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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for PRDM14

Z-value: 0.49

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_709835620.001.0e+00Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_34250861 0.57 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr14_+_21492331 0.34 ENST00000533984.1
ENST00000532213.2
AL161668.5
AL161668.5
chr3_-_134092561 0.34 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2
angiomotin like 2
chr15_+_63188009 0.31 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr9_+_132597722 0.25 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
USP20
ubiquitin specific peptidase 20
chr11_-_65625014 0.22 ENST00000534784.1
CFL1
cofilin 1 (non-muscle)
chr1_+_155006300 0.20 ENST00000295542.1
ENST00000392480.1
ENST00000423025.2
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr5_-_55777586 0.19 ENST00000506836.1
CTC-236F12.4
Uncharacterized protein
chr1_+_39796810 0.16 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr17_+_75450075 0.16 ENST00000592951.1
SEPT9
septin 9
chr12_-_124456598 0.15 ENST00000539761.1
ENST00000539551.1
CCDC92
coiled-coil domain containing 92
chr1_+_27114589 0.15 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr1_-_155006254 0.14 ENST00000295536.5
DCST2
DC-STAMP domain containing 2
chr1_+_36621529 0.14 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr2_-_208030295 0.14 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_+_49760639 0.14 ENST00000549538.1
ENST00000548654.1
ENST00000550643.1
ENST00000548710.1
ENST00000549179.1
ENST00000548377.1
SPATS2
spermatogenesis associated, serine-rich 2
chr19_+_49838653 0.14 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr19_-_6279932 0.14 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr5_+_32710736 0.13 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_+_36621174 0.13 ENST00000429533.2
MAP7D1
MAP7 domain containing 1
chr19_+_39109735 0.13 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr3_-_114477962 0.12 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_49351228 0.12 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr17_+_36873677 0.11 ENST00000471200.1
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr12_-_49351148 0.11 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr17_-_17485731 0.11 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr11_-_46615498 0.10 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr15_+_45694567 0.10 ENST00000559860.1
SPATA5L1
spermatogenesis associated 5-like 1
chr7_-_139763521 0.09 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr17_-_17726907 0.08 ENST00000423161.3
SREBF1
sterol regulatory element binding transcription factor 1
chr17_-_46692457 0.08 ENST00000468443.1
HOXB8
homeobox B8
chr11_-_65624415 0.08 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr1_-_155006224 0.07 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr17_-_73775839 0.07 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3F3B
H3 histone, family 3B (H3.3B)
chr21_+_26934165 0.07 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr17_-_46691990 0.07 ENST00000576562.1
HOXB8
homeobox B8
chr17_-_19651668 0.07 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr1_+_109102652 0.07 ENST00000370035.3
ENST00000405454.1
FAM102B
family with sequence similarity 102, member B
chr19_-_53757941 0.06 ENST00000594517.1
ENST00000601413.1
ENST00000594681.1
ZNF677
zinc finger protein 677
chr17_-_19651654 0.06 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr12_-_49351303 0.06 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr3_-_47517302 0.06 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr6_+_43140095 0.05 ENST00000457278.2
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_-_192711968 0.05 ENST00000304141.4
SDPR
serum deprivation response
chr1_+_27668505 0.05 ENST00000318074.5
SYTL1
synaptotagmin-like 1
chr17_+_75450146 0.05 ENST00000585929.1
ENST00000590917.1
SEPT9
septin 9
chr18_+_57567180 0.05 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chrX_+_51636629 0.05 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr12_+_121647962 0.05 ENST00000542067.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr16_-_55866997 0.04 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr12_+_121647868 0.04 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr5_-_24645078 0.04 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr14_-_21492113 0.04 ENST00000554094.1
NDRG2
NDRG family member 2
chr11_+_64879317 0.03 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr10_+_12171636 0.03 ENST00000379051.1
ENST00000379033.3
ENST00000441368.1
ENST00000298428.9
ENST00000304267.8
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae)
chr1_+_27114418 0.03 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chrX_+_41193407 0.03 ENST00000457138.2
ENST00000441189.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr3_+_10289707 0.03 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr17_+_75450099 0.03 ENST00000586433.1
SEPT9
septin 9
chr11_+_85566422 0.03 ENST00000342404.3
CCDC83
coiled-coil domain containing 83
chr6_+_133561725 0.02 ENST00000452339.2
EYA4
eyes absent homolog 4 (Drosophila)
chr1_+_153963227 0.02 ENST00000368567.4
ENST00000392558.4
RPS27
ribosomal protein S27
chr12_-_56326402 0.02 ENST00000547925.1
WIBG
within bgcn homolog (Drosophila)
chr6_-_109777128 0.01 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr7_+_39989611 0.01 ENST00000181839.4
CDK13
cyclin-dependent kinase 13
chr15_+_69850521 0.01 ENST00000558781.1
RP11-279F6.1
RP11-279F6.1
chr19_+_3572758 0.00 ENST00000416526.1
HMG20B
high mobility group 20B
chr17_-_2117600 0.00 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0051511 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0060532 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.0 0.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.0 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.0 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.1 GO:0010736 serum response element binding(GO:0010736)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.