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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NKX2-3

Z-value: 0.87

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_101292706-0.099.1e-01Click!

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_65266507 1.01 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr3_+_149192475 0.84 ENST00000465758.1
TM4SF4
transmembrane 4 L six family member 4
chr16_-_66952779 0.60 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr3_+_149191723 0.59 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr15_-_56757329 0.55 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr16_-_66952742 0.53 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chrX_+_69509870 0.46 ENST00000374388.3
KIF4A
kinesin family member 4A
chr9_-_116840728 0.43 ENST00000265132.3
AMBP
alpha-1-microglobulin/bikunin precursor
chr5_+_150404904 0.38 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr14_+_94547628 0.37 ENST00000555523.1
IFI27L1
interferon, alpha-inducible protein 27-like 1
chr14_+_100531738 0.36 ENST00000555706.1
EVL
Enah/Vasp-like
chr14_+_100531615 0.35 ENST00000392920.3
EVL
Enah/Vasp-like
chr20_+_32782375 0.35 ENST00000568305.1
ASIP
agouti signaling protein
chr2_-_239198743 0.34 ENST00000440245.1
ENST00000431832.1
PER2
period circadian clock 2
chr16_-_69166031 0.34 ENST00000398235.2
ENST00000520529.1
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr18_-_43684230 0.34 ENST00000592989.1
ENST00000589869.1
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr19_-_17622269 0.33 ENST00000595116.1
CTD-3131K8.2
CTD-3131K8.2
chr18_-_25616519 0.33 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr18_-_53735601 0.32 ENST00000589754.1
CTD-2008L17.2
CTD-2008L17.2
chr4_-_100242549 0.32 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr16_+_53412368 0.32 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr7_-_29186008 0.31 ENST00000396276.3
ENST00000265394.5
CPVL
carboxypeptidase, vitellogenic-like
chr17_+_26662679 0.30 ENST00000578158.1
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr10_-_32345305 0.28 ENST00000302418.4
KIF5B
kinesin family member 5B
chr1_+_205682497 0.28 ENST00000598338.1
AC119673.1
AC119673.1
chr7_-_84569561 0.28 ENST00000439105.1
AC074183.4
AC074183.4
chr7_+_7196565 0.27 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr12_-_52604607 0.27 ENST00000551894.1
ENST00000553017.1
C12orf80
chromosome 12 open reading frame 80
chr11_+_62379194 0.27 ENST00000525801.1
ENST00000534093.1
ROM1
retinal outer segment membrane protein 1
chr6_+_31126291 0.27 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr3_+_30648066 0.26 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr8_+_41386761 0.26 ENST00000523277.2
GINS4
GINS complex subunit 4 (Sld5 homolog)
chr1_-_197036364 0.25 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr19_-_39368887 0.25 ENST00000340740.3
ENST00000591812.1
RINL
Ras and Rab interactor-like
chr10_+_99332198 0.24 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr3_+_57094469 0.24 ENST00000334325.1
SPATA12
spermatogenesis associated 12
chr3_+_30647994 0.24 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr16_+_32264040 0.24 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr20_+_56964253 0.24 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr13_+_50570019 0.23 ENST00000442421.1
TRIM13
tripartite motif containing 13
chr2_+_120687335 0.23 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr2_+_204103663 0.23 ENST00000356079.4
ENST00000429815.2
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr14_+_94547675 0.23 ENST00000393115.3
ENST00000554166.1
ENST00000556381.1
ENST00000553664.1
ENST00000555341.1
ENST00000557218.1
ENST00000554544.1
ENST00000557066.1
IFI27L1
interferon, alpha-inducible protein 27-like 1
chr2_+_114163945 0.23 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr10_-_5227096 0.22 ENST00000488756.1
ENST00000334314.3
AKR1CL1
aldo-keto reductase family 1, member C-like 1
chr19_+_14492217 0.22 ENST00000587606.1
ENST00000586517.1
ENST00000591080.1
CD97
CD97 molecule
chr15_+_40674920 0.22 ENST00000416151.2
ENST00000249776.8
KNSTRN
kinetochore-localized astrin/SPAG5 binding protein
chr10_+_103348031 0.22 ENST00000370151.4
ENST00000370147.1
ENST00000370148.2
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr1_+_43824669 0.22 ENST00000372462.1
CDC20
cell division cycle 20
chr1_+_65613217 0.22 ENST00000545314.1
AK4
adenylate kinase 4
chr13_-_46679144 0.22 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr10_+_1120312 0.22 ENST00000436154.1
WDR37
WD repeat domain 37
chr22_+_44427230 0.21 ENST00000444029.1
PARVB
parvin, beta
chr13_-_46679185 0.21 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr20_-_1317555 0.21 ENST00000537552.1
AL136531.1
HCG2043693; Uncharacterized protein
chr11_+_64950801 0.21 ENST00000526468.1
CAPN1
calpain 1, (mu/I) large subunit
chr16_+_68877496 0.21 ENST00000261778.1
TANGO6
transport and golgi organization 6 homolog (Drosophila)
chr11_-_64856497 0.21 ENST00000524632.1
ENST00000530719.1
AP003068.6
transmembrane protein 262
chr1_-_26633480 0.20 ENST00000450041.1
UBXN11
UBX domain protein 11
chrX_+_153029633 0.20 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr18_-_43684186 0.20 ENST00000590406.1
ENST00000282050.2
ENST00000590324.1
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chrX_-_21776281 0.20 ENST00000379494.3
SMPX
small muscle protein, X-linked
chrX_-_14891150 0.20 ENST00000452869.1
ENST00000398334.1
ENST00000324138.3
FANCB
Fanconi anemia, complementation group B
chr12_+_49761147 0.20 ENST00000549298.1
SPATS2
spermatogenesis associated, serine-rich 2
chr15_-_78369994 0.19 ENST00000300584.3
ENST00000409931.3
TBC1D2B
TBC1 domain family, member 2B
chr18_+_72166564 0.19 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr11_-_62342375 0.19 ENST00000378019.3
EEF1G
eukaryotic translation elongation factor 1 gamma
chr4_+_76439649 0.18 ENST00000507557.1
THAP6
THAP domain containing 6
chr6_+_36562132 0.18 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr17_+_38444115 0.18 ENST00000580824.1
ENST00000577249.1
CDC6
cell division cycle 6
chr22_-_37584321 0.18 ENST00000397110.2
ENST00000337843.2
C1QTNF6
C1q and tumor necrosis factor related protein 6
chr12_+_116985896 0.17 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr5_+_138210919 0.17 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr11_-_46638720 0.17 ENST00000326737.3
HARBI1
harbinger transposase derived 1
chr1_-_26633067 0.17 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
UBXN11
UBX domain protein 11
chr22_+_45714672 0.16 ENST00000424557.1
FAM118A
family with sequence similarity 118, member A
chr7_+_56032652 0.16 ENST00000437587.1
GBAS
glioblastoma amplified sequence
chr10_-_70092671 0.16 ENST00000358769.2
ENST00000432941.1
ENST00000495025.2
PBLD
phenazine biosynthesis-like protein domain containing
chr1_-_165668100 0.16 ENST00000354775.4
ALDH9A1
aldehyde dehydrogenase 9 family, member A1
chr3_+_124223586 0.16 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr1_+_174670143 0.16 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr19_+_15751689 0.16 ENST00000586182.2
ENST00000591058.1
ENST00000221307.8
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr9_+_116263778 0.15 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr12_+_48178706 0.15 ENST00000599515.1
AC004466.1
Uncharacterized protein
chr2_+_64069240 0.15 ENST00000497883.1
UGP2
UDP-glucose pyrophosphorylase 2
chr22_+_45714361 0.15 ENST00000452238.1
FAM118A
family with sequence similarity 118, member A
chr3_-_123512688 0.15 ENST00000475616.1
MYLK
myosin light chain kinase
chr12_+_41136144 0.15 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr2_+_90458201 0.15 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr11_-_62607036 0.15 ENST00000311713.7
ENST00000278856.4
WDR74
WD repeat domain 74
chr12_+_111051902 0.15 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chr3_-_131753830 0.15 ENST00000429747.1
CPNE4
copine IV
chr1_+_65613340 0.15 ENST00000546702.1
AK4
adenylate kinase 4
chr2_+_204103733 0.15 ENST00000443941.1
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr5_+_162930114 0.14 ENST00000280969.5
MAT2B
methionine adenosyltransferase II, beta
chr19_+_14492247 0.14 ENST00000357355.3
ENST00000592261.2
ENST00000242786.5
CD97
CD97 molecule
chr2_+_132044330 0.14 ENST00000416266.1
CYP4F31P
cytochrome P450, family 4, subfamily F, polypeptide 31, pseudogene
chr6_-_111927062 0.14 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr2_-_172291273 0.14 ENST00000442778.1
ENST00000453846.1
METTL8
methyltransferase like 8
chr5_-_159846066 0.14 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chr14_+_36295638 0.14 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr10_+_13203543 0.14 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr1_-_68962805 0.14 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr1_+_174669653 0.14 ENST00000325589.5
RABGAP1L
RAB GTPase activating protein 1-like
chrX_-_49121165 0.14 ENST00000376207.4
ENST00000376199.2
FOXP3
forkhead box P3
chr1_+_158901329 0.13 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr7_-_67162002 0.13 ENST00000420758.1
RP4-736H5.3
RP4-736H5.3
chr2_+_64073187 0.13 ENST00000491621.1
UGP2
UDP-glucose pyrophosphorylase 2
chr2_+_64069459 0.13 ENST00000445915.2
ENST00000475462.1
UGP2
UDP-glucose pyrophosphorylase 2
chr4_-_100212132 0.13 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr10_+_135207598 0.13 ENST00000477902.2
MTG1
mitochondrial ribosome-associated GTPase 1
chr9_+_135906076 0.13 ENST00000372097.5
ENST00000440319.1
GTF3C5
general transcription factor IIIC, polypeptide 5, 63kDa
chr2_+_161993465 0.13 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr4_-_104021009 0.13 ENST00000509245.1
ENST00000296424.4
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr14_-_90798273 0.13 ENST00000357904.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr7_+_6071007 0.13 ENST00000409061.1
ANKRD61
ankyrin repeat domain 61
chr5_-_180688105 0.12 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr5_-_38557561 0.12 ENST00000511561.1
LIFR
leukemia inhibitory factor receptor alpha
chr11_+_35211429 0.12 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr12_-_120315074 0.12 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr1_+_168195229 0.12 ENST00000271375.4
ENST00000367825.3
SFT2D2
SFT2 domain containing 2
chr1_+_109632425 0.12 ENST00000338272.8
TMEM167B
transmembrane protein 167B
chr4_-_46911223 0.12 ENST00000396533.1
COX7B2
cytochrome c oxidase subunit VIIb2
chr15_+_43477580 0.12 ENST00000356633.5
CCNDBP1
cyclin D-type binding-protein 1
chr2_-_38303218 0.12 ENST00000407341.1
ENST00000260630.3
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr22_+_25202232 0.12 ENST00000400358.4
ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr15_+_67841330 0.12 ENST00000354498.5
MAP2K5
mitogen-activated protein kinase kinase 5
chr17_-_41132410 0.11 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr11_+_120195992 0.11 ENST00000314475.2
ENST00000529187.1
TMEM136
transmembrane protein 136
chr6_-_144329531 0.11 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr11_-_75017734 0.11 ENST00000532525.1
ARRB1
arrestin, beta 1
chr3_+_113775576 0.11 ENST00000485050.1
ENST00000281273.4
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr12_+_79371565 0.11 ENST00000551304.1
SYT1
synaptotagmin I
chr2_+_234590556 0.11 ENST00000373426.3
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr17_+_53345080 0.11 ENST00000572002.1
HLF
hepatic leukemia factor
chr12_+_111051832 0.11 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr10_+_99332529 0.11 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr7_-_86849883 0.11 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr2_-_54197915 0.11 ENST00000404125.1
PSME4
proteasome (prosome, macropain) activator subunit 4
chr10_-_13523073 0.11 ENST00000440282.1
BEND7
BEN domain containing 7
chr5_+_156693091 0.10 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr17_-_8059638 0.10 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr9_-_39239171 0.10 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr9_+_131447342 0.10 ENST00000409104.3
SET
SET nuclear oncogene
chr16_-_79804394 0.10 ENST00000567993.1
RP11-345M22.2
RP11-345M22.2
chr15_+_58702742 0.10 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr5_-_114631958 0.10 ENST00000395557.4
CCDC112
coiled-coil domain containing 112
chr2_+_71357744 0.10 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr20_+_56964169 0.10 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr11_-_71753188 0.10 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr12_-_131478468 0.10 ENST00000536673.1
ENST00000542980.1
RP11-76C10.5
RP11-76C10.5
chr17_+_75401152 0.10 ENST00000585930.1
SEPT9
septin 9
chr17_+_53344945 0.10 ENST00000575345.1
HLF
hepatic leukemia factor
chr12_+_56546363 0.10 ENST00000551834.1
ENST00000552568.1
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr2_+_64068844 0.10 ENST00000337130.5
UGP2
UDP-glucose pyrophosphorylase 2
chr1_-_240775447 0.10 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr14_-_69262947 0.10 ENST00000557086.1
ZFP36L1
ZFP36 ring finger protein-like 1
chr18_-_33702078 0.10 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr12_-_122296755 0.10 ENST00000289004.4
HPD
4-hydroxyphenylpyruvate dioxygenase
chr3_-_47950745 0.10 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr13_-_45048386 0.10 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chrX_-_106362013 0.10 ENST00000372487.1
ENST00000372479.3
ENST00000203616.8
RBM41
RNA binding motif protein 41
chr4_-_156297919 0.10 ENST00000450097.1
MAP9
microtubule-associated protein 9
chr6_+_8652370 0.10 ENST00000503668.1
HULC
hepatocellular carcinoma up-regulated long non-coding RNA
chr18_-_64271363 0.09 ENST00000262150.2
CDH19
cadherin 19, type 2
chr10_+_116697946 0.09 ENST00000298746.3
TRUB1
TruB pseudouridine (psi) synthase family member 1
chr10_+_27793197 0.09 ENST00000356940.6
ENST00000535776.1
RAB18
RAB18, member RAS oncogene family
chr11_+_28131821 0.09 ENST00000379199.2
ENST00000303459.6
METTL15
methyltransferase like 15
chr4_-_84035905 0.09 ENST00000311507.4
PLAC8
placenta-specific 8
chr7_-_38948774 0.09 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr7_+_1609765 0.09 ENST00000437964.1
ENST00000533935.1
ENST00000532358.1
ENST00000524978.1
PSMG3-AS1
PSMG3 antisense RNA 1 (head to head)
chr1_+_202317855 0.09 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr12_-_104532062 0.09 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr21_-_46131470 0.09 ENST00000323084.4
TSPEAR
thrombospondin-type laminin G domain and EAR repeats
chr14_-_21516590 0.09 ENST00000555026.1
NDRG2
NDRG family member 2
chr10_-_76868931 0.09 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr18_+_43684298 0.09 ENST00000282058.6
HAUS1
HAUS augmin-like complex, subunit 1
chr5_-_132200477 0.09 ENST00000296875.2
GDF9
growth differentiation factor 9
chr10_-_73976884 0.09 ENST00000317126.4
ENST00000545550.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr19_+_33865218 0.09 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr1_-_35325318 0.08 ENST00000423898.1
ENST00000456842.1
SMIM12
small integral membrane protein 12
chr14_+_55494323 0.08 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr4_-_84035868 0.08 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chr14_-_45252031 0.08 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr3_-_122134882 0.08 ENST00000330689.4
WDR5B
WD repeat domain 5B
chr5_-_54988448 0.08 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr19_+_14491948 0.08 ENST00000358600.3
CD97
CD97 molecule
chr12_-_122711968 0.08 ENST00000485724.1
DIABLO
diablo, IAP-binding mitochondrial protein
chr4_-_141677267 0.08 ENST00000442267.2
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr1_+_230193521 0.08 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr4_+_146403912 0.08 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1
SMAD family member 1
chr9_-_99382065 0.08 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr7_+_134430212 0.08 ENST00000436461.2
CALD1
caldesmon 1
chr16_-_2031464 0.08 ENST00000356120.4
ENST00000354249.4
NOXO1
NADPH oxidase organizer 1
chr1_+_110091189 0.08 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr4_+_128802016 0.08 ENST00000270861.5
ENST00000515069.1
ENST00000513090.1
ENST00000507249.1
PLK4
polo-like kinase 4
chr3_+_186743261 0.08 ENST00000423451.1
ENST00000446170.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_46806452 0.07 ENST00000536062.1
NSUN4
NOP2/Sun domain family, member 4
chrX_-_134049233 0.07 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chr3_-_42623805 0.07 ENST00000456515.1
SEC22C
SEC22 vesicle trafficking protein homolog C (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 0.4 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.3 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.2 GO:1902744 negative regulation of lamellipodium assembly(GO:0010593) negative regulation of lamellipodium organization(GO:1902744)
0.1 0.3 GO:0019249 lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 0.3 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.3 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.1 0.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0002669 tolerance induction dependent upon immune response(GO:0002461) positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.2 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.3 GO:2000809 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.4 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0036100 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.0 0.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.3 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.4 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.1 GO:1903939 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.1 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 1.4 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 0.5 GO:0019184 nonribosomal peptide biosynthetic process(GO:0019184)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 0.5 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.5 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019862 IgA binding(GO:0019862)
0.1 0.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.3 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.5 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.3 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1 0.4 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1 0.4 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.2 GO:0052871 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.1 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.2 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.1 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.7 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0048257 3'-flap endonuclease activity(GO:0048257)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA