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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for PITX2

Z-value: 0.68

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544207_1115442400.946.3e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_46661575 0.33 ENST00000450697.1
TDRD6
tudor domain containing 6
chr17_+_4643337 0.30 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr17_-_4643161 0.29 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr22_-_30234218 0.29 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2
activating signal cointegrator 1 complex subunit 2
chr17_+_4643300 0.27 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr9_-_110251836 0.17 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr8_-_42360015 0.16 ENST00000522707.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr6_-_33297013 0.16 ENST00000453407.1
DAXX
death-domain associated protein
chr12_+_6949964 0.15 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr18_-_47017956 0.14 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr6_-_41673552 0.14 ENST00000419574.1
ENST00000445214.1
TFEB
transcription factor EB
chr9_-_127358087 0.14 ENST00000475178.1
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr19_+_48325097 0.13 ENST00000221996.7
ENST00000539067.1
CRX
cone-rod homeobox
chr7_+_73868439 0.13 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr19_+_2476116 0.12 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr17_-_46657473 0.12 ENST00000332503.5
HOXB4
homeobox B4
chr8_-_27462822 0.12 ENST00000522098.1
CLU
clusterin
chr17_-_4643114 0.12 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr9_-_131486367 0.11 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr7_+_73868220 0.11 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr2_-_121223697 0.11 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr9_-_8857776 0.11 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr16_+_28722684 0.10 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr1_+_201979645 0.10 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr6_-_53013620 0.09 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr9_+_34458851 0.09 ENST00000545019.1
DNAI1
dynein, axonemal, intermediate chain 1
chr13_+_73632897 0.09 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr3_+_139062838 0.08 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr16_-_15736345 0.08 ENST00000549219.1
KIAA0430
KIAA0430
chrX_-_21676442 0.07 ENST00000379499.2
KLHL34
kelch-like family member 34
chr3_-_69249863 0.07 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr9_-_95166841 0.07 ENST00000262551.4
OGN
osteoglycin
chrX_-_54384425 0.06 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr3_-_50388522 0.06 ENST00000232501.3
NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr8_+_123875624 0.06 ENST00000534247.1
ZHX2
zinc fingers and homeoboxes 2
chrX_-_6146876 0.06 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr3_+_158787041 0.05 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr11_-_36619771 0.05 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr2_+_3622893 0.05 ENST00000407445.3
ENST00000403564.1
RPS7
ribosomal protein S7
chr11_+_61522844 0.05 ENST00000265460.5
MYRF
myelin regulatory factor
chrM_+_9207 0.05 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr19_-_19314162 0.05 ENST00000420605.3
ENST00000544883.1
ENST00000538165.2
ENST00000331552.7
NR2C2AP
nuclear receptor 2C2-associated protein
chr17_-_40021656 0.04 ENST00000319121.3
KLHL11
kelch-like family member 11
chr22_-_39096661 0.04 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr6_+_35310312 0.04 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr17_-_10633535 0.04 ENST00000341871.3
TMEM220
transmembrane protein 220
chr3_-_49837254 0.03 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
CDHR4
cadherin-related family member 4
chr1_-_98515395 0.02 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr4_+_146560245 0.01 ENST00000541599.1
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr13_-_95131923 0.01 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr10_+_103986085 0.01 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr6_+_35310391 0.01 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr19_-_46142362 0.01 ENST00000586770.1
ENST00000591721.1
EML2
echinoderm microtubule associated protein like 2
chr10_-_49482907 0.01 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr17_+_79495397 0.00 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.1 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.3 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.1 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)