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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NKX6-2

Z-value: 1.36

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.6 NK6 homeobox 2

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_74686314 1.28 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr1_+_229440129 1.13 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr2_-_228244013 1.13 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr5_+_31193847 1.06 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_-_200379180 0.94 ENST00000294740.3
ZNF281
zinc finger protein 281
chr1_+_85527987 0.83 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr16_+_53483983 0.81 ENST00000544545.1
RBL2
retinoblastoma-like 2 (p130)
chr12_-_122241812 0.79 ENST00000538335.1
AC084018.1
AC084018.1
chr17_-_57232596 0.76 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr2_+_179318295 0.76 ENST00000442710.1
DFNB59
deafness, autosomal recessive 59
chr7_-_92146729 0.71 ENST00000541751.1
PEX1
peroxisomal biogenesis factor 1
chr4_+_113568207 0.71 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr4_+_169418195 0.70 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr13_+_27844464 0.70 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr16_+_70695570 0.69 ENST00000597002.1
FLJ00418
FLJ00418
chr4_+_95174445 0.69 ENST00000509418.1
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr6_-_160209471 0.69 ENST00000539948.1
TCP1
t-complex 1
chr4_-_23891693 0.67 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr17_+_57233087 0.66 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr17_-_57232525 0.65 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr2_+_200472779 0.64 ENST00000427045.1
ENST00000419243.1
AC093590.1
AC093590.1
chr19_+_52772832 0.63 ENST00000593703.1
ENST00000601711.1
ENST00000599581.1
ZNF766
zinc finger protein 766
chr9_-_77643307 0.62 ENST00000376834.3
ENST00000376830.3
C9orf41
chromosome 9 open reading frame 41
chr8_+_42873548 0.60 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr8_-_103876965 0.60 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr20_-_7921090 0.59 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr10_-_71169031 0.57 ENST00000373307.1
TACR2
tachykinin receptor 2
chr12_+_28410128 0.57 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr4_+_54927213 0.56 ENST00000595906.1
AC110792.1
HCG2027126; Uncharacterized protein
chr5_+_68513622 0.54 ENST00000512880.1
ENST00000602380.1
MRPS36
mitochondrial ribosomal protein S36
chr17_+_57232690 0.54 ENST00000262293.4
PRR11
proline rich 11
chr7_-_111032971 0.54 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chrX_-_80457385 0.53 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr1_-_221915418 0.53 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr15_+_69857515 0.51 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr18_+_72922710 0.50 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr3_-_98241358 0.50 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr6_-_116833500 0.50 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr12_-_94673956 0.50 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr10_-_75168071 0.48 ENST00000394847.3
ANXA7
annexin A7
chr5_+_95066823 0.48 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr4_+_55095428 0.48 ENST00000508170.1
ENST00000512143.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr1_-_200379129 0.47 ENST00000367353.1
ZNF281
zinc finger protein 281
chr11_-_8892900 0.47 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr7_-_140482926 0.46 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr1_+_196621002 0.45 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr2_-_191115229 0.45 ENST00000409820.2
ENST00000410045.1
HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr19_+_52772821 0.44 ENST00000439461.1
ZNF766
zinc finger protein 766
chr4_-_110723194 0.44 ENST00000394635.3
CFI
complement factor I
chr8_+_26150628 0.44 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr9_+_130026756 0.41 ENST00000314904.5
ENST00000373387.4
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr1_+_149858461 0.41 ENST00000331380.2
HIST2H2AC
histone cluster 2, H2ac
chr12_+_72061563 0.40 ENST00000551238.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr15_+_93443419 0.40 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr12_-_76462713 0.40 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr17_-_56494882 0.38 ENST00000584437.1
RNF43
ring finger protein 43
chr1_+_145477060 0.38 ENST00000369308.3
LIX1L
Lix1 homolog (mouse)-like
chr10_-_115904361 0.38 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr10_-_14574705 0.37 ENST00000489100.1
FAM107B
family with sequence similarity 107, member B
chr15_-_49103235 0.37 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr14_-_98444461 0.36 ENST00000499006.2
C14orf64
chromosome 14 open reading frame 64
chr1_-_243326612 0.36 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr17_-_56494908 0.35 ENST00000577716.1
RNF43
ring finger protein 43
chr19_-_49220084 0.35 ENST00000595591.1
ENST00000356751.4
ENST00000594582.1
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr10_-_63995871 0.34 ENST00000315289.2
RTKN2
rhotekin 2
chr2_+_211342432 0.34 ENST00000430249.2
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr20_+_57467204 0.34 ENST00000603546.1
GNAS
GNAS complex locus
chr18_+_61575200 0.33 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr18_+_76829441 0.33 ENST00000458297.2
ATP9B
ATPase, class II, type 9B
chr16_+_31271274 0.33 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr3_-_141747459 0.33 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_-_49103184 0.32 ENST00000399334.3
ENST00000325747.5
CEP152
centrosomal protein 152kDa
chr4_-_25865159 0.32 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr8_+_92114873 0.32 ENST00000343709.3
ENST00000448384.2
LRRC69
leucine rich repeat containing 69
chrX_+_55744228 0.30 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr22_-_33968239 0.30 ENST00000452586.2
ENST00000421768.1
LARGE
like-glycosyltransferase
chr14_+_77582905 0.30 ENST00000557408.1
TMEM63C
transmembrane protein 63C
chr2_-_136678123 0.29 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr5_-_111091948 0.29 ENST00000447165.2
NREP
neuronal regeneration related protein
chr21_-_36421401 0.29 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr3_-_79816965 0.28 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr20_-_18477862 0.28 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr5_+_145316120 0.28 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr2_-_74570520 0.28 ENST00000394019.2
ENST00000346834.4
ENST00000359484.4
ENST00000423644.1
ENST00000377634.4
ENST00000436454.1
SLC4A5
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr6_-_33864684 0.27 ENST00000506222.2
ENST00000533304.1
LINC01016
long intergenic non-protein coding RNA 1016
chr14_+_24407940 0.27 ENST00000354854.1
DHRS4-AS1
DHRS4-AS1
chr6_+_42749759 0.27 ENST00000314073.5
GLTSCR1L
GLTSCR1-like
chr6_-_113953705 0.26 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr8_+_76452097 0.26 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr1_-_150849208 0.26 ENST00000358595.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr11_+_100558384 0.26 ENST00000524892.2
ENST00000298815.8
ARHGAP42
Rho GTPase activating protein 42
chr2_+_172309634 0.25 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr2_+_108994466 0.25 ENST00000272452.2
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr6_+_12290586 0.24 ENST00000379375.5
EDN1
endothelin 1
chr7_-_37024665 0.24 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr6_+_3259122 0.24 ENST00000438998.2
ENST00000380305.4
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr18_+_76829385 0.24 ENST00000426216.2
ENST00000307671.7
ENST00000586672.1
ENST00000586722.1
ATP9B
ATPase, class II, type 9B
chr7_-_77325545 0.24 ENST00000447009.1
ENST00000416650.1
ENST00000440088.1
ENST00000430801.1
ENST00000398043.2
RSBN1L-AS1
RSBN1L antisense RNA 1
chr2_-_175712270 0.23 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr8_+_97597148 0.23 ENST00000521590.1
SDC2
syndecan 2
chr17_-_40829026 0.22 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr5_-_159546396 0.22 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr6_-_64029879 0.22 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr9_-_71869642 0.22 ENST00000600472.1
AL358113.1
Tight junction protein 2 (Zona occludens 2) isoform 1 variant; Uncharacterized protein
chr17_-_40828969 0.21 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_+_180601139 0.21 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr22_+_24198890 0.20 ENST00000345044.6
SLC2A11
solute carrier family 2 (facilitated glucose transporter), member 11
chr14_-_51027838 0.20 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr11_-_31531121 0.19 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr16_+_21610879 0.19 ENST00000396014.4
METTL9
methyltransferase like 9
chr14_+_76776957 0.19 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr1_+_156095951 0.19 ENST00000448611.2
ENST00000368297.1
LMNA
lamin A/C
chr12_-_28124903 0.18 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr11_+_57529234 0.18 ENST00000360682.6
ENST00000361796.4
ENST00000529526.1
ENST00000426142.2
ENST00000399050.4
ENST00000361391.6
ENST00000361332.4
ENST00000532463.1
ENST00000529986.1
ENST00000358694.6
ENST00000532787.1
ENST00000533667.1
ENST00000532649.1
ENST00000528621.1
ENST00000530748.1
ENST00000428599.2
ENST00000527467.1
ENST00000528232.1
ENST00000531014.1
ENST00000526772.1
ENST00000529873.1
ENST00000525902.1
ENST00000532844.1
ENST00000526357.1
ENST00000530094.1
ENST00000415361.2
ENST00000532245.1
ENST00000534579.1
ENST00000526938.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr6_-_26199499 0.18 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr1_+_201617450 0.18 ENST00000295624.6
ENST00000367297.4
ENST00000367300.3
NAV1
neuron navigator 1
chr9_-_110540419 0.18 ENST00000398726.3
AL162389.1
Uncharacterized protein
chr7_-_107880508 0.18 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr19_+_48112371 0.17 ENST00000594866.1
GLTSCR1
glioma tumor suppressor candidate region gene 1
chr3_-_138048682 0.17 ENST00000383180.2
NME9
NME/NM23 family member 9
chr1_+_110993795 0.17 ENST00000271331.3
PROK1
prokineticin 1
chr7_+_77325738 0.17 ENST00000334955.8
RSBN1L
round spermatid basic protein 1-like
chr17_-_56494713 0.17 ENST00000407977.2
RNF43
ring finger protein 43
chr4_+_77356248 0.16 ENST00000296043.6
SHROOM3
shroom family member 3
chr2_-_208030886 0.16 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_+_11864458 0.16 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr22_-_29137771 0.15 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr9_-_26892342 0.15 ENST00000535437.1
CAAP1
caspase activity and apoptosis inhibitor 1
chr10_+_123951957 0.15 ENST00000514539.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr10_-_94257512 0.14 ENST00000371581.5
IDE
insulin-degrading enzyme
chr5_+_7373230 0.14 ENST00000500616.2
CTD-2296D1.5
CTD-2296D1.5
chr16_+_19422035 0.13 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chrX_+_55744166 0.13 ENST00000374941.4
ENST00000414239.1
RRAGB
Ras-related GTP binding B
chr4_+_74269956 0.13 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr1_+_244515930 0.13 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr1_+_174670143 0.13 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr14_+_88852059 0.12 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr1_-_174992544 0.12 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chr21_-_36421535 0.11 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr16_+_84801852 0.11 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chr21_-_36421626 0.11 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr14_-_64804814 0.11 ENST00000554572.1
ENST00000358599.5
ESR2
estrogen receptor 2 (ER beta)
chr13_+_97928395 0.11 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr7_+_16700806 0.11 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr1_-_17766198 0.10 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr17_-_67057047 0.10 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_+_32379174 0.10 ENST00000391369.1
AL136115.1
HCG2032337; PRO1848; Uncharacterized protein
chr7_-_112635675 0.10 ENST00000447785.1
ENST00000451962.1
AC018464.3
AC018464.3
chr15_+_49715293 0.10 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr7_+_77469439 0.10 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr12_+_54422142 0.09 ENST00000243108.4
HOXC6
homeobox C6
chr4_-_40477766 0.09 ENST00000507180.1
RBM47
RNA binding motif protein 47
chr6_-_26199471 0.09 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr18_-_10701979 0.09 ENST00000538948.1
ENST00000285141.4
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr3_+_169539710 0.08 ENST00000340806.6
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr2_+_218990727 0.08 ENST00000318507.2
ENST00000454148.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr6_+_12007897 0.08 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr2_-_208030295 0.08 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_+_211342400 0.08 ENST00000417946.1
ENST00000518043.1
ENST00000523702.1
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_80247140 0.07 ENST00000392959.1
ENST00000467898.3
LCA5
Leber congenital amaurosis 5
chr8_+_104831554 0.07 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_109685630 0.07 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr5_-_150727111 0.07 ENST00000335244.4
ENST00000521967.1
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr16_-_67517716 0.07 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr7_-_102184083 0.07 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr14_-_27066960 0.07 ENST00000539517.2
NOVA1
neuro-oncological ventral antigen 1
chr8_+_104831440 0.06 ENST00000515551.1
RIMS2
regulating synaptic membrane exocytosis 2
chr19_+_45394477 0.06 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_210501589 0.06 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr1_+_244624678 0.06 ENST00000366534.4
ENST00000366533.4
ENST00000428042.1
ENST00000366531.3
C1orf101
chromosome 1 open reading frame 101
chr1_+_78383813 0.06 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr1_-_226926864 0.06 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr6_-_80247105 0.06 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr2_-_65593784 0.06 ENST00000443619.2
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_-_150849174 0.06 ENST00000515192.1
ARNT
aryl hydrocarbon receptor nuclear translocator
chr7_-_102283238 0.05 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr16_-_80926457 0.05 ENST00000563626.1
ENST00000562231.1
RP11-314O13.1
RP11-314O13.1
chr8_+_79428539 0.05 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr14_-_27066636 0.05 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
NOVA1
neuro-oncological ventral antigen 1
chrX_+_134887233 0.05 ENST00000443882.1
CT45A3
cancer/testis antigen family 45, member A3
chr5_+_67586465 0.05 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr2_+_68962014 0.05 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr12_+_32655110 0.05 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr22_+_29138013 0.05 ENST00000216027.3
ENST00000398941.2
HSCB
HscB mitochondrial iron-sulfur cluster co-chaperone
chr4_-_87374330 0.04 ENST00000511328.1
ENST00000503911.1
MAPK10
mitogen-activated protein kinase 10
chr14_-_75530693 0.04 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr3_+_130650738 0.04 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr4_-_185139062 0.04 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr1_+_201617264 0.04 ENST00000367296.4
NAV1
neuron navigator 1
chr10_+_26505179 0.04 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr6_-_74231444 0.04 ENST00000331523.2
ENST00000356303.2
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr7_+_150065278 0.03 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr4_-_87374283 0.03 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr7_-_22233442 0.03 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr3_-_141747439 0.03 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr18_-_52989217 0.03 ENST00000570287.2
TCF4
transcription factor 4
chr12_+_32655048 0.02 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_170115142 0.02 ENST00000439373.2
METTL11B
methyltransferase like 11B
chr16_+_89228757 0.02 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr18_-_12656715 0.02 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.2 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 0.7 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 0.7 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.6 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 0.6 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.1 0.4 GO:0070408 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.1 0.5 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.5 GO:0060023 soft palate development(GO:0060023)
0.1 0.3 GO:1904640 positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640)
0.1 0.7 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.6 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.2 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.1 0.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.3 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.2 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 1.4 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:0001897 cytolysis by symbiont of host cells(GO:0001897)
0.0 0.4 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.3 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.2 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.6 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.3 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.2 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.7 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.5 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.5 GO:0009651 response to salt stress(GO:0009651)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 1.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.1 0.6 GO:0070695 FHF complex(GO:0070695)
0.1 1.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0044297 cell body(GO:0044297)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.6 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.4 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.6 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.2 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0048156 tau protein binding(GO:0048156)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint