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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NKX6-3

Z-value: 0.43

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41508855_41508855-0.415.9e-01Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_44550441 0.82 ENST00000420756.1
ENST00000444696.1
PREPL
prolyl endopeptidase-like
chr17_-_64225508 0.61 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_+_43515467 0.53 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr14_+_88851874 0.24 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chr3_+_138340067 0.22 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr20_-_7921090 0.22 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr21_-_39705323 0.21 ENST00000436845.1
AP001422.3
AP001422.3
chr10_-_27529486 0.19 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr18_+_20494078 0.19 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
RBBP8
retinoblastoma binding protein 8
chr17_+_4692230 0.17 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr5_-_142780280 0.17 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_+_130339710 0.16 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr12_-_94673956 0.16 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr7_+_138145076 0.16 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr15_+_93443419 0.14 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr4_+_80584903 0.14 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr3_+_136649311 0.14 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr14_+_67831576 0.13 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr9_+_125133315 0.12 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr18_+_32558380 0.12 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_+_66820058 0.08 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr18_+_32558208 0.08 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr14_+_88852059 0.08 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr14_-_51027838 0.07 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_151431909 0.07 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr9_+_124329336 0.06 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr1_-_151431647 0.05 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr19_+_50016610 0.03 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chrX_-_130423200 0.03 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr21_-_35796241 0.02 ENST00000450895.1
AP000322.53
AP000322.53
chr13_-_81801115 0.02 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr9_-_215744 0.02 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr16_-_67517716 0.01 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr8_+_77593474 0.01 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr4_+_76481258 0.00 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr1_-_151431674 0.00 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.2 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.5 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.8 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.0 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle