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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 1.33

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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1

Gene Symbol Gene ID Gene Info
NOTO
ENSG00000214513.3 notochord homeobox
VSX2
ENSG00000119614.2 visual system homeobox 2
DLX2
ENSG00000115844.6 distal-less homeobox 2
DLX6
ENSG00000006377.9 distal-less homeobox 6
NKX6-1
ENSG00000163623.5 NK6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX6hg19_v2_chr7_+_96635277_96635301-0.891.1e-01Click!
NKX6-1hg19_v2_chr4_-_85418103_854181030.693.1e-01Click!
DLX2hg19_v2_chr2_-_172967621_172967637-0.425.8e-01Click!
NOTOhg19_v2_chr2_+_73429386_734293860.178.3e-01Click!

Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_37051798 2.58 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr7_-_92777606 1.53 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr11_-_33913708 1.48 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_+_129015484 1.48 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr15_+_80351910 1.44 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr17_-_71223839 1.38 ENST00000579872.1
ENST00000580032.1
FAM104A
family with sequence similarity 104, member A
chr8_-_42234745 1.32 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr17_-_78450398 1.25 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr6_-_31107127 1.11 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr17_+_56833184 1.09 ENST00000308249.2
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr9_-_16276311 1.00 ENST00000380685.1
C9orf92
chromosome 9 open reading frame 92
chr3_+_173116225 0.96 ENST00000457714.1
NLGN1
neuroligin 1
chr5_-_126409159 0.96 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr3_-_157824292 0.96 ENST00000483851.2
SHOX2
short stature homeobox 2
chr5_+_174151536 0.95 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr2_+_66918558 0.95 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr11_+_35222629 0.86 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr7_+_129015671 0.81 ENST00000466993.1
AHCYL2
adenosylhomocysteinase-like 2
chr13_-_46716969 0.80 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_128231299 0.78 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr3_-_108248169 0.77 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr8_-_139926236 0.77 ENST00000303045.6
ENST00000435777.1
COL22A1
collagen, type XXII, alpha 1
chr14_-_36988882 0.74 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr1_-_190446759 0.73 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr17_-_39203519 0.71 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr12_-_16761007 0.69 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_169013666 0.68 ENST00000359299.3
ANXA10
annexin A10
chr12_+_52695617 0.67 ENST00000293525.5
KRT86
keratin 86
chr11_-_8290263 0.66 ENST00000428101.2
LMO1
LIM domain only 1 (rhombotin 1)
chr12_-_30887948 0.66 ENST00000433722.2
CAPRIN2
caprin family member 2
chr17_-_38928414 0.65 ENST00000335552.4
KRT26
keratin 26
chr14_+_61654271 0.63 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
PRKCH
protein kinase C, eta
chr12_+_78359999 0.62 ENST00000550503.1
NAV3
neuron navigator 3
chr5_-_141030943 0.61 ENST00000522783.1
ENST00000519800.1
ENST00000435817.2
FCHSD1
FCH and double SH3 domains 1
chr6_+_131571535 0.60 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr13_-_36050819 0.59 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr2_+_234826016 0.59 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr11_-_121986923 0.56 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr19_-_7697857 0.53 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr12_-_16760195 0.52 ENST00000546281.1
ENST00000537757.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_210444142 0.52 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chrX_-_18690210 0.52 ENST00000379984.3
RS1
retinoschisin 1
chr4_-_41884620 0.51 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chrX_-_133792480 0.49 ENST00000359237.4
PLAC1
placenta-specific 1
chr1_+_74701062 0.49 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr12_+_54378849 0.48 ENST00000515593.1
HOXC10
homeobox C10
chr9_-_16253112 0.47 ENST00000380683.1
C9orf92
chromosome 9 open reading frame 92
chrX_-_106243294 0.47 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr14_+_72052983 0.47 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr22_+_39101728 0.45 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr5_-_24645078 0.45 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr4_-_89205705 0.45 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr20_-_60294804 0.45 ENST00000317652.1
RP11-429E11.3
Uncharacterized protein
chr13_-_95131923 0.44 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr2_-_182545603 0.44 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr20_+_42136308 0.44 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr14_+_101295638 0.43 ENST00000523671.2
MEG3
maternally expressed 3 (non-protein coding)
chr18_-_31803435 0.43 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chr7_+_37723336 0.43 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr14_-_101295407 0.42 ENST00000596284.1
AL117190.2
AL117190.2
chr2_-_203735586 0.42 ENST00000454326.1
ENST00000432273.1
ENST00000450143.1
ENST00000411681.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr6_+_55192267 0.42 ENST00000340465.2
GFRAL
GDNF family receptor alpha like
chr12_-_89746264 0.41 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr2_-_145188137 0.41 ENST00000440875.1
ZEB2
zinc finger E-box binding homeobox 2
chrX_-_110655306 0.41 ENST00000371993.2
DCX
doublecortin
chr3_-_141747950 0.39 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_92952433 0.39 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr6_+_151646800 0.39 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_56110859 0.38 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr8_+_92261516 0.37 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr11_-_115127611 0.37 ENST00000545094.1
CADM1
cell adhesion molecule 1
chrX_-_73512177 0.37 ENST00000603672.1
ENST00000418855.1
FTX
FTX transcript, XIST regulator (non-protein coding)
chr18_+_32173276 0.37 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr14_-_98444386 0.37 ENST00000556462.1
ENST00000556138.1
C14orf64
chromosome 14 open reading frame 64
chr15_+_91411810 0.36 ENST00000268171.3
FURIN
furin (paired basic amino acid cleaving enzyme)
chr1_+_225600404 0.35 ENST00000366845.2
AC092811.1
AC092811.1
chr14_-_54425475 0.34 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr3_-_114790179 0.34 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr22_+_46449674 0.33 ENST00000381051.2
FLJ27365
hsa-mir-4763
chr12_-_58135903 0.32 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr4_-_74486347 0.32 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr16_+_69139467 0.32 ENST00000569188.1
HAS3
hyaluronan synthase 3
chr1_+_168250194 0.32 ENST00000367821.3
TBX19
T-box 19
chr11_+_4470525 0.31 ENST00000325719.4
OR52K2
olfactory receptor, family 52, subfamily K, member 2
chr16_+_69345243 0.31 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chrX_+_135252050 0.31 ENST00000449474.1
ENST00000345434.3
FHL1
four and a half LIM domains 1
chr15_+_67390920 0.31 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chrX_+_135251783 0.31 ENST00000394153.2
FHL1
four and a half LIM domains 1
chr17_-_46690839 0.30 ENST00000498634.2
HOXB8
homeobox B8
chr7_-_14028488 0.30 ENST00000405358.4
ETV1
ets variant 1
chr11_-_16419067 0.30 ENST00000533411.1
SOX6
SRY (sex determining region Y)-box 6
chr8_+_77593448 0.30 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr10_-_21186144 0.30 ENST00000377119.1
NEBL
nebulette
chr7_-_99716952 0.30 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr16_+_22501658 0.30 ENST00000415833.2
NPIPB5
nuclear pore complex interacting protein family, member B5
chr12_+_19358192 0.30 ENST00000538305.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr2_-_99871570 0.30 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr2_+_210443993 0.29 ENST00000392193.1
MAP2
microtubule-associated protein 2
chr7_-_99717463 0.29 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr11_+_65554493 0.29 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr15_+_80351977 0.29 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chrM_+_10758 0.28 ENST00000361381.2
MT-ND4
mitochondrially encoded NADH dehydrogenase 4
chr1_+_206557366 0.28 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr12_-_52761262 0.28 ENST00000257901.3
KRT85
keratin 85
chrX_-_13835147 0.28 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr4_-_184243561 0.28 ENST00000514470.1
ENST00000541814.1
CLDN24
claudin 24
chrX_-_106243451 0.28 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr5_-_1882858 0.28 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr5_+_66300464 0.27 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_66796401 0.27 ENST00000528771.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_71457970 0.27 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chr4_+_41614720 0.27 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr8_-_49833978 0.27 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr3_-_157221357 0.27 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr7_-_107642348 0.27 ENST00000393561.1
LAMB1
laminin, beta 1
chr12_-_6233828 0.27 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr1_-_150738261 0.27 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr1_-_232598163 0.26 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr7_-_20826504 0.26 ENST00000418710.2
ENST00000361443.4
SP8
Sp8 transcription factor
chr2_-_70780770 0.26 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
TGFA
transforming growth factor, alpha
chr1_-_109399682 0.26 ENST00000369995.3
ENST00000370001.3
AKNAD1
AKNA domain containing 1
chr17_-_39093672 0.26 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_190927447 0.26 ENST00000260950.4
MSTN
myostatin
chr15_+_91416092 0.26 ENST00000559353.1
FURIN
furin (paired basic amino acid cleaving enzyme)
chr15_+_90735145 0.26 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr15_-_55562479 0.26 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chrM_+_7586 0.26 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr1_-_9953295 0.26 ENST00000377258.1
CTNNBIP1
catenin, beta interacting protein 1
chr8_-_109799793 0.25 ENST00000297459.3
TMEM74
transmembrane protein 74
chr20_-_50418947 0.25 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr2_-_145278475 0.25 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr14_-_73360796 0.25 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr12_+_26348246 0.25 ENST00000422622.2
SSPN
sarcospan
chrX_-_19817869 0.25 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr4_+_71458012 0.25 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr12_-_16760021 0.25 ENST00000540445.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_+_35484793 0.25 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr11_-_115375107 0.25 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr10_-_10504285 0.24 ENST00000602311.1
RP11-271F18.4
RP11-271F18.4
chr4_+_183065793 0.24 ENST00000512480.1
TENM3
teneurin transmembrane protein 3
chr19_+_48949030 0.24 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr11_-_115158193 0.24 ENST00000543540.1
CADM1
cell adhesion molecule 1
chr5_-_141249154 0.24 ENST00000357517.5
ENST00000536585.1
PCDH1
protocadherin 1
chr6_+_135502501 0.24 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr19_-_7968427 0.24 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr19_+_48949087 0.24 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr14_-_95236551 0.24 ENST00000238558.3
GSC
goosecoid homeobox
chr4_+_26324474 0.24 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr8_-_116673894 0.23 ENST00000395713.2
TRPS1
trichorhinophalangeal syndrome I
chr20_-_56285595 0.23 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chrX_+_135251835 0.23 ENST00000456445.1
FHL1
four and a half LIM domains 1
chr4_-_120243545 0.23 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr2_+_171034646 0.23 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr18_+_61445205 0.23 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr20_-_50419055 0.23 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr15_+_48483736 0.23 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr9_-_75488984 0.22 ENST00000423171.1
ENST00000449235.1
ENST00000453787.1
RP11-151D14.1
RP11-151D14.1
chr2_-_61697862 0.22 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr4_+_74301880 0.22 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr16_+_24741013 0.22 ENST00000315183.7
ENST00000395799.3
TNRC6A
trinucleotide repeat containing 6A
chr1_-_68698222 0.22 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr12_+_93096619 0.22 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chrX_+_68835911 0.22 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr8_-_10512569 0.22 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr6_-_5261141 0.22 ENST00000330636.4
ENST00000500576.2
LYRM4
LYR motif containing 4
chr7_+_73442102 0.21 ENST00000445912.1
ENST00000252034.7
ELN
elastin
chr7_-_78400598 0.21 ENST00000536571.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_-_140223614 0.21 ENST00000394223.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr1_+_214161272 0.21 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr2_-_87248975 0.21 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr1_+_28527070 0.21 ENST00000596102.1
AL353354.2
AL353354.2
chr10_+_4828815 0.21 ENST00000533295.1
AKR1E2
aldo-keto reductase family 1, member E2
chr18_-_47792851 0.20 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chr21_+_33671160 0.20 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr2_+_145780725 0.20 ENST00000451478.1
TEX41
testis expressed 41 (non-protein coding)
chr20_+_60174827 0.20 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr2_+_101437487 0.20 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chrX_-_21676442 0.20 ENST00000379499.2
KLHL34
kelch-like family member 34
chr4_-_140223670 0.20 ENST00000394228.1
ENST00000539387.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr2_-_224467002 0.20 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr4_-_44653636 0.20 ENST00000415895.4
ENST00000332990.5
YIPF7
Yip1 domain family, member 7
chr11_+_110001723 0.20 ENST00000528673.1
ZC3H12C
zinc finger CCCH-type containing 12C
chr2_+_149402989 0.20 ENST00000397424.2
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr4_-_74486217 0.19 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chrX_-_19688475 0.19 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr3_-_157221128 0.19 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr5_+_61874696 0.19 ENST00000491184.2
LRRC70
leucine rich repeat containing 70
chr11_-_62313090 0.19 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr6_-_66417107 0.19 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr8_-_49834299 0.19 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr13_-_103719196 0.19 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr1_+_214161854 0.19 ENST00000435016.1
PROX1
prospero homeobox 1
chr18_+_21572737 0.19 ENST00000304621.6
TTC39C
tetratricopeptide repeat domain 39C
chr14_+_62462541 0.18 ENST00000430451.2
SYT16
synaptotagmin XVI
chr3_-_157221380 0.18 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_39760129 0.18 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr21_+_17443434 0.18 ENST00000400178.2
LINC00478
long intergenic non-protein coding RNA 478
chr8_-_74495065 0.18 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr17_-_48133054 0.18 ENST00000499842.1
RP11-1094H24.4
RP11-1094H24.4
chr2_+_210444298 0.18 ENST00000445941.1
MAP2
microtubule-associated protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.3 1.0 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.3 2.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 0.8 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 0.6 GO:0032904 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.2 1.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.2 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.4 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.1 1.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.5 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.4 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 1.8 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.6 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.3 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 1.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.3 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.3 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.8 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.6 GO:0050955 thermoception(GO:0050955)
0.1 0.2 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.2 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.3 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.5 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.1 0.9 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.1 0.2 GO:0039020 pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric nephron tubule development(GO:0039020) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121)
0.1 0.3 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 0.3 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 1.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0015855 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.6 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.2 GO:0001834 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.2 GO:0060489 dichotomous subdivision of terminal units involved in lung branching(GO:0060448) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.3 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.3 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 1.7 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 1.9 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.5 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.2 GO:1901295 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) blood vessel endothelial cell fate specification(GO:0097101) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
0.0 0.1 GO:2000426 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.4 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.2 GO:1904879 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.5 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.1 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0006196 AMP catabolic process(GO:0006196)
0.0 0.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.5 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 1.9 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.6 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.0 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.2 GO:0014029 neural crest formation(GO:0014029)
0.0 0.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.5 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.6 GO:0046039 GTP metabolic process(GO:0046039)
0.0 0.0 GO:1905069 allantois development(GO:1905069)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.0 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.3 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.2 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 2.3 GO:0001889 liver development(GO:0001889)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.1 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.3 GO:0036117 hyaluranon cable(GO:0036117)
0.1 0.3 GO:0043257 laminin-8 complex(GO:0043257)
0.0 1.1 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 1.0 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838)
0.0 0.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0032010 phagolysosome(GO:0032010)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.4 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.6 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.6 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.5 GO:0031013 troponin I binding(GO:0031013)
0.1 0.2 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.1 0.2 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.1 0.2 GO:0015265 pyrimidine nucleobase transmembrane transporter activity(GO:0005350) glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.8 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.0 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 1.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation