0.13 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chrX_-_153236620 0.12 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr17_+_46048376 0.12 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr5_+_140345820 0.12 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr16_-_58663720 0.12 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr15_+_74911430 0.12 ENST00000562670.1
ENST00000564096.1
CLK3
CDC-like kinase 3
chr8_-_114389353 0.12 ENST00000343508.3
CSMD3
CUB and Sushi multiple domains 3
chrX_-_153236819 0.12 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr8_+_132916318 0.12 ENST00000254624.5
ENST00000522709.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr1_+_178694300 0.12 ENST00000367635.3
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chrX_-_153237258 0.11 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_25451065 0.11 ENST00000606328.1
RP11-458N5.1
RP11-458N5.1
chr1_-_15735925 0.11 ENST00000427824.1
RP3-467K16.4
RP3-467K16.4
chr16_+_2022036 0.11 ENST00000568546.1
TBL3
transducin (beta)-like 3
chr3_+_121311966 0.11 ENST00000338040.4
FBXO40
F-box protein 40
chr17_+_38375528 0.11 ENST00000583268.1
WIPF2
WAS/WASL interacting protein family, member 2
chr15_-_43029252 0.11 ENST00000563260.1
ENST00000356231.3
CDAN1
codanin 1
chr1_+_204485571 0.11 ENST00000454264.2
ENST00000367183.3
MDM4
Mdm4 p53 binding protein homolog (mouse)
chr3_+_4535025 0.11 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr6_-_134373732 0.10 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr17_+_76210367 0.10 ENST00000592734.1
ENST00000587746.1
BIRC5
baculoviral IAP repeat containing 5
chr3_-_11685345 0.10 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr16_+_71929397 0.10 ENST00000537613.1
ENST00000424485.2
ENST00000606369.1
ENST00000329908.8
ENST00000538850.1
ENST00000541918.1
ENST00000534994.1
ENST00000378798.5
ENST00000539186.1
IST1
increased sodium tolerance 1 homolog (yeast)
chr19_+_40477062 0.10 ENST00000455878.2
PSMC4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr17_-_8198636 0.10 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35
solute carrier family 25, member 35
chr2_+_128848740 0.10 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr12_+_13349711 0.10 ENST00000538364.1
ENST00000396301.3
EMP1
epithelial membrane protein 1
chr7_+_99156212 0.10 ENST00000454654.1
ZNF655
zinc finger protein 655
chr11_-_65325430 0.10 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr22_+_35653445 0.10 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr19_-_45748628 0.09 ENST00000590022.1
AC006126.4
AC006126.4
chr19_+_36235964 0.09 ENST00000587708.2
PSENEN
presenilin enhancer gamma secretase subunit
chr19_+_38924316 0.09 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr1_-_68698222 0.09 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr3_+_4535155 0.09 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr8_+_145065705 0.09 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr12_-_54694758 0.09 ENST00000553070.1
NFE2
nuclear factor, erythroid 2
chrX_-_110655306 0.08 ENST00000371993.2
DCX
doublecortin
chr1_+_66999268 0.08 ENST00000371039.1
ENST00000424320.1
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr5_+_140079919 0.08 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr19_+_48972265 0.08 ENST00000452733.2
CYTH2
cytohesin 2
chrX_-_32173579 0.08 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr6_-_71012773 0.08 ENST00000370496.3
ENST00000357250.6
COL9A1
collagen, type IX, alpha 1
chr15_-_44116873 0.08 ENST00000267812.3
MFAP1
microfibrillar-associated protein 1
chr2_-_121223697 0.08 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr19_-_38720354 0.08 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chr1_+_150266256 0.08 ENST00000309092.7
ENST00000369084.5
MRPS21
mitochondrial ribosomal protein S21
chr12_+_6961279 0.07 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5
ubiquitin specific peptidase 5 (isopeptidase T)
chr3_+_19189946 0.07 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr14_-_73360796 0.07 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr11_-_65325203 0.07 ENST00000526927.1
ENST00000536982.1
LTBP3
latent transforming growth factor beta binding protein 3
chr1_-_156051789 0.07 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr6_-_42858534 0.07 ENST00000408925.2
C6orf226
chromosome 6 open reading frame 226
chr5_-_58335281 0.07 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_+_136648643 0.07 ENST00000370606.3
ZIC3
Zic family member 3
chr3_-_16524357 0.07 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr12_+_60058458 0.07 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr16_+_640055 0.07 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chr14_+_67708137 0.07 ENST00000556345.1
ENST00000555925.1
ENST00000557783.1
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr11_+_66512089 0.07 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr3_-_52029958 0.06 ENST00000294189.6
RPL29
ribosomal protein L29
chrX_+_78003204 0.06 ENST00000435339.3
ENST00000514744.1
LPAR4
lysophosphatidic acid receptor 4
chr19_+_1942453 0.06 ENST00000591752.1
CSNK1G2
casein kinase 1, gamma 2
chr1_-_153538292 0.06 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr9_-_7800067 0.06 ENST00000358227.4
TMEM261
transmembrane protein 261
chr17_-_40169429 0.06 ENST00000316603.7
ENST00000588641.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr3_-_52029830 0.06 ENST00000492277.1
ENST00000475248.1
ENST00000479017.1
ENST00000495383.1
ENST00000466397.1
ENST00000481629.1
RPL29
ribosomal protein L29
chr14_-_103989033 0.06 ENST00000553878.1
ENST00000557530.1
CKB
creatine kinase, brain
chr17_-_47492164 0.06 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB
prohibitin
chr6_-_55740352 0.06 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chrX_+_153170455 0.05 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
AVPR2
arginine vasopressin receptor 2
chr17_-_47492236 0.05 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr2_+_99797636 0.05 ENST00000409145.1
MRPL30
mitochondrial ribosomal protein L30
chr14_+_81421861 0.05 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr4_+_55524085 0.05 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr22_-_30925150 0.05 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr2_-_225266802 0.05 ENST00000243806.2
FAM124B
family with sequence similarity 124B
chr1_-_25291475 0.05 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr10_-_98031265 0.05 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr3_+_187930429 0.05 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_+_136289030 0.05 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chrX_+_153170189 0.05 ENST00000358927.2
AVPR2
arginine vasopressin receptor 2
chr16_+_5121814 0.04 ENST00000262374.5
ENST00000586840.1
ALG1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr16_-_67493110 0.04 ENST00000602876.1
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr4_-_54930790 0.04 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr19_+_48972459 0.04 ENST00000427476.1
CYTH2
cytohesin 2
chr12_-_21810765 0.04 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr6_-_75828774 0.04 ENST00000493109.2
COL12A1
collagen, type XII, alpha 1
chr10_-_98031310 0.04 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr7_+_65338230 0.04 ENST00000360768.3
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr14_-_74892805 0.04 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr11_+_22688150 0.04 ENST00000454584.2
GAS2
growth arrest-specific 2
chr16_+_66638567 0.04 ENST00000567572.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr20_-_45142154 0.04 ENST00000347606.4
ENST00000457685.2
ZNF334
zinc finger protein 334
chr15_-_66790146 0.04 ENST00000316634.5
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr12_-_21810726 0.03 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr7_-_24957699 0.03 ENST00000441059.1
ENST00000415162.1
OSBPL3
oxysterol binding protein-like 3
chr16_+_66638003 0.03 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr1_-_41487415 0.03 ENST00000372611.1
SLFNL1
schlafen-like 1
chr17_+_40610862 0.03 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr17_+_26684604 0.03 ENST00000292114.3
ENST00000509083.1
TMEM199
transmembrane protein 199
chr8_-_144679296 0.03 ENST00000317198.6
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr16_+_1359138 0.03 ENST00000325437.5
UBE2I
ubiquitin-conjugating enzyme E2I
chr18_+_72166564 0.03 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr1_-_153518270 0.02 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr6_-_160679905 0.02 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chrX_+_23928500 0.02 ENST00000435707.1
CXorf58
chromosome X open reading frame 58
chr14_+_81421355 0.02 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr1_-_175712665 0.02 ENST00000263525.2
TNR
tenascin R
chr1_-_153599426 0.02 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chr16_-_28222797 0.02 ENST00000569951.1
ENST00000565698.1
XPO6
exportin 6
chr6_+_31554779 0.02 ENST00000376090.2
LST1
leukocyte specific transcript 1
chr17_+_66521936 0.02 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr10_-_129691195 0.02 ENST00000368671.3
CLRN3
clarin 3
chr17_-_37123646 0.02 ENST00000378079.2
FBXO47
F-box protein 47
chr1_-_236445251 0.02 ENST00000354619.5
ENST00000327333.8
ERO1LB
ERO1-like beta (S. cerevisiae)
chr1_+_24019099 0.02 ENST00000443624.1
ENST00000458455.1
RPL11
ribosomal protein L11
chr22_+_24999114 0.02 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr17_+_61571746 0.02 ENST00000579409.1
ACE
angiotensin I converting enzyme
chr1_+_32930647 0.01 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chr1_+_202431859 0.01 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_-_180610767 0.01 ENST00000409343.1
ZNF385B
zinc finger protein 385B
chr14_+_67707826 0.01 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr6_-_137113604 0.01 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr1_-_160232197 0.01 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr20_+_30407105 0.01 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr2_-_225266711 0.01 ENST00000389874.3
FAM124B
family with sequence similarity 124B
chr20_+_30407151 0.01 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr11_-_18813353 0.01 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr11_+_66512303 0.01 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr3_+_32726774 0.01 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr4_+_144354644 0.01 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr4_+_184826418 0.01 ENST00000308497.4
ENST00000438269.1
STOX2
storkhead box 2
chr1_-_153538011 0.00 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chrX_+_131157290 0.00 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:0019046 release from viral latency(GO:0019046)
0.1 0.3 GO:0010966 regulation of phosphate transport(GO:0010966)
0.1 0.2 GO:0007037 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.1 0.2 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.3 GO:0018197 peptidyl-aspartic acid modification(GO:0018197)
0.1 0.3 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.1 0.2 GO:1904729 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729) activation of protein kinase C activity(GO:1990051) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.1 0.5 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.5 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.4 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.2 GO:0097168 mesenchymal stem cell proliferation(GO:0097168) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.0 0.1 GO:0035811 regulation of systemic arterial blood pressure by vasopressin(GO:0001992) negative regulation of urine volume(GO:0035811)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.1 GO:1905069 allantois development(GO:1905069)
0.0 0.1 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.5 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.0 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.3 GO:0031264 death-inducing signaling complex(GO:0031264)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 0.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.6 GO:0008384 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.1 0.5 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996)
0.1 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.5 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.2 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.4 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.4 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D